Grk3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grk3
Entrez Gene ID	320129
Full Name	G protein-coupled receptor kinase 3
Synonyms	4833444A01Rik,AI851927,AW551196,Adrbk-2,Adrbk2,Bark-2
General protein information	Preferred Names G protein-coupled receptor kinase 3 Names beta-adrenergic receptor kinase 2 adrenergic receptor kinase, beta 2 beta ARK2 beta-ARK-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 F\|5 55.29 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_177078.4	NP_796052.2	beta-adrenergic receptor kinase 2 isoform 1
NM_001285806.1	NP_001272735.1	beta-adrenergic receptor kinase 2 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADRBK2	NP_005151.2
Caenorhabditis elegans (roundworm)	grk-2	NP_497235.2
Pan troglodytes (chimpanzee)	ADRBK2	XP_003317197.1
Mus musculus (house mouse)	Adrbk2	NP_796052.2
Canis lupus familiaris (dog)	ADRBK2	XP_543453.3
Drosophila melanogaster (fruit fly)	Gprk1	NP_001163051.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012026	XP_320502.4
Xenopus tropicalis (tropical clawed frog)	adrbk2	XP_002932117.2
	ADRBK2	XP_001104308.1
Bos taurus (cattle)	ADRBK2	NP_776925.1
Rattus norvegicus (Norway rat)	Adrbk2	NP_037029.1
Gallus gallus (chicken)	ADRBK2	XP_415195.4
Danio rerio (zebrafish)	adrbk2	NP_001128197.1

Gene Ontology
Bibliography

Related articles in PubMed

Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.
Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Pr?stel T, Germain RN, Meier-Schellersheim M
Immunity47(5)862-874.e3(2017 Nov)

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP
Journal of leukocyte biology94(6)1243-51(2013 Dec)

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.
Melief EJ, Miyatake M, Bruchas MR, Chavkin C
Proceedings of the National Academy of Sciences of the United States of America107(25)11608-13(2010 Jun)

Identification of transcripts with enriched expression in the developing and adult pancreas.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD
Genome biology9(6)R99(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
Title: Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.

The following Grk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08862	NM_001285806.1 Latest version!	Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu05918	NM_177078.4 Latest version!	Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$405.30 $579.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grk3 ( NM_001285806.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001272735.1 Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu08862
Clone ID Related Accession (Same CDS sequence)	NM_001285806.1
