H4c3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H4c3
Entrez Gene ID	319155
Full Name	histone cluster 1, H4c
General protein information	Preferred Names histone cluster 1, H4c Names histone H4 germinal histone H4 histone 1, H4c
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_178208.2	NP_835515.1	histone H4

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H4F	NP_003531.1
Mus musculus (house mouse)	Hist1h4c	NP_835515.1
Danio rerio (zebrafish)	si:ch211-113a14.9	XP_005163250.1
Drosophila melanogaster (fruit fly)	His4:CG31611	NP_724344.1
Xenopus tropicalis (tropical clawed frog)	LOC100495622	XP_002944667.1
Pan troglodytes (chimpanzee)	LOC457262	XP_003308404.1
Rattus norvegicus (Norway rat)	LOC102548682	XP_006254038.1
	LOC704565	XP_001096216.1
Bos taurus (cattle)	LOC527388	XP_002697555.1

Gene Ontology
Bibliography

Related articles in PubMed

Excess NF-?B induces ectopic odontogenesis in embryonic incisor epithelium.
Blackburn J, Kawasaki K, Porntaveetus T, Kawasaki M, Otsuka-Tanaka Y, Miake Y, Ota MS, Watanabe M, Hishinuma M, Nomoto T, Oommen S, Ghafoor S, Harada F, Nozawa-Inoue K, Maeda T, Peterkov? R, Lesot H, Inoue J, Akiyama T, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ram?rez ?, Sharpe PT, Ohazama A
Journal of dental research94(1)121-8(2015 Jan)

Dynamic expression of combinatorial replication-dependent histone variant genes during mouse spermatogenesis.
Sun R, Qi H
Gene expression patterns : GEP14(1)30-41(2014 Jan)

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
Huegel J, Mundy C, Sgariglia F, Nygren P, Billings PC, Yamaguchi Y, Koyama E, Pacifici M
Developmental biology377(1)100-12(2013 May)

The role of Irf6 in tooth epithelial invagination.
Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, Rountree RB, Hu Y, Kawasaki M, Birchmeier W, Schmidt-Ullrich R, Kinoshita A, Schutte BC, Hammond NL, Dixon MJ, Sharpe PT
Developmental biology365(1)61-70(2012 May)

Trps1 is necessary for normal temporomandibular joint development.
Michikami I, Fukushi T, Honma S, Yoshioka S, Itoh S, Muragaki Y, Kurisu K, Ooshima T, Wakisaka S, Abe M
Cell and tissue research348(1)131-40(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Oocyte cryopreservation can alter acetylation patterns on lysine 12 of histone H4 in oocytes and zygotes.
Title: Effect of cryopreservation on acetylation patterns of lysine 12 of histone H4 (acH4K12) in mouse oocytes and zygotes.

The acetylated H4K12 levels in oocytes significantly increased during the aging process, and such changes may affect the acetylation patterns and morphology of pronuclei during fertilization and lead to a reduction in oocyte developmental potential
Title: Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development.

Animal models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing drug-induced dyskinesia.
Title: Striatal histone modifications in models of levodopa-induced dyskinesia.

The following H4c3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H4c3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20005	NM_178208.2 Latest version!	Mus musculus H4 clustered histone 3 (H4c3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H4c3 ( NM_178208.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_835515.1 Mus musculus H4 clustered histone 3 (H4c3), mRNA.

Price & Availability↑

CloneID	OMu20005
Clone ID Related Accession (Same CDS sequence)	NM_178208.2
Accession Version	NM_178208.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	histone H4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL592149.8. On Feb 21, 2014 this sequence version replaced NM_178208.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGAC GTGGTAAGGG TGGTAAAGGC CTTGGGAAAG GCGGCGCTAA GCGCCACCGT 
AAGGTTCTCC GTGATAACAT CCAGGGCATT ACCAAGCCCG CCATCCGCCG CCTGGCCCGG 
CGCGGGGGAG TGAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACCCGCGG TGTGCTGAAG 
GTGTTCCTGG AGAACGTGAT CCGCGACGCC GTCACCTACA CGGAGCACGC CAAGCGCAAG 
ACCGTCACCG CCATGGACGT GGTCTACGCG CTCAAGCGCC AGGGCCGCAC TCTCTACGGA 
TTCGGCGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835515.1
CDS	10..321
Translation	MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target ORF information:

RefSeq Version	NM_178208.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus H4 clustered histone 3 (H4c3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178208.2

ORF Insert Sequence:

ATGTCTGGAC GTGGTAAGGG TGGTAAAGGC CTTGGGAAAG GCGGCGCTAA GCGCCACCGT 
AAGGTTCTCC GTGATAACAT CCAGGGCATT ACCAAGCCCG CCATCCGCCG CCTGGCCCGG 
CGCGGGGGAG TGAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACCCGCGG TGTGCTGAAG 
GTGTTCCTGG AGAACGTGAT CCGCGACGCC GTCACCTACA CGGAGCACGC CAAGCGCAAG 
ACCGTCACCG CCATGGACGT GGTCTACGCG CTCAAGCGCC AGGGCCGCAC TCTCTACGGA 
TTCGGCGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Excess NF-?B induces ectopic odontogenesis in embryonic incisor epithelium.
Journal of dental research94(1)121-8(2015 Jan)
Blackburn J,Kawasaki K,Porntaveetus T,Kawasaki M,Otsuka-Tanaka Y,Miake Y,Ota MS,Watanabe M,Hishinuma M,Nomoto T,Oommen S,Ghafoor S,Harada F,Nozawa-Inoue K,Maeda T,Peterkov? R,Lesot H,Inoue J,Akiyama T,Schmidt-Ullrich R,Liu B,Hu Y,Page A,Ram?rez ?,Sharpe PT,Ohazama A

Dynamic expression of combinatorial replication-dependent histone variant genes during mouse spermatogenesis.
Gene expression patterns : GEP14(1)30-41(2014 Jan)
Sun R,Qi H

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
Developmental biology377(1)100-12(2013 May)
Huegel J,Mundy C,Sgariglia F,Nygren P,Billings PC,Yamaguchi Y,Koyama E,Pacifici M

The role of Irf6 in tooth epithelial invagination.
Developmental biology365(1)61-70(2012 May)
Blackburn J,Ohazama A,Kawasaki K,Otsuka-Tanaka Y,Liu B,Honda K,Rountree RB,Hu Y,Kawasaki M,Birchmeier W,Schmidt-Ullrich R,Kinoshita A,Schutte BC,Hammond NL,Dixon MJ,Sharpe PT

Trps1 is necessary for normal temporomandibular joint development.
Cell and tissue research348(1)131-40(2012 Apr)
Michikami I,Fukushi T,Honma S,Yoshioka S,Itoh S,Muragaki Y,Kurisu K,Ooshima T,Wakisaka S,Abe M

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H4c3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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