Itgb8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgb8
Entrez Gene ID	320910
Full Name	integrin beta 8
Synonyms	4832412O06Rik
General protein information	Preferred Names integrin beta 8 Names integrin beta-8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 F2

mRNA and Protein(s)

mRNA	Protein	Name
NM_177290.3	NP_796264.2	integrin beta-8 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ITGB8	XP_518987.2
Gallus gallus (chicken)	ITGB8	XP_003640734.2
Xenopus tropicalis (tropical clawed frog)	itgb8	XP_002933344.2
	ITGB8	XP_001103130.1
Mus musculus (house mouse)	Itgb8	NP_796264.2
Rattus norvegicus (Norway rat)	Itgb8	NP_001102196.1
Homo sapiens (human)	ITGB8	NP_002205.1
Canis lupus familiaris (dog)	ITGB8	XP_532487.1
Bos taurus (cattle)	ITGB8	NP_001179804.1
Danio rerio (zebrafish)	itgb8	XP_001919626.4

Gene Ontology
Bibliography

Related articles in PubMed

D-mannose induces regulatory T cells and suppresses immunopathology.
Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen ZJ, Chen W
Nature medicine23(9)1036-1045(2017 Sep)

A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Ma S, Santhosh D, Kumar T P, Huang Z
Developmental cell41(4)366-381.e4(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF. Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.
Title: Integrin ?8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.

data show that the combination of cell lineage, immune mediators and both dietary and microbe-derived environmental factors shape intestinal dendritic cells into critical gatekeepers of TGF-beta-dependent immune responses through regulation of beta8 integrin expression
Title: ?8 Integrin Expression and Activation of TGF-? by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.

Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.
Title: Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-?.

Nrp1 in endothelial cells suppresses TGFbeta activation and signaling by forming intercellular protein complexes with beta8 integrin.
Title: Neuropilin 1 balances ?8 integrin-activated TGF? signaling to control sprouting angiogenesis in the brain.

ITGB8 is involved in the embryo implantation process through regulation of activation of TGFB1
Title: Integrin beta 8 (ITGB8) regulates embryo implantation potentially via controlling the activity of TGF-B1 in mice.

The following Itgb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13350	NM_177290.3 Latest version!	Mus musculus integrin beta 8 (Itgb8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgb8 ( NM_177290.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796264.2 Mus musculus integrin beta 8 (Itgb8), mRNA.

