Rfx6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rfx6
Entrez Gene ID	320995
Full Name	regulatory factor X, 6
Synonyms	4930572O07Rik,Rfxdc1
General protein information	Preferred Names regulatory factor X, 6 Names DNA-binding protein RFX6 regulatory factor X domain containing 1 regulatory factor X domain-containing protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_177306.3	NP_796280.1	DNA-binding protein RFX6 isoform 2
NM_001159389.1	NP_001152861.1	DNA-binding protein RFX6 isoform 1

Pathways from BioSystems

Homologies

	RFX6	XP_001110999.1
Rattus norvegicus (Norway rat)	Rfx6	NP_001099858.1
Xenopus tropicalis (tropical clawed frog)	rfx6	XP_002938344.2
Canis lupus familiaris (dog)	RFX6	XP_541213.2
Bos taurus (cattle)	RFX6	XP_003586511.1
Mus musculus (house mouse)	Rfx6	NP_001152861.1
Homo sapiens (human)	RFX6	NP_775831.2
Danio rerio (zebrafish)	rfx6	XP_684953.4
Pan troglodytes (chimpanzee)	RFX6	XP_527584.2
Gallus gallus (chicken)	RFX6	XP_419769.4

Gene Ontology
Bibliography

Related articles in PubMed

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.
Churchill AJ, Guti?rrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L
eLife6(2017 Jan)

?-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S
PloS one11(2)e0150010(2016)

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.
Mu?oz-Bravo JL, Flores-Mart?nez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA
PloS one11(10)e0164714(2016)

Rfx6 maintains the functional identity of adult pancreatic ? cells.
Piccand J, Strasser P, Hodson DJ, Meunier A, Ye T, Keime C, Birling MC, Rutter GA, Gradwohl G
Cell reports9(6)2219-32(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rfx6 loss in adult beta cells leads to glucose intolerance, impaired beta cell glucose sensing, and defective insulin secretion.
Title: Rfx6 maintains the functional identity of adult pancreatic ? cells.

Rfx6 increases GIP expression and content in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.
Title: Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.

studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans
Title: Rfx6 directs islet formation and insulin production in mice and humans.

Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. It is dependent on Ngn3 and during islet cell differentiation.
Title: Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.

The following Rfx6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rfx6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15726	NM_177306.3 Latest version!	Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$391.30 $559.00
OMu16097	NM_001159389.1 Latest version!	Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rfx6 ( NM_177306.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796280.1 Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15726
Clone ID Related Accession (Same CDS sequence)	NM_177306.3
Accession Version	NM_177306.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-10
Organism	Mus musculus(house mouse)
Product	DNA-binding protein RFX6 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK029809.1. On Apr 6, 2007 this sequence version replaced NM_177306.2. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029809.1 [ECO:0000332] ##Evidence-Data-END##

