Frs2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Frs2
Entrez Gene ID	327826
Full Name	fibroblast growth factor receptor substrate 2
Synonyms	4732458E18,C330018A15Rik,Frs2alpha,SNT1
General protein information	Preferred Names fibroblast growth factor receptor substrate 2 Names fibroblast growth factor receptor substrate 2 FGFR substrate 2 FGFR-signaling adaptor SNT FRS2-alpha SNT-1 suc1-associated neurotrophic factor target 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_177798.3	NP_808466.1	fibroblast growth factor receptor substrate 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FRS2	XP_001155588.1
	LOC717117	XP_001108342.2
Canis lupus familiaris (dog)	FRS2	XP_005625670.1
Homo sapiens (human)	FRS2	NP_001265285.1
Mus musculus (house mouse)	Frs2	NP_808466.1
Rattus norvegicus (Norway rat)	Frs2	NP_001101567.2
Gallus gallus (chicken)	FRS2	NP_001186555.1
Danio rerio (zebrafish)	frs2a	NP_001038363.1
Xenopus tropicalis (tropical clawed frog)	frs2	NP_001128281.1
Bos taurus (cattle)	FRS2	XP_002687431.1

Gene Ontology
Bibliography

Related articles in PubMed

Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.
Puri P, Schaefer CM, Bushnell D, Taglienti ME, Kreidberg JA, Yoder BK, Bates CM
The American journal of pathology188(1)84-94(2018 Jan)

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X
eLife7(2018 Jan)

Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
Nandi S, Alvi?a K, Lituma PJ, Castillo PE, H?bert JM
Neuroscience369192-201(2018 Jan)

Loss of peri-Wolffian duct stromal Frs2? expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.
Narla D, Slagle SB, Schaefer CM, Bushnell DS, Puri P, Bates CM
Pediatric research82(6)1022-1029(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fgfr signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
Title: Fibroblast growth factor receptor-Frs2? signaling is critical for nephron progenitors.

Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be regulated by MAP kinase.
Title: FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.

data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK pathway components in the epididymis.
Title: The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis.

Genetic evidence further supports that the formation of an Frs2alpha-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process.
Title: Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma.

Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.
Title: Frs2? enhances fibroblast growth factor-mediated survival and differentiation in lens development.

The following Frs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Frs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17520	NM_177798.3 Latest version!	Mus musculus fibroblast growth factor receptor substrate 2 (Frs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Frs2 ( NM_177798.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808466.1 Mus musculus fibroblast growth factor receptor substrate 2 (Frs2), mRNA.

Price & Availability↑

CloneID	OMu17520
Clone ID Related Accession (Same CDS sequence)	NM_177798.3
Accession Version	NM_177798.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	fibroblast growth factor receptor substrate 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC043109.1. On or before May 4, 2006 this sequence version replaced XM_984180.1, NM_177022.2, NM_177798.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC043109.1, BC055334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGGTAGCT GTTGTAGCTG TCCAGATAAA GACACTGTCC CAGATAACCA TCGGAACAAG 
TTTAAGGTCA TTAATGTGGA TGATGATGGG AATGAGCTAG GCTCTGGTGT GATGGAACTC 
ACAGACACAG AGCTGATTCT GTACACCCGG AAACGGGACT CGGTAAAATG GCACTACCTC 
TGCCTACGAC GATACGGCTA TGACTCAAAT CTGTTTTCTT TTGAAAGTGG TCGAAGGTGT 
CAGACTGGAC AAGGAATTTT TGCTTTTAAG TGTGCCCGTG CAGAAGAATT ATTTAACATG 
TTGCAAGAGA TTATGCAAAA TAATAGTATA AATGTGGTGG AAGAGCCGGT TGTAGAAAGG 
AGTAGTCATC AGACAGAGCT GGAAGTCCCT AGGACACCTC GGACACCTAC AACTCCAGGG 
CTCGGTGCTC AGAACTTACC TAATGGGTAT CCCCGCTACC CCTCGTTTGG AGACGCTTCA 
TCCCACCCCT CAAGCCGGCA TCCTTCGGTG GGAAGTGCTC GCTTACCTTC AGTCGGTGAA 
GAGTCCACAC ACCCTTTGCT CGTGGCTGAG GAACAAGTAC ATACTTATGT TAACACTACA 
GGTGTGCAAG AGGAGCGAAA AAACCGTGCA AGTGTGCATG TTCCCCCAGA GGCAAGGGTT 
TCTAATGCTG AGAGCAACAC ACCAAAAGAA GAGCCGAGTA ACCCCGAGGA CAGGGACCCG 
CAAGTGCTTC TTAAGCCTGA AGGAGTCAGG TTTGTGCTAG GACCAACCCC TGTCCAGAAG 
CAGTTAATGG AAAAGGAGAA ACTGGAGCAA CTGGGAAAAG ACCCAGTCAG TGGGAGTGGA 
GCGGGCAACA CGGAGTGGGA CACCGGCTAT GACAGTGACG AGCGCAGAGA TGTGCCCCCT 
GTCAACAAAC TGGTGTATGA AAATATAAAC GGGCTATCTA TTCCCAGTGC CTCAGGGGTC 
AGGAGAGGTC GTCTGACATC TACCAGCACC TCAGACACCC AGAATATCAA CAACTCAGCG 
CAGAGAAGAC CTGCACTATT AAACTATGAA AATTTACCAT CTTTGCCTCC TGTTTGGGAA 
GCCCGCAAGC TCAGTAGGGA TGAAGATGAC AATTTAGGAC CAAAGACCCC ATCTCTAAAT 
GGCTACCATA ATAATCTAGA TCCAATGCAT AACTATGTTA ATACAGAGAA TGTAACAGTG 
CCGGCAAGTG CTCACAAAAT AGACTATTCG AAGCGCAGGG ATTGTACACC GACAGTCTTT 
AACTTTGATA TCAGGCGACC CAGTTTAGAA CATAGGCAAC TCAATTATAT ACAGGTGGAT 
TTGGAAGGGG GCAGTGACTC TGACAACCCT CAGACTCCAA AAACGCCGAC CACTCCCCTC 
CCGCAAACCC CCACGCGGCG CACAGAGCTG TACGCTGTGA TAGACATTGA GAGAACTGCT 
GCTATGTCCA ACTTGCAGAA AGCGCTGCCT CGAGACGACG GTACATCTCG GAAGACGAGG 
CACAATAGTA CTGACCTGCC CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808466.1
CDS	356..1882
Translation	MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGVMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTPGLGAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRASVHVPPEARVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGPTPVQKQLMEKEKLEQLGKDPVSGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIDYSKRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM

Target ORF information:

RefSeq Version	NM_177798.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibroblast growth factor receptor substrate 2 (Frs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177798.3

ORF Insert Sequence:

ATGGGTAGCT GTTGTAGCTG TCCAGATAAA GACACTGTCC CAGATAACCA TCGGAACAAG 
TTTAAGGTCA TTAATGTGGA TGATGATGGG AATGAGCTAG GCTCTGGTGT GATGGAACTC 
ACAGACACAG AGCTGATTCT GTACACCCGG AAACGGGACT CGGTAAAATG GCACTACCTC 
TGCCTACGAC GATACGGCTA TGACTCAAAT CTGTTTTCTT TTGAAAGTGG TCGAAGGTGT 
CAGACTGGAC AAGGAATTTT TGCTTTTAAG TGTGCCCGTG CAGAAGAATT ATTTAACATG 
TTGCAAGAGA TTATGCAAAA TAATAGTATA AATGTGGTGG AAGAGCCGGT TGTAGAAAGG 
AGTAGTCATC AGACAGAGCT GGAAGTCCCT AGGACACCTC GGACACCTAC AACTCCAGGG 
CTCGGTGCTC AGAACTTACC TAATGGGTAT CCCCGCTACC CCTCGTTTGG AGACGCTTCA 
TCCCACCCCT CAAGCCGGCA TCCTTCGGTG GGAAGTGCTC GCTTACCTTC AGTCGGTGAA 
GAGTCCACAC ACCCTTTGCT CGTGGCTGAG GAACAAGTAC ATACTTATGT TAACACTACA 
GGTGTGCAAG AGGAGCGAAA AAACCGTGCA AGTGTGCATG TTCCCCCAGA GGCAAGGGTT 
TCTAATGCTG AGAGCAACAC ACCAAAAGAA GAGCCGAGTA ACCCCGAGGA CAGGGACCCG 
CAAGTGCTTC TTAAGCCTGA AGGAGTCAGG TTTGTGCTAG GACCAACCCC TGTCCAGAAG 
CAGTTAATGG AAAAGGAGAA ACTGGAGCAA CTGGGAAAAG ACCCAGTCAG TGGGAGTGGA 
GCGGGCAACA CGGAGTGGGA CACCGGCTAT GACAGTGACG AGCGCAGAGA TGTGCCCCCT 
GTCAACAAAC TGGTGTATGA AAATATAAAC GGGCTATCTA TTCCCAGTGC CTCAGGGGTC 
AGGAGAGGTC GTCTGACATC TACCAGCACC TCAGACACCC AGAATATCAA CAACTCAGCG 
CAGAGAAGAC CTGCACTATT AAACTATGAA AATTTACCAT CTTTGCCTCC TGTTTGGGAA 
GCCCGCAAGC TCAGTAGGGA TGAAGATGAC AATTTAGGAC CAAAGACCCC ATCTCTAAAT 
GGCTACCATA ATAATCTAGA TCCAATGCAT AACTATGTTA ATACAGAGAA TGTAACAGTG 
CCGGCAAGTG CTCACAAAAT AGACTATTCG AAGCGCAGGG ATTGTACACC GACAGTCTTT 
AACTTTGATA TCAGGCGACC CAGTTTAGAA CATAGGCAAC TCAATTATAT ACAGGTGGAT 
TTGGAAGGGG GCAGTGACTC TGACAACCCT CAGACTCCAA AAACGCCGAC CACTCCCCTC 
CCGCAAACCC CCACGCGGCG CACAGAGCTG TACGCTGTGA TAGACATTGA GAGAACTGCT 
GCTATGTCCA ACTTGCAGAA AGCGCTGCCT CGAGACGACG GTACATCTCG GAAGACGAGG 
CACAATAGTA CTGACCTGCC CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.
The American journal of pathology188(1)84-94(2018 Jan)
Puri P,Schaefer CM,Bushnell D,Taglienti ME,Kreidberg JA,Yoder BK,Bates CM

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
eLife7(2018 Jan)
Collins TN,Mao Y,Li H,Bouaziz M,Hong A,Feng GS,Wang F,Quilliam LA,Chen L,Park T,Curran T,Zhang X

Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
Neuroscience369192-201(2018 Jan)
Nandi S,Alvi?a K,Lituma PJ,Castillo PE,H?bert JM

Loss of peri-Wolffian duct stromal Frs2? expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.
Pediatric research82(6)1022-1029(2017 Dec)
Narla D,Slagle SB,Schaefer CM,Bushnell DS,Puri P,Bates CM

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Frs2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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