Opa3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Opa3
Entrez Gene ID	403187
Full Name	optic atrophy 3
Synonyms	D630048P19Rik,Gm1425,Gm472
General protein information	Preferred Names optic atrophy 3 Names optic atrophy 3 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_207525.3	NP_997408.2	optic atrophy 3 protein homolog

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OPA3	NP_001232863.1
Danio rerio (zebrafish)	opa3	NP_001073635.1
Homo sapiens (human)	OPA3	NP_001017989.2
Mus musculus (house mouse)	Opa3	NP_997408.2
Xenopus tropicalis (tropical clawed frog)	opa3	XP_002932648.1
Canis lupus familiaris (dog)	OPA3	XP_855096.1
Drosophila melanogaster (fruit fly)	CG13601	NP_001262890.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001401	XP_321733.4

Gene Ontology
Bibliography

Related articles in PubMed

Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity.
Navein AE, Cooke EJ, Davies JR, Smith TG, Wells LH, Ohazama A, Healy C, Sharpe PT, Evans SL, Evans BA, Votruba M, Wells T
Human molecular genetics25(12)2404-2416(2016 06)

Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome.
Wells T, Davies JR, Guschina IA, Ball DJ, Davies JS, Davies VJ, Evans BA, Votruba M
Human molecular genetics21(22)4836-44(2012 Nov)

Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.
Powell KA, Davies JR, Taylor E, Wride MA, Votruba M
Investigative ophthalmology & visual science52(7)4369-80(2011 Jun)

A missense mutation in the murine Opa3 gene models human Costeff syndrome.
Davies VJ, Powell KA, White KE, Yip W, Hogan V, Hollins AJ, Davies JR, Piechota M, Brownstein DG, Moat SJ, Nichols PP, Wride MA, Boulton ME, Votruba M
Brain : a journal of neurology131(Pt 2)368-80(2008 Feb)

Proteomic analysis of the mouse liver mitochondrial inner membrane.
Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA, Martinou JC
The Journal of biological chemistry278(42)41566-71(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Opa3(L122P) mice displayed craniofacial abnormalities, including undergrowth of the lower mandible, accompanied in some individuals by cranial asymmetry and incisor malocclusion
Title: Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity.

Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome.
Title: Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome.

Mutant Opa3 protein retains its mitochondrial localization and induces disrupted mitochondrial morphology. Opa3 accumulates in the lens. The results may reflect a slow turnover of Opa3 protein in vivo and may be important in normal lens physiology.
Title: Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.

to investigate the OPA3 function we have generated a novel ENU-induced mutant mouse carrying a missense mutation in the OPA3 gene. In the heterozygous state, the mice appear uncompromised. In the homozygous state mice display some of the features of MGA.
Title: A missense mutation in the murine Opa3 gene models human Costeff syndrome.

The following Opa3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Opa3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18703	NM_207525.3 Latest version!	Mus musculus optic atrophy 3 (Opa3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Opa3 ( NM_207525.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_997408.2 Mus musculus optic atrophy 3 (Opa3), mRNA.

Price & Availability↑

CloneID	OMu18703
Clone ID Related Accession (Same CDS sequence)	NM_207525.3
Accession Version	NM_207525.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-19
Organism	Mus musculus(house mouse)
Product	optic atrophy 3 protein homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK164755.1. On Apr 5, 2007 this sequence version replaced NM_207525.2. ##Evidence-Data-START## Transcript exon combination :: AK164755.1, AK154917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 18614015, 12865426; reported by MitoCarta ##RefSeq-Attributes-END##