ATGATGTACA AAACTCACTG CCAGTGCATA CTCGACAATG CCATCAATGG GAACTTTGAA 
GAGATCCAGC ATTTCTTACT ACACTTTTGG CAAGGAATGC CAGACCATCT CCTTCCCCTG 
CTTGAAAATC CTGTTATCAT TGATATTTTC TGTGTCTGTG ACTCAATTCT TTATAAGGTT 
CTTACAGATG TCCTCATTCC TGCAACAATG CAAGAAATGC CTGAAAGTTT GTTAGCAGAT 
ATAAGAAATT TTGCTAAAAA TTGGGAACAG TGGGTTGTTT CATCCTTGGA AAACTTGCCA 
GAAGCCCTCA TTGATAAGAA AATCCCCATT TTGCGAAGAT TTGTATCTTC CCTGAAGCGA 
CAGACATCTT TCTTGCATCT TGCTCAGATT GCCAGACCAG CTCTCTTTGA CCAGCATGTG 
GTGAATGCCA TGGTATCTGA TATTGAAAAG GTTGACTTAA ATAGTATTGG GTCTCAGGCT 
CTTCTTACCA TATCCAACAG CACAGACACG GAATCTGACA TCTACAGTGA ACATGACTCT 
ATTACTGTGT TCCAAGAACT GAAAGATCTC CTTAAGAAGA ATGCTACAGT GGAGGCATTT 
ATTGAATGGT TGGACACTGT GGTAGAGCAG AGAGTTATTA AGATGAGCAA ACAAAATGGA 
AGATCTCTGA AGAAGAGGGC TCAAGACTTT CTGCTCAAAT GGAGCTTTTT TGGTGCCCGC 
GTGATGCATA ATCTTACCTT GAACAACGCA TCAAGTTTTG GCTCTTTCCA TCTGATCCGA 
ATGCTTCTGG ATGAGTACAT TCTCCTGGCC ATGGAGACTC AATTTAACAA TGACAAAGAG 
CAGGAACTAC AGAATTTATT GGACAAGTAT ATGAAGAACT CGGATGCGAG TAAAGCTGCC 
TTCACAGCTT CCCCGAGCTC TTGCTTTCTG GCCAACCGAA ATAAGGCTAG CTCACTTGCC 
AGTGACACTG TGAAGAACGA AAGCCACGTG GAGACATCCT ATGTCCCTCT GCCTTCCAGC 
CAGCCTGGAG CCATACCCCC TGCTCTGCAC CCATTCTCAA CTGAGGACAC TGATAACATG 
CCACTCCCAG GTCAAATAGA GCTTTCACAA AGTACTGGCC ATCTGATGAC ACCACCGATT 
TCTCCAGCCA TAGCAAGCAG AGGAAGTGTT ATTAACCAAG GGCCAATGGC GAGCAGACCC 
CCGAGCGTGG GCACAGTTCT CTCAGCTCCA ACACATTGCT CAACATATGC AGAACCAATT 
TATCCTACGC TCTCTCCAGC CAACCACGAC TTTTATGGGA CCAACTCTAA CTATCAGACT 
ATGTTTAGGA CACAGTCTCA CCCTGCATCA AGCCTCTATG CTCACCGTGC AGAGCATGGG 
CGGTGCATGG CCTGGACTGA ACAGCAGCTT TCTAGAGACT TCTTTGGTGG CAGTTGTGCT 
GGGTCTCCAT ATAATTGTAG GCCACCTTCC AGTTATGGAC CATCCACACA CACACAAGAG 
TCACACAGCA TGCAGGTTTT GAACACAGGA AGCTTCAATT TCCTTAGTAA TGCAGGAGCT 
GGCAGCTGCC AAGGGTCAAC ATTGCCTTCT AATTCTCCCA ATGGATACTA TGGAAACAAT 
ATAAACTACT CAGAGGCACA TAGGCTTGGA TCGATGGTGA ACCAACATGT TTCAGTCATC 
AGCAGTGTGC GCTCCCTGCC TCCCTACAGT GATATTCATG ATCCACTTAA CATTTTAGAT 
GACAGCAGCC GGAAGCAGAA CAACTCGTTT TATGCAGACA CATTGTCTCC TGTTGCATGT 
CGTACTACTG TAGTAGCTTC CAACTTGCAA ACCCAGATTC CTTCATCTTC ATCCCAGTGT 
ATGTATGGAA CTTCCAATCA GTATCCAGTG CAAGATAGTC TGGACTCCAA TGCAGCAAGC 
AACAGAGAAA TGGTGTCCTC TTTACCACCC ATCAACACCG TGTTTATGGG GACAGCAGCT 
GGAGACACTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796280.1
CDS	474..2465
Translation	MMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSSLKRQTSFLHLAQIARPALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDTESDIYSEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKMSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKASSLASDTVKNESHVETSYVPLPSSQPGAIPPALHPFSTEDTDNMPLPGQIELSQSTGHLMTPPISPAIASRGSVINQGPMASRPPSVGTVLSAPTHCSTYAEPIYPTLSPANHDFYGTNSNYQTMFRTQSHPASSLYAHRAEHGRCMAWTEQQLSRDFFGGSCAGSPYNCRPPSSYGPSTHTQESHSMQVLNTGSFNFLSNAGAGSCQGSTLPSNSPNGYYGNNINYSEAHRLGSMVNQHVSVISSVRSLPPYSDIHDPLNILDDSSRKQNNSFYADTLSPVACRTTVVASNLQTQIPSSSSQCMYGTSNQYPVQDSLDSNAASNREMVSSLPPINTVFMGTAAGDT

