Hmgn5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hmgn5
Entrez Gene ID	50887
Full Name	high-mobility group nucleosome binding domain 5
Synonyms	GARP45,NBP-45,Nsbp1
General protein information	Preferred Names high-mobility group nucleosome binding domain 5 Names high mobility group nucleosome-binding domain-containing protein 5 nucleosome binding protein 1 nucleosome binding protein 45
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X D

mRNA and Protein(s)

mRNA	Protein	Name
NM_016710.2	NP_057919.2	high mobility group nucleosome-binding domain-containing protein 5

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hmgn5	NP_057919.2
Mus musculus (house mouse)	LOC102636589	XP_006522867.1

Gene Ontology
Bibliography

Related articles in PubMed

Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.
Li DD, Zhao SY, Yang ZQ, Duan CC, Guo CH, Zhang HL, Geng S, Yue ZP, Guo B
Cell cycle (Georgetown, Tex.)15(20)2792-805(2016 Oct)

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.
Moretti F, Rolando C, Winker M, Ivanek R, Rodriguez J, Von Kriegsheim A, Taylor V, Bustin M, Pertz O
Molecular and cellular biology35(11)2035-50(2015 Jun)

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.
Furusawa T, Rochman M, Taher L, Dimitriadis EK, Nagashima K, Anderson S, Bustin M
Nature communications66138(2015 Jan)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.
Ciappio ED, Krausz KW, Rochman M, Furusawa T, Bonzo JA, Tessarollo L, Gonzalez FJ, Bustin M
PloS one9(1)e84583(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2.
Title: Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.

HMGN5 overexpression induces neurite outgrowth.
Title: Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted lamina, and die of cardiac malfunction.
Title: Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.

functional loss of HMGN5 leads to changes in transcription of Gpx6 and Hk1 that alter glutathione metabolism.
Title: Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.

Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.
Title: High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.

The following Hmgn5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmgn5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20888	NM_016710.2 Latest version!	Mus musculus high-mobility group nucleosome binding domain 5 (Hmgn5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hmgn5 ( NM_016710.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_057919.2 Mus musculus high-mobility group nucleosome binding domain 5 (Hmgn5), mRNA.

Price & Availability↑

CloneID	OMu20888
Clone ID Related Accession (Same CDS sequence)	NM_016710.2
Accession Version	NM_016710.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	high mobility group nucleosome-binding domain-containing protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY279928.1, AK146755.1 and BY387611.1. On Mar 20, 2007 this sequence version replaced NM_016710.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW259877.1, AF213454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAAAA GAAAGGCTGC AGGTGATGTG AGCCAGGAGC CAAAGAGAAG ATCAGCCCGA 
CTGTCTGCTA TGCCTGTGCC CTTTACACCG GAGTTGAAAC CTAAAAGAGC ATCAACTTCA 
AGGAAAACCA AGACCACAAA TGTCGTGGAA GAAAACAAAG ATGCAAGTAC CATACCAATT 
CCTGAAACCA AGCCAGAAGA TGTTAAAGAC GAATGCAACA TGGAAAATGC TGAAAATGGA 
GAAGCCAAGA TTATGGAGGC ACCCATTCCT AAAATGGAAG CTGAGGAAGT AAAAGAACAG 
ATAAATGAAG ACACTGAAGA AGATGGAGGA GAAAAGAAAG AAGCAGTGGC AGCAGAAGCC 
AAAGATGATG AGCTAAAAGC AAACATTCAA GATGTGGAGA AAGATGAAGA TGGAAAAGAG 
CACAAAGATA CAGGTGAGGA GGTGGAAGAC GGAAAAATAG AAGAAGAAGG CCTAAACGAG 
AAACCAGGTA CAGCCAAAAG TGAAGATGCA GAGGTGTCCA AAGATGAAGA AGAGAAAGGA 
GACAATGAAA AAGGAGAAGA TGGCAAAGAA GAAGGTGATG AGAAGGAAGA AGAGAAAGAT 
GACAAAGAGG GGGACACTGG AACAGAAAAA GAAGTAAAAG AACAAAACAA GGAAGCCGAG 
GAGGATGATG GGAAATGCAA AGAGGAGGAA AACAAGGAAG TTGGAAAGGA AGGTCAGCCT 
GAGGAAGATG GAAAGGAAGA TCTGCATGAG GAAGTTGGAA AGGAAGATCT GCATGAGGAA 
GATGGAAAGG AAGGTCAGCC TGAGGAAGAT GGGAAGGAAA TTCATCATGA GGAAGATGGA 
AAGGAAGGTC AGCCTGAAGA AGATGGAAAG GAATATCTGC ATGAGGAAGA TGGAGAGGAA 
GGTCAGCCTA AGGAAGATCA AAAGGAAGGT CAGCCTGAGG AAGATGGAAA GGAAGATCAG 
CCTGAGGAAG ATGGAAAGGA AGGTCAGTGT AAGGAAGATG GGAAGGAAGG TCATCATGAG 
GAAGGTGGAA AGGAAGATCT GCATGAGGAA GATGGAAAGG AGAAAGATGG TGGAAAAGAG 
GATAGAAAGG AAGAAGGAGA GCAAGAGGTT GCTGTAGATG AAGGGAGTGA TGAAAACAAG 
GTGGAGGCAG AAGAAGAAGG AGCCGAAAAC AAAGACTTCA AACAAGACGG AGAGAAAGAG 
GAGCCTCTGA GTATTGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057919.2
CDS	115..1335
Translation	MPKRKAAGDVSQEPKRRSARLSAMPVPFTPELKPKRASTSRKTKTTNVVEENKDASTIPIPETKPEDVKDECNMENAENGEAKIMEAPIPKMEAEEVKEQINEDTEEDGGEKKEAVAAEAKDDELKANIQDVEKDEDGKEHKDTGEEVEDGKIEEEGLNEKPGTAKSEDAEVSKDEEEKGDNEKGEDGKEEGDEKEEEKDDKEGDTGTEKEVKEQNKEAEEDDGKCKEEENKEVGKEGQPEEDGKEDLHEEVGKEDLHEEDGKEGQPEEDGKEIHHEEDGKEGQPEEDGKEYLHEEDGEEGQPKEDQKEGQPEEDGKEDQPEEDGKEGQCKEDGKEGHHEEGGKEDLHEEDGKEKDGGKEDRKEEGEQEVAVDEGSDENKVEAEEEGAENKDFKQDGEKEEPLSIV

