Hist2h2bb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hist2h2bb
Entrez Gene ID	319189
Full Name	histone cluster 2, H2bb
Synonyms	H2b-616
General protein information	Preferred Names histone cluster 2, H2bb Names histone H2B type 2-B H2b 616 histone 2, H2bb
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F2.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_175666.3	NP_783597.2	histone H2B type 2-B
NM_175666.2	NP_783597.2	histone H2B type 2-B

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST2H2BF	NP_001154806.1
Pan troglodytes (chimpanzee)	LOC457260	XP_003308398.1
Mus musculus (house mouse)	Hist2h2bb	NP_783597.2
	LOC704845	XP_001096522.2
Canis lupus familiaris (dog)	LOC608682	XP_005640186.1
Bos taurus (cattle)	LOC505183	XP_002697561.1
Rattus norvegicus (Norway rat)	LOC100912338	XP_006233057.1

Gene Ontology
Bibliography

Related articles in PubMed

Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.
Doyle HA, Aswad DW, Mamula MJ
Autoimmunity46(1)6-13(2013 Feb)

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons.
Santoro SW, Dulac C
eLife1e00070(2012 Dec)

Histone H2B as a functionally important plasminogen receptor on macrophages.
Das R, Burke T, Plow EF
Blood110(10)3763-72(2007 Nov)

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Molecular cell23(4)607-18(2006 Aug)

Histone modifications associated with somatic hypermutation.
Odegard VH, Kim ST, Anderson SM, Shlomchik MJ, Schatz DG
Immunity23(1)101-10(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Autoimmunity to isoAsp H2B suggests that this form of the autoantigen may be critical in the induction of anti-histone autoantibodies in murine models of human SLE.
Title: Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons.
Title: The activity-dependent histone variant H2BE modulates the life span of olfactory neurons.

H2B plays a very prominent and functionally important role as plasminogen receptor.
Title: Histone H2B as a functionally important plasminogen receptor on macrophages.

The following Hist2h2bb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hist2h2bb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14513	NM_175666.2 Latest version!	Mus musculus histone cluster 2, H2bb (Hist2h2bb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu84602	NM_175666.3 Latest version!	Mus musculus H2B clustered histone 18 (H2bc18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hist2h2bb ( NM_175666.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_783597.2 Mus musculus histone cluster 2, H2bb (Hist2h2bb), mRNA.

Price & Availability↑

CloneID	OMu14513
Clone ID Related Accession (Same CDS sequence)	NM_175666.2
Accession Version	NM_175666.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-09
Organism	Mus musculus(house mouse)
Product	histone H2B type 2-B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U62675.1. On Jun 25, 2005 this sequence version replaced NM_175666.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGGATC CAGCGAAGTC TGCTCCTGCC CCAAAGAAGG GCTCTAAGAA AGCTGTCACG 
AAAGTGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTATTCTGTC 
TACGTGTACA AGGTCCTGAA GCAAGTGCAC CCCGACACGG GCATCTCATC TAAGGCTATG 
GGAATCATGA ATTCCTTCGT GAACGATATC TTCGAGCGCA TCGCAGGTGA GGCTTCCCGT 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCCCGGG AGATCCAGAC AGCCGTGCGT 
CTGCTGCTGC CGGGAGAGTT GGCTAAACAC GCTGTGTCGG AAGGCACCAA GGCTGTCACC 
AAGTACACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783597.2
CDS	53..433
Translation	MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_175666.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histone cluster 2, H2bb (Hist2h2bb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175666.2

ORF Insert Sequence:

ATGCCGGATC CAGCGAAGTC TGCTCCTGCC CCAAAGAAGG GCTCTAAGAA AGCTGTCACG 
AAAGTGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTATTCTGTC 
TACGTGTACA AGGTCCTGAA GCAAGTGCAC CCCGACACGG GCATCTCATC TAAGGCTATG 
GGAATCATGA ATTCCTTCGT GAACGATATC TTCGAGCGCA TCGCAGGTGA GGCTTCCCGT 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCCCGGG AGATCCAGAC AGCCGTGCGT 
CTGCTGCTGC CGGGAGAGTT GGCTAAACAC GCTGTGTCGG AAGGCACCAA GGCTGTCACC 
AAGTACACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hist2h2bb ( NM_175666.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_783597.2 Mus musculus H2B clustered histone 18 (H2bc18), mRNA.

Price & Availability↑

CloneID	OMu84602
Clone ID Related Accession (Same CDS sequence)	NM_175666.3
Accession Version	NM_175666.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	histone H2B type 2-B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC125099.3. On Jan 18, 2019 this sequence version replaced NM_175666.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BB622628.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGGATC CAGCGAAGTC TGCTCCTGCC CCAAAGAAGG GCTCTAAGAA AGCTGTCACG 
AAAGTGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTATTCTGTT 
TACGTGTACA AGGTCCTGAA GCAAGTGCAC CCCGACACGG GCATCTCATC TAAGGCTATG 
GGAATCATGA ATTCCTTCGT GAACGATATC TTCGAGCGCA TCGCAGGTGA GGCTTCCCGT 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCCCGGG AGATCCAGAC AGCCGTGCGT 
CTGCTGCTGC CGGGAGAGTT GGCTAAACAC GCTGTGTCGG AAGGCACCAA GGCCGTCACC 
AAGTACACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783597.2
CDS	53..433
Translation	MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_175666.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus H2B clustered histone 18 (H2bc18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175666.3

ORF Insert Sequence:

ATGCCGGATC CAGCGAAGTC TGCTCCTGCC CCAAAGAAGG GCTCTAAGAA AGCTGTCACG 
AAAGTGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTATTCTGTT 
TACGTGTACA AGGTCCTGAA GCAAGTGCAC CCCGACACGG GCATCTCATC TAAGGCTATG 
GGAATCATGA ATTCCTTCGT GAACGATATC TTCGAGCGCA TCGCAGGTGA GGCTTCCCGT 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCCCGGG AGATCCAGAC AGCCGTGCGT 
CTGCTGCTGC CGGGAGAGTT GGCTAAACAC GCTGTGTCGG AAGGCACCAA GGCCGTCACC 
AAGTACACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.
Autoimmunity46(1)6-13(2013 Feb)
Doyle HA,Aswad DW,Mamula MJ

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons.
eLife1e00070(2012 Dec)
Santoro SW,Dulac C

Histone H2B as a functionally important plasminogen receptor on macrophages.
Blood110(10)3763-72(2007 Nov)
Das R,Burke T,Plow EF

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Molecular cell23(4)607-18(2006 Aug)
Kim SC,Sprung R,Chen Y,Xu Y,Ball H,Pei J,Cheng T,Kho Y,Xiao H,Xiao L,Grishin NV,White M,Yang XJ,Zhao Y

Histone modifications associated with somatic hypermutation.
Immunity23(1)101-10(2005 Jul)
Odegard VH,Kim ST,Anderson SM,Shlomchik MJ,Schatz DG

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Hist2h2bb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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