Accession Version	NM_001285806.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	beta-adrenergic receptor kinase 2 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ104587.1, AK141186.1, AK076533.1, AK134672.1 and AI851927.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141186.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACGACG CCTACATCAT GAGGGAGCTC CTATCCAGCA CACACCAATT CTCAAAGCAA 
GCTGTAGAAC ATGTCCAGAG CCATCTCTCC AAGAAACAGG TGACGGCTAC ACTTTTCCAG 
CCATACATAG AAGAAATCTG TGAAAGCCTT CGTGGGGATA TTTTCCAAAA GTTTATGGAA 
AGCGATAAAT TCACTAGATT CTGTCAGTGG AAGAACGTGG AGTTGAATAT TCACCTGAGC 
ATGAACGACT TCAGTGTGCA CAGGATCATC GGCCGAGGAG GGTTTGGGGA AGTTTATGGC 
TGCAGGAAAG CAGACACCGG TAAAATGTAT GCCATGAAGT GCTTAGACAA GAAAAGGGTG 
AAGATGAAGC AGGGGGAGAC TCTGGCTTTG AACGAGAGGA TCATGCTGTC TCTCGTTAGC 
ACTGGGGATT GTCCCTTTAT TGTCTGCATG ACCTACGCCT TCCACACGCC GGACAAACTC 
TGCTTCATCC TGGACCTGAT GAACGGGGGC GACATGCACT ACCATCTCTC TCAACACGGG 
GTGTTTTCTG AGAAGGAGAT GCGGTTTTAT GCCAGCGAGA TCATCCTGGG CCTCGAGCAC 
ATGCACACCT GCTTCGTAGT CTACAGAGAC CTGAAGCCTG CGAACATCCT CCTAGATGAA 
TATGGGCACG TGAGGATATC GGATCTCGGC CTTGCCTGCG ATTTCTCCAA AAAGAAGCCT 
CATGCCAGCG TGGGCACCCA TGGGTACATG GCTCCCGAGG TGTTGCAGAA GGGAACGTGC 
TATGACAGCA GCGCCGACTG GTTCTCCCTG GGCTGTATGC TCTTCAAGCT TCTGCGGGGC 
CACAGCCCCT TCAGGCAGCA TAAAACCAAA GACAAGCATG AGATAGACCG AATGACCCTG 
ACCGTGAACG TGCAGCTTCC AGATGCCTTC TCCCCTGAGC TGAGGTCCCT CTTAGAGGGT 
TTGCTCCAGC GGGACGTGAG CCAGCGGCTG GGCTGCGGAG GAGGAGGGGC ACGAGAGTTG 
AAGGAGCACA TCTTCTTCAA GGGCATTGAC TGGCAGCATG TGTACTTACG GAAGTACCCG 
CCACCCCTAA TCCCTCCTCG GGGAGAGGTC AACGCTGCAG ATGCCTTCGA TATCGGCTCC 
TTCGATGAGG AAGACACCAA AGGCATTAAG CTGTTGGACT GTGACCAGGA CCTCTATAAG 
AACTTCCCAC TGGTGATCTC CGAGCGCTGG CAGCAAGAAG TGGTGGAGAC CATCTATGAC 
GCCGTCAATG CTGATACTGA TAAAATCGAG GCCAGGAGGA AGGCTAAAAA TAAGCAACTT 
GGTCAAGAGG AAGATTACGC TATGGGGAAG GACTGCATCA TGCACGGGTA CATGCTGAAG 
CTGGGGAACC CCTTTCTCAC ACAGTGGCAA AGACGCTATT TTTACCTGTT CCCCAACAGA 
CTGGAGTGGA GAGGAGAGGG CGAGTCTCGG CAAAGTCTAC TGACCATGGA ACAGATCATG 
TCTGTGGAGG AGACCCAGAT TAAAGACAGA AAGTGCATCT TACTCAGGAT AAAGGGAGGG 
AAGCAATTTG TCTTGCAATG TGAGAGTGAC CCCGAGTTTG CACAGTGGCT GAAGGAGCTG 
ACCTGCACCT TCAATGAGGC CCAGAGACTG CTGCGCCGTG CCCCCAAATT CCTCAACAAA 
CCACGGGCCG CCATCCTGGA GTTCTCCAAG CCACCACTGT GTCACAGAAA TAGCAGCGGC 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272735.1
CDS	420..2165
Translation	MYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCGGGGARELKEHIFFKGIDWQHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQEVVETIYDAVNADTDKIEARRKAKNKQLGQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSLLTMEQIMSVEETQIKDRKCILLRIKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL

Target ORF information:

RefSeq Version	NM_001285806.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001285806.1

ORF Insert Sequence:

ATGTACGACG CCTACATCAT GAGGGAGCTC CTATCCAGCA CACACCAATT CTCAAAGCAA 
GCTGTAGAAC ATGTCCAGAG CCATCTCTCC AAGAAACAGG TGACGGCTAC ACTTTTCCAG 
CCATACATAG AAGAAATCTG TGAAAGCCTT CGTGGGGATA TTTTCCAAAA GTTTATGGAA 
AGCGATAAAT TCACTAGATT CTGTCAGTGG AAGAACGTGG AGTTGAATAT TCACCTGAGC 
ATGAACGACT TCAGTGTGCA CAGGATCATC GGCCGAGGAG GGTTTGGGGA AGTTTATGGC 
TGCAGGAAAG CAGACACCGG TAAAATGTAT GCCATGAAGT GCTTAGACAA GAAAAGGGTG 
AAGATGAAGC AGGGGGAGAC TCTGGCTTTG AACGAGAGGA TCATGCTGTC TCTCGTTAGC 
ACTGGGGATT GTCCCTTTAT TGTCTGCATG ACCTACGCCT TCCACACGCC GGACAAACTC 
TGCTTCATCC TGGACCTGAT GAACGGGGGC GACATGCACT ACCATCTCTC TCAACACGGG 
GTGTTTTCTG AGAAGGAGAT GCGGTTTTAT GCCAGCGAGA TCATCCTGGG CCTCGAGCAC 
ATGCACACCT GCTTCGTAGT CTACAGAGAC CTGAAGCCTG CGAACATCCT CCTAGATGAA 
TATGGGCACG TGAGGATATC GGATCTCGGC CTTGCCTGCG ATTTCTCCAA AAAGAAGCCT 
CATGCCAGCG TGGGCACCCA TGGGTACATG GCTCCCGAGG TGTTGCAGAA GGGAACGTGC 
TATGACAGCA GCGCCGACTG GTTCTCCCTG GGCTGTATGC TCTTCAAGCT TCTGCGGGGC 
CACAGCCCCT TCAGGCAGCA TAAAACCAAA GACAAGCATG AGATAGACCG AATGACCCTG 
ACCGTGAACG TGCAGCTTCC AGATGCCTTC TCCCCTGAGC TGAGGTCCCT CTTAGAGGGT 
TTGCTCCAGC GGGACGTGAG CCAGCGGCTG GGCTGCGGAG GAGGAGGGGC ACGAGAGTTG 
AAGGAGCACA TCTTCTTCAA GGGCATTGAC TGGCAGCATG TGTACTTACG GAAGTACCCG 
CCACCCCTAA TCCCTCCTCG GGGAGAGGTC AACGCTGCAG ATGCCTTCGA TATCGGCTCC 
TTCGATGAGG AAGACACCAA AGGCATTAAG CTGTTGGACT GTGACCAGGA CCTCTATAAG 
AACTTCCCAC TGGTGATCTC CGAGCGCTGG CAGCAAGAAG TGGTGGAGAC CATCTATGAC 
GCCGTCAATG CTGATACTGA TAAAATCGAG GCCAGGAGGA AGGCTAAAAA TAAGCAACTT 
GGTCAAGAGG AAGATTACGC TATGGGGAAG GACTGCATCA TGCACGGGTA CATGCTGAAG 
CTGGGGAACC CCTTTCTCAC ACAGTGGCAA AGACGCTATT TTTACCTGTT CCCCAACAGA 
CTGGAGTGGA GAGGAGAGGG CGAGTCTCGG CAAAGTCTAC TGACCATGGA ACAGATCATG 
TCTGTGGAGG AGACCCAGAT TAAAGACAGA AAGTGCATCT TACTCAGGAT AAAGGGAGGG 
AAGCAATTTG TCTTGCAATG TGAGAGTGAC CCCGAGTTTG CACAGTGGCT GAAGGAGCTG 
ACCTGCACCT TCAATGAGGC CCAGAGACTG CTGCGCCGTG CCCCCAAATT CCTCAACAAA 
CCACGGGCCG CCATCCTGGA GTTCTCCAAG CCACCACTGT GTCACAGAAA TAGCAGCGGC 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grk3 ( NM_177078.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796052.2 Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05918
Clone ID Related Accession (Same CDS sequence)	NM_177078.4
Accession Version	NM_177078.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	beta-adrenergic receptor kinase 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ104587.1, AK134672.1, AK076533.1 and AI851927.1. On Oct 23, 2013 this sequence version replaced NM_177078.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK134672.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACC TGGAGGCCGT GCTGGCCGAC GTCAGCTACC TGATGGCCAT GGAGAAGAGC 
