Cnrip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnrip1
Entrez Gene ID	380686
Full Name	cannabinoid receptor interacting protein 1
Synonyms	1500041B16Rik,3110054C06Rik,5330437A18Rik,AI854501,C2orf32
General protein information	Preferred Names cannabinoid receptor interacting protein 1 Names CB1 cannabinoid receptor-interacting protein 1 CRIP-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_029861.2	NP_084137.1	CB1 cannabinoid receptor-interacting protein 1
NM_029861.3	NP_084137.1	CB1 cannabinoid receptor-interacting protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CNRIP1	XP_515523.2
	CNRIP1	XP_001094135.1
Rattus norvegicus (Norway rat)	Cnrip1	NP_001014254.1
Xenopus tropicalis (tropical clawed frog)	cnrip1	NP_001120556.1
Mus musculus (house mouse)	Cnrip1	NP_084137.1
Canis lupus familiaris (dog)	CNRIP1	XP_005642505.1
Bos taurus (cattle)	CNRIP1	NP_001069651.1
Gallus gallus (chicken)	CNRIP1	NP_001264459.1
Homo sapiens (human)	CNRIP1	NP_056278.1
Danio rerio (zebrafish)	cnrip1b	XP_684894.2

Gene Ontology
Bibliography

Related articles in PubMed

Cannabinoid receptor interacting protein suppresses agonist-driven CB
Blume LC, Leone-Kabler S, Luessen DJ, Marrs GS, Lyons E, Bass CE, Chen R, Selley DE, Howlett AC
Journal of neurochemistry139(3)396-407(2016 11)

Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.
Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M
Brain structure & function221(4)2061-74(2016 05)

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertov? M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE
Molecular pharmacology87(4)747-65(2015 Apr)

Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
Blume LC, Eldeeb K, Bass CE, Selley DE, Howlett AC
Cellular signalling27(3)716-726(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies demonstrate a novel role for CRIP1a in agonist-driven CB1 R cell surface regulation postulated to occur by two mechanisms: 1) attenuating internalization that is agonist-mediated, but not that in the absence of exogenous agonists, and 2) biased agonist-dependent trafficking of de novo synthesized receptor to the cell surface
Title: Cannabinoid receptor interacting protein suppresses agonist-driven CB

Ddata indicate that cannabinoid receptor-interacting protein 1a enhances hippocampal cannabinoid type 1 receptor signaling in vivo.
Title: Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.

CRIP1a appears to act as a broad negative regulator of CB1 receptor function
Title: Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.

Endogenous levels of CRIP1a modulate CB1R-mediated signal transduction by facilitating a Gi/o protein subtype preference for Gi1 and Gi2, accompanied by an overall suppression of G-protein-mediated signaling in neuronal cells.
Title: Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.

The following Cnrip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnrip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17915	NM_029861.3 Latest version!	Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu17915	NM_029861.2	Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnrip1 ( NM_029861.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084137.1 Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.

Price & Availability↑

CloneID	OMu17915
Clone ID Related Accession (Same CDS sequence)	NM_029861.2 , NM_029861.3
Accession Version	NM_029861.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Mus musculus(house mouse)
Product	CB1 cannabinoid receptor-interacting protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087946.1. On Apr 5, 2007 this sequence version replaced NM_029861.1. ##Evidence-Data-START## Transcript exon combination :: BC087946.1, AK171947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGACC TACCCGGACT CGTGCGCCTT TCCATCGCGC TGCGCATCCA GCCCAACGAC 
GGCCCTGTTT TCTTCAAGGT GGACGGGCAG CGTTTTGGCC AGAACCGCAC AATCAAGCTG 
CTCACCGGCT CCTCCTACAA GGTGGAGGTG AAGATTAAGC CCACAACACT GCAGGTCGAG 
AACATTTCCA TTGGTGGTGT CCTTGTCCCA CTGGAGCTGA AGGGTAAAGA GCCTGACGGG 
GAGAGAGTTG TCTACACCGG CATCTATGAC ACAGAAGGTG TAGCCCCAAC CAAAAGTGGA 
GAGCGACAAC CCATCCAGAT CACCATGCCT TTCACAGACA TTGGGACCTT CGAGACAGTG 
TGGCAAGTCA AATTCTACAA TTACCACAAG CGAGACCATT GCCAGTGGGG AAGTCCTTTC 
TCTGTCATTG AGTATGAATG CAAGCCCAAT GAGACCCGCA GCCTCATGTG GGTGAATAAG 
GAGTCCTTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084137.1
CDS	237..731
Translation	MGDLPGLVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKGKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL

Target ORF information:

RefSeq Version	NM_029861.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029861.2

ORF Insert Sequence:

