Mfap5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mfap5
Entrez Gene ID	50530
Full Name	microfibrillar associated protein 5
Synonyms	MAGP-2,MFAP-5
General protein information	Preferred Names microfibrillar associated protein 5 Names microfibrillar-associated protein 5 microfibril-associated glycoprotein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_015776.2	NP_056591.1	microfibrillar-associated protein 5 isoform 1 precursor
NM_001347434.1	NP_001334363.1	microfibrillar-associated protein 5 isoform 2 precursor
NM_015776.3	NP_056591.1	microfibrillar-associated protein 5 isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MFAP5	NP_003471.1
Mus musculus (house mouse)	Mfap5	NP_056591.1
	MFAP5	XP_002798521.1
Gallus gallus (chicken)	MFAP5	XP_004938158.1
Pan troglodytes (chimpanzee)	MFAP5	XP_001136544.1
Canis lupus familiaris (dog)	MFAP5	XP_534895.1
Bos taurus (cattle)	MFAP5	NP_776811.1
Rattus norvegicus (Norway rat)	Mfap5	NP_001102114.1
Xenopus tropicalis (tropical clawed frog)	LOC101734819	XP_004921077.1

Gene Ontology
Bibliography

Related articles in PubMed

FGF receptors control alveolar elastogenesis.
Li R, Herriges JC, Chen L, Mecham RP, Sun X
Development (Cambridge, England)144(24)4563-4572(2017 Dec)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.
Mecham RP, Gibson MA
Matrix biology : journal of the International Society for Matrix Biology4713-33(2015 Sep)

Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Miyamoto A, Donovan LJ, Perez E, Connett B, Cervantes R, Lai K, Withers G, Hogrebe G
Matrix biology : journal of the International Society for Matrix Biology4027-33(2014 Nov)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Title: Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.

Loss of MAGP2 expression in vivo has pleiotropic effects.
Title: Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.

MAGP-2 is identified as a novel regulator of angiogenesis.
Title: Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis.

microfibril-associated MAGP-2 may stimulate elastic fiber macroassembly by targeting the release of elastin globules from the cell membrane onto developing elastic fibers
Title: Microfibril-associated MAGP-2 stimulates elastic fiber assembly.

Tight skin fibrillin 1 altered extracellular matrix organization and caused fibrosis by affecting deposition of MAGP-2 or other fibrillin-1-associated proteins.
Title: Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen.

The following Mfap5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mfap5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu37432	NM_001347434.1 Latest version!	Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu10251	NM_015776.3 Latest version!	Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu10251	NM_015776.2	Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mfap5 ( NM_001347434.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334363.1 Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu37432
Clone ID Related Accession (Same CDS sequence)	NM_001347434.1
Accession Version	NM_001347434.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	microfibrillar-associated protein 5 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155946.7. On Nov 26, 2016 this sequence version replaced XM_006506364.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV061445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTCT TGGGGCAGAA GGCCTTGCTG CTTGTCTTGG CAATCAGCAT CCCCTCTGAC 
TGGCTACCCC TAGGGGTCAG TGGTCAACGC GGAGATGATG TGCCTGAGAC ATTCACAGAC 
GACCCTAATC TGGTGAACGA TCCCTCTACA GACGATACAG CTGGTGACAA AAATGCTACT 
GCAGAGTGCC GGGATGAGAA GTTTGCTTGT ACAAGACTGT ACTCTGTCCA TCGGCCAGTC 
AGACAGTGTG TGCACCAGTC CTGCTTCACC AGTTTACGGC GCATGTACAT CATCAATAAT 
GAGATCTGTT CCCGACTCGT CTGTAAAGAA CATGAAGCTA TGAAAGATGA GCTTTGCCGG 
CAGATGGCAG GCCTGCCTCC AAGGCGACTT CGGCGCTCCA ACTACTTCCG ACTTCCTCCC 
TGTGAAAATA TGAATTTGCA GAGACCCGAT GGTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334363.1
CDS	152..610
Translation	MLFLGQKALLLVLAISIPSDWLPLGVSGQRGDDVPETFTDDPNLVNDPSTDDTAGDKNATAECRDEKFACTRLYSVHRPVRQCVHQSCFTSLRRMYIINNEICSRLVCKEHEAMKDELCRQMAGLPPRRLRRSNYFRLPPCENMNLQRPDGL

