Lmcd1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lmcd1
Entrez Gene ID	30937
Full Name	LIM and cysteine-rich domains 1
Synonyms	AW455500,AW553074,dyxin
General protein information	Preferred Names LIM and cysteine-rich domains 1 Names LIM and cysteine-rich domains protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_144799.2	NP_659048.1	LIM and cysteine-rich domains protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LMCD1	XP_516253.3
Mus musculus (house mouse)	Lmcd1	NP_659048.1
Gallus gallus (chicken)	LMCD1	XP_414443.2
Rattus norvegicus (Norway rat)	Lmcd1	NP_001008562.1
Danio rerio (zebrafish)	lmcd1	NP_957364.2
Homo sapiens (human)	LMCD1	NP_055398.1
Canis lupus familiaris (dog)	LMCD1	XP_533751.3
Bos taurus (cattle)	LMCD1	NP_001069690.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.
Metzakopian E, Bouhali K, Alvarez-Saavedra M, Whitsett JA, Picketts DJ, Ang SL
Development (Cambridge, England)142(7)1315-24(2015 Apr)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
Gene expression patterns : GEP11(1-2)84-92(2011 Jan-Feb)

Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.
Frank D, Frauen R, Hanselmann C, Kuhn C, Will R, Gantenberg J, F?zesi L, Katus HA, Frey N
Journal of molecular and cellular cardiology49(4)673-82(2010 Oct)

LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling.
Bian ZY, Huang H, Jiang H, Shen DF, Yan L, Zhu LH, Wang L, Cao F, Liu C, Tang QZ, Li H
Hypertension (Dallas, Tex. : 1979)55(2)257-63(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study show that the novel LIM protein Lmcd1/Dyxin is both sufficient and necessary for cardiomyocyte hypertrophy.
Title: Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.

Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium.
Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.

The following Lmcd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lmcd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11096	NM_144799.2 Latest version!	Mus musculus LIM and cysteine-rich domains 1 (Lmcd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lmcd1 ( NM_144799.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_659048.1 Mus musculus LIM and cysteine-rich domains 1 (Lmcd1), mRNA.

Price & Availability↑

CloneID	OMu11096
Clone ID Related Accession (Same CDS sequence)	NM_144799.2
Accession Version	NM_144799.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	LIM and cysteine-rich domains protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK075847.1, AK159946.1 and AI845609.1. On Dec 17, 2009 this sequence version replaced NM_144799.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075847.1, BC019124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAAAAG TGGCTAAGGA CCTCAACCCT GGAGTGCAAA AGATGTCCTT GGGCCAGCAG 
CAGTCCGCAA GAGGAGTGGC TTGTCTGCGG TGCAAGGGAA TGTGCTCCGG CTTCGAGCCT 
CACTCGTGGA GGAAAATATG CAAGTCTTGT AAATGCAGCC AGGAGGAGCA CTGCCTAAGC 
TCTGACCTGG ACGATGATCG GAAAATTGGG CGCCTGCTGA TGGACTCCAA GTATGCCACT 
CTCACCGCCA GGGTGAAAGG CGGAGACGGC ATCCGCATCT ATAAGAGGAA CCGCATGATC 
ATGACCAACC CCATCGCCAC CGGCAAAGAC CCCACCTTTG ACACTATCAC CTACGAGTGG 
GCTCCCCCAG GAGTCACCCA GAAACTGGGC CTGCAGTACA TGGAACTCAT CCCCAAGGAG 
AGGCAGCCTG TGACAGGCAC TGAGGGTGCC CTCTACCGCC GACGCCAGCT CATGCATCAG 
CTCCCTATCT ATGACCAGGA CCCCTCTCGA TGCCGTGGAC TTGTGGAGAA TGAGCTGAAA 
GCTATGGAGG AGTTCGTCAA GCACTACAAG AGCGAGGCCC TTGGGGTGGG CGAGGTGGCC 
CTCCCAGGGC AGGGAGGCTT GCCCAAGGAA GAAAACAAGA CACAGGAAAA GCCAGAGGGC 
ACAGAGACCA CTGCCCCAAC CACCAATGGC AGCCTGGGTG ATCCATCCAA AGAAGTGGAA 
TACGTCTGTG AGCTCTGCAA GGGAGCAGCC CCAGTTGACA GCCCTGTGGT CTACGCTGAC 
AGGGCTGGAT ACAGCAAACA GTGGCACCCC ACGTGCTTTC AGTGTATCAA GTGCTCAGAG 
CCACTGGTGG ACCTCATCTA CTTCTGGAAG GATGGTGCAC CCTGGTGTGG CCGCCACTAC 
TGTGAGAGTG TGCGGCCCCG GTGCTCAGGC TGTGATGAGA TCATCTTCTC AGAAGACTAC 
CAGCGTGTGG AAGACCTGGC CTGGCATCGG AAGCACTTCA TTTGCGAGGG CTGTGAGCAG 
CTGCTGAGCG GCCGTGCGTA CATCGTCACC AAGGGTCAGC TCCTGTGCCC CACATGCAGC 
AAGTCAAAAC GCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659048.1
CDS	174..1271
Translation	MAKVAKDLNPGVQKMSLGQQQSARGVACLRCKGMCSGFEPHSWRKICKSCKCSQEEHCLSSDLDDDRKIGRLLMDSKYATLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKERQPVTGTEGALYRRRQLMHQLPIYDQDPSRCRGLVENELKAMEEFVKHYKSEALGVGEVALPGQGGLPKEENKTQEKPEGTETTAPTTNGSLGDPSKEVEYVCELCKGAAPVDSPVVYADRAGYSKQWHPTCFQCIKCSEPLVDLIYFWKDGAPWCGRHYCESVRPRCSGCDEIIFSEDYQRVEDLAWHRKHFICEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS

Target ORF information:

RefSeq Version	NM_144799.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus LIM and cysteine-rich domains 1 (Lmcd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144799.2

ORF Insert Sequence:

ATGGCAAAAG TGGCTAAGGA CCTCAACCCT GGAGTGCAAA AGATGTCCTT GGGCCAGCAG 
CAGTCCGCAA GAGGAGTGGC TTGTCTGCGG TGCAAGGGAA TGTGCTCCGG CTTCGAGCCT 
CACTCGTGGA GGAAAATATG CAAGTCTTGT AAATGCAGCC AGGAGGAGCA CTGCCTAAGC 
TCTGACCTGG ACGATGATCG GAAAATTGGG CGCCTGCTGA TGGACTCCAA GTATGCCACT 
CTCACCGCCA GGGTGAAAGG CGGAGACGGC ATCCGCATCT ATAAGAGGAA CCGCATGATC 
ATGACCAACC CCATCGCCAC CGGCAAAGAC CCCACCTTTG ACACTATCAC CTACGAGTGG 
GCTCCCCCAG GAGTCACCCA GAAACTGGGC CTGCAGTACA TGGAACTCAT CCCCAAGGAG 
AGGCAGCCTG TGACAGGCAC TGAGGGTGCC CTCTACCGCC GACGCCAGCT CATGCATCAG 
CTCCCTATCT ATGACCAGGA CCCCTCTCGA TGCCGTGGAC TTGTGGAGAA TGAGCTGAAA 
GCTATGGAGG AGTTCGTCAA GCACTACAAG AGCGAGGCCC TTGGGGTGGG CGAGGTGGCC 
CTCCCAGGGC AGGGAGGCTT GCCCAAGGAA GAAAACAAGA CACAGGAAAA GCCAGAGGGC 
ACAGAGACCA CTGCCCCAAC CACCAATGGC AGCCTGGGTG ATCCATCCAA AGAAGTGGAA 
TACGTCTGTG AGCTCTGCAA GGGAGCAGCC CCAGTTGACA GCCCTGTGGT CTACGCTGAC 
AGGGCTGGAT ACAGCAAACA GTGGCACCCC ACGTGCTTTC AGTGTATCAA GTGCTCAGAG 
CCACTGGTGG ACCTCATCTA CTTCTGGAAG GATGGTGCAC CCTGGTGTGG CCGCCACTAC 
TGTGAGAGTG TGCGGCCCCG GTGCTCAGGC TGTGATGAGA TCATCTTCTC AGAAGACTAC 
CAGCGTGTGG AAGACCTGGC CTGGCATCGG AAGCACTTCA TTTGCGAGGG CTGTGAGCAG 
CTGCTGAGCG GCCGTGCGTA CATCGTCACC AAGGGTCAGC TCCTGTGCCC CACATGCAGC 
AAGTCAAAAC GCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.
Development (Cambridge, England)142(7)1315-24(2015 Apr)
Metzakopian E,Bouhali K,Alvarez-Saavedra M,Whitsett JA,Picketts DJ,Ang SL

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Gene expression patterns : GEP11(1-2)84-92(2011 Jan-Feb)
Chung YC,Tsai YJ,Shiu TY,Sun YY,Wang PF,Chen CL

Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.
Journal of molecular and cellular cardiology49(4)673-82(2010 Oct)
Frank D,Frauen R,Hanselmann C,Kuhn C,Will R,Gantenberg J,F?zesi L,Katus HA,Frey N

LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling.
Hypertension (Dallas, Tex. : 1979)55(2)257-63(2010 Feb)
Bian ZY,Huang H,Jiang H,Shen DF,Yan L,Zhu LH,Wang L,Cao F,Liu C,Tang QZ,Li H

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Lmcd1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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