Target ORF information:

RefSeq Version	NM_177306.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177306.3

ORF Insert Sequence:

ATGATGTACA AAACTCACTG CCAGTGCATA CTCGACAATG CCATCAATGG GAACTTTGAA 
GAGATCCAGC ATTTCTTACT ACACTTTTGG CAAGGAATGC CAGACCATCT CCTTCCCCTG 
CTTGAAAATC CTGTTATCAT TGATATTTTC TGTGTCTGTG ACTCAATTCT TTATAAGGTT 
CTTACAGATG TCCTCATTCC TGCAACAATG CAAGAAATGC CTGAAAGTTT GTTAGCAGAT 
ATAAGAAATT TTGCTAAAAA TTGGGAACAG TGGGTTGTTT CATCCTTGGA AAACTTGCCA 
GAAGCCCTCA TTGATAAGAA AATCCCCATT TTGCGAAGAT TTGTATCTTC CCTGAAGCGA 
CAGACATCTT TCTTGCATCT TGCTCAGATT GCCAGACCAG CTCTCTTTGA CCAGCATGTG 
GTGAATGCCA TGGTATCTGA TATTGAAAAG GTTGACTTAA ATAGTATTGG GTCTCAGGCT 
CTTCTTACCA TATCCAACAG CACAGACACG GAATCTGACA TCTACAGTGA ACATGACTCT 
ATTACTGTGT TCCAAGAACT GAAAGATCTC CTTAAGAAGA ATGCTACAGT GGAGGCATTT 
ATTGAATGGT TGGACACTGT GGTAGAGCAG AGAGTTATTA AGATGAGCAA ACAAAATGGA 
AGATCTCTGA AGAAGAGGGC TCAAGACTTT CTGCTCAAAT GGAGCTTTTT TGGTGCCCGC 
GTGATGCATA ATCTTACCTT GAACAACGCA TCAAGTTTTG GCTCTTTCCA TCTGATCCGA 
ATGCTTCTGG ATGAGTACAT TCTCCTGGCC ATGGAGACTC AATTTAACAA TGACAAAGAG 
CAGGAACTAC AGAATTTATT GGACAAGTAT ATGAAGAACT CGGATGCGAG TAAAGCTGCC 
TTCACAGCTT CCCCGAGCTC TTGCTTTCTG GCCAACCGAA ATAAGGCTAG CTCACTTGCC 
AGTGACACTG TGAAGAACGA AAGCCACGTG GAGACATCCT ATGTCCCTCT GCCTTCCAGC 
CAGCCTGGAG CCATACCCCC TGCTCTGCAC CCATTCTCAA CTGAGGACAC TGATAACATG 
CCACTCCCAG GTCAAATAGA GCTTTCACAA AGTACTGGCC ATCTGATGAC ACCACCGATT 
TCTCCAGCCA TAGCAAGCAG AGGAAGTGTT ATTAACCAAG GGCCAATGGC GAGCAGACCC 
CCGAGCGTGG GCACAGTTCT CTCAGCTCCA ACACATTGCT CAACATATGC AGAACCAATT 
TATCCTACGC TCTCTCCAGC CAACCACGAC TTTTATGGGA CCAACTCTAA CTATCAGACT 
ATGTTTAGGA CACAGTCTCA CCCTGCATCA AGCCTCTATG CTCACCGTGC AGAGCATGGG 
CGGTGCATGG CCTGGACTGA ACAGCAGCTT TCTAGAGACT TCTTTGGTGG CAGTTGTGCT 
GGGTCTCCAT ATAATTGTAG GCCACCTTCC AGTTATGGAC CATCCACACA CACACAAGAG 
TCACACAGCA TGCAGGTTTT GAACACAGGA AGCTTCAATT TCCTTAGTAA TGCAGGAGCT 
GGCAGCTGCC AAGGGTCAAC ATTGCCTTCT AATTCTCCCA ATGGATACTA TGGAAACAAT 
ATAAACTACT CAGAGGCACA TAGGCTTGGA TCGATGGTGA ACCAACATGT TTCAGTCATC 
AGCAGTGTGC GCTCCCTGCC TCCCTACAGT GATATTCATG ATCCACTTAA CATTTTAGAT 
GACAGCAGCC GGAAGCAGAA CAACTCGTTT TATGCAGACA CATTGTCTCC TGTTGCATGT 
CGTACTACTG TAGTAGCTTC CAACTTGCAA ACCCAGATTC CTTCATCTTC ATCCCAGTGT 
ATGTATGGAA CTTCCAATCA GTATCCAGTG CAAGATAGTC TGGACTCCAA TGCAGCAAGC 
AACAGAGAAA TGGTGTCCTC TTTACCACCC ATCAACACCG TGTTTATGGG GACAGCAGCT 
GGAGACACTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rfx6 ( NM_001159389.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001152861.1 Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16097
Clone ID Related Accession (Same CDS sequence)	NM_001159389.1
Accession Version	NM_001159389.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2784bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-10
Organism	Mus musculus(house mouse)
Product	DNA-binding protein RFX6 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153527.9. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849376, SAMN00849377 [ECO:0000350] ##Evidence-Data-END##

