Ero1l cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ero1l
Entrez Gene ID	50527
Full Name	ERO1-like (S. cerevisiae)
Synonyms	ERO1-L,Ero1a
General protein information	Preferred Names ERO1-like (S. cerevisiae) Names ERO1-like protein alpha ERO1-L-alpha endoplasmic oxidoreductin-1-like protein endoplasmic reticulum oxidation 1 endoplasmic reticulum oxidoreductase alpha endoplasmic reticulum oxidoreductin-1-like protein oxidoreductin-1-L-alpha
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C1
Summary	This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_015774.3	NP_056589.1	ERO1-like protein alpha precursor

Pathways from BioSystems

Homologies

	ERO1L	XP_001103965.1
Danio rerio (zebrafish)	ero1l	NP_956644.1
Xenopus tropicalis (tropical clawed frog)	ero1lb	NP_001016058.1
Magnaporthe oryzae (rice blast fungus)	MGG_00683	XP_003718326.1
Pan troglodytes (chimpanzee)	ERO1L	XP_509950.2
Canis lupus familiaris (dog)	ERO1L	XP_547813.2
Mus musculus (house mouse)	Ero1l	NP_056589.1
Kluyveromyces lactis	KLLA0D10241g	XP_453517.1
Eremothecium gossypii	AGOS_ADL348W	NP_983747.2
Schizosaccharomyces pombe (fission yeast)	ero12	NP_588313.2
Arabidopsis thaliana (thale cress)	ERO1	NP_177372.1
Bos taurus (cattle)	ERO1L	NP_001096818.1
Gallus gallus (chicken)	ERO1L	NP_001264498.1
Saccharomyces cerevisiae (baker's yeast)	ERO1	NP_013576.1
Arabidopsis thaliana (thale cress)	ERO2	NP_973637.1
Homo sapiens (human)	ERO1L	NP_055399.1
Rattus norvegicus (Norway rat)	Ero1l	NP_612537.1
Neurospora crassa	NCU02074	XP_964601.1
Oryza sativa (rice)	Os03g0733800	NP_001051175.2

Gene Ontology
Bibliography

Related articles in PubMed

Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-?-mediated oxidative folding in murine tumor cells.
Kajiwara T, Tanaka T, Kukita K, Kutomi G, Saito K, Okuya K, Takaya A, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Sato N, Tamura Y
European journal of immunology46(12)2842-2851(2016 12)

Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
Grigaravicius P, Kaminska E, H?bner CA, McKinnon PJ, von Deimling A, Frappart PO
Cell death and differentiation23(3)454-68(2016 Mar)

SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity.
Marino M, Stoilova T, Giorgi C, Bachi A, Cattaneo A, Auricchio A, Pinton P, Zito E
Human molecular genetics24(7)1843-55(2015 Apr)

Cancer-associated oxidoreductase ERO1-? drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.
Tanaka T, Kajiwara T, Torigoe T, Okamoto Y, Sato N, Tamura Y
Journal of immunology (Baltimore, Md. : 1950)194(4)2004-10(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that the hypoxia-inducible ER-resident oxidase ERO1-alpha plays an important role in the hypoxia-induced augmentation of MHC class I-peptide complex expression
Title: Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-?-mediated oxidative folding in murine tumor cells.

Data (including data from knockout mice) suggest that up-regulation of expression of ERO1alpha (oxidoreductin-1-L-alpha) and CHOP (c/EBP-homologous protein) is involved in liver apoptosis/necrosis exhibited in acute liver failure.
Title: C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1? signalling in acute liver failure.

These results suggest that overexpression of ERO1-alpha in the tumor inhibits the T cell response by recruiting polymorphonuclear myeloid-derived suppressor cells
Title: Cancer-associated oxidoreductase ERO1-? drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.

ER stress induced by misfolded proinsulin was limited by increased expression of Ero1alpha, suggesting that enhancing the oxidative folding of proinsulin may be a viable therapeutic strategy in the treatment of type 2 diabetes.
Title: Endoplasmic reticulum oxidoreductin-1? (Ero1?) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.

combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1alpha, ERO1beta, and PRDX4 compromised the extracellular matrix and interfered with the intracellular maturation of procollagen
Title: Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice.

The following Ero1l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ero1l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10249	NM_015774.3 Latest version!	Mus musculus ERO1-like (S. cerevisiae) (Ero1l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ero1l ( NM_015774.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056589.1 Mus musculus ERO1-like (S. cerevisiae) (Ero1l), mRNA.

