CREG1 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	CREG1
Entrez Gene ID	433375
Full Name	cellular repressor of E1A-stimulated genes 1
Synonyms	AA755314,Creg
General protein information	Preferred Names cellular repressor of E1A-stimulated genes 1 Names protein CREG1
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H2.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_011804.3	NP_035934.1	protein CREG1 precursor
XM_006496930.1	XP_006496993.1	protein CREG1 isoform X1
NM_011804.2	NP_035934.1	protein CREG1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CREG1	NP_003842.1
Rattus norvegicus (Norway rat)	Creg1	NP_001099436.1
Bos taurus (cattle)	CREG1	NP_001069410.1
Drosophila melanogaster (fruit fly)	CREG	NP_524385.2
Pan troglodytes (chimpanzee)	CREG1	XP_001157266.2
Mus musculus (house mouse)	Creg1	NP_035934.1
Danio rerio (zebrafish)	creg1	NP_001074159.1
	CREG1	XP_001089325.1
Canis lupus familiaris (dog)	CREG1	XP_003435040.2
Gallus gallus (chicken)	CREG1	XP_003640512.1
Xenopus tropicalis (tropical clawed frog)	creg1	XP_002936277.2

Gene Ontology
Bibliography

Related articles in PubMed

The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance.
Zhang QY, Zhao LP, Tian XX, Yan CH, Li Y, Liu YX, Wang PX, Zhang XJ, Han YL
Hepatology (Baltimore, Md.)66(3)834-854(2017 09)

Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
Li Y, Liu Y, Tian X, Zhang Y, Song H, Liu M, Zhang X, Liu H, Zhang J, Zhang Q, Liu D, Peng C, Yan C, Han Y
Arteriosclerosis, thrombosis, and vascular biology37(3)485-494(2017 Mar)

CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.
Tian X, Yan C, Liu M, Zhang Q, Liu D, Liu Y, Li S, Han Y
PloS one12(5)e0176873(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CREG is a novel mediator of vascular remodeling in response to Ang II.
Title: Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.

Study demonstrated that haplodeficiency of Creg1 exacerbated high fat diet-induced obesity, insulin resistance and dyslipidemia. In addition, Creg1+/- mice showed increased systemic and adipose tissue inflammation, possibly through activation of the NF-kappaB pathway.
Title: CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.

CREG inhibits inflammation and promotes autophagy mediated by lysosome formation; it might be a potential therapeutic target in atherosclerosis.
Title: Cellular repressor of E1A-stimulated genes inhibits inflammation to decrease atherosclerosis in ApoE(-/-) mice.

CREG1 deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1-induced cardiomyocyte autophagy.
Title: CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression.

Data indicate cellular repressor of E1A-stimulated gene (CREG) as a factor in regulating endothelial differentiation and vasculogenesis via VEGF/PI3K/Akt pathway.
Title: CREG promotes vasculogenesis by activation of VEGF/PI3K/Akt pathway.

The following CREG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CREG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu28808	XM_006496930.1 Latest version!	Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu08882	NM_011804.3 Latest version!	Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu08882	NM_011804.2	Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CREG1 ( XM_006496930.1 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006496993.1 Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28808
Clone ID Related Accession (Same CDS sequence)	XM_006496930.1
Accession Version	XM_006496930.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	protein CREG1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG 
CTGGTGGCAC TACTGGTGTC GCCGGCCTCG GGTCGCGGAG GCCGGGACCA CGGGGACTGG 
GACGTGGACA GGCGATTGCC TCCGCTGCCA CCCCGCGAAG ACGGGCCGCG CGTGGCCCGC 
TTCGTGACTC ACGTCTCAGA CTGGGGCTCG CTGGCCACTA TCTCCACAAT AAAGGAGGTG 
CGCGGCTGGC CCTTCGCGGA CATCATCTCA ATCAGTGACG GTCCTCCGGG AGAAGGCACG 
GGCGAGCCCT ACATGTACCT GAGTCCACTG CAGCAAGCCG TGAGCGACCT GCAGGAAAAT 
CCAGAGGCTA CGCTGACTAT GTCTTTAGCA CAGACTGTCT ACTGTAGGAA TCATGGATTT 
GATCCCCAGA GTCCCCTGTG TGTTCATATA ATGATGTCGG GAACTGTGAC CAAGGTGAAC 
AAGACAGAAG AGGACTATGC AAGGGATTCG CTGTTTGTTC GACACCCTGA GATGAAGCAC 
TGGCCTTCCA GCCATAACTG GTTCTTTGCT AAATTAAAAA TAAGCCGTAT CTGGGTCTTG 
GACTACTTTG GTGGACCTAA AGTAGTGACA CCTGAAGAAT ATTTTAACGT CACGCTGCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496993.1
CDS	54..716
Translation	MAARAPELARSLLAALLAPALVALLVSPASGRGGRDHGDWDVDRRLPPLPPREDGPRVARFVTHVSDWGSLATISTIKEVRGWPFADIISISDGPPGEGTGEPYMYLSPLQQAVSDLQENPEATLTMSLAQTVYCRNHGFDPQSPLCVHIMMSGTVTKVNKTEEDYARDSLFVRHPEMKHWPSSHNWFFAKLKISRIWVLDYFGGPKVVTPEEYFNVTLQ