ATGGCTAAGG TCCGGGAACT GGAGGAAGCT TTCGTGCAGG AGCAGCCTTC GCCCCAACTT 
CCCTCCGAGA TCGCGGAGGA GTGCTGCGCG CAGCTGCTTG GCAAGGGCTT GCTGGTCTAC 
CCTGAGGACA GTGCTTACCT GCTGGCTGAA ACAGCCGCGG GCGCTCGGAG CAGCGGTGAG 
AAAGGCGGAG ATCCCGGGCT GCAGGTGGGA GTTAAATCAG AAATGCAGTT AAACAACGGC 
AACTTTTCCT CGGAAGAAGA GGATGCGGAC ACCCAGGAGA GCAAGACCAA AGCAGCCGAC 
CCACAGCTCT CTCAGAAGAA GAGCATCACG CAGATGATGA AGGATAAGAA GAAGCAGACT 
CAGCTCACCC TGCAGTGGCT TGAAGACAAT TACATAGTGT GTGAAGGAGT TTGCCTCCCA 
CGGTGCATTC TTTATGCTCA CTACCTAGAT TTCTGCAGGA AAGAGAAACT GGAGCCAGCT 
TGTGCAGCCA CCTTTGGAAA GACAATTCGC CAAAAATTTC CCCTCCTAAC AACTCGAAGA 
CTTGGAACAA GAGGACATTC AAAGTACCAT TACTATGGGA TTGGCATCAA AGAAAGCAGT 
GCATATTACC ACTCTGTTTA TTCTGGAAAG GGCTTGACAA GGTTTTCGGG GAGCAAACTG 
AAGAATGAGG GTGGTTTTAC ACGTAAATAC TCACTTAGCT CAAAAACAGG AACACTTCTT 
CCAGAATTTC CCAGCGCTCA ACATCTTGTG TACCAAGGAT GCATTTCTAA GGACAAGGTT 
GATACTCTCA TAATGATGTA CAAAACTCAC TGCCAGTGCA TACTCGACAA TGCCATCAAT 
GGGAACTTTG AAGAGATCCA GCATTTCTTA CTACACTTTT GGCAAGGAAT GCCAGACCAT 
CTCCTTCCCC TGCTTGAAAA TCCTGTTATC ATTGATATTT TCTGTGTCTG TGACTCAATT 
CTTTATAAGG TTCTTACAGA TGTCCTCATT CCTGCAACAA TGCAAGAAAT GCCTGAAAGT 
TTGTTAGCAG ATATAAGAAA TTTTGCTAAA AATTGGGAAC AGTGGGTTGT TTCATCCTTG 
GAAAACTTGC CAGAAGCCCT CATTGATAAG AAAATCCCCA TTTTGCGAAG ATTTGTATCT 
TCCCTGAAGC GACAGACATC TTTCTTGCAT CTTGCTCAGA TTGCCAGACC AGCTCTCTTT 
GACCAGCATG TGGTGAATGC CATGGTATCT GATATTGAAA AGGTTGACTT AAATAGTATT 
GGGTCTCAGG CTCTTCTTAC CATATCCAAC AGCACAGACA CGGAATCTGA CATCTACAGT 
GAACATGACT CTATTACTGT GTTCCAAGAA CTGAAAGATC TCCTTAAGAA GAATGCTACA 
GTGGAGGCAT TTATTGAATG GTTGGACACT GTGGTAGAGC AGAGAGTTAT TAAGATGAGC 
AAACAAAATG GAAGATCTCT GAAGAAGAGG GCTCAAGACT TTCTGCTCAA ATGGAGCTTT 
TTTGGTGCCC GCGTGATGCA TAATCTTACC TTGAACAACG CATCAAGTTT TGGCTCTTTC 
CATCTGATCC GAATGCTTCT GGATGAGTAC ATTCTCCTGG CCATGGAGAC TCAATTTAAC 
AATGACAAAG AGCAGGAACT ACAGAATTTA TTGGACAAGT ATATGAAGAA CTCGGATGCG 
AGTAAAGCTG CCTTCACAGC TTCCCCGAGC TCTTGCTTTC TGGCCAACCG AAATAAGGCT 
