Adamts8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adamts8
Entrez Gene ID	30806
Full Name	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
Synonyms	METH-2,METH2
General protein information	Preferred Names a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 Names A disintegrin and metalloproteinase with thrombospondin motifs 8 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 A4\|9 16.49 cM
Summary	This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is expressed in mouse lung, heart and macrophage-rich areas of atherosclerotic plaques. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. This gene is located adjacent to a related ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001326292.1	NP_001313221.1	A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2
NM_013906.3	NP_038934.2	A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 1 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ADAMTS8	XP_005620353.1
Danio rerio (zebrafish)	adamts8a	XP_698107.4
Xenopus tropicalis (tropical clawed frog)	adamts8	XP_002940685.2
Rattus norvegicus (Norway rat)	Adamts8	XP_003750503.1
Pan troglodytes (chimpanzee)	ADAMTS8	XP_522252.2
Bos taurus (cattle)	ADAMTS8	NP_001179254.1
Mus musculus (house mouse)	Adamts8	NP_038934.2
Gallus gallus (chicken)	ADAMTS8	XP_001232457.3
	ADAMTS8	XP_001112387.2
Danio rerio (zebrafish)	adamts15	XP_001341878.1
Homo sapiens (human)	ADAMTS8	NP_008968.4

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL
Developmental dynamics : an official publication of the American Association of Anatomists245(5)614-26(2016 May)

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.
Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins EC, Brown WT, Zhong N
American journal of reproductive immunology (New York, N.Y. : 1989)74(3)237-57(2015 Sep)

Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
Rossier J, Bernard A, Cabungcal JH, Perrenoud Q, Savoye A, Gallopin T, Hawrylycz M, Cu?nod M, Do K, Urban A, Lein ES
Molecular psychiatry20(2)154-61(2015 Feb)

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC
Developmental biology346(1)25-38(2010 Oct)

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.
McCulloch DR, Nelson CM, Dixon LJ, Silver DL, Wylie JD, Lindner V, Sasaki T, Cooley MA, Argraves WS, Apte SS
Developmental cell17(5)687-98(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.
Title: Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.

ADAMTS-4 expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
Title: ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.

The following Adamts8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adamts8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu83508	NM_001326292.1 Latest version!	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$307.30 $439.00
OMu20732	NM_013906.3 Latest version!	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adamts8 ( NM_001326292.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001313221.1 Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83508
Clone ID Related Accession (Same CDS sequence)	NM_001326292.1
Accession Version	NM_001326292.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT025653.7 and AK043875.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK043875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGCCCCATG ATGATTCTAA GCCCTGTGTG AGATTGTTTG GGCCCATGGG CAAGTACCAC 
ATGATGGCGC CATTCTTCAT CCACGTGAAC AAGACGCTGC CCTGGTCTCC CTGCAGTGCT 
GTCTACCTCA CAGAGCTCCT GGATGATGGT CACGGAGATT GTCTTCTGGA TGCCCCCACC 
TCGGTTCTGC CCCTCCCCAC AGGCCTCCCG GGCCACAGCA CCCTCTACGA GCTGGACCAG 
CAGTGCAAGC AGATCTTTGG GCCTGATTTC CGACACTGCC CCAACACCTC TGTGGAGGAC 
ATCTGTGTCC AGCTCTGGTG CCGTCATCGG GATAGTGATG AGCCCATTTG CCACACAAAG 
AATGGTAGCC TGCTCTGGGC TGATGGTACA CCCTGTGGCC CTGGGCACCT GTGCCTGGAT 
GGTAGCTGTG TACTCAAGGA GGATGTGGAG AATCCCAAGG CTGTGGTAGA TGGAGACTGG 
GGTCCCTGGA GACCCTGGGG ACAATGTTCT CGCACCTGTG GTGGAGGGAT ACAATTCTCG 
AACCGTGAAT GTGATAATCC AATGCCTCAG AATGGAGGAA GATTTTGCCT GGGTGAAAGA 
GTCAAGTACC AATCATGCAA CACAGAGGAA TGTCCACCAA ACGGAAAAAG CTTCCGGGAG 
CAGCAGTGTG AGAAATATAA TGCCTACAAC CACACTGACC TGGATGGGAA TTTCCTGCAG 
TGGGTCCCCA AGTATTCAGG AGTGTCCCCC CGAGACCGAT GCAAGCTGTT TTGCAGAGCC 
CGTGGGAGGA GTGAGTTCAA AGTGTTTGAA GCTAAGGTGA TCGATGGCAC TCTGTGTGGA 
CCGGATACTC TGTCCATCTG CGTCCGGGGG CAATGTGTTA AGGCTGGCTG TGACCATGTG 
GTGAACTCAC CTAAGAAGCT GGACAAATGT GGGGTGTGTG GGGGCAAAGG CACTGCCTGT 
AGGAAGATCT CCGGTTCTTT CACCCCCTTC AGTTATGGCT ACAATGACAT TGTCACCATC 
CCAGCTGGTG CCACAAACAT TGATGTGAAA CAGCGGAGTC ACCCAGGGGT CAGGAACGAC 
GGCAGCTACC TGGCGCTGAA GACAGCCAAT GGGCAGTACC TGCTCAATGG TAACCTGGCC 
ATCTCTGCCA TAGAGCAAGA CATCTTGGTG AAGGGGACCA TCCTGAAGTA CAGTGGCTCC 
ATGGCTACCC TGGAGCGGCT GCAGAGCTTC CAGGCCCTGC CTGAGCCTCT TACAGTACAG 
CTCCTGACTG TGTCTGGTGA GGTCTTCCCT CCAAAAGTCA GATATACCTT CTTTGTCCCC 
AATGACATGG ACTTCAGCGT GCAGAATAGC AAGGAAAGAG CAACCACCAA CATCATTCAG 
TCACTGCCCT CTGCGGAGTG GGTTCTGGGA GACTGGTCTG AATGTCCGAG CACGTGCAGA 
GGTAGCTGGC AGCGGCGGAC TGTGGAATGC AGGGACCCCT CAGGTCAGGC CTCTGACACC 
TGTGATGAGG CTCTGAAACC TGAGGATGCC AAGCCCTGTG GAAGCCAGCC GTGTCCCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313221.1
CDS	1295..2857
Translation	MPHDDSKPCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPLPTGLPGHSTLYELDQQCKQIFGPDFRHCPNTSVEDICVQLWCRHRDSDEPICHTKNGSLLWADGTPCGPGHLCLDGSCVLKEDVENPKAVVDGDWGPWRPWGQCSRTCGGGIQFSNRECDNPMPQNGGRFCLGERVKYQSCNTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPDTLSICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRKISGSFTPFSYGYNDIVTIPAGATNIDVKQRSHPGVRNDGSYLALKTANGQYLLNGNLAISAIEQDILVKGTILKYSGSMATLERLQSFQALPEPLTVQLLTVSGEVFPPKVRYTFFVPNDMDFSVQNSKERATTNIIQSLPSAEWVLGDWSECPSTCRGSWQRRTVECRDPSGQASDTCDEALKPEDAKPCGSQPCPL