Target ORF information:

RefSeq Version	XM_006496930.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496930.1

ORF Insert Sequence:

ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG 
CTGGTGGCAC TACTGGTGTC GCCGGCCTCG GGTCGCGGAG GCCGGGACCA CGGGGACTGG 
GACGTGGACA GGCGATTGCC TCCGCTGCCA CCCCGCGAAG ACGGGCCGCG CGTGGCCCGC 
TTCGTGACTC ACGTCTCAGA CTGGGGCTCG CTGGCCACTA TCTCCACAAT AAAGGAGGTG 
CGCGGCTGGC CCTTCGCGGA CATCATCTCA ATCAGTGACG GTCCTCCGGG AGAAGGCACG 
GGCGAGCCCT ACATGTACCT GAGTCCACTG CAGCAAGCCG TGAGCGACCT GCAGGAAAAT 
CCAGAGGCTA CGCTGACTAT GTCTTTAGCA CAGACTGTCT ACTGTAGGAA TCATGGATTT 
GATCCCCAGA GTCCCCTGTG TGTTCATATA ATGATGTCGG GAACTGTGAC CAAGGTGAAC 
AAGACAGAAG AGGACTATGC AAGGGATTCG CTGTTTGTTC GACACCCTGA GATGAAGCAC 
TGGCCTTCCA GCCATAACTG GTTCTTTGCT AAATTAAAAA TAAGCCGTAT CTGGGTCTTG 
GACTACTTTG GTGGACCTAA AGTAGTGACA CCTGAAGAAT ATTTTAACGT CACGCTGCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CREG1 ( NM_011804.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_035934.1 Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu08882
Clone ID Related Accession (Same CDS sequence)	NM_011804.3 , NM_011804.2
Accession Version	NM_011804.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	protein CREG1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124587.5 and AW495378.1. On Sep 20, 2017 this sequence version replaced NM_011804.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144101.1, BC027426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG 
CTGGTGGCAC TACTGGTGTC GCCGGCCTCG GGTCGCGGAG GCCGGGACCA CGGGGACTGG 
GACGTGGACA GGCGATTGCC TCCGCTGCCA CCCCGCGAAG ACGGGCCGCG CGTGGCCCGC 
TTCGTGACTC ACGTCTCAGA CTGGGGCTCG CTGGCCACTA TCTCCACAAT AAAGGAGGTG 
CGCGGCTGGC CCTTCGCGGA CATCATCTCA ATCAGTGACG GTCCTCCGGG AGAAGGCACG 
GGCGAGCCCT ACATGTACCT GAGTCCACTG CAGCAAGCCG TGAGCGACCT GCAGGAAAAT 
CCAGAGGCTA CGCTGACTAT GTCTTTAGCA CAGACTGTCT ACTGTAGGAA TCATGGATTT 
GATCCCCAGA GTCCCCTGTG TGTTCATATA ATGATGTCGG GAACTGTGAC CAAGGTGAAC 
AAGACAGAAG AGGACTATGC AAGGGATTCG CTGTTTGTTC GACACCCTGA GATGAAGCAC 
TGGCCTTCCA GCCATAACTG GTTCTTTGCT AAATTAAAAA TAAGCCGTAT CTGGGTCTTG 
GACTACTTTG GTGGACCTAA AGTAGTGACA CCTGAAGAAT ATTTTAACGT CACGCTGCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035934.1
CDS	28..690
Translation	MAARAPELARSLLAALLAPALVALLVSPASGRGGRDHGDWDVDRRLPPLPPREDGPRVARFVTHVSDWGSLATISTIKEVRGWPFADIISISDGPPGEGTGEPYMYLSPLQQAVSDLQENPEATLTMSLAQTVYCRNHGFDPQSPLCVHIMMSGTVTKVNKTEEDYARDSLFVRHPEMKHWPSSHNWFFAKLKISRIWVLDYFGGPKVVTPEEYFNVTLQ

Target ORF information:

RefSeq Version	NM_011804.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011804.3

ORF Insert Sequence:

ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG 
CTGGTGGCAC TACTGGTGTC GCCGGCCTCG GGTCGCGGAG GCCGGGACCA CGGGGACTGG 
GACGTGGACA GGCGATTGCC TCCGCTGCCA CCCCGCGAAG ACGGGCCGCG CGTGGCCCGC 
TTCGTGACTC ACGTCTCAGA CTGGGGCTCG CTGGCCACTA TCTCCACAAT AAAGGAGGTG 
CGCGGCTGGC CCTTCGCGGA CATCATCTCA ATCAGTGACG GTCCTCCGGG AGAAGGCACG 
GGCGAGCCCT ACATGTACCT GAGTCCACTG CAGCAAGCCG TGAGCGACCT GCAGGAAAAT 
CCAGAGGCTA CGCTGACTAT GTCTTTAGCA CAGACTGTCT ACTGTAGGAA TCATGGATTT 
GATCCCCAGA GTCCCCTGTG TGTTCATATA ATGATGTCGG GAACTGTGAC CAAGGTGAAC 
AAGACAGAAG AGGACTATGC AAGGGATTCG CTGTTTGTTC GACACCCTGA GATGAAGCAC 
TGGCCTTCCA GCCATAACTG GTTCTTTGCT AAATTAAAAA TAAGCCGTAT CTGGGTCTTG 
GACTACTTTG GTGGACCTAA AGTAGTGACA CCTGAAGAAT ATTTTAACGT CACGCTGCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CREG1 ( NM_011804.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_035934.1 Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), mRNA.