AGCTCACTTG CCAGTGACAC TGTGAAGAAC GAAAGCCACG TGGAGACATC CTATGTCCCT 
CTGCCTTCCA GCCAGCCTGG AGCCATACCC CCTGCTCTGC ACCCATTCTC AACTGAGGAC 
ACTGATAACA TGCCACTCCC AGGTCAAATA GAGCTTTCAC AAAGTACTGG CCATCTGATG 
ACACCACCGA TTTCTCCAGC CATAGCAAGC AGAGGAAGTG TTATTAACCA AGGGCCAATG 
GCGAGCAGAC CCCCGAGCGT GGGCACAGTT CTCTCAGCTC CAACACATTG CTCAACATAT 
GCAGAACCAA TTTATCCTAC GCTCTCTCCA GCCAACCACG ACTTTTATGG GACCAACTCT 
AACTATCAGA CTATGTTTAG GACACAGTCT CACCCTGCAT CAAGCCTCTA TGCTCACCGT 
GCAGAGCATG GGCGGTGCAT GGCCTGGACT GAACAGCAGC TTTCTAGAGA CTTCTTTGGT 
GGCAGTTGTG CTGGGTCTCC ATATAATTGT AGGCCACCTT CCAGTTATGG ACCATCCACA 
CACACACAAG AGTCACACAG CATGCAGGTT TTGAACACAG GAAGCTTCAA TTTCCTTAGT 
AATGCAGGAG CTGGCAGCTG CCAAGGGTCA ACATTGCCTT CTAATTCTCC CAATGGATAC 
TATGGAAACA ATATAAACTA CTCAGAGGCA CATAGGCTTG GATCGATGGT GAACCAACAT 
GTTTCAGTCA TCAGCAGTGT GCGCTCCCTG CCTCCCTACA GTGATATTCA TGATCCACTT 
AACATTTTAG ATGACAGCAG CCGGAAGCAG AACAACTCGT TTTATGCAGA CACATTGTCT 
CCTGTTGCAT GTCGTACTAC TGTAGTAGCT TCCAACTTGC AAACCCAGAT TCCTTCATCT 
TCATCCCAGT GTATGTATGG AACTTCCAAT CAGTATCCAG TGCAAGATAG TCTGGACTCC 
AATGCAGCAA GCAACAGAGA AATGGTGTCC TCTTTACCAC CCATCAACAC CGTGTTTATG 
GGGACAGCAG CTGGAGACAC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001152861.1
CDS	51..2834
Translation	MAKVRELEEAFVQEQPSPQLPSEIAEECCAQLLGKGLLVYPEDSAYLLAETAAGARSSGEKGGDPGLQVGVKSEMQLNNGNFSSEEEDADTQESKTKAADPQLSQKKSITQMMKDKKKQTQLTLQWLEDNYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSSLKRQTSFLHLAQIARPALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDTESDIYSEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKMSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKASSLASDTVKNESHVETSYVPLPSSQPGAIPPALHPFSTEDTDNMPLPGQIELSQSTGHLMTPPISPAIASRGSVINQGPMASRPPSVGTVLSAPTHCSTYAEPIYPTLSPANHDFYGTNSNYQTMFRTQSHPASSLYAHRAEHGRCMAWTEQQLSRDFFGGSCAGSPYNCRPPSSYGPSTHTQESHSMQVLNTGSFNFLSNAGAGSCQGSTLPSNSPNGYYGNNINYSEAHRLGSMVNQHVSVISSVRSLPPYSDIHDPLNILDDSSRKQNNSFYADTLSPVACRTTVVASNLQTQIPSSSSQCMYGTSNQYPVQDSLDSNAASNREMVSSLPPINTVFMGTAAGDT

