Nanos1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nanos1
Entrez Gene ID	332397
Full Name	nanos C2HC-type zinc finger 1
Synonyms	NOS-1
General protein information	Preferred Names nanos C2HC-type zinc finger 1 Names nanos homolog 1 nanos 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 D3
Summary	This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2and may be involved in regulating translation as a post-transcriptional repressor. Mutations in a similar protein in human are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]. COMPLETENESS: complete on the 3' end.

mRNA and Protein(s)

mRNA	Protein	Name
NM_178421.3	NP_848508.2	nanos homolog 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NANOS1	NP_955631.1
Rattus norvegicus (Norway rat)	Nanos1	XP_006231749.1
Gallus gallus (chicken)	NANOS1	XP_003641548.1
Canis lupus familiaris (dog)	NANOS1	XP_005637940.1
Bos taurus (cattle)	NANOS1	XP_005225853.1
Mus musculus (house mouse)	Nanos1	NP_848508.2

Gene Ontology
Bibliography

Related articles in PubMed

A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.
Amadei G, Zander MA, Yang G, Dumelie JG, Vessey JP, Lipshitz HD, Smibert CA, Kaplan DR, Miller FD
The Journal of neuroscience : the official journal of the Society for Neuroscience35(47)15666-81(2015 Nov)

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.
Miles WO, Korenjak M, Griffiths LM, Dyer MA, Provero P, Dyson NJ
The EMBO journal33(19)2201-15(2014 Oct)

Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.
Glassmann A, Topka S, Wang-Eckardt L, Anders S, Weisheit G, Endl E, Zimmer A, Schilling K
Neuroscience159(1)69-82(2009 Mar)

Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes.
Kurokawa H, Aoki Y, Nakamura S, Ebe Y, Kobayashi D, Tanaka M
Development, growth & differentiation48(3)209-21(2006 Apr)

nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development.
Haraguchi S, Tsuda M, Kitajima S, Sasaoka Y, Nomura-Kitabayashid A, Kurokawa K, Saga Y
Mechanisms of development120(6)721-31(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both Nanos1 and Smaug2 function as a bimodal translational repression switch to control neurogenesis.
Title: A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.

The following Nanos1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nanos1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58282	NM_178421.3 Latest version!	Mus musculus nanos C2HC-type zinc finger 1 (Nanos1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nanos1 ( NM_178421.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848508.2 Mus musculus nanos C2HC-type zinc finger 1 (Nanos1), mRNA.

Price & Availability↑

CloneID	OMu58282
Clone ID Related Accession (Same CDS sequence)	NM_178421.3
Accession Version	NM_178421.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	nanos homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC085512.1 and BC056473.1. On or before May 4, 2006 this sequence version replaced XM_977064.1, XM_986182.1, NM_178421.2. COMPLETENESS: complete on the 3' end.

ATGGAGGCTT TCCCTTGGGC GCCACGCTCG CCCCGCCGCG CCCGCGCCCC CGCGCCTATG 
GCGCTCGTGC CCAGCGCCCG CTACGTGAGC GCCTCGGGCC CGGTGCACCC GCAGCCCTTC 
AGCTCCTGGA ACGACTACCT GGGGCTTGCC ACGCTCATCA CCAGGGCTAG CGACCGCGGC 
TCCCCGCATG AGGGGCCCGG GCCCACGGCG GCGGGGCCCA CGATGGGGCC GCCCGAGGAC 
GATGAAGACG ATGACGGCGA AGAGCCGGAG GCCGGGGGCC GCTACCTGGG CGGTGCGTTG 
GAACTGCGCG CACTAGAGCT GTGTGCCGGC CCCGCTGAGC CCGGGTTGCT GGAGGAGCGC 
TTCGCTGAGC TGAACCCGTT TGCAGGGCGC GCCGCCGCGG TTCTGCTGGG CTGCGCGCCC 
ACCGCCTCCA CCACCGCCGC CGCCGCATCC ACGGCCGAAG TGACGCCGCG CGAAGAGCCA 
AGCCCTGCGT GGGCTGCCGA GCCTCGTCTG CACGCGGCTT CCGGGGCGAC CGCCGCACGT 
CTGCTGAAAC CGGAGCTTCA GGTGTGTGTG TTTTGCCGGA ACAACAAGGA GGCGGTGGCG 
CTCTACACCA CACACATCCT CAAGGGCCCG GACGGCCGGG TGCTGTGCCC GGTCTTGCGC 
CGCTACACGT GCCCCCTGTG CGGCGCCAGC GGCGACAACG CACATACCAT CAAGTATTGC 
CCGCTCTCCA AAGTGCCACC GCCCACCGTC CGCCCGCCGC CGCGCAGCAA CAGGGACAGC 
CTGCCCAGCA AGAAGCTGCG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848508.2
CDS	280..1083
Translation	MEAFPWAPRSPRRARAPAPMALVPSARYVSASGPVHPQPFSSWNDYLGLATLITRASDRGSPHEGPGPTAAGPTMGPPEDDEDDDGEEPEAGGRYLGGALELRALELCAGPAEPGLLEERFAELNPFAGRAAAVLLGCAPTASTTAAAASTAEVTPREEPSPAWAAEPRLHAASGATAARLLKPELQVCVFCRNNKEAVALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPTVRPPPRSNRDSLPSKKLR

Target ORF information:

RefSeq Version	NM_178421.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus nanos C2HC-type zinc finger 1 (Nanos1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178421.3

ORF Insert Sequence:

ATGGAGGCTT TCCCTTGGGC GCCACGCTCG CCCCGCCGCG CCCGCGCCCC CGCGCCTATG 
GCGCTCGTGC CCAGCGCCCG CTACGTGAGC GCCTCGGGCC CGGTGCACCC GCAGCCCTTC 
AGCTCCTGGA ACGACTACCT GGGGCTTGCC ACGCTCATCA CCAGGGCTAG CGACCGCGGC 
TCCCCGCATG AGGGGCCCGG GCCCACGGCG GCGGGGCCCA CGATGGGGCC GCCCGAGGAC 
GATGAAGACG ATGACGGCGA AGAGCCGGAG GCCGGGGGCC GCTACCTGGG CGGTGCGTTG 
GAACTGCGCG CACTAGAGCT GTGTGCCGGC CCCGCTGAGC CCGGGTTGCT GGAGGAGCGC 
TTCGCTGAGC TGAACCCGTT TGCAGGGCGC GCCGCCGCGG TTCTGCTGGG CTGCGCGCCC 
ACCGCCTCCA CCACCGCCGC CGCCGCATCC ACGGCCGAAG TGACGCCGCG CGAAGAGCCA 
AGCCCTGCGT GGGCTGCCGA GCCTCGTCTG CACGCGGCTT CCGGGGCGAC CGCCGCACGT 
CTGCTGAAAC CGGAGCTTCA GGTGTGTGTG TTTTGCCGGA ACAACAAGGA GGCGGTGGCG 
CTCTACACCA CACACATCCT CAAGGGCCCG GACGGCCGGG TGCTGTGCCC GGTCTTGCGC 
CGCTACACGT GCCCCCTGTG CGGCGCCAGC GGCGACAACG CACATACCAT CAAGTATTGC 
CCGCTCTCCA AAGTGCCACC GCCCACCGTC CGCCCGCCGC CGCGCAGCAA CAGGGACAGC 
CTGCCCAGCA AGAAGCTGCG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(47)15666-81(2015 Nov)
Amadei G,Zander MA,Yang G,Dumelie JG,Vessey JP,Lipshitz HD,Smibert CA,Kaplan DR,Miller FD

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.
The EMBO journal33(19)2201-15(2014 Oct)
Miles WO,Korenjak M,Griffiths LM,Dyer MA,Provero P,Dyson NJ

Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.
Neuroscience159(1)69-82(2009 Mar)
Glassmann A,Topka S,Wang-Eckardt L,Anders S,Weisheit G,Endl E,Zimmer A,Schilling K

Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes.
Development, growth & differentiation48(3)209-21(2006 Apr)
Kurokawa H,Aoki Y,Nakamura S,Ebe Y,Kobayashi D,Tanaka M

nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development.
Mechanisms of development120(6)721-31(2003 Jun)
Haraguchi S,Tsuda M,Kitajima S,Sasaoka Y,Nomura-Kitabayashid A,Kurokawa K,Saga Y

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Nanos1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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