Price & Availability↑

CloneID	OMu10249
Clone ID Related Accession (Same CDS sequence)	NM_015774.3
Accession Version	NM_015774.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	ERO1-like protein alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC154575.2, AK142595.1, AK009667.1, BP753202.1 and CJ215857.1. On Feb 8, 2011 this sequence version replaced NM_015774.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.36336.1, AK142595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCG CCTGGGGCTT GCTCGTTGGA CTCCTGGGCG TCGTGTGGCT GCTGCGCTTG 
GGCCACGGCG AGGAGCGGCG GCCGGAGACA GCGGCACAGC GCTGCTTCTG CCAGGTTAGT 
GGTTACCTGG ACGACTGTAC CTGTGATGTC GAGACCATCG ATAAGTTTAA TAACTACAGA 
CTTTTCCCAA GACTACAAAA GCTTCTTGAA AGTGACTACT TTAGATATTA CAAGGTGAAC 
TTGAAGAAGC CTTGTCCTTT CTGGAATGAC ATCAACCAGT GTGGAAGAAG AGACTGTGCC 
GTCAAACCCT GCCATTCTGA TGAAGTTCCT GATGGAATTA AGTCTGCGAG CTACAAGTAT 
TCTGAGGAAG CCAACCGCAT TGAAGAATGT GAGCAAGCTG AGCGACTTGG AGCCGTGGAT 
GAGTCTCTGA GTGAGGAGAC CCAGAAAGCT GTACTTCAGT GGACCAAGCA TGATGATTCG 
TCAGACAGCT TCTGCGAAAT TGACGATATA CAGTCCCCCG ATGCTGAGTA TGTGGACTTA 
CTCCTTAACC CTGAGCGCTA CACAGGCTAC AAGGGGCCAG ACGCTTGGAG GATATGGAGT 
GTCATCTATG AAGAAAACTG TTTTAAGCCA CAGACAATTC AAAGGCCTTT GGCTTCTGGG 
CGAGGAAAAA GTAAAGAGAA CACATTTTAC AACTGGCTAG AAGGCCTCTG TGTAGAAAAG 
AGAGCATTCT ACAGACTTAT ATCTGGCCTG CACGCAAGCA TTAATGTGCA TTTGAGTGCA 
AGGTATCTTT TACAAGATAC TTGGCTGGAA AAGAAATGGG GTCACAATGT CACAGAGTTC 
CAGCAGCGCT TTGATGGGAT TCTGACTGAA GGAGAAGGCC CACGAAGGCT GAGGAACTTG 
TACTTCCTGT ACCTGATAGA GTTAAGGGCT CTCTCCAAAG TGCTTCCATT TTTTGAGCGT 
CCAGATTTTC AGCTCTTCAC TGGGAATAAA GTTCAGGATG CAGAAAACAA AGCGTTACTT 
CTGGAGATAC TTCATGAAAT CAAGTCATTT CCTTTGCACT TCGATGAGAA TTCTTTTTTT 
GCTGGGGATA AAAACGAAGC ACATAAACTA AAGGAGGACT TCCGGCTACA CTTTAGGAAC 
ATTTCAAGAA TCATGGACTG TGTTGGCTGC TTCAAGTGCC GCCTGTGGGG CAAGCTTCAG 
ACGCAGGGGC TGGGCACTGC TCTGAAGATC TTGTTTTCCG AAAAACTGAT CGCAAATATG 
CCGGAAAGCG GACCAAGTTA TGAGTTCCAG CTAACCAGAC AAGAAATAGT ATCACTGTTT 
AATGCATTTG GAAGGATTTC CACAAGTGTG AGAGAACTAG AGAACTTCAG GCACTTGTTA 
CAGAATGTTC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056589.1
CDS	83..1477
Translation	MGRAWGLLVGLLGVVWLLRLGHGEERRPETAAQRCFCQVSGYLDDCTCDVETIDKFNNYRLFPRLQKLLESDYFRYYKVNLKKPCPFWNDINQCGRRDCAVKPCHSDEVPDGIKSASYKYSEEANRIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDSFCEIDDIQSPDAEYVDLLLNPERYTGYKGPDAWRIWSVIYEENCFKPQTIQRPLASGRGKSKENTFYNWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHNVTEFQQRFDGILTEGEGPRRLRNLYFLYLIELRALSKVLPFFERPDFQLFTGNKVQDAENKALLLEILHEIKSFPLHFDENSFFAGDKNEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFQLTRQEIVSLFNAFGRISTSVRELENFRHLLQNVH

Target ORF information:

RefSeq Version	NM_015774.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ERO1-like (S. cerevisiae) (Ero1l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015774.3

ORF Insert Sequence:

ATGGGCCGCG CCTGGGGCTT GCTCGTTGGA CTCCTGGGCG TCGTGTGGCT GCTGCGCTTG 
GGCCACGGCG AGGAGCGGCG GCCGGAGACA GCGGCACAGC GCTGCTTCTG CCAGGTTAGT 
GGTTACCTGG ACGACTGTAC CTGTGATGTC GAGACCATCG ATAAGTTTAA TAACTACAGA 
CTTTTCCCAA GACTACAAAA GCTTCTTGAA AGTGACTACT TTAGATATTA CAAGGTGAAC 
TTGAAGAAGC CTTGTCCTTT CTGGAATGAC ATCAACCAGT GTGGAAGAAG AGACTGTGCC 
GTCAAACCCT GCCATTCTGA TGAAGTTCCT GATGGAATTA AGTCTGCGAG CTACAAGTAT 
TCTGAGGAAG CCAACCGCAT TGAAGAATGT GAGCAAGCTG AGCGACTTGG AGCCGTGGAT 
GAGTCTCTGA GTGAGGAGAC CCAGAAAGCT GTACTTCAGT GGACCAAGCA TGATGATTCG 
TCAGACAGCT TCTGCGAAAT TGACGATATA CAGTCCCCCG ATGCTGAGTA TGTGGACTTA 
CTCCTTAACC CTGAGCGCTA CACAGGCTAC AAGGGGCCAG ACGCTTGGAG GATATGGAGT 
GTCATCTATG AAGAAAACTG TTTTAAGCCA CAGACAATTC AAAGGCCTTT GGCTTCTGGG 
CGAGGAAAAA GTAAAGAGAA CACATTTTAC AACTGGCTAG AAGGCCTCTG TGTAGAAAAG 
AGAGCATTCT ACAGACTTAT ATCTGGCCTG CACGCAAGCA TTAATGTGCA TTTGAGTGCA 
AGGTATCTTT TACAAGATAC TTGGCTGGAA AAGAAATGGG GTCACAATGT CACAGAGTTC 
CAGCAGCGCT TTGATGGGAT TCTGACTGAA GGAGAAGGCC CACGAAGGCT GAGGAACTTG 
TACTTCCTGT ACCTGATAGA GTTAAGGGCT CTCTCCAAAG TGCTTCCATT TTTTGAGCGT 
CCAGATTTTC AGCTCTTCAC TGGGAATAAA GTTCAGGATG CAGAAAACAA AGCGTTACTT 
CTGGAGATAC TTCATGAAAT CAAGTCATTT CCTTTGCACT TCGATGAGAA TTCTTTTTTT 
GCTGGGGATA AAAACGAAGC ACATAAACTA AAGGAGGACT TCCGGCTACA CTTTAGGAAC 
ATTTCAAGAA TCATGGACTG TGTTGGCTGC TTCAAGTGCC GCCTGTGGGG CAAGCTTCAG 
ACGCAGGGGC TGGGCACTGC TCTGAAGATC TTGTTTTCCG AAAAACTGAT CGCAAATATG 
CCGGAAAGCG GACCAAGTTA TGAGTTCCAG CTAACCAGAC AAGAAATAGT ATCACTGTTT 
AATGCATTTG GAAGGATTTC CACAAGTGTG AGAGAACTAG AGAACTTCAG GCACTTGTTA 
CAGAATGTTC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-?-mediated oxidative folding in murine tumor cells.
European journal of immunology46(12)2842-2851(2016 12)
Kajiwara T,Tanaka T,Kukita K,Kutomi G,Saito K,Okuya K,Takaya A,Kochin V,Kanaseki T,Tsukahara T,Hirohashi Y,Torigoe T,Hirata K,Sato N,Tamura Y

Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
Cell death and differentiation23(3)454-68(2016 Mar)
Grigaravicius P,Kaminska E,H?bner CA,McKinnon PJ,von Deimling A,Frappart PO

SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity.
Human molecular genetics24(7)1843-55(2015 Apr)
Marino M,Stoilova T,Giorgi C,Bachi A,Cattaneo A,Auricchio A,Pinton P,Zito E

Cancer-associated oxidoreductase ERO1-? drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.
Journal of immunology (Baltimore, Md. : 1950)194(4)2004-10(2015 Feb)
Tanaka T,Kajiwara T,Torigoe T,Okamoto Y,Sato N,Tamura Y

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Ero1l cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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