ATGGTGGTGG GCGCGTTCCC CATGGCGAAG CTGTTCTACT TGGGCATCCG GCAGGTTAGC 
AAGCCGCTGG CCAACCGTAT CAAGGATGCT GCCCGCCGCA GCGAGTTCTT CAAGACCTAC 
ATCTGCCTAC CGCCAGCCCA GCTGTACCAC TGGGTGGAGA TGCGGACGAA GATGCGCATA 
ATGGGTTTCC GGGGCACTAC CATCAAGCCA CTGAATGAGG AGGCAGCAGC AGAGCTGGGT 
GCTGAGCTGC TGGGCGAGGC CACCATCTTC ATTGTGGGCG GAGGCTGCCT GGTCCTGGAG 
TACTGGCGCC ACCAGACTCA GCAGCGCAAT AAGGAGGAGG AACAGCGGGC AGCCTGGAAC 
GCTCTGCAGG ATGAGGTGGG CCGCCTGGCA CTGGCCTTAG AGGCGCTGCA GGCTCAGGCA 
CAAGCGATGC CCTCCTTGAG TGCCCTGGAG GAGCTGCGGG AGGAGCTGCA GGAGGTGCGT 
GGTCAGGTCT GCAATGCTCA CTGTACTTCC AAGTGCCAGG CAGCATCTTC CAAGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997408.2
CDS	55..594
Translation	MVVGAFPMAKLFYLGIRQVSKPLANRIKDAARRSEFFKTYICLPPAQLYHWVEMRTKMRIMGFRGTTIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQTQQRNKEEEQRAAWNALQDEVGRLALALEALQAQAQAMPSLSALEELREELQEVRGQVCNAHCTSKCQAASSKK

Target ORF information:

RefSeq Version	NM_207525.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus optic atrophy 3 (Opa3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207525.3

ORF Insert Sequence:

ATGGTGGTGG GCGCGTTCCC CATGGCGAAG CTGTTCTACT TGGGCATCCG GCAGGTTAGC 
AAGCCGCTGG CCAACCGTAT CAAGGATGCT GCCCGCCGCA GCGAGTTCTT CAAGACCTAC 
ATCTGCCTAC CGCCAGCCCA GCTGTACCAC TGGGTGGAGA TGCGGACGAA GATGCGCATA 
ATGGGTTTCC GGGGCACTAC CATCAAGCCA CTGAATGAGG AGGCAGCAGC AGAGCTGGGT 
GCTGAGCTGC TGGGCGAGGC CACCATCTTC ATTGTGGGCG GAGGCTGCCT GGTCCTGGAG 
TACTGGCGCC ACCAGACTCA GCAGCGCAAT AAGGAGGAGG AACAGCGGGC AGCCTGGAAC 
GCTCTGCAGG ATGAGGTGGG CCGCCTGGCA CTGGCCTTAG AGGCGCTGCA GGCTCAGGCA 
CAAGCGATGC CCTCCTTGAG TGCCCTGGAG GAGCTGCGGG AGGAGCTGCA GGAGGTGCGT 
GGTCAGGTCT GCAATGCTCA CTGTACTTCC AAGTGCCAGG CAGCATCTTC CAAGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity.
Human molecular genetics25(12)2404-2416(2016 06)
Navein AE,Cooke EJ,Davies JR,Smith TG,Wells LH,Ohazama A,Healy C,Sharpe PT,Evans SL,Evans BA,Votruba M,Wells T

Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome.
Human molecular genetics21(22)4836-44(2012 Nov)
Wells T,Davies JR,Guschina IA,Ball DJ,Davies JS,Davies VJ,Evans BA,Votruba M

Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.
Investigative ophthalmology & visual science52(7)4369-80(2011 Jun)
Powell KA,Davies JR,Taylor E,Wride MA,Votruba M

A missense mutation in the murine Opa3 gene models human Costeff syndrome.
Brain : a journal of neurology131(Pt 2)368-80(2008 Feb)
Davies VJ,Powell KA,White KE,Yip W,Hogan V,Hollins AJ,Davies JR,Piechota M,Brownstein DG,Moat SJ,Nichols PP,Wride MA,Boulton ME,Votruba M

Proteomic analysis of the mouse liver mitochondrial inner membrane.
The Journal of biological chemistry278(42)41566-71(2003 Oct)
Da Cruz S,Xenarios I,Langridge J,Vilbois F,Parone PA,Martinou JC

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Opa3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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