Nptx2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nptx2
Entrez Gene ID	53324
Full Name	neuronal pentraxin 2
Synonyms	Narp,np2
General protein information	Preferred Names neuronal pentraxin 2 Names neuronal pentraxin-2 NP-II neuro activity regulated petaxin neuronal pentraxin II
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 G2\|5 84.58 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_016789.3	NP_058069.1	neuronal pentraxin-2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	NPTX2	NP_002514.1
Bos taurus (cattle)	NPTX2	XP_002698264.1
	NPTX2	XP_001111081.2
Rattus norvegicus (Norway rat)	Nptx2	NP_001029371.1
Gallus gallus (chicken)	NPTX2	XP_414750.3
Mus musculus (house mouse)	Nptx2	NP_058069.1
Danio rerio (zebrafish)	nptx2a	NP_001103238.1
Danio rerio (zebrafish)	nptx2b	NP_001165055.1
Pan troglodytes (chimpanzee)	NPTX2	XP_001136152.2
Canis lupus familiaris (dog)	NPTX2	XP_003639131.1
Xenopus tropicalis (tropical clawed frog)	nptx2	NP_001096304.1

Gene Ontology
Bibliography

Related articles in PubMed

Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.
Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, Hempstead BL, Martinowich K, Ann Wilson M, Baraban JM, Reti IM
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology(2017 Oct)

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
Muczynski V, Aym? G, Regnault V, Vasse M, Borgel D, Legendre P, Bazaa A, Harel A, Loubi?re C, Lenting PJ, Denis CV, Christophe OD
Blood129(17)2443-2454(2017 04)

NPTX2 and cognitive dysfunction in Alzheimer's Disease.
Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF
eLife6(2017 Mar)

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ
Neuron85(6)1257-72(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
Title: Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.

Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
Title: Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.

Nptx2 contributes to the development of L-DOPA-induced dyskinesia.
Title: Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.

These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.
Title: Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury.

Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.
Title: Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.

The following Nptx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nptx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22625	NM_016789.3 Latest version!	Mus musculus neuronal pentraxin 2 (Nptx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nptx2 ( NM_016789.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058069.1 Mus musculus neuronal pentraxin 2 (Nptx2), mRNA.

Price & Availability↑

CloneID	OMu22625
Clone ID Related Accession (Same CDS sequence)	NM_016789.3
Accession Version	NM_016789.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	neuronal pentraxin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK134806.1, DV649643.1 and AC164119.4. On Mar 19, 2008 this sequence version replaced NM_016789.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026054.1, AK134806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGCGC TGCTGACCGT CGGCGTGGCG CTCGCCGTGG CCGCCGGACG AGCCCAGGAC 
AGCCCGATAC CTGGCAGCCG CTTCGTGTGC ACCGCGTTGC CCCCCGAAGC GGCGCGCGCC 
GGCTGCCCGC TGCCCGCGAT GCCCATGCAG GGAGGCGCTC TGAGCCCCGA GGAGGAGCTG 
CGAGCCGCTG TGCTGCAGCT GCGCGAGACC GTCGTGCAGC AGAAGGAGAC GCTGGGCGCC 
CAGCGAGAAG CCATCCGAGA GCTCACCGGC AAGCTGGCCC GCTGCGAGGG GCTGGCGGGC 
GGCAAGGCGC GCGGCACAGG CAAGGACACC ATGGGCGACC TGCCGCGGGA CCCGGGCCAC 
GTCGTGGAGC AGCTTAGCCG CTCCTTGCAA ACCCTCAAGG ACCGCTTGGA GAGCCTCGAG 
CTCCAGCTCC GCACAAATGT GTCTAACGCT GGGCTGCCGA GCGACTTCCG AGAGGTGCTC 
CAGCGGAGGC TCGGGGAGCT GGAGAGGCAG TTGCTACGCA AGGTGGCGGA GCTGGAAGAT 
GAGAAGTCCC TGCTTCATAA TGAGACCTCG GCTCACCGGC AGAAGACAGA GAGCACGCTG 
AACGCCCTGC TGCAGAGGGT GACTGAGCTG GAGCGAGGCA ACAGTGCATT CAAGTCACCA 
GATGCATTCA AAGTGTCCCT TCCTCTCCGT ACAAACTACC TGTATGGCAA GATCAAGAAG 
ACATTGCCTG AGCTGTACGC CTTTACCATC TGCCTGTGGC TGCGGTCCAG TGCCTCGCCA 
GGCATCGGTA CGCCATTCTC CTACGCTGTG CCCGGGCAAG CCAACGAGAT TGTGCTGATA 
GAGTGGGGCA ATAACCCCAT TGAGCTGCTC ATCAACGACA AGGTCGCACA GCTGCCGCTG 
TTTGTCAGTG ATGGCAAGTG GCACCACATC TGCATCACCT GGACCACTCG AGACGGCATG 
TGGGAAGCGT TCCAGGATGG GGAGAAGCTG GGCACTGGGG AAAACCTGGC ACCCTGGCAC 
CCCATTAAGC CAGGGGGCGT GCTCATCCTG GGGCAGGAGC AGGACACGGT GGGAGGCAGA 
TTTGATGCCA CGCAGGCCTT TGTTGGAGAG CTCAGCCAGT TCAACATATG GGACCGCGTC 
CTCCGGGCGC AGGAGATCAT CAACATCGCC AACTGCTCCA CGAACATGCC CGGCAACATC 
ATCCCGTGGG TGGACAACAA TGTCGATGTG TTCGGCGGGG CTTCCAAGTG GCCTGTGGAG 
ACCTGTGAAG AGCGGCTCCT GGACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058069.1
CDS	178..1467
Translation	MLALLTVGVALAVAAGRAQDSPIPGSRFVCTALPPEAARAGCPLPAMPMQGGALSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGTGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLELQLRTNVSNAGLPSDFREVLQRRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL

Target ORF information:

RefSeq Version	NM_016789.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuronal pentraxin 2 (Nptx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016789.3

ORF Insert Sequence:

ATGCTGGCGC TGCTGACCGT CGGCGTGGCG CTCGCCGTGG CCGCCGGACG AGCCCAGGAC 
AGCCCGATAC CTGGCAGCCG CTTCGTGTGC ACCGCGTTGC CCCCCGAAGC GGCGCGCGCC 
GGCTGCCCGC TGCCCGCGAT GCCCATGCAG GGAGGCGCTC TGAGCCCCGA GGAGGAGCTG 
CGAGCCGCTG TGCTGCAGCT GCGCGAGACC GTCGTGCAGC AGAAGGAGAC GCTGGGCGCC 
CAGCGAGAAG CCATCCGAGA GCTCACCGGC AAGCTGGCCC GCTGCGAGGG GCTGGCGGGC 
GGCAAGGCGC GCGGCACAGG CAAGGACACC ATGGGCGACC TGCCGCGGGA CCCGGGCCAC 
GTCGTGGAGC AGCTTAGCCG CTCCTTGCAA ACCCTCAAGG ACCGCTTGGA GAGCCTCGAG 
CTCCAGCTCC GCACAAATGT GTCTAACGCT GGGCTGCCGA GCGACTTCCG AGAGGTGCTC 
CAGCGGAGGC TCGGGGAGCT GGAGAGGCAG TTGCTACGCA AGGTGGCGGA GCTGGAAGAT 
GAGAAGTCCC TGCTTCATAA TGAGACCTCG GCTCACCGGC AGAAGACAGA GAGCACGCTG 
AACGCCCTGC TGCAGAGGGT GACTGAGCTG GAGCGAGGCA ACAGTGCATT CAAGTCACCA 
GATGCATTCA AAGTGTCCCT TCCTCTCCGT ACAAACTACC TGTATGGCAA GATCAAGAAG 
ACATTGCCTG AGCTGTACGC CTTTACCATC TGCCTGTGGC TGCGGTCCAG TGCCTCGCCA 
GGCATCGGTA CGCCATTCTC CTACGCTGTG CCCGGGCAAG CCAACGAGAT TGTGCTGATA 
GAGTGGGGCA ATAACCCCAT TGAGCTGCTC ATCAACGACA AGGTCGCACA GCTGCCGCTG 
TTTGTCAGTG ATGGCAAGTG GCACCACATC TGCATCACCT GGACCACTCG AGACGGCATG 
TGGGAAGCGT TCCAGGATGG GGAGAAGCTG GGCACTGGGG AAAACCTGGC ACCCTGGCAC 
CCCATTAAGC CAGGGGGCGT GCTCATCCTG GGGCAGGAGC AGGACACGGT GGGAGGCAGA 
TTTGATGCCA CGCAGGCCTT TGTTGGAGAG CTCAGCCAGT TCAACATATG GGACCGCGTC 
CTCCGGGCGC AGGAGATCAT CAACATCGCC AACTGCTCCA CGAACATGCC CGGCAACATC 
ATCCCGTGGG TGGACAACAA TGTCGATGTG TTCGGCGGGG CTTCCAAGTG GCCTGTGGAG 
ACCTGTGAAG AGCGGCTCCT GGACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology(2017 Oct)
Chang AD,Vaidya PV,Retzbach EP,Chung SJ,Kim U,Baselice K,Maynard K,Stepanian A,Staley M,Xiao L,Blouin A,Han S,Lee J,Worley PF,Tamashiro KL,Hempstead BL,Martinowich K,Ann Wilson M,Baraban JM,Reti IM

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
Blood129(17)2443-2454(2017 04)
Muczynski V,Aym? G,Regnault V,Vasse M,Borgel D,Legendre P,Bazaa A,Harel A,Loubi?re C,Lenting PJ,Denis CV,Christophe OD

NPTX2 and cognitive dysfunction in Alzheimer's Disease.
eLife6(2017 Mar)
Xiao MF,Xu D,Craig MT,Pelkey KA,Chien CC,Shi Y,Zhang J,Resnick S,Pletnikova O,Salmon D,Brewer J,Edland S,Wegiel J,Tycko B,Savonenko A,Reeves RH,Troncoso JC,McBain CJ,Galasko D,Worley PF

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Neuron85(6)1257-72(2015 Mar)
Pelkey KA,Barksdale E,Craig MT,Yuan X,Sukumaran M,Vargish GA,Mitchell RM,Wyeth MS,Petralia RS,Chittajallu R,Karlsson RM,Cameron HA,Murata Y,Colonnese MT,Worley PF,McBain CJ

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Nptx2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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