AAGACGGCGC CGGCCGCGCG CGCCAGCAAG AAGGTCGTCC TGCCGGAGCC CAGTATCCGG 
AGTGTGATGC AGAGGTATCT GGCAGAGAGA AACGAAATAA CCTTTGACAA GATTTTCAAT 
CAGAAAATCG GCTTCCTACT ATTTAAAGAC TTCTGCTTGA ATGAAATTGG GGAAGCAGTG 
CCTCAGGTGA AATTTTATGA AGAGATAAAA GAATATGAGA AGCTGGACAA CGAAGAGGAT 
AGGCTACGCC GGAGCCGGCA GATGTACGAC GCCTACATCA TGAGGGAGCT CCTATCCAGC 
ACACACCAAT TCTCAAAGCA AGCTGTAGAA CATGTCCAGA GCCATCTCTC CAAGAAACAG 
GTGACGGCTA CACTTTTCCA GCCATACATA GAAGAAATCT GTGAAAGCCT TCGTGGGGAT 
ATTTTCCAAA AGTTTATGGA AAGCGATAAA TTCACTAGAT TCTGTCAGTG GAAGAACGTG 
GAGTTGAATA TTCACCTGAG CATGAACGAC TTCAGTGTGC ACAGGATCAT CGGCCGAGGA 
GGGTTTGGGG AAGTTTATGG CTGCAGGAAA GCAGACACCG GTAAAATGTA TGCCATGAAG 
TGCTTAGACA AGAAAAGGGT GAAGATGAAG CAGGGGGAGA CTCTGGCTTT GAACGAGAGG 
ATCATGCTGT CTCTCGTTAG CACTGGGGAT TGTCCCTTTA TTGTCTGCAT GACCTACGCC 
TTCCACACGC CGGACAAACT CTGCTTCATC CTGGACCTGA TGAACGGGGG CGACATGCAC 
TACCATCTCT CTCAACACGG GGTGTTTTCT GAGAAGGAGA TGCGGTTTTA TGCCAGCGAG 
ATCATCCTGG GCCTCGAGCA CATGCACACC TGCTTCGTAG TCTACAGAGA CCTGAAGCCT 
GCGAACATCC TCCTAGATGA ATATGGGCAC GTGAGGATAT CGGATCTCGG CCTTGCCTGC 
GATTTCTCCA AAAAGAAGCC TCATGCCAGC GTGGGCACCC ATGGGTACAT GGCTCCCGAG 
GTGTTGCAGA AGGGAACGTG CTATGACAGC AGCGCCGACT GGTTCTCCCT GGGCTGTATG 
CTCTTCAAGC TTCTGCGGGG CCACAGCCCC TTCAGGCAGC ATAAAACCAA AGACAAGCAT 
GAGATAGACC GAATGACCCT GACCGTGAAC GTGCAGCTTC CAGATGCCTT CTCCCCTGAG 
CTGAGGTCCC TCTTAGAGGG TTTGCTCCAG CGGGACGTGA GCCAGCGGCT GGGCTGCGGA 
GGAGGAGGGG CACGAGAGTT GAAGGAGCAC ATCTTCTTCA AGGGCATTGA CTGGCAGCAT 
GTGTACTTAC GGAAGTACCC GCCACCCCTA ATCCCTCCTC GGGGAGAGGT CAACGCTGCA 
GATGCCTTCG ATATCGGCTC CTTCGATGAG GAAGACACCA AAGGCATTAA GCTGTTGGAC 
TGTGACCAGG ACCTCTATAA GAACTTCCCA CTGGTGATCT CCGAGCGCTG GCAGCAAGAA 
GTGGTGGAGA CCATCTATGA CGCCGTCAAT GCTGATACTG ATAAAATCGA GGCCAGGAGG 
AAGGCTAAAA ATAAGCAACT TGGTCAAGAG GAAGATTACG CTATGGGGAA GGACTGCATC 
ATGCACGGGT ACATGCTGAA GCTGGGGAAC CCCTTTCTCA CACAGTGGCA AAGACGCTAT 
TTTTACCTGT TCCCCAACAG ACTGGAGTGG AGAGGAGAGG GCGAGTCTCG GCAAAGTCTA 
CTGACCATGG AACAGATCAT GTCTGTGGAG GAGACCCAGA TTAAAGACAG AAAGTGCATC 
TTACTCAGGA TAAAGGGAGG GAAGCAATTT GTCTTGCAAT GTGAGAGTGA CCCCGAGTTT 
GCACAGTGGC TGAAGGAGCT GACCTGCACC TTCAATGAGG CCCAGAGACT GCTGCGCCGT 
GCCCCCAAAT TCCTCAACAA ACCACGGGCC GCCATCCTGG AGTTCTCCAA GCCACCACTG 
TGTCACAGAA ATAGCAGCGG CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796052.2
CDS	60..2126
Translation	MADLEAVLADVSYLMAMEKSKTAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLRRSRQMYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCGGGGARELKEHIFFKGIDWQHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQEVVETIYDAVNADTDKIEARRKAKNKQLGQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSLLTMEQIMSVEETQIKDRKCILLRIKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL

Target ORF information:

RefSeq Version	NM_177078.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177078.4

ORF Insert Sequence:

ATGGCGGACC TGGAGGCCGT GCTGGCCGAC GTCAGCTACC TGATGGCCAT GGAGAAGAGC 
AAGACGGCGC CGGCCGCGCG CGCCAGCAAG AAGGTCGTCC TGCCGGAGCC CAGTATCCGG 
AGTGTGATGC AGAGGTATCT GGCAGAGAGA AACGAAATAA CCTTTGACAA GATTTTCAAT 
CAGAAAATCG GCTTCCTACT ATTTAAAGAC TTCTGCTTGA ATGAAATTGG GGAAGCAGTG 
CCTCAGGTGA AATTTTATGA AGAGATAAAA GAATATGAGA AGCTGGACAA CGAAGAGGAT 
AGGCTACGCC GGAGCCGGCA GATGTACGAC GCCTACATCA TGAGGGAGCT CCTATCCAGC 
ACACACCAAT TCTCAAAGCA AGCTGTAGAA CATGTCCAGA GCCATCTCTC CAAGAAACAG 
GTGACGGCTA CACTTTTCCA GCCATACATA GAAGAAATCT GTGAAAGCCT TCGTGGGGAT 
ATTTTCCAAA AGTTTATGGA AAGCGATAAA TTCACTAGAT TCTGTCAGTG GAAGAACGTG 
GAGTTGAATA TTCACCTGAG CATGAACGAC TTCAGTGTGC ACAGGATCAT CGGCCGAGGA 
GGGTTTGGGG AAGTTTATGG CTGCAGGAAA GCAGACACCG GTAAAATGTA TGCCATGAAG 
TGCTTAGACA AGAAAAGGGT GAAGATGAAG CAGGGGGAGA CTCTGGCTTT GAACGAGAGG 
ATCATGCTGT CTCTCGTTAG CACTGGGGAT TGTCCCTTTA TTGTCTGCAT GACCTACGCC 
TTCCACACGC CGGACAAACT CTGCTTCATC CTGGACCTGA TGAACGGGGG CGACATGCAC 
TACCATCTCT CTCAACACGG GGTGTTTTCT GAGAAGGAGA TGCGGTTTTA TGCCAGCGAG 
ATCATCCTGG GCCTCGAGCA CATGCACACC TGCTTCGTAG TCTACAGAGA CCTGAAGCCT 
GCGAACATCC TCCTAGATGA ATATGGGCAC GTGAGGATAT CGGATCTCGG CCTTGCCTGC 
GATTTCTCCA AAAAGAAGCC TCATGCCAGC GTGGGCACCC ATGGGTACAT GGCTCCCGAG 
GTGTTGCAGA AGGGAACGTG CTATGACAGC AGCGCCGACT GGTTCTCCCT GGGCTGTATG 
CTCTTCAAGC TTCTGCGGGG CCACAGCCCC TTCAGGCAGC ATAAAACCAA AGACAAGCAT 
GAGATAGACC GAATGACCCT GACCGTGAAC GTGCAGCTTC CAGATGCCTT CTCCCCTGAG 
CTGAGGTCCC TCTTAGAGGG TTTGCTCCAG CGGGACGTGA GCCAGCGGCT GGGCTGCGGA 
GGAGGAGGGG CACGAGAGTT GAAGGAGCAC ATCTTCTTCA AGGGCATTGA CTGGCAGCAT 
GTGTACTTAC GGAAGTACCC GCCACCCCTA ATCCCTCCTC GGGGAGAGGT CAACGCTGCA 
GATGCCTTCG ATATCGGCTC CTTCGATGAG GAAGACACCA AAGGCATTAA GCTGTTGGAC 
TGTGACCAGG ACCTCTATAA GAACTTCCCA CTGGTGATCT CCGAGCGCTG GCAGCAAGAA 
GTGGTGGAGA CCATCTATGA CGCCGTCAAT GCTGATACTG ATAAAATCGA GGCCAGGAGG 
AAGGCTAAAA ATAAGCAACT TGGTCAAGAG GAAGATTACG CTATGGGGAA GGACTGCATC 
ATGCACGGGT ACATGCTGAA GCTGGGGAAC CCCTTTCTCA CACAGTGGCA AAGACGCTAT 
TTTTACCTGT TCCCCAACAG ACTGGAGTGG AGAGGAGAGG GCGAGTCTCG GCAAAGTCTA 
CTGACCATGG AACAGATCAT GTCTGTGGAG GAGACCCAGA TTAAAGACAG AAAGTGCATC 
TTACTCAGGA TAAAGGGAGG GAAGCAATTT GTCTTGCAAT GTGAGAGTGA CCCCGAGTTT 
GCACAGTGGC TGAAGGAGCT GACCTGCACC TTCAATGAGG CCCAGAGACT GCTGCGCCGT 
GCCCCCAAAT TCCTCAACAA ACCACGGGCC GCCATCCTGG AGTTCTCCAA GCCACCACTG 
TGTCACAGAA ATAGCAGCGG CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.
Immunity47(5)862-874.e3(2017 Nov)
Petrie Aronin CE,Zhao YM,Yoon JS,Morgan NY,Pr?stel T,Germain RN,Meier-Schellersheim M

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
Journal of leukocyte biology94(6)1243-51(2013 Dec)
Tarrant TK,Billard MJ,Timoshchenko RG,McGinnis MW,Serafin DS,Foreman O,Esserman DA,Chao NJ,Lento WE,Lee DM,Patel D,Siderovski DP

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America107(25)11608-13(2010 Jun)
Melief EJ,Miyatake M,Bruchas MR,Chavkin C

Identification of transcripts with enriched expression in the developing and adult pancreas.
Genome biology9(6)R99(2008)
Hoffman BG,Zavaglia B,Witzsche J,Ruiz de Algara T,Beach M,Hoodless PA,Jones SJ,Marra MA,Helgason CD

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Grk3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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