Target ORF information:

RefSeq Version	NM_001347434.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347434.1

ORF Insert Sequence:

ATGCTGTTCT TGGGGCAGAA GGCCTTGCTG CTTGTCTTGG CAATCAGCAT CCCCTCTGAC 
TGGCTACCCC TAGGGGTCAG TGGTCAACGC GGAGATGATG TGCCTGAGAC ATTCACAGAC 
GACCCTAATC TGGTGAACGA TCCCTCTACA GACGATACAG CTGGTGACAA AAATGCTACT 
GCAGAGTGCC GGGATGAGAA GTTTGCTTGT ACAAGACTGT ACTCTGTCCA TCGGCCAGTC 
AGACAGTGTG TGCACCAGTC CTGCTTCACC AGTTTACGGC GCATGTACAT CATCAATAAT 
GAGATCTGTT CCCGACTCGT CTGTAAAGAA CATGAAGCTA TGAAAGATGA GCTTTGCCGG 
CAGATGGCAG GCCTGCCTCC AAGGCGACTT CGGCGCTCCA ACTACTTCCG ACTTCCTCCC 
TGTGAAAATA TGAATTTGCA GAGACCCGAT GGTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mfap5 ( NM_015776.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056591.1 Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10251
Clone ID Related Accession (Same CDS sequence)	NM_015776.2 , NM_015776.3
Accession Version	NM_015776.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-30
Organism	Mus musculus(house mouse)
Product	microfibrillar-associated protein 5 isoform 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC155946.7. On Nov 17, 2006 this sequence version replaced NM_015776.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF180805.1, AK003479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCTGTTCT TGGGGCAGAA GGCCTTGCTG CTTGTCTTGG CAATCAGCAT CCCCTCTGAC 
TGGCTACCCC TAGGGGTCAG TGGTCAACGC GGAGATGATG TGCCTGAGAC ATTCACAGAC 
GACCCTAATC TGGTGAACGA TCCCTCTACA GACGATACAG CTCTGGCTGA TATCACACCT 
TCCACAGATG ACCTAGCTGG TGACAAAAAT GCTACTGCAG AGTGCCGGGA TGAGAAGTTT 
GCTTGTACAA GACTGTACTC TGTCCATCGG CCAGTCAGAC AGTGTGTGCA CCAGTCCTGC 
TTCACCAGTT TACGGCGCAT GTACATCATC AATAATGAGA TCTGTTCCCG ACTCGTCTGT 
AAAGAACATG AAGCTATGAA AGATGAGCTT TGCCGGCAGA TGGCAGGCCT GCCTCCAAGG 
CGACTTCGGC GCTCCAACTA CTTCCGACTT CCTCCCTGTG AAAATATGAA TTTGCAGAGA 
CCCGATGGTC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056591.1
CDS	60..554
Translation	MLFLGQKALLLVLAISIPSDWLPLGVSGQRGDDVPETFTDDPNLVNDPSTDDTALADITPSTDDLAGDKNATAECRDEKFACTRLYSVHRPVRQCVHQSCFTSLRRMYIINNEICSRLVCKEHEAMKDELCRQMAGLPPRRLRRSNYFRLPPCENMNLQRPDGL

Target ORF information:

RefSeq Version	NM_015776.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015776.2

ORF Insert Sequence:

ATGCTGTTCT TGGGGCAGAA GGCCTTGCTG CTTGTCTTGG CAATCAGCAT CCCCTCTGAC 
TGGCTACCCC TAGGGGTCAG TGGTCAACGC GGAGATGATG TGCCTGAGAC ATTCACAGAC 
GACCCTAATC TGGTGAACGA TCCCTCTACA GACGATACAG CTCTGGCTGA TATCACACCT 
TCCACAGATG ACCTAGCTGG TGACAAAAAT GCTACTGCAG AGTGCCGGGA TGAGAAGTTT 
GCTTGTACAA GACTGTACTC TGTCCATCGG CCAGTCAGAC AGTGTGTGCA CCAGTCCTGC 
TTCACCAGTT TACGGCGCAT GTACATCATC AATAATGAGA TCTGTTCCCG ACTCGTCTGT 
AAAGAACATG AAGCTATGAA AGATGAGCTT TGCCGGCAGA TGGCAGGCCT GCCTCCAAGG 
CGACTTCGGC GCTCCAACTA CTTCCGACTT CCTCCCTGTG AAAATATGAA TTTGCAGAGA 
CCCGATGGTC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mfap5 ( NM_015776.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056591.1 Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10251
Clone ID Related Accession (Same CDS sequence)	NM_015776.2 , NM_015776.3
Accession Version	NM_015776.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	microfibrillar-associated protein 5 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155946.7. On Mar 19, 2018 this sequence version replaced NM_015776.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF180805.1, AK003479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTCT TGGGGCAGAA GGCCTTGCTG CTTGTCTTGG CAATCAGCAT CCCCTCTGAC 
TGGCTACCCC TAGGGGTCAG TGGTCAACGC GGAGATGATG TGCCTGAGAC ATTCACAGAC 
GACCCTAATC TGGTGAACGA TCCCTCTACA GACGATACAG CTCTGGCTGA TATCACACCT 
TCCACAGATG ACCTAGCTGG TGACAAAAAT GCTACTGCAG AGTGCCGGGA TGAGAAGTTT 
GCTTGTACAA GACTGTACTC TGTCCATCGG CCAGTCAGAC AGTGTGTGCA CCAGTCCTGC 
TTCACCAGTT TACGGCGCAT GTACATCATC AATAATGAGA TCTGTTCCCG ACTCGTCTGT 
AAAGAACATG AAGCTATGAA AGATGAGCTT TGCCGGCAGA TGGCAGGCCT GCCTCCAAGG 
CGACTTCGGC GCTCCAACTA CTTCCGACTT CCTCCCTGTG AAAATATGAA TTTGCAGAGA 
CCCGATGGTC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056591.1
CDS	152..646
Translation	MLFLGQKALLLVLAISIPSDWLPLGVSGQRGDDVPETFTDDPNLVNDPSTDDTALADITPSTDDLAGDKNATAECRDEKFACTRLYSVHRPVRQCVHQSCFTSLRRMYIINNEICSRLVCKEHEAMKDELCRQMAGLPPRRLRRSNYFRLPPCENMNLQRPDGL

Target ORF information:

RefSeq Version	NM_015776.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus microfibrillar associated protein 5 (Mfap5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015776.3

ORF Insert Sequence:

ATGCTGTTCT TGGGGCAGAA GGCCTTGCTG CTTGTCTTGG CAATCAGCAT CCCCTCTGAC 
TGGCTACCCC TAGGGGTCAG TGGTCAACGC GGAGATGATG TGCCTGAGAC ATTCACAGAC 
GACCCTAATC TGGTGAACGA TCCCTCTACA GACGATACAG CTCTGGCTGA TATCACACCT 
TCCACAGATG ACCTAGCTGG TGACAAAAAT GCTACTGCAG AGTGCCGGGA TGAGAAGTTT 
GCTTGTACAA GACTGTACTC TGTCCATCGG CCAGTCAGAC AGTGTGTGCA CCAGTCCTGC 
TTCACCAGTT TACGGCGCAT GTACATCATC AATAATGAGA TCTGTTCCCG ACTCGTCTGT 
AAAGAACATG AAGCTATGAA AGATGAGCTT TGCCGGCAGA TGGCAGGCCT GCCTCCAAGG 
CGACTTCGGC GCTCCAACTA CTTCCGACTT CCTCCCTGTG AAAATATGAA TTTGCAGAGA 
CCCGATGGTC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FGF receptors control alveolar elastogenesis.
Development (Cambridge, England)144(24)4563-4572(2017 Dec)
Li R,Herriges JC,Chen L,Mecham RP,Sun X

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.
Matrix biology : journal of the International Society for Matrix Biology4713-33(2015 Sep)
Mecham RP,Gibson MA

Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Matrix biology : journal of the International Society for Matrix Biology4027-33(2014 Nov)
Miyamoto A,Donovan LJ,Perez E,Connett B,Cervantes R,Lai K,Withers G,Hogrebe G

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

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Mfap5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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