Target ORF information:

RefSeq Version	NM_001159389.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159389.1

ORF Insert Sequence:

ATGGCTAAGG TCCGGGAACT GGAGGAAGCT TTCGTGCAGG AGCAGCCTTC GCCCCAACTT 
CCCTCCGAGA TCGCGGAGGA GTGCTGCGCG CAGCTGCTTG GCAAGGGCTT GCTGGTCTAC 
CCTGAGGACA GTGCTTACCT GCTGGCTGAA ACAGCCGCGG GCGCTCGGAG CAGCGGTGAG 
AAAGGCGGAG ATCCCGGGCT GCAGGTGGGA GTTAAATCAG AAATGCAGTT AAACAACGGC 
AACTTTTCCT CGGAAGAAGA GGATGCGGAC ACCCAGGAGA GCAAGACCAA AGCAGCCGAC 
CCACAGCTCT CTCAGAAGAA GAGCATCACG CAGATGATGA AGGATAAGAA GAAGCAGACT 
CAGCTCACCC TGCAGTGGCT TGAAGACAAT TACATAGTGT GTGAAGGAGT TTGCCTCCCA 
CGGTGCATTC TTTATGCTCA CTACCTAGAT TTCTGCAGGA AAGAGAAACT GGAGCCAGCT 
TGTGCAGCCA CCTTTGGAAA GACAATTCGC CAAAAATTTC CCCTCCTAAC AACTCGAAGA 
CTTGGAACAA GAGGACATTC AAAGTACCAT TACTATGGGA TTGGCATCAA AGAAAGCAGT 
GCATATTACC ACTCTGTTTA TTCTGGAAAG GGCTTGACAA GGTTTTCGGG GAGCAAACTG 
AAGAATGAGG GTGGTTTTAC ACGTAAATAC TCACTTAGCT CAAAAACAGG AACACTTCTT 
CCAGAATTTC CCAGCGCTCA ACATCTTGTG TACCAAGGAT GCATTTCTAA GGACAAGGTT 
GATACTCTCA TAATGATGTA CAAAACTCAC TGCCAGTGCA TACTCGACAA TGCCATCAAT 
GGGAACTTTG AAGAGATCCA GCATTTCTTA CTACACTTTT GGCAAGGAAT GCCAGACCAT 
CTCCTTCCCC TGCTTGAAAA TCCTGTTATC ATTGATATTT TCTGTGTCTG TGACTCAATT 
CTTTATAAGG TTCTTACAGA TGTCCTCATT CCTGCAACAA TGCAAGAAAT GCCTGAAAGT 
TTGTTAGCAG ATATAAGAAA TTTTGCTAAA AATTGGGAAC AGTGGGTTGT TTCATCCTTG 
GAAAACTTGC CAGAAGCCCT CATTGATAAG AAAATCCCCA TTTTGCGAAG ATTTGTATCT 
TCCCTGAAGC GACAGACATC TTTCTTGCAT CTTGCTCAGA TTGCCAGACC AGCTCTCTTT 
GACCAGCATG TGGTGAATGC CATGGTATCT GATATTGAAA AGGTTGACTT AAATAGTATT 
GGGTCTCAGG CTCTTCTTAC CATATCCAAC AGCACAGACA CGGAATCTGA CATCTACAGT 
GAACATGACT CTATTACTGT GTTCCAAGAA CTGAAAGATC TCCTTAAGAA GAATGCTACA 
GTGGAGGCAT TTATTGAATG GTTGGACACT GTGGTAGAGC AGAGAGTTAT TAAGATGAGC 
AAACAAAATG GAAGATCTCT GAAGAAGAGG GCTCAAGACT TTCTGCTCAA ATGGAGCTTT 
TTTGGTGCCC GCGTGATGCA TAATCTTACC TTGAACAACG CATCAAGTTT TGGCTCTTTC 
CATCTGATCC GAATGCTTCT GGATGAGTAC ATTCTCCTGG CCATGGAGAC TCAATTTAAC 
AATGACAAAG AGCAGGAACT ACAGAATTTA TTGGACAAGT ATATGAAGAA CTCGGATGCG 
AGTAAAGCTG CCTTCACAGC TTCCCCGAGC TCTTGCTTTC TGGCCAACCG AAATAAGGCT 