Target ORF information:

RefSeq Version	NM_016710.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus high-mobility group nucleosome binding domain 5 (Hmgn5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016710.2

ORF Insert Sequence:

ATGCCCAAAA GAAAGGCTGC AGGTGATGTG AGCCAGGAGC CAAAGAGAAG ATCAGCCCGA 
CTGTCTGCTA TGCCTGTGCC CTTTACACCG GAGTTGAAAC CTAAAAGAGC ATCAACTTCA 
AGGAAAACCA AGACCACAAA TGTCGTGGAA GAAAACAAAG ATGCAAGTAC CATACCAATT 
CCTGAAACCA AGCCAGAAGA TGTTAAAGAC GAATGCAACA TGGAAAATGC TGAAAATGGA 
GAAGCCAAGA TTATGGAGGC ACCCATTCCT AAAATGGAAG CTGAGGAAGT AAAAGAACAG 
ATAAATGAAG ACACTGAAGA AGATGGAGGA GAAAAGAAAG AAGCAGTGGC AGCAGAAGCC 
AAAGATGATG AGCTAAAAGC AAACATTCAA GATGTGGAGA AAGATGAAGA TGGAAAAGAG 
CACAAAGATA CAGGTGAGGA GGTGGAAGAC GGAAAAATAG AAGAAGAAGG CCTAAACGAG 
AAACCAGGTA CAGCCAAAAG TGAAGATGCA GAGGTGTCCA AAGATGAAGA AGAGAAAGGA 
GACAATGAAA AAGGAGAAGA TGGCAAAGAA GAAGGTGATG AGAAGGAAGA AGAGAAAGAT 
GACAAAGAGG GGGACACTGG AACAGAAAAA GAAGTAAAAG AACAAAACAA GGAAGCCGAG 
GAGGATGATG GGAAATGCAA AGAGGAGGAA AACAAGGAAG TTGGAAAGGA AGGTCAGCCT 
GAGGAAGATG GAAAGGAAGA TCTGCATGAG GAAGTTGGAA AGGAAGATCT GCATGAGGAA 
GATGGAAAGG AAGGTCAGCC TGAGGAAGAT GGGAAGGAAA TTCATCATGA GGAAGATGGA 
AAGGAAGGTC AGCCTGAAGA AGATGGAAAG GAATATCTGC ATGAGGAAGA TGGAGAGGAA 
GGTCAGCCTA AGGAAGATCA AAAGGAAGGT CAGCCTGAGG AAGATGGAAA GGAAGATCAG 
CCTGAGGAAG ATGGAAAGGA AGGTCAGTGT AAGGAAGATG GGAAGGAAGG TCATCATGAG 
GAAGGTGGAA AGGAAGATCT GCATGAGGAA GATGGAAAGG AGAAAGATGG TGGAAAAGAG 
GATAGAAAGG AAGAAGGAGA GCAAGAGGTT GCTGTAGATG AAGGGAGTGA TGAAAACAAG 
GTGGAGGCAG AAGAAGAAGG AGCCGAAAAC AAAGACTTCA AACAAGACGG AGAGAAAGAG 
GAGCCTCTGA GTATTGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.
Cell cycle (Georgetown, Tex.)15(20)2792-805(2016 Oct)
Li DD,Zhao SY,Yang ZQ,Duan CC,Guo CH,Zhang HL,Geng S,Yue ZP,Guo B

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.
Molecular and cellular biology35(11)2035-50(2015 Jun)
Moretti F,Rolando C,Winker M,Ivanek R,Rodriguez J,Von Kriegsheim A,Taylor V,Bustin M,Pertz O

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.
Nature communications66138(2015 Jan)
Furusawa T,Rochman M,Taher L,Dimitriadis EK,Nagashima K,Anderson S,Bustin M

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.
PloS one9(1)e84583(2014)
Ciappio ED,Krausz KW,Rochman M,Furusawa T,Bonzo JA,Tessarollo L,Gonzalez FJ,Bustin M

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Hmgn5 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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