Pbk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pbk
Entrez Gene ID	52033
Full Name	PDZ binding kinase
Synonyms	2810434B10Rik,AW538537,D14Ertd732e,TOPK
General protein information	Preferred Names PDZ binding kinase Names lymphokine-activated killer T-cell-originated protein kinase MAPKK-like protein kinase T-LAK cell-originated protein kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 D1\|14 34.36 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006519257.2	XP_006519320.1	lymphokine-activated killer T-cell-originated protein kinase isoform X1
XM_006519257.4	XP_006519320.1	lymphokine-activated killer T-cell-originated protein kinase isoform X1
XM_006519257.3	XP_006519320.1	lymphokine-activated killer T-cell-originated protein kinase isoform X1
NM_023209.2	NP_075698.1	lymphokine-activated killer T-cell-originated protein kinase

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG8173	NP_573239.1
Homo sapiens (human)	PBK	NP_060962.2
Canis lupus familiaris (dog)	PBK	XP_534564.1
Danio rerio (zebrafish)	pbk	NP_001002387.1
	PBK	XP_001109768.1
Xenopus tropicalis (tropical clawed frog)	pbk	NP_001011346.1
Bos taurus (cattle)	PBK	NP_001095648.1
Rattus norvegicus (Norway rat)	Pbk	NP_001073406.1
Pan troglodytes (chimpanzee)	PBK	NP_001233441.1
Mus musculus (house mouse)	Pbk	NP_075698.1
Gallus gallus (chicken)	PBK	NP_001264928.1

Gene Ontology
Bibliography

Related articles in PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Rutledge EA, Benazet JD, McMahon AP
Development (Cambridge, England)144(17)3177-3188(2017 09)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation.
Gao S, Zhu Y, Li H, Xia Z, Wu Q, Yao S, Wang T, Yuan S
International immunopharmacology38395-401(2016 Sep)

The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.
Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S
Development (Cambridge, England)143(1)133-46(2016 Jan)

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt signaling pathway
Title: Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation.

T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.
Title: T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.

Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
Title: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.

The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Title: Expression and phosphorylation of TOPK during spermatogenesis.

The following Pbk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pbk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00700	NM_023209.2 Latest version!	Mus musculus PDZ binding kinase (Pbk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu00700	XM_006519257.4 Latest version!	Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu00700	XM_006519257.2	Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu00700	XM_006519257.3	Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pbk ( NM_023209.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075698.1 Mus musculus PDZ binding kinase (Pbk), mRNA.

Price & Availability↑

CloneID	OMu00700
Clone ID Related Accession (Same CDS sequence)	XM_006519257.2 , XM_006519257.4 , XM_006519257.3 , NM_023209.2
Accession Version	NM_023209.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	lymphokine-activated killer T-cell-originated protein kinase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB041882.1. On Apr 5, 2007 this sequence version replaced NM_023209.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020099.1, AB041882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075698.1
CDS	245..1237
Translation	MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH

Target ORF information:

RefSeq Version	NM_023209.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus PDZ binding kinase (Pbk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023209.2

ORF Insert Sequence:

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pbk ( XM_006519257.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006519320.1 Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu00700
Clone ID Related Accession (Same CDS sequence)	XM_006519257.2 , XM_006519257.4 , XM_006519257.3 , NM_023209.2
Accession Version	XM_006519257.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	lymphokine-activated killer T-cell-originated protein kinase isoform X1
Comment

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006519320.1
Translation	MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH

Target ORF information:

RefSeq Version	XM_006519257.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006519257.2

ORF Insert Sequence:

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pbk ( XM_006519257.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006519320.1 Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu00700
Clone ID Related Accession (Same CDS sequence)	XM_006519257.2 , XM_006519257.4 , XM_006519257.3 , NM_023209.2
Accession Version	XM_006519257.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	lymphokine-activated killer T-cell-originated protein kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006519257.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006519320.1
CDS	91..1083
Translation	MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH

Target ORF information:

RefSeq Version	XM_006519257.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006519257.4

ORF Insert Sequence:

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pbk ( XM_006519257.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006519320.1 Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu00700
Clone ID Related Accession (Same CDS sequence)	XM_006519257.2 , XM_006519257.4 , XM_006519257.3 , NM_023209.2
Accession Version	XM_006519257.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	lymphokine-activated killer T-cell-originated protein kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006519257.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006519320.1
CDS	92..1084
Translation	MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH

Target ORF information:

RefSeq Version	XM_006519257.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus PDZ binding kinase (Pbk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006519257.3

ORF Insert Sequence:

ATGGAAGGAA TTAATAATTT CAAGACGCCA AACAAATCTG AAAAAAGGAA ATCTGTATTA 
TGTTCCACTC CATGTGTAAA TATCCCTGCC TCTCCATTTA TGCAGAAGCT TGGCTTTGGG 
ACTGGGGTCA GCGTTTACCT AATGAAAAGA TCTCCAAGAG GGTTGTCTCA TTCTCCTTGG 
GCCGTGAAAA AGATAAGTCT TTTATGCGAT GATCATTATC GAACTGTGTA TCAGAAGAGA 
CTAACTGATG AAGCTAAGAT TTTAAAAAAC CTTAATCACC CAAACATTAT AGGATATCGT 
GCTTTTACTG AAGCCAGTGA TGGTAGTCTG TGCCTTGCTA TGGAGTATGG AGGTGAAAAG 
TCTCTGAATG ACTTAATAGA AGAGCGGAAC AAAGACAGTG GAAGTCCTTT TCCAGCAGCT 
GTAATTCTCA GAGTTGCTTT GCACATGGCC AGAGGGCTAA AGTACCTGCA CCAAGAAAAG 
AAGCTGCTTC ATGGAGACAT AAAGTCTTCA AATGTTGTAA TTAAAGGTGA TTTTGAAACA 
ATTAAAATCT GTGATGTAGG AGTCTCTCTG CCATTGGATG AAAATATGAC TGTGACTGAT 
CCTGAGGCCT GTTATATTGG TACTGAGCCA TGGAAACCCA AGGAAGCGTT GGAAGAAAAT 
GGCATCATTA CTGACAAGGC AGATGTGTTT GCTTTTGGCC TTACTCTGTG GGAAATGATG 
ACTTTATGTA TTCCACACGT CAATCTTCCA GATGATGATG TTGATGAAGA TGCAACCTTT 
GATGAGAGTG ACTTCGATGA TGAAGCATAT TATGCAGCTC TGGGGACAAG GCCATCCATC 
AACATGGAAG AGCTGGATGA CTCCTACCAG AAGGCCATTG AACTCTTCTG TGTGTGCACT 
AATGAGGATC CTAAAGATCG CCCGTCTGCT GCACACATCG TTGAAGCTTT GGAACTAGAT 
GGCCAATGTT GTGGTCTAAG CTCAAAGCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Development (Cambridge, England)144(17)3177-3188(2017 09)
Rutledge EA,Benazet JD,McMahon AP

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation.
International immunopharmacology38395-401(2016 Sep)
Gao S,Zhu Y,Li H,Xia Z,Wu Q,Yao S,Wang T,Yuan S

The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.
Development (Cambridge, England)143(1)133-46(2016 Jan)
Park JY,Hughes LJ,Moon UY,Park R,Kim SB,Tran K,Lee JS,Cho SH,Kim S

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)
Gineste C,De Winter JM,Kohl C,Witt CC,Giannesini B,Brohm K,Le Fur Y,Gretz N,Vilmen C,Pecchi E,Jubeau M,Cozzone PJ,Stienen GJ,Granzier H,Labeit S,Ottenheijm CA,Bendahan D,Gondin J

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Pbk cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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