Tomm40 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tomm40
Entrez Gene ID	53333
Full Name	translocase of outer mitochondrial membrane 40 homolog (yeast)
Synonyms	AW539759,Mom35,Tom40
General protein information	Preferred Names translocase of outer mitochondrial membrane 40 homolog (yeast) Names mitochondrial import receptor subunit TOM40 homolog haymaker protein mitochondrial outer membrane protein 35 mitochondrial outer membrane protein of 35 kDa translocase of outer membrane 40 kDa subunit homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_016871.2	NP_058567.2	mitochondrial import receptor subunit TOM40 homolog
NM_001109748.1	NP_001103218.1	mitochondrial import receptor subunit TOM40 homolog
XM_030242769.1	XP_030098629.1	mitochondrial import receptor subunit TOM40 homolog isoform X1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	tomboy40	NP_610213.1
Saccharomyces cerevisiae (baker's yeast)	TOM40	NP_013930.1
	TOMM40	XP_001109661.1
Drosophila melanogaster (fruit fly)	Tom40	NP_001259313.1
Caenorhabditis elegans (roundworm)	tomm-40	NP_495912.1
Kluyveromyces lactis	KLLA0F06292g	XP_455365.1
Eremothecium gossypii	AGOS_AFL183C	NP_985367.1
Xenopus tropicalis (tropical clawed frog)	tomm40	NP_989125.1
Homo sapiens (human)	TOMM40	NP_006105.1
Bos taurus (cattle)	TOMM40	NP_001068906.1
Rattus norvegicus (Norway rat)	Tomm40	NP_997685.1
Danio rerio (zebrafish)	tomm40	NP_955908.1
Schizosaccharomyces pombe (fission yeast)	tom40	NP_595546.2
Arabidopsis thaliana (thale cress)	AT1G50400	NP_175457.1
Canis lupus familiaris (dog)	TOMM40	XP_852633.1
Magnaporthe oryzae (rice blast fungus)	MGG_08637	XP_003711067.1
Neurospora crassa	NCU01179	XP_961545.1
Mus musculus (house mouse)	Tomm40	NP_001103218.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007871	XP_317621.2

Gene Ontology
Bibliography

Related articles in PubMed

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria.
Hilander T, Zhou XL, Konovalova S, Zhang FP, Euro L, Chilov D, Poutanen M, Chihade J, Wang ED, Tyynismaa H
Nucleic acids research(2017 Dec)

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics13(4)e1006656(2017 Apr)

Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Ishihara T, Ban-Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, Aoki H, Katada S, Nakada K, Nomura M, Mizushima N, Mihara K, Ishihara N
Molecular and cellular biology35(1)211-23(2015 Jan)

TOM40 mediates mitochondrial dysfunction induced by ?-synuclein accumulation in Parkinson's disease.
Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E
PloS one8(4)e62277(2013)

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K
Nature cell biology11(8)958-66(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.
Title: TOM40 mediates mitochondrial dysfunction induced by ?-synuclein accumulation in Parkinson's disease.

imported into the outer mitochondrial membrane
Title: Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40.

The following Tomm40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tomm40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13027	NM_001109748.1 Latest version!	Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu13027	NM_016871.2 Latest version!	Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu89563	XM_030242769.1 Latest version!	Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tomm40 ( NM_016871.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058567.2 Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13027
Clone ID Related Accession (Same CDS sequence)	NM_016871.2 , NM_001109748.1
Accession Version	NM_016871.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	mitochondrial import receptor subunit TOM40 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY231811.1, AK165173.1 and AW493492.1. On Oct 5, 2007 this sequence version replaced NM_016871.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK164570.1, AK170991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGGGAACG TGTTGGCTGC CAGCTCTCCG CCCGCAGGGC CACCGCCGCC TCCTACGCCG 
TCCCTCGTGG GGCTCCCGCC GCCGCCTCCT TCGCCGCCAG GCTTCACTCT GCCGCCGCTC 
GGCGGCGGCC TGGGCACTGG GTCAAGCACT GGCCGTGGTT CGGAACGGAC TCCCGGGGCT 
GCGGCCAGCG GCGCTGCGGC GGCCTCGGAA GATGGGAGCT GCGGATGCCT GCCCAACCCG 
GGGACGTTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCAGTTCA GATGGAAGGT 
GTCAAACTTA CAGTCAACAA AGGGTTGAGC AACCGTTTCC AGGTGACCCA CACAGTAGCC 
CTCGGCACAA TTGGGGAGTC CAACTACCAC TTTGGGGTCA CATACGTGGG GACGAAGCAG 
CTGAGTCCCA CAGAGGCGTT CCCCGTGCTG GTGGGTGACA TGGACAATAG TGGCAGCCTC 
AATGCACAGG TCATCCACCA GCTGAGCCCA GGCCTCAGGT CCAAAATGGC CATCCAGACC 
CAGCAGTCCA AGTTCGTGAA CTGGCAGGTG GATGGCGAGT ACCGTGGTTC TGACTTCACA 
GCTGCTGTCA CCCTGGGCAA CCCAGATGTC TTGGTGGGTT CAGGAATCCT CGTGGCCCAC 
TACCTCCAGA GCATCACACC GTGTCTGGCC CTGGGTGGAG AGCTCGTCTA CCACCGGCGG 
CCAGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACACTGAA CAACTGGTTG 
GCTACAGTAA CGCTGGGCCA GGCAGGCATG CATGCGACGT ATTACCACAA AGCCAGTGAC 
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACCAGGA TGCAGGACAC CAGTGCCTCC 
TTTGGGTATC AGCTGGACCT GCCCAAGGCC AACTTCCTTT TTAAAGGCTC TGTGAACAGT 
AACTGGATCG TGGGCGCCAC GCTGGAGAAG AAGCTTCCGC CCTTGCCCCT GACACTGTCC 
CTCTGCGCCT TCCTGAACCA CCGCAAGAAT AAGTTCCTGT GTGGCTTCGG CCTCACCATC 
GGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058567.2
CDS	78..1163
Translation	MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSSTGRGSERTPGAAASGAAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG

Target ORF information:

RefSeq Version	NM_016871.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016871.2

ORF Insert Sequence:

ATGGGGAACG TGTTGGCTGC CAGCTCTCCG CCCGCAGGGC CACCGCCGCC TCCTACGCCG 
TCCCTCGTGG GGCTCCCGCC GCCGCCTCCT TCGCCGCCAG GCTTCACTCT GCCGCCGCTC 
GGCGGCGGCC TGGGCACTGG GTCAAGCACT GGCCGTGGTT CGGAACGGAC TCCCGGGGCT 
GCGGCCAGCG GCGCTGCGGC GGCCTCGGAA GATGGGAGCT GCGGATGCCT GCCCAACCCG 
GGGACGTTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCAGTTCA GATGGAAGGT 
GTCAAACTTA CAGTCAACAA AGGGTTGAGC AACCGTTTCC AGGTGACCCA CACAGTAGCC 
CTCGGCACAA TTGGGGAGTC CAACTACCAC TTTGGGGTCA CATACGTGGG GACGAAGCAG 
CTGAGTCCCA CAGAGGCGTT CCCCGTGCTG GTGGGTGACA TGGACAATAG TGGCAGCCTC 
AATGCACAGG TCATCCACCA GCTGAGCCCA GGCCTCAGGT CCAAAATGGC CATCCAGACC 
CAGCAGTCCA AGTTCGTGAA CTGGCAGGTG GATGGCGAGT ACCGTGGTTC TGACTTCACA 
GCTGCTGTCA CCCTGGGCAA CCCAGATGTC TTGGTGGGTT CAGGAATCCT CGTGGCCCAC 
TACCTCCAGA GCATCACACC GTGTCTGGCC CTGGGTGGAG AGCTCGTCTA CCACCGGCGG 
CCAGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACACTGAA CAACTGGTTG 
GCTACAGTAA CGCTGGGCCA GGCAGGCATG CATGCGACGT ATTACCACAA AGCCAGTGAC 
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACCAGGA TGCAGGACAC CAGTGCCTCC 
TTTGGGTATC AGCTGGACCT GCCCAAGGCC AACTTCCTTT TTAAAGGCTC TGTGAACAGT 
AACTGGATCG TGGGCGCCAC GCTGGAGAAG AAGCTTCCGC CCTTGCCCCT GACACTGTCC 
CTCTGCGCCT TCCTGAACCA CCGCAAGAAT AAGTTCCTGT GTGGCTTCGG CCTCACCATC 
GGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tomm40 ( NM_001109748.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103218.1 Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13027
Clone ID Related Accession (Same CDS sequence)	NM_016871.2 , NM_001109748.1
Accession Version	NM_001109748.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	mitochondrial import receptor subunit TOM40 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY231811.1, AK165173.1, AK150019.1 and AW493492.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150019.1, AF316403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGGGAACG TGTTGGCTGC CAGCTCTCCG CCCGCAGGGC CACCGCCGCC TCCTACGCCG 
TCCCTCGTGG GGCTCCCGCC GCCGCCTCCT TCGCCGCCAG GCTTCACTCT GCCGCCGCTC 
GGCGGCGGCC TGGGCACTGG GTCAAGCACT GGCCGTGGTT CGGAACGGAC TCCCGGGGCT 
GCGGCCAGCG GCGCTGCGGC GGCCTCGGAA GATGGGAGCT GCGGATGCCT GCCCAACCCG 
GGGACGTTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCAGTTCA GATGGAAGGT 
GTCAAACTTA CAGTCAACAA AGGGTTGAGC AACCGTTTCC AGGTGACCCA CACAGTAGCC 
CTCGGCACAA TTGGGGAGTC CAACTACCAC TTTGGGGTCA CATACGTGGG GACGAAGCAG 
CTGAGTCCCA CAGAGGCGTT CCCCGTGCTG GTGGGTGACA TGGACAATAG TGGCAGCCTC 
AATGCACAGG TCATCCACCA GCTGAGCCCA GGCCTCAGGT CCAAAATGGC CATCCAGACC 
CAGCAGTCCA AGTTCGTGAA CTGGCAGGTG GATGGCGAGT ACCGTGGTTC TGACTTCACA 
GCTGCTGTCA CCCTGGGCAA CCCAGATGTC TTGGTGGGTT CAGGAATCCT CGTGGCCCAC 
TACCTCCAGA GCATCACACC GTGTCTGGCC CTGGGTGGAG AGCTCGTCTA CCACCGGCGG 
CCAGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACACTGAA CAACTGGTTG 
GCTACAGTAA CGCTGGGCCA GGCAGGCATG CATGCGACGT ATTACCACAA AGCCAGTGAC 
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACCAGGA TGCAGGACAC CAGTGCCTCC 
TTTGGGTATC AGCTGGACCT GCCCAAGGCC AACTTCCTTT TTAAAGGCTC TGTGAACAGT 
AACTGGATCG TGGGCGCCAC GCTGGAGAAG AAGCTTCCGC CCTTGCCCCT GACACTGTCC 
CTCTGCGCCT TCCTGAACCA CCGCAAGAAT AAGTTCCTGT GTGGCTTCGG CCTCACCATC 
GGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103218.1
CDS	176..1261
Translation	MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSSTGRGSERTPGAAASGAAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG

Target ORF information:

RefSeq Version	NM_001109748.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109748.1

ORF Insert Sequence:

ATGGGGAACG TGTTGGCTGC CAGCTCTCCG CCCGCAGGGC CACCGCCGCC TCCTACGCCG 
TCCCTCGTGG GGCTCCCGCC GCCGCCTCCT TCGCCGCCAG GCTTCACTCT GCCGCCGCTC 
GGCGGCGGCC TGGGCACTGG GTCAAGCACT GGCCGTGGTT CGGAACGGAC TCCCGGGGCT 
GCGGCCAGCG GCGCTGCGGC GGCCTCGGAA GATGGGAGCT GCGGATGCCT GCCCAACCCG 
GGGACGTTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCAGTTCA GATGGAAGGT 
GTCAAACTTA CAGTCAACAA AGGGTTGAGC AACCGTTTCC AGGTGACCCA CACAGTAGCC 
CTCGGCACAA TTGGGGAGTC CAACTACCAC TTTGGGGTCA CATACGTGGG GACGAAGCAG 
CTGAGTCCCA CAGAGGCGTT CCCCGTGCTG GTGGGTGACA TGGACAATAG TGGCAGCCTC 
AATGCACAGG TCATCCACCA GCTGAGCCCA GGCCTCAGGT CCAAAATGGC CATCCAGACC 
CAGCAGTCCA AGTTCGTGAA CTGGCAGGTG GATGGCGAGT ACCGTGGTTC TGACTTCACA 
GCTGCTGTCA CCCTGGGCAA CCCAGATGTC TTGGTGGGTT CAGGAATCCT CGTGGCCCAC 
TACCTCCAGA GCATCACACC GTGTCTGGCC CTGGGTGGAG AGCTCGTCTA CCACCGGCGG 
CCAGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACACTGAA CAACTGGTTG 
GCTACAGTAA CGCTGGGCCA GGCAGGCATG CATGCGACGT ATTACCACAA AGCCAGTGAC 
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACCAGGA TGCAGGACAC CAGTGCCTCC 
TTTGGGTATC AGCTGGACCT GCCCAAGGCC AACTTCCTTT TTAAAGGCTC TGTGAACAGT 
AACTGGATCG TGGGCGCCAC GCTGGAGAAG AAGCTTCCGC CCTTGCCCCT GACACTGTCC 
CTCTGCGCCT TCCTGAACCA CCGCAAGAAT AAGTTCCTGT GTGGCTTCGG CCTCACCATC 
GGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tomm40 ( XM_030242769.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030098629.1 Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu89563
Clone ID Related Accession (Same CDS sequence)	XM_030242769.1
Accession Version	XM_030242769.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	mitochondrial import receptor subunit TOM40 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACAATA GTGGCAGCCT CAATGCACAG GTCATCCACC AGCTGAGCCC AGGCCTCAGG 
TCCAAAATGG CCATCCAGAC CCAGCAGTCC AAGTTCGTGA ACTGGCAGGT GGATGGCGAG 
TACCGTGGTT CTGACTTCAC AGCTGCTGTC ACCCTGGGCA ACCCAGATGT CTTGGTGGGT 
TCAGGAATCC TCGTGGCCCA CTACCTCCAG AGCATCACAC CGTGTCTGGC CCTGGGTGGA 
GAGCTCGTCT ACCACCGGCG GCCAGGAGAG GAGGGCACTG TCATGTCTCT AGCTGGGAAA 
TACACACTGA ACAACTGGTT GGCTACAGTA ACGCTGGGCC AGGCAGGCAT GCATGCGACG 
TATTACCACA AAGCCAGTGA CCAGCTGCAG GTGGGTGTGG AGTTTGAGGC CAGCACCAGG 
ATGCAGGACA CCAGTGCCTC CTTTGGGTAT CAGCTGGACC TGCCCAAGGC CAACTTCCTT 
TTTAAAGGCT CTGTGAACAG TAACTGGATC GTGGGCGCCA CGCTGGAGAA GAAGCTTCCG 
CCCTTGCCCC TGACACTGTC CCTCTGCGCC TTCCTGAACC ACCGCAAGAA TAAGTTCCTG 
TGTGGCTTCG GCCTCACCAT CGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030098629.1
CDS	695..1321
Translation	MDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG

Target ORF information:

RefSeq Version	XM_030242769.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus translocase of outer mitochondrial membrane 40 (Tomm40), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242769.1

ORF Insert Sequence:

ATGGACAATA GTGGCAGCCT CAATGCACAG GTCATCCACC AGCTGAGCCC AGGCCTCAGG 
TCCAAAATGG CCATCCAGAC CCAGCAGTCC AAGTTCGTGA ACTGGCAGGT GGATGGCGAG 
TACCGTGGTT CTGACTTCAC AGCTGCTGTC ACCCTGGGCA ACCCAGATGT CTTGGTGGGT 
TCAGGAATCC TCGTGGCCCA CTACCTCCAG AGCATCACAC CGTGTCTGGC CCTGGGTGGA 
GAGCTCGTCT ACCACCGGCG GCCAGGAGAG GAGGGCACTG TCATGTCTCT AGCTGGGAAA 
TACACACTGA ACAACTGGTT GGCTACAGTA ACGCTGGGCC AGGCAGGCAT GCATGCGACG 
TATTACCACA AAGCCAGTGA CCAGCTGCAG GTGGGTGTGG AGTTTGAGGC CAGCACCAGG 
ATGCAGGACA CCAGTGCCTC CTTTGGGTAT CAGCTGGACC TGCCCAAGGC CAACTTCCTT 
TTTAAAGGCT CTGTGAACAG TAACTGGATC GTGGGCGCCA CGCTGGAGAA GAAGCTTCCG 
CCCTTGCCCC TGACACTGTC CCTCTGCGCC TTCCTGAACC ACCGCAAGAA TAAGTTCCTG 
TGTGGCTTCG GCCTCACCAT CGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria.
Nucleic acids research(2017 Dec)
Hilander T,Zhou XL,Konovalova S,Zhang FP,Euro L,Chilov D,Poutanen M,Chihade J,Wang ED,Tyynismaa H

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
PLoS genetics13(4)e1006656(2017 Apr)
Terzenidou ME,Segklia A,Kano T,Papastefanaki F,Karakostas A,Charalambous M,Ioakeimidis F,Papadaki M,Kloukina I,Chrysanthou-Piterou M,Samiotaki M,Panayotou G,Matsas R,Douni E

Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Molecular and cellular biology35(1)211-23(2015 Jan)
Ishihara T,Ban-Ishihara R,Maeda M,Matsunaga Y,Ichimura A,Kyogoku S,Aoki H,Katada S,Nakada K,Nomura M,Mizushima N,Mihara K,Ishihara N

TOM40 mediates mitochondrial dysfunction induced by ?-synuclein accumulation in Parkinson's disease.
PloS one8(4)e62277(2013)
Bender A,Desplats P,Spencer B,Rockenstein E,Adame A,Elstner M,Laub C,Mueller S,Koob AO,Mante M,Pham E,Klopstock T,Masliah E

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.
Nature cell biology11(8)958-66(2009 Aug)
Ishihara N,Nomura M,Jofuku A,Kato H,Suzuki SO,Masuda K,Otera H,Nakanishi Y,Nonaka I,Goto Y,Taguchi N,Morinaga H,Maeda M,Takayanagi R,Yokota S,Mihara K

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Tomm40 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報