Target ORF information:

RefSeq Version	NM_001326292.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326292.1

ORF Insert Sequence:

ATGCCCCATG ATGATTCTAA GCCCTGTGTG AGATTGTTTG GGCCCATGGG CAAGTACCAC 
ATGATGGCGC CATTCTTCAT CCACGTGAAC AAGACGCTGC CCTGGTCTCC CTGCAGTGCT 
GTCTACCTCA CAGAGCTCCT GGATGATGGT CACGGAGATT GTCTTCTGGA TGCCCCCACC 
TCGGTTCTGC CCCTCCCCAC AGGCCTCCCG GGCCACAGCA CCCTCTACGA GCTGGACCAG 
CAGTGCAAGC AGATCTTTGG GCCTGATTTC CGACACTGCC CCAACACCTC TGTGGAGGAC 
ATCTGTGTCC AGCTCTGGTG CCGTCATCGG GATAGTGATG AGCCCATTTG CCACACAAAG 
AATGGTAGCC TGCTCTGGGC TGATGGTACA CCCTGTGGCC CTGGGCACCT GTGCCTGGAT 
GGTAGCTGTG TACTCAAGGA GGATGTGGAG AATCCCAAGG CTGTGGTAGA TGGAGACTGG 
GGTCCCTGGA GACCCTGGGG ACAATGTTCT CGCACCTGTG GTGGAGGGAT ACAATTCTCG 
AACCGTGAAT GTGATAATCC AATGCCTCAG AATGGAGGAA GATTTTGCCT GGGTGAAAGA 
GTCAAGTACC AATCATGCAA CACAGAGGAA TGTCCACCAA ACGGAAAAAG CTTCCGGGAG 
CAGCAGTGTG AGAAATATAA TGCCTACAAC CACACTGACC TGGATGGGAA TTTCCTGCAG 
TGGGTCCCCA AGTATTCAGG AGTGTCCCCC CGAGACCGAT GCAAGCTGTT TTGCAGAGCC 
CGTGGGAGGA GTGAGTTCAA AGTGTTTGAA GCTAAGGTGA TCGATGGCAC TCTGTGTGGA 
CCGGATACTC TGTCCATCTG CGTCCGGGGG CAATGTGTTA AGGCTGGCTG TGACCATGTG 
GTGAACTCAC CTAAGAAGCT GGACAAATGT GGGGTGTGTG GGGGCAAAGG CACTGCCTGT 
AGGAAGATCT CCGGTTCTTT CACCCCCTTC AGTTATGGCT ACAATGACAT TGTCACCATC 
CCAGCTGGTG CCACAAACAT TGATGTGAAA CAGCGGAGTC ACCCAGGGGT CAGGAACGAC 
GGCAGCTACC TGGCGCTGAA GACAGCCAAT GGGCAGTACC TGCTCAATGG TAACCTGGCC 
ATCTCTGCCA TAGAGCAAGA CATCTTGGTG AAGGGGACCA TCCTGAAGTA CAGTGGCTCC 
ATGGCTACCC TGGAGCGGCT GCAGAGCTTC CAGGCCCTGC CTGAGCCTCT TACAGTACAG 
CTCCTGACTG TGTCTGGTGA GGTCTTCCCT CCAAAAGTCA GATATACCTT CTTTGTCCCC