Price & Availability↑

CloneID	OMu08882
Clone ID Related Accession (Same CDS sequence)	NM_011804.3 , NM_011804.2
Accession Version	NM_011804.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	protein CREG1 precursor
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC027426.1. On or before Sep 16, 2004 this sequence version replaced XM_358337.2, NM_011804.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027426.1, AK144101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG 
CTGGTGGCAC TACTGGTGTC GCCGGCCTCG GGTCGCGGAG GCCGGGACCA CGGGGACTGG 
GACGTGGACA GGCGATTGCC TCCGCTGCCA CCCCGCGAAG ACGGGCCGCG CGTGGCCCGC 
TTCGTGACTC ACGTCTCAGA CTGGGGCTCG CTGGCCACTA TCTCCACAAT AAAGGAGGTG 
CGCGGCTGGC CCTTCGCGGA CATCATCTCA ATCAGTGACG GTCCTCCGGG AGAAGGCACG 
GGCGAGCCCT ACATGTACCT GAGTCCACTG CAGCAAGCCG TGAGCGACCT GCAGGAAAAT 
CCAGAGGCTA CGCTGACTAT GTCTTTAGCA CAGACTGTCT ACTGTAGGAA TCATGGATTT 
GATCCCCAGA GTCCCCTGTG TGTTCATATA ATGATGTCGG GAACTGTGAC CAAGGTGAAC 
AAGACAGAAG AGGACTATGC AAGGGATTCG CTGTTTGTTC GACACCCTGA GATGAAGCAC 
TGGCCTTCCA GCCATAACTG GTTCTTTGCT AAATTAAAAA TAAGCCGTAT CTGGGTCTTG 
GACTACTTTG GTGGACCTAA AGTAGTGACA CCTGAAGAAT ATTTTAACGT CACGCTGCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035934.1
CDS	6..668
Translation	MAARAPELARSLLAALLAPALVALLVSPASGRGGRDHGDWDVDRRLPPLPPREDGPRVARFVTHVSDWGSLATISTIKEVRGWPFADIISISDGPPGEGTGEPYMYLSPLQQAVSDLQENPEATLTMSLAQTVYCRNHGFDPQSPLCVHIMMSGTVTKVNKTEEDYARDSLFVRHPEMKHWPSSHNWFFAKLKISRIWVLDYFGGPKVVTPEEYFNVTLQ

Target ORF information:

RefSeq Version	NM_011804.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011804.2

ORF Insert Sequence:

ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG 
CTGGTGGCAC TACTGGTGTC GCCGGCCTCG GGTCGCGGAG GCCGGGACCA CGGGGACTGG 
GACGTGGACA GGCGATTGCC TCCGCTGCCA CCCCGCGAAG ACGGGCCGCG CGTGGCCCGC 
TTCGTGACTC ACGTCTCAGA CTGGGGCTCG CTGGCCACTA TCTCCACAAT AAAGGAGGTG 
CGCGGCTGGC CCTTCGCGGA CATCATCTCA ATCAGTGACG GTCCTCCGGG AGAAGGCACG 
GGCGAGCCCT ACATGTACCT GAGTCCACTG CAGCAAGCCG TGAGCGACCT GCAGGAAAAT 
CCAGAGGCTA CGCTGACTAT GTCTTTAGCA CAGACTGTCT ACTGTAGGAA TCATGGATTT 
GATCCCCAGA GTCCCCTGTG TGTTCATATA ATGATGTCGG GAACTGTGAC CAAGGTGAAC 
AAGACAGAAG AGGACTATGC AAGGGATTCG CTGTTTGTTC GACACCCTGA GATGAAGCAC 
TGGCCTTCCA GCCATAACTG GTTCTTTGCT AAATTAAAAA TAAGCCGTAT CTGGGTCTTG 
GACTACTTTG GTGGACCTAA AGTAGTGACA CCTGAAGAAT ATTTTAACGT CACGCTGCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance.
Hepatology (Baltimore, Md.)66(3)834-854(2017 09)
Zhang QY,Zhao LP,Tian XX,Yan CH,Li Y,Liu YX,Wang PX,Zhang XJ,Han YL

Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
Arteriosclerosis, thrombosis, and vascular biology37(3)485-494(2017 Mar)
Li Y,Liu Y,Tian X,Zhang Y,Song H,Liu M,Zhang X,Liu H,Zhang J,Zhang Q,Liu D,Peng C,Yan C,Han Y

CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.
PloS one12(5)e0176873(2017)
Tian X,Yan C,Liu M,Zhang Q,Liu D,Liu Y,Li S,Han Y

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CREG1 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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