Grxcr1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grxcr1
Entrez Gene ID	433899
Full Name	glutaredoxin, cysteine rich 1
Synonyms	Tg(Eno2-Gabrb3)0370Brll,pi,tde
General protein information	Preferred Names glutaredoxin, cysteine rich 1 Names glutaredoxin domain-containing cysteine-rich protein 1 glutaredoxin cysteine-rich 1 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 C3.1\|5 36.59 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001018019.2	NP_001018019.2	glutaredoxin domain-containing cysteine-rich protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GRXCR1	XP_517170.2
Mus musculus (house mouse)	Grxcr1	NP_001018019.2
Xenopus tropicalis (tropical clawed frog)	grxcr1	XP_002933496.2
Canis lupus familiaris (dog)	GRXCR1	XP_003431852.1
Rattus norvegicus (Norway rat)	Grxcr1	NP_001178864.1
Homo sapiens (human)	GRXCR1	NP_001073945.1
	GRXCR1	XP_001099443.1
Gallus gallus (chicken)	GRXCR1	XP_004936128.1
Danio rerio (zebrafish)	LOC100332873	XP_002664501.1
Caenorhabditis elegans (roundworm)	Y46E12A.3	NP_497453.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Potter PK, Bowl MR, Jeyarajan P, Wisby L, Blease A, Goldsworthy ME, Simon MM, Greenaway S, Michel V, Barnard A, Aguilar C, Agnew T, Banks G, Blake A, Chessum L, Dorning J, Falcone S, Goosey L, Harris S, Haynes A, Heise I, Hillier R, Hough T, Hoslin A, Hutchison M, King R, Kumar S, Lad HV, Law G, MacLaren RE, Morse S, Nicol T, Parker A, Pickford K, Sethi S, Starbuck B, Stelma F, Cheeseman M, Cross SH, Foster RG, Jackson IJ, Peirson SN, Thakker RV, Vincent T, Scudamore C, Wells S, El-Amraoui A, Petit C, Acevedo-Arozena A, Nolan PM, Cox R, Mallon AM, Brown SD
Nature communications712444(2016 Aug)

Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays.
Rodr?guez-de la Rosa L, S?nchez-Calder?n H, Contreras J, Murillo-Cuesta S, Falagan S, Avenda?o C, Dopazo J, Varela-Nieto I, Milo M
Hearing research330(Pt A)62-77(2015 Dec)

Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.
Odeh H, Hunker KL, Belyantseva IA, Azaiez H, Avenarius MR, Zheng L, Peters LM, Gagnon LH, Hagiwara N, Skynner MJ, Brilliant MH, Allen ND, Riazuddin S, Johnson KR, Raphael Y, Najmabadi H, Friedman TB, Bartles JR, Smith RJ, Kohrman DC
American journal of human genetics86(2)148-60(2010 Feb)

Characterization of two transgene insertional mutations at pirouette, a mouse deafness locus.
Odeh H, Hagiwara N, Skynner M, Mitchem KL, Beyer LA, Allen ND, Brilliant MH, Lebart MC, Dolan DF, Raphael Y, Kohrman DC
Audiology & neuro-otology9(5)303-14(2004 Sep-Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Deafness in pirouette mutants is associated with loss of GRXCR1 function in modulating actin cytoskeletal architecture in the developing stereocilia of sensory hair cells.
Title: Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.

The following Grxcr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grxcr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11787	NM_001018019.2 Latest version!	Mus musculus glutaredoxin, cysteine rich 1 (Grxcr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grxcr1 ( NM_001018019.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001018019.2 Mus musculus glutaredoxin, cysteine rich 1 (Grxcr1), mRNA.

Price & Availability↑

CloneID	OMu11787
Clone ID Related Accession (Same CDS sequence)	NM_001018019.2
Accession Version	NM_001018019.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	glutaredoxin domain-containing cysteine-rich protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY616753.1 and BE955109.1. On May 15, 2009 this sequence version replaced NM_001018019.1. CCDS Note: The coding region has been updated to extend the N-terminus to one that is supported by available conservation data. This results in a protein that is 6 aa longer at the N-terminal. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY616753.1, BC147268.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164132, SAMN01164138 [ECO:0000350] ##Evidence-Data-END##

ATGTGGGTGG AGGTGACCAT GCTAAGAAGG GAGACAAAGC CAGAAAGTGA CAGGCCACGG 
AAAGTCCGGT TTCGAATTGC CTCATCTCAC AGTGGGAGAG TTCTGAAAGA GGTCTATGAA 
GATGGACAAG CACCAGGCTC TCTGGATTCT GAATGTGCTA GTATTTGTGC CATAGATGGG 
CTAAGTGACT CTGAGGGACA GCAAAACGGC CACATTGGAT CAGAGGATAA TGAACAGGAG 
AAAGATCAGG ATAACCTGCT GGTATTAGCC AGGACAGCCA GCGAGAAGGC TTTTGGCACA 
AGAAGAGTCA ACATTTTAAG CAAAAATGGT ACAGTCAGAG GCGTCAAGTA CAAAGTGAGT 
GCTGGCCAGG CTCTGTTTAA CAATTTGACC AAAGTGTTGC AGCAGCCATC AGCTGACCTG 
GAATTTGACC GTGTGGTAAT TTATACAACC TGCCTTCGTG TGGTGAGGAC GACCTTCGAG 
AGATGCGAAC TGGTTAGAAA GATCTTCCAA AACCATCGAG TAAAGTTTGA AGAGAAAAAC 
ATAGCTCTAA ACGGTGACTA TGGGAAAGAG TTGGATGAAC GGTGCAGGAG AGTCTCCGAA 
GCTCCTTCCC TTCCTGTTGT CTTCATTGAT GGCCATTATC TTGGGGGTGC TGAGAAAATT 
TTGTCAATGA ATGAATCAGG AGAACTGCAA GACCTTTTAA CCAAAATTGA GAGGGTCCAG 
CATCCGCACG AGTGTCCTTC CTGTGGAGGC TTTGGCTTCC TTCCATGCTC TGTGTGCCAC 
GGAAGCAAGA TGTCAGTGTT TCGCAATTGC TTTACGGACG CTTTCAAAGC CCTCAAGTGT 
ACAGCTTGCA ATGAGAATGG TCTCCAGCGT TGTAAGAACT GCACCTGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018019.2
CDS	54..944
Translation	MWVEVTMLRRETKPESDRPRKVRFRIASSHSGRVLKEVYEDGQAPGSLDSECASICAIDGLSDSEGQQNGHIGSEDNEQEKDQDNLLVLARTASEKAFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSADLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDAFKALKCTACNENGLQRCKNCTC