Price & Availability↑

CloneID	OMu13350
Clone ID Related Accession (Same CDS sequence)	NM_177290.3
Accession Version	NM_177290.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2304bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	integrin beta-8 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC120691.1. On or before Jan 29, 2007 this sequence version replaced XM_484197.3, XM_901358.2, XM_901353.2, XM_986421.1, XM_986389.1, XM_986358.1, XM_906066.2, XM_919665.2, XM_919658.2, NM_177290.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC120691.1, SRR1660815.282081.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGTGCGGCT CGGCCCTGGC TTTTCTGACT GCTGCACTGC TCTCTCTGCA CAACTGCCAG 
CGAGGTCCAG CCTTGGTTCT TGGGGCAGCC TGGGTATTTT CACTTGTTCT CGGACTGGGC 
CAAAGTGAAC ACAATAGATG TGGCTCTGCA AATGTGGTCT CCTGTGCCAG GTGCCTCCAG 
CTGGGTCCGG AATGCGGATG GTGTGTTCAA GAGGATTTTG TTTCAGGTGG ATCAGGAAGT 
GAACGTTGTG ATACTGTTTC CAGTTTGATA AGCAAAGGCT GTCCAGTTGA TTCAATAGAA 
TACCTGTCTG TGCATGTTGT AACGTCAAGT GAGAATGAAA TCAATACCCA GGTGACACCG 
GGAGAAGTCT CAGTCCAACT GCATCCAGGA GCTGAAGCTA ATTTTATGTT AAAAGTCCGT 
CCTCTGAAGA AATACCCCGT GGATCTTTAT TATCTGGTTG ATGTGTCAGC ATCAATGCAC 
AATAATATAG AAAAATTGAA TTCCGTTGGA AATGATTTAT CTAAAAAAAT GGCCCTTTAT 
TCCCGTGACT TCCGTCTTGG TTTTGGCTCA TATGTGGATA AAACTGTCTC GCCATACATT 
AGTATCCACC CGGAAAGGAT CCACAATCAG TGCAGTGACT ACAATTTAGA CTGTATGCCT 
CCCCATGGAT ACATTCATGT GCTGTCTCTG ACAGAAAACA TCACTGAGTT TGAAAAAGCA 
GTCCACAGAC AAAAGATCTC TGGAAACATA GACACCCCTG AAGGAGGTTT TGATGCCATG 
CTTCAGGCTG CCGTCTGTGA GAGTCATATT GGATGGCGAA AAGAAGCTAA AAGATTGCTG 
CTGGTGATGA CAGACCAGAC ATCACATCTT GCTCTTGACA GCAAATTGGC AGGCATAGTG 
GTGCCGAATG ACGGAAACTG CCATCTCAAA AACAATGTCT ACGTCAAATC GACAACCATG 
GAACATCCGT CATTAGGCCA ACTTTCTGAA AAGTTAATAG ACAACAACAT AAATGTCATT 
TTTGCAGTTC AAGGAAAGCA GTTTCATTGG TACAAGGACC TTCTGCCCCT TTTGCCTGGT 
GCCATTGCTG GTGAAATAGA ATCCAAAGCT GCAAATCTCA ACAATTTAGT AGTAGAAGCC 
TACAAGAAGA TTATCTCAGA AGTAAAAGTG CAGCTGGAAA ACCAGGTACA CGGTGTCCAT 