AGCTCACTTG CCAGTGACAC TGTGAAGAAC GAAAGCCACG TGGAGACATC CTATGTCCCT 
CTGCCTTCCA GCCAGCCTGG AGCCATACCC CCTGCTCTGC ACCCATTCTC AACTGAGGAC 
ACTGATAACA TGCCACTCCC AGGTCAAATA GAGCTTTCAC AAAGTACTGG CCATCTGATG 
ACACCACCGA TTTCTCCAGC CATAGCAAGC AGAGGAAGTG TTATTAACCA AGGGCCAATG 
GCGAGCAGAC CCCCGAGCGT GGGCACAGTT CTCTCAGCTC CAACACATTG CTCAACATAT 
GCAGAACCAA TTTATCCTAC GCTCTCTCCA GCCAACCACG ACTTTTATGG GACCAACTCT 
AACTATCAGA CTATGTTTAG GACACAGTCT CACCCTGCAT CAAGCCTCTA TGCTCACCGT 
GCAGAGCATG GGCGGTGCAT GGCCTGGACT GAACAGCAGC TTTCTAGAGA CTTCTTTGGT 
GGCAGTTGTG CTGGGTCTCC ATATAATTGT AGGCCACCTT CCAGTTATGG ACCATCCACA 
CACACACAAG AGTCACACAG CATGCAGGTT TTGAACACAG GAAGCTTCAA TTTCCTTAGT 
AATGCAGGAG CTGGCAGCTG CCAAGGGTCA ACATTGCCTT CTAATTCTCC CAATGGATAC 
TATGGAAACA ATATAAACTA CTCAGAGGCA CATAGGCTTG GATCGATGGT GAACCAACAT 
GTTTCAGTCA TCAGCAGTGT GCGCTCCCTG CCTCCCTACA GTGATATTCA TGATCCACTT 
AACATTTTAG ATGACAGCAG CCGGAAGCAG AACAACTCGT TTTATGCAGA CACATTGTCT 
CCTGTTGCAT GTCGTACTAC TGTAGTAGCT TCCAACTTGC AAACCCAGAT TCCTTCATCT 
TCATCCCAGT GTATGTATGG AACTTCCAAT CAGTATCCAG TGCAAGATAG TCTGGACTCC 
AATGCAGCAA GCAACAGAGA AATGGTGTCC TCTTTACCAC CCATCAACAC CGTGTTTATG 
GGGACAGCAG CTGGAGACAC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.
eLife6(2017 Jan)
Churchill AJ,Guti?rrez GD,Singer RA,Lorberbaum DS,Fischer KA,Sussel L

?-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
PloS one11(2)e0150010(2016)
Abdellatif AM,Oishi H,Itagaki T,Jung Y,Shawki HH,Okita Y,Hasegawa Y,Suzuki H,El-Morsy SE,El-Sayed MA,Shoaib MB,Sugiyama F,Takahashi S

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.
PloS one11(10)e0164714(2016)
Mu?oz-Bravo JL,Flores-Mart?nez A,Herrero-Martin G,Puri S,Taketo MM,Rojas A,Hebrok M,Cano DA

Rfx6 maintains the functional identity of adult pancreatic ? cells.
Cell reports9(6)2219-32(2014 Dec)
Piccand J,Strasser P,Hodson DJ,Meunier A,Ye T,Keime C,Birling MC,Rutter GA,Gradwohl G

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Rfx6 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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