ATGGGGGACC TACCCGGACT CGTGCGCCTT TCCATCGCGC TGCGCATCCA GCCCAACGAC 
GGCCCTGTTT TCTTCAAGGT GGACGGGCAG CGTTTTGGCC AGAACCGCAC AATCAAGCTG 
CTCACCGGCT CCTCCTACAA GGTGGAGGTG AAGATTAAGC CCACAACACT GCAGGTCGAG 
AACATTTCCA TTGGTGGTGT CCTTGTCCCA CTGGAGCTGA AGGGTAAAGA GCCTGACGGG 
GAGAGAGTTG TCTACACCGG CATCTATGAC ACAGAAGGTG TAGCCCCAAC CAAAAGTGGA 
GAGCGACAAC CCATCCAGAT CACCATGCCT TTCACAGACA TTGGGACCTT CGAGACAGTG 
TGGCAAGTCA AATTCTACAA TTACCACAAG CGAGACCATT GCCAGTGGGG AAGTCCTTTC 
TCTGTCATTG AGTATGAATG CAAGCCCAAT GAGACCCGCA GCCTCATGTG GGTGAATAAG 
GAGTCCTTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cnrip1 ( NM_029861.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084137.1 Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.

Price & Availability↑

CloneID	OMu17915
Clone ID Related Accession (Same CDS sequence)	NM_029861.2 , NM_029861.3
Accession Version	NM_029861.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	CB1 cannabinoid receptor-interacting protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL606466.12. On Aug 21, 2018 this sequence version replaced NM_029861.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.2298740.1, SRR7345562.1313356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGACC TACCCGGACT CGTGCGCCTT TCCATCGCGC TGCGCATCCA GCCCAACGAC 
GGCCCTGTTT TCTTCAAGGT GGACGGGCAG CGTTTTGGCC AGAACCGCAC AATCAAGCTG 
CTCACCGGCT CCTCCTACAA GGTGGAGGTG AAGATTAAGC CCACAACACT GCAGGTCGAG 
AACATTTCCA TTGGTGGTGT CCTTGTCCCA CTGGAGCTGA AGGGTAAAGA GCCTGACGGG 
GAGAGAGTTG TCTACACCGG CATCTATGAC ACAGAAGGTG TAGCCCCAAC CAAAAGTGGA 
GAGCGACAAC CCATCCAGAT CACCATGCCT TTCACAGACA TTGGGACCTT CGAGACAGTG 
TGGCAAGTCA AATTCTACAA TTACCACAAG CGAGACCATT GCCAGTGGGG AAGTCCTTTC 
TCTGTCATTG AGTATGAATG CAAGCCCAAT GAGACCCGCA GCCTCATGTG GGTGAATAAG 
GAGTCCTTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084137.1
CDS	312..806
Translation	MGDLPGLVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKGKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL

Target ORF information:

RefSeq Version	NM_029861.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029861.3

ORF Insert Sequence:

ATGGGGGACC TACCCGGACT CGTGCGCCTT TCCATCGCGC TGCGCATCCA GCCCAACGAC 
GGCCCTGTTT TCTTCAAGGT GGACGGGCAG CGTTTTGGCC AGAACCGCAC AATCAAGCTG 
CTCACCGGCT CCTCCTACAA GGTGGAGGTG AAGATTAAGC CCACAACACT GCAGGTCGAG 
AACATTTCCA TTGGTGGTGT CCTTGTCCCA CTGGAGCTGA AGGGTAAAGA GCCTGACGGG 
GAGAGAGTTG TCTACACCGG CATCTATGAC ACAGAAGGTG TAGCCCCAAC CAAAAGTGGA 
GAGCGACAAC CCATCCAGAT CACCATGCCT TTCACAGACA TTGGGACCTT CGAGACAGTG 
TGGCAAGTCA AATTCTACAA TTACCACAAG CGAGACCATT GCCAGTGGGG AAGTCCTTTC 
TCTGTCATTG AGTATGAATG CAAGCCCAAT GAGACCCGCA GCCTCATGTG GGTGAATAAG 
GAGTCCTTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cannabinoid receptor interacting protein suppresses agonist-driven CB
Journal of neurochemistry139(3)396-407(2016 11)
Blume LC,Leone-Kabler S,Luessen DJ,Marrs GS,Lyons E,Bass CE,Chen R,Selley DE,Howlett AC

Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.
Brain structure & function221(4)2061-74(2016 05)
Guggenhuber S,Alpar A,Chen R,Schmitz N,Wickert M,Mattheus T,Harasta AE,Purrio M,Kaiser N,Elphick MR,Monory K,Kilb W,Luhmann HJ,Harkany T,Lutz B,Klugmann M

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Molecular pharmacology87(4)747-65(2015 Apr)
Smith TH,Blume LC,Straiker A,Cox JO,David BG,McVoy JR,Sayers KW,Poklis JL,Abdullah RA,Egertov? M,Chen CK,Mackie K,Elphick MR,Howlett AC,Selley DE

Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
Cellular signalling27(3)716-726(2015 Mar)
Blume LC,Eldeeb K,Bass CE,Selley DE,Howlett AC

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Cnrip1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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