Scn4b cDNA ORF clone, Mus musculus(house mouse)

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel ?4 subunit explain its role in cell-cell adhesion.
Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S
The Journal of biological chemistry292(32)13428-13440(2017 08)

Loss of Nav?4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.
Ransdell JL, Dranoff E, Lau B, Lo WL, Donermeyer DL, Allen PM, Nerbonne JM
Cell reports19(3)532-544(2017 Apr)

The Sodium Channel ?4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons.
Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE
Frontiers in cellular neuroscience1117(2017)

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Menendez-Montes I, Escobar B, Palacios B, G?mez MJ, Izquierdo-Garcia JL, Flores L, Jim?nez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S
Developmental cell39(6)724-739(2016 12)

Data suggest that extracellular domains of Scn4b directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); Scn4b homodimers appear to play role in cell-cell adhesion.
Title: Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel ?4 subunit explain its role in cell-cell adhesion.

Scn4b(-/-) animals have deficits in motor coordination and balance and that firing rates in Scn4b(-/-) Purkinje neurons are markedly attenuated.
Title: Loss of Nav?4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.

NaVbeta4 plays a blocking role that indicates the relative importance of different residues in inducing open-channel block.
Title: Cross-species conservation of open-channel block by Na channel ?4 peptides reveals structural features required for resurgent Na current.

Data show that Na(V)beta4 (Scn4b} expression determines multiple aspects of Na channel gating, thereby regulating excitability in cultured cerebellar granule cells.
Title: Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neurons.

These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation.
Title: Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.