Target ORF information:

RefSeq Version	NM_001018019.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin, cysteine rich 1 (Grxcr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018019.2

ORF Insert Sequence:

ATGTGGGTGG AGGTGACCAT GCTAAGAAGG GAGACAAAGC CAGAAAGTGA CAGGCCACGG 
AAAGTCCGGT TTCGAATTGC CTCATCTCAC AGTGGGAGAG TTCTGAAAGA GGTCTATGAA 
GATGGACAAG CACCAGGCTC TCTGGATTCT GAATGTGCTA GTATTTGTGC CATAGATGGG 
CTAAGTGACT CTGAGGGACA GCAAAACGGC CACATTGGAT CAGAGGATAA TGAACAGGAG 
AAAGATCAGG ATAACCTGCT GGTATTAGCC AGGACAGCCA GCGAGAAGGC TTTTGGCACA 
AGAAGAGTCA ACATTTTAAG CAAAAATGGT ACAGTCAGAG GCGTCAAGTA CAAAGTGAGT 
GCTGGCCAGG CTCTGTTTAA CAATTTGACC AAAGTGTTGC AGCAGCCATC AGCTGACCTG 
GAATTTGACC GTGTGGTAAT TTATACAACC TGCCTTCGTG TGGTGAGGAC GACCTTCGAG 
AGATGCGAAC TGGTTAGAAA GATCTTCCAA AACCATCGAG TAAAGTTTGA AGAGAAAAAC 
ATAGCTCTAA ACGGTGACTA TGGGAAAGAG TTGGATGAAC GGTGCAGGAG AGTCTCCGAA 
GCTCCTTCCC TTCCTGTTGT CTTCATTGAT GGCCATTATC TTGGGGGTGC TGAGAAAATT 
TTGTCAATGA ATGAATCAGG AGAACTGCAA GACCTTTTAA CCAAAATTGA GAGGGTCCAG 
CATCCGCACG AGTGTCCTTC CTGTGGAGGC TTTGGCTTCC TTCCATGCTC TGTGTGCCAC 
GGAAGCAAGA TGTCAGTGTT TCGCAATTGC TTTACGGACG CTTTCAAAGC CCTCAAGTGT 
ACAGCTTGCA ATGAGAATGG TCTCCAGCGT TGTAAGAACT GCACCTGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Nature communications712444(2016 Aug)
Potter PK,Bowl MR,Jeyarajan P,Wisby L,Blease A,Goldsworthy ME,Simon MM,Greenaway S,Michel V,Barnard A,Aguilar C,Agnew T,Banks G,Blake A,Chessum L,Dorning J,Falcone S,Goosey L,Harris S,Haynes A,Heise I,Hillier R,Hough T,Hoslin A,Hutchison M,King R,Kumar S,Lad HV,Law G,MacLaren RE,Morse S,Nicol T,Parker A,Pickford K,Sethi S,Starbuck B,Stelma F,Cheeseman M,Cross SH,Foster RG,Jackson IJ,Peirson SN,Thakker RV,Vincent T,Scudamore C,Wells S,El-Amraoui A,Petit C,Acevedo-Arozena A,Nolan PM,Cox R,Mallon AM,Brown SD

Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays.
Hearing research330(Pt A)62-77(2015 Dec)
Rodr?guez-de la Rosa L,S?nchez-Calder?n H,Contreras J,Murillo-Cuesta S,Falagan S,Avenda?o C,Dopazo J,Varela-Nieto I,Milo M

Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.
American journal of human genetics86(2)148-60(2010 Feb)
Odeh H,Hunker KL,Belyantseva IA,Azaiez H,Avenarius MR,Zheng L,Peters LM,Gagnon LH,Hagiwara N,Skynner MJ,Brilliant MH,Allen ND,Riazuddin S,Johnson KR,Raphael Y,Najmabadi H,Friedman TB,Bartles JR,Smith RJ,Kohrman DC

Characterization of two transgene insertional mutations at pirouette, a mouse deafness locus.
Audiology & neuro-otology9(5)303-14(2004 Sep-Oct)
Odeh H,Hagiwara N,Skynner M,Mitchem KL,Beyer LA,Allen ND,Brilliant MH,Lebart MC,Dolan DF,Raphael Y,Kohrman DC

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Grxcr1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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