Slc46a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc46a1
Entrez Gene ID	52466
Full Name	solute carrier family 46, member 1
Synonyms	1110002C08Rik,D11Ertd18e,HCP1,Pcft
General protein information	Preferred Names solute carrier family 46, member 1 Names proton-coupled folate transporter PCFT/HCP1 heme carrier protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B5\|11 46.74 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_026740.2	NP_081016.2	proton-coupled folate transporter

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC46A1	XP_003435354.1
Caenorhabditis elegans (roundworm)	Y4C6B.5	NP_500781.2
Bos taurus (cattle)	SLC46A1	NP_001073053.1
Gallus gallus (chicken)	SLC46A1	NP_001191995.1
Xenopus tropicalis (tropical clawed frog)	slc46a1	NP_001120610.1
	SLC46A1	XP_001106954.1
Mus musculus (house mouse)	Slc46a1	NP_081016.2
Homo sapiens (human)	SLC46A1	NP_542400.2
Rattus norvegicus (Norway rat)	Slc46a1	NP_001013991.1
Danio rerio (zebrafish)	slc46a1	NP_956579.1
Caenorhabditis elegans (roundworm)	Y43F8A.5	NP_507773.1

Gene Ontology
Bibliography

Related articles in PubMed

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.
Kooistra M, Trasler JM, Baltz JM
Biology of reproduction89(3)63(2013 Sep)

Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.
Wang X, Cabrera RM, Li Y, Miller DS, Finnell RH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(3)1167-75(2013 Mar)

Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.
Cherukad J, Wainwright V, Watson ED
Placenta33(5)440-8(2012 May)

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.
Gnana-Prakasam JP, Reddy SK, Veeranan-Karmegam R, Smith SB, Martin PM, Ganapathy V
Investigative ophthalmology & visual science52(12)9279-86(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.
Title: Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.

expressed in placenta at highest level during early development
Title: Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.

Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.
Title: Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated intestinal folate uptake, thus confirming in vivo a critical role of the PCFT protein in intestinal folate transport and erythropoiesis.
Title: A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.

Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC and PCFT.
Title: Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine.

The following Slc46a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc46a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19664	NM_026740.2 Latest version!	Mus musculus solute carrier family 46, member 1 (Slc46a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc46a1 ( NM_026740.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081016.2 Mus musculus solute carrier family 46, member 1 (Slc46a1), mRNA.

Price & Availability↑

CloneID	OMu19664
Clone ID Related Accession (Same CDS sequence)	NM_026740.2
Accession Version	NM_026740.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Mus musculus(house mouse)
Product	proton-coupled folate transporter
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX219335.1, AK003278.1, AL591177.14 and BE984585.1. On Jun 17, 2009 this sequence version replaced NM_026740.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057976.1, AK003278.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGC GCGTGAGCTC CGTGGGCTCG CCCCACAGTT TCCTCAACGC TCCCGTGCTT 
TTCCGCGGCC CCGTGGAGCC CCTAGTCTTC CTGGCCAACT TTGCCCTGGT TCTGCAGGGA 
CCGCTCACCA CACAGTACCT TTGGCACCGG TTCAGCACGG AGCTCGGCTA CAATGGCACC 
CGCCACCGGG AGAACTGTGG GAACCAAAGC GCGGATCCCC TCATGAAGGA AGTGGAGACC 
CTGACATCTC ACTGGACCCT CTACATGAAC GTGGGAGGCT TCCTGGTGGG ACTCTTCTGG 
TCCACCCTGC TGGGAGCCTG GAGTGACCGC GTGGGTCGCC GCCCATTGCT GGTGCTGGCC 
TCTCTTGGTC TGCTGCTCCA GGCCGTGGTG TCCATCTTTG TGGTGCAGCT AGAACTGCAC 
GTCGGGTTCT TCGTGCTTGG CCGAGCTCTT TGTGCCCTTC TGGGAGACTT CAACGGCCTC 
CTTGCTGCTA GCTTTGCCTC TGTGGCAGAT GTTAGCTCTA ACCACAGTCG CACCTTCCGG 
ATGGCTCTGC TGGAAGCATG CATTGGTGTG GCCGGGACCC TGGCAAGCCT TCTCGGGGGT 
CACTGGCTCC GGGCCCAGGG TTATGCCAAC CCCTTCTGGC TGGCTTTGGC CCTGCTGATT 
GTCATGGCTC TATACGCAGC ATTTTGTTTT GGTGAGACGG TGAAGGAGCC AAAGTCCACC 
AGGCTTTTCA CGCTCCGCCA TCATCGATCC ATTGCCCGGC TATATGTGGT TCCAGCCCCA 
GAAAAGTCCA GGATGCATCT AGCCCTGTAC TCTTTGGCCA TATTCGTGGT GGTTACTGTG 
CATTTTGGGG CTCAAGATAT CCTGACACTC TATGAGCTGA GCGCACCCCT CTGCTGGGAC 
TCCAAGCTGA TTGGCTATGG CTCAGCAGCC CAGCACCTAC CCTACCTCAC CAGCCTGCTG 
GGCCTAAGGC TTCTGCAATT CTGCCTGGCT GACACCTGGG TGGCTGAGAT TGGCCTGGCT 
TTCAACATCC TGGGAATGGT GGTCTTTGCG TTTGCTACCA TTACACCCCT CATGTTCACA 
GGGTACGGAT TGCTCTTCCT GTCATTGGTC ACGACGCCTG TCATCCGGGC CAAGCTTTCC 
AAGCTGGTGA GCGAGTCGGA GCAGGGTGCT CTGTTCTCTG CTGTGGCCTG TGTGAATAGC 
TTGGCCATGT TGATGGCCTC CGGCATCTTC AACTCCATCT ACCCGGCCAC TCTGAACTTC 
ATGAAGGGCT TCCCCTTCCT CCTGGGAGCT GGCCTCCTCT TCATTCCAGC CATTCTGATT 
GGGGTACTGG AAAAGGTTAA TCCACACCCG GAGTTCCAGC AGTTTCCTCA GAGCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081016.2
CDS	78..1457
Translation	MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQSP

Target ORF information:

RefSeq Version	NM_026740.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 46, member 1 (Slc46a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026740.2

ORF Insert Sequence:

ATGGAGGGGC GCGTGAGCTC CGTGGGCTCG CCCCACAGTT TCCTCAACGC TCCCGTGCTT 
TTCCGCGGCC CCGTGGAGCC CCTAGTCTTC CTGGCCAACT TTGCCCTGGT TCTGCAGGGA 
CCGCTCACCA CACAGTACCT TTGGCACCGG TTCAGCACGG AGCTCGGCTA CAATGGCACC 
CGCCACCGGG AGAACTGTGG GAACCAAAGC GCGGATCCCC TCATGAAGGA AGTGGAGACC 
CTGACATCTC ACTGGACCCT CTACATGAAC GTGGGAGGCT TCCTGGTGGG ACTCTTCTGG 
TCCACCCTGC TGGGAGCCTG GAGTGACCGC GTGGGTCGCC GCCCATTGCT GGTGCTGGCC 
TCTCTTGGTC TGCTGCTCCA GGCCGTGGTG TCCATCTTTG TGGTGCAGCT AGAACTGCAC 
GTCGGGTTCT TCGTGCTTGG CCGAGCTCTT TGTGCCCTTC TGGGAGACTT CAACGGCCTC 
CTTGCTGCTA GCTTTGCCTC TGTGGCAGAT GTTAGCTCTA ACCACAGTCG CACCTTCCGG 
ATGGCTCTGC TGGAAGCATG CATTGGTGTG GCCGGGACCC TGGCAAGCCT TCTCGGGGGT 
CACTGGCTCC GGGCCCAGGG TTATGCCAAC CCCTTCTGGC TGGCTTTGGC CCTGCTGATT 
GTCATGGCTC TATACGCAGC ATTTTGTTTT GGTGAGACGG TGAAGGAGCC AAAGTCCACC 
AGGCTTTTCA CGCTCCGCCA TCATCGATCC ATTGCCCGGC TATATGTGGT TCCAGCCCCA 
GAAAAGTCCA GGATGCATCT AGCCCTGTAC TCTTTGGCCA TATTCGTGGT GGTTACTGTG 
CATTTTGGGG CTCAAGATAT CCTGACACTC TATGAGCTGA GCGCACCCCT CTGCTGGGAC 
TCCAAGCTGA TTGGCTATGG CTCAGCAGCC CAGCACCTAC CCTACCTCAC CAGCCTGCTG 
GGCCTAAGGC TTCTGCAATT CTGCCTGGCT GACACCTGGG TGGCTGAGAT TGGCCTGGCT 
TTCAACATCC TGGGAATGGT GGTCTTTGCG TTTGCTACCA TTACACCCCT CATGTTCACA 
GGGTACGGAT TGCTCTTCCT GTCATTGGTC ACGACGCCTG TCATCCGGGC CAAGCTTTCC 
AAGCTGGTGA GCGAGTCGGA GCAGGGTGCT CTGTTCTCTG CTGTGGCCTG TGTGAATAGC 
TTGGCCATGT TGATGGCCTC CGGCATCTTC AACTCCATCT ACCCGGCCAC TCTGAACTTC 
ATGAAGGGCT TCCCCTTCCT CCTGGGAGCT GGCCTCCTCT TCATTCCAGC CATTCTGATT 
GGGGTACTGG AAAAGGTTAA TCCACACCCG GAGTTCCAGC AGTTTCCTCA GAGCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.
Biology of reproduction89(3)63(2013 Sep)
Kooistra M,Trasler JM,Baltz JM

Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(3)1167-75(2013 Mar)
Wang X,Cabrera RM,Li Y,Miller DS,Finnell RH

Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.
Placenta33(5)440-8(2012 May)
Cherukad J,Wainwright V,Watson ED

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.
Investigative ophthalmology & visual science52(12)9279-86(2011 Nov)
Gnana-Prakasam JP,Reddy SK,Veeranan-Karmegam R,Smith SB,Martin PM,Ganapathy V

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Slc46a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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