Siva1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Siva1
Entrez Gene ID	30954
Full Name	SIVA1, apoptosis-inducing factor
Synonyms	CD27bp,Siva
General protein information	Preferred Names SIVA1, apoptosis-inducing factor Names apoptosis regulatory protein Siva CD27-binding protein Cd27 binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_013929.2	NP_038957.2	apoptosis regulatory protein Siva isoform 1
NM_001161737.1	NP_001155209.1	apoptosis regulatory protein Siva isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Siva1	NP_038957.2
Gallus gallus (chicken)	SIVA1	NP_001264464.1
Bos taurus (cattle)	SIVA1	NP_001180107.1
Rattus norvegicus (Norway rat)	Siva1	NP_001094452.1
Danio rerio (zebrafish)	siva1	XP_700568.6
Canis lupus familiaris (dog)	SIVA1	XP_855513.1
Homo sapiens (human)	SIVA1	NP_006418.2
Pan troglodytes (chimpanzee)	SIVA1	XP_510197.3
	SIVA1	XP_001095069.2
Xenopus tropicalis (tropical clawed frog)	siva1	NP_001039138.1

Gene Ontology
Bibliography

Related articles in PubMed

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.
Park IK, Blum W, Baker SD, Caligiuri MA
Leukemia31(2)502-505(2017 02)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Van Nostrand JL, Brisac A, Mello SS, Jacobs SB, Luong R, Attardi LD
Cancer discovery5(6)622-35(2015 Jun)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Li N, Jiang P, Du W, Wu Z, Li C, Qiao M, Yang X, Wu M
Proceedings of the National Academy of Sciences of the United States of America108(31)12851-6(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.

Data indicate that p53 target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
Title: p53 target Siva regulates apoptosis in ischemic kidneys.

Data show that SLIMMER delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
Title: SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.

lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
Title: The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.

Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53-dependent apoptosis in cerebellar granule neurons.
Title: Siva is an apoptosis-selective p53 target gene important for neuronal cell death.

The following Siva1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Siva1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08216	NM_001161737.1 Latest version!	Mus musculus SIVA1, apoptosis-inducing factor (Siva1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu10178	NM_013929.2 Latest version!	Mus musculus SIVA1, apoptosis-inducing factor (Siva1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Siva1 ( NM_001161737.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001155209.1 Mus musculus SIVA1, apoptosis-inducing factor (Siva1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu08216
Clone ID Related Accession (Same CDS sequence)	NM_001161737.1
Accession Version	NM_001161737.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	apoptosis regulatory protein Siva isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB524656.1, AF033112.1, AW060433.1 and AC124373.4. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV576296.1, BY367725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG 
GGCCTGAAAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCACGCGA GGTCTTCGGC 
CTTCCCAGGA CAGCGCCCAT CGCTTGTTCA TCGTGCATGA GATCTGTGGA TGGGAAGGCG 
GTCTGCAGCC AGTGCGAGCG GGCCCTGTGT GGGCAGTGTG TATACACCTG CTGGGGCTGC 
GGTGCTTTGG CCTGTGTGCT GTGTGGCCTT GCAGACTATG CCGACGATGG TGAGAAGACA 
CTGTGCACCA GCTGTGCTAT GTTTGAAGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155209.1
CDS	140..472
Translation	MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFGLPRTAPIACSSCMRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA

Target ORF information:

RefSeq Version	NM_001161737.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SIVA1, apoptosis-inducing factor (Siva1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161737.1

ORF Insert Sequence:

ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG 
GGCCTGAAAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCACGCGA GGTCTTCGGC 
CTTCCCAGGA CAGCGCCCAT CGCTTGTTCA TCGTGCATGA GATCTGTGGA TGGGAAGGCG 
GTCTGCAGCC AGTGCGAGCG GGCCCTGTGT GGGCAGTGTG TATACACCTG CTGGGGCTGC 
GGTGCTTTGG CCTGTGTGCT GTGTGGCCTT GCAGACTATG CCGACGATGG TGAGAAGACA 
CTGTGCACCA GCTGTGCTAT GTTTGAAGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Siva1 ( NM_013929.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038957.2 Mus musculus SIVA1, apoptosis-inducing factor (Siva1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10178
Clone ID Related Accession (Same CDS sequence)	NM_013929.2
Accession Version	NM_013929.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	apoptosis regulatory protein Siva isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB524656.1, AK017570.1, AW060433.1 and AC124373.4. On Jun 18, 2009 this sequence version replaced NM_013929.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012279.1, CB204343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG 
GGCCTGAAAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCACGCGA GGTCTTCGAA 
AGAACCAAGC AGCTCCTTTT CCAAGGGGCT CGGGCCTATA GAGATCACAT ATCGAGCGAA 
GATTGTTCCG TGAACCACCT GCAGGAGTCA CTGAAGTCTG GTGTGGTAGG AGCCCCTCAA 
CCTGCGAGGG GACAGATGTT GATTGGACCT GATGGCCGAC TGACACGGTG CCAAGCTCAG 
GCCTCAGAAG GTGGCCTTCC CAGGACAGCG CCCATCGCTT GTTCATCGTG CATGAGATCT 
GTGGATGGGA AGGCGGTCTG CAGCCAGTGC GAGCGGGCCC TGTGTGGGCA GTGTGTATAC 
ACCTGCTGGG GCTGCGGTGC TTTGGCCTGT GTGCTGTGTG GCCTTGCAGA CTATGCCGAC 
GATGGTGAGA AGACACTGTG CACCAGCTGT GCTATGTTTG AAGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038957.2
CDS	140..667
Translation	MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFERTKQLLFQGARAYRDHISSEDCSVNHLQESLKSGVVGAPQPARGQMLIGPDGRLTRCQAQASEGGLPRTAPIACSSCMRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA

Target ORF information:

RefSeq Version	NM_013929.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SIVA1, apoptosis-inducing factor (Siva1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013929.2

ORF Insert Sequence:

ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG 
GGCCTGAAAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCACGCGA GGTCTTCGAA 
AGAACCAAGC AGCTCCTTTT CCAAGGGGCT CGGGCCTATA GAGATCACAT ATCGAGCGAA 
GATTGTTCCG TGAACCACCT GCAGGAGTCA CTGAAGTCTG GTGTGGTAGG AGCCCCTCAA 
CCTGCGAGGG GACAGATGTT GATTGGACCT GATGGCCGAC TGACACGGTG CCAAGCTCAG 
GCCTCAGAAG GTGGCCTTCC CAGGACAGCG CCCATCGCTT GTTCATCGTG CATGAGATCT 
GTGGATGGGA AGGCGGTCTG CAGCCAGTGC GAGCGGGCCC TGTGTGGGCA GTGTGTATAC 
ACCTGCTGGG GCTGCGGTGC TTTGGCCTGT GTGCTGTGTG GCCTTGCAGA CTATGCCGAC 
GATGGTGAGA AGACACTGTG CACCAGCTGT GCTATGTTTG AAGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.
Leukemia31(2)502-505(2017 02)
Park IK,Blum W,Baker SD,Caligiuri MA

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Cancer discovery5(6)622-35(2015 Jun)
Van Nostrand JL,Brisac A,Mello SS,Jacobs SB,Luong R,Attardi LD

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Proceedings of the National Academy of Sciences of the United States of America108(31)12851-6(2011 Aug)
Li N,Jiang P,Du W,Wu Z,Li C,Qiao M,Yang X,Wu M

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Siva1 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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