TTTAACATCA CTGCCATCTG TCCAGATGGG GCCAGAAAGC CAGGCATAAG TGGGTGTGGA 
AACGTGACAA GCAATGACGA AGTTCTTTTC AATGTAACTG TTGTGATGAA AACATGTGAT 
ATCATGGGAG GAAAAAACTA TGCAATAATC AAGCCTATTG GTTTCAATGA AACCACTAAA 
GTCCACATAC ACAGAAGCTG CAGTTGCCAG TGTGAGAACC ACAGAGGACT CAAAGGACAG 
TGTGCGGAAG CTGCCCCAGA CCCCAAGTGT CCACAGTGTG ATGACAGCAG ATGTCATTTT 
GATGAAGACC AGTTTCCTTC TGAAACTTGC AAGCCACAGG AGGATCAACC TGTCTGCAGT 
GGCCGAGGTG TTTGCATCTG TGGGAAATGT TTATGTCACA AAACCAAGCT AGGAAGAGTG 
TATGGCCAGT ACTGTGAGAA GGATGACTTC TCCTGTCCCT ATCTCCATGG GGATGTGTGT 
GCTGGGCATG GGGAGTGTGA AGGTGGCAGA TGCCAGTGCT TTAGTGGCTG GGAAGGAGAT 
CGGTGTCAGT GCCCATCAGC CTCAGCACAG CACTGTGTCA ACTCCAAGGG CCAAGTTTGC 
AGCGGGAGAG GCACCTGCGT GTGTGGCAGG TGTGAGTGTA CTGATCCCAG AAGCATTGGC 
CGTCTCTGTG AGCACTGCCC AACCTGCCAT CTCTCCTGCA GTGAAAACTG GAATTGTCTG 
CAGTGCCTTC ACCCTCACAA TCTGTCTCAG GCTGCCCTTG ATCAGTGTAA ATCCTCCTGT 
GCTGTCATGG AACAGCATCG CATGGACCAA ACATCAGAAT GTTTATCTGG CCCAAGCTAT 
CTGCGAATAT TTTTCATCAT ATTCATAGTC ACATTCTTGA TCGGGTTGCT TAAAGTTCTT 
ATCATTAGAC AAGTGATACT ACAATGGAAT AATAATAAAA TAAAGTCCTC ATCAGATTAT 
AGAATGTCTG CTTCTAAAAA GGATAAACTG ATTCTGCAAA GTGTTTGCAC GAGAGCTGTA 
ACCTACCGAC GAGAAAAGCC TGAGGAAATA AAAATGGATA TCAGCAAACT AAATGCTCAG 
GAGGCCTTCA GGTGCAACTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796264.2
CDS	479..2782
Translation	MCGSALAFLTAALLSLHNCQRGPALVLGAAWVFSLVLGLGQSEHNRCGSANVVSCARCLQLGPECGWCVQEDFVSGGSGSERCDTVSSLISKGCPVDSIEYLSVHVVTSSENEINTQVTPGEVSVQLHPGAEANFMLKVRPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSKKMALYSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPGAIAGEIESKAANLNNLVVEAYKKIISEVKVQLENQVHGVHFNITAICPDGARKPGISGCGNVTSNDEVLFNVTVVMKTCDIMGGKNYAIIKPIGFNETTKVHIHRSCSCQCENHRGLKGQCAEAAPDPKCPQCDDSRCHFDEDQFPSETCKPQEDQPVCSGRGVCICGKCLCHKTKLGRVYGQYCEKDDFSCPYLHGDVCAGHGECEGGRCQCFSGWEGDRCQCPSASAQHCVNSKGQVCSGRGTCVCGRCECTDPRSIGRLCEHCPTCHLSCSENWNCLQCLHPHNLSQAALDQCKSSCAVMEQHRMDQTSECLSGPSYLRIFFIIFIVTFLIGLLKVLIIRQVILQWNNNKIKSSSDYRMSASKKDKLILQSVCTRAVTYRREKPEEIKMDISKLNAQEAFRCNF

Target ORF information:

RefSeq Version	NM_177290.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus integrin beta 8 (Itgb8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177290.3

ORF Insert Sequence:

ATGTGCGGCT CGGCCCTGGC TTTTCTGACT GCTGCACTGC TCTCTCTGCA CAACTGCCAG 
CGAGGTCCAG CCTTGGTTCT TGGGGCAGCC TGGGTATTTT CACTTGTTCT CGGACTGGGC 
CAAAGTGAAC ACAATAGATG TGGCTCTGCA AATGTGGTCT CCTGTGCCAG GTGCCTCCAG 
CTGGGTCCGG AATGCGGATG GTGTGTTCAA GAGGATTTTG TTTCAGGTGG ATCAGGAAGT 
GAACGTTGTG ATACTGTTTC CAGTTTGATA AGCAAAGGCT GTCCAGTTGA TTCAATAGAA 
TACCTGTCTG TGCATGTTGT AACGTCAAGT GAGAATGAAA TCAATACCCA GGTGACACCG 
GGAGAAGTCT CAGTCCAACT GCATCCAGGA GCTGAAGCTA ATTTTATGTT AAAAGTCCGT 
CCTCTGAAGA AATACCCCGT GGATCTTTAT TATCTGGTTG ATGTGTCAGC ATCAATGCAC 
AATAATATAG AAAAATTGAA TTCCGTTGGA AATGATTTAT CTAAAAAAAT GGCCCTTTAT 
TCCCGTGACT TCCGTCTTGG TTTTGGCTCA TATGTGGATA AAACTGTCTC GCCATACATT 
AGTATCCACC CGGAAAGGAT CCACAATCAG TGCAGTGACT ACAATTTAGA CTGTATGCCT 
CCCCATGGAT ACATTCATGT GCTGTCTCTG ACAGAAAACA TCACTGAGTT TGAAAAAGCA 
GTCCACAGAC AAAAGATCTC TGGAAACATA GACACCCCTG AAGGAGGTTT TGATGCCATG 
CTTCAGGCTG CCGTCTGTGA GAGTCATATT GGATGGCGAA AAGAAGCTAA AAGATTGCTG 
CTGGTGATGA CAGACCAGAC ATCACATCTT GCTCTTGACA GCAAATTGGC AGGCATAGTG 
GTGCCGAATG ACGGAAACTG CCATCTCAAA AACAATGTCT ACGTCAAATC GACAACCATG 
GAACATCCGT CATTAGGCCA ACTTTCTGAA AAGTTAATAG ACAACAACAT AAATGTCATT 
TTTGCAGTTC AAGGAAAGCA GTTTCATTGG TACAAGGACC TTCTGCCCCT TTTGCCTGGT 
GCCATTGCTG GTGAAATAGA ATCCAAAGCT GCAAATCTCA ACAATTTAGT AGTAGAAGCC 
TACAAGAAGA TTATCTCAGA AGTAAAAGTG CAGCTGGAAA ACCAGGTACA CGGTGTCCAT 
TTTAACATCA CTGCCATCTG TCCAGATGGG GCCAGAAAGC CAGGCATAAG TGGGTGTGGA 
AACGTGACAA GCAATGACGA AGTTCTTTTC AATGTAACTG TTGTGATGAA AACATGTGAT 
ATCATGGGAG GAAAAAACTA TGCAATAATC AAGCCTATTG GTTTCAATGA AACCACTAAA 
GTCCACATAC ACAGAAGCTG CAGTTGCCAG TGTGAGAACC ACAGAGGACT CAAAGGACAG 
TGTGCGGAAG CTGCCCCAGA CCCCAAGTGT CCACAGTGTG ATGACAGCAG ATGTCATTTT 
GATGAAGACC AGTTTCCTTC TGAAACTTGC AAGCCACAGG AGGATCAACC TGTCTGCAGT 
GGCCGAGGTG TTTGCATCTG TGGGAAATGT TTATGTCACA AAACCAAGCT AGGAAGAGTG 
TATGGCCAGT ACTGTGAGAA GGATGACTTC TCCTGTCCCT ATCTCCATGG GGATGTGTGT 
GCTGGGCATG GGGAGTGTGA AGGTGGCAGA TGCCAGTGCT TTAGTGGCTG GGAAGGAGAT 
CGGTGTCAGT GCCCATCAGC CTCAGCACAG CACTGTGTCA ACTCCAAGGG CCAAGTTTGC 
AGCGGGAGAG GCACCTGCGT GTGTGGCAGG TGTGAGTGTA CTGATCCCAG AAGCATTGGC 
CGTCTCTGTG AGCACTGCCC AACCTGCCAT CTCTCCTGCA GTGAAAACTG GAATTGTCTG 
CAGTGCCTTC ACCCTCACAA TCTGTCTCAG GCTGCCCTTG ATCAGTGTAA ATCCTCCTGT 
GCTGTCATGG AACAGCATCG CATGGACCAA ACATCAGAAT GTTTATCTGG CCCAAGCTAT 
CTGCGAATAT TTTTCATCAT ATTCATAGTC ACATTCTTGA TCGGGTTGCT TAAAGTTCTT 
ATCATTAGAC AAGTGATACT ACAATGGAAT AATAATAAAA TAAAGTCCTC ATCAGATTAT 
AGAATGTCTG CTTCTAAAAA GGATAAACTG ATTCTGCAAA GTGTTTGCAC GAGAGCTGTA 
ACCTACCGAC GAGAAAAGCC TGAGGAAATA AAAATGGATA TCAGCAAACT AAATGCTCAG 
GAGGCCTTCA GGTGCAACTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

D-mannose induces regulatory T cells and suppresses immunopathology.
Nature medicine23(9)1036-1045(2017 Sep)
Zhang D,Chia C,Jiao X,Jin W,Kasagi S,Wu R,Konkel JE,Nakatsukasa H,Zanvit P,Goldberg N,Chen Q,Sun L,Chen ZJ,Chen W

A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Developmental cell41(4)366-381.e4(2017 05)
Ma S,Santhosh D,Kumar T P,Huang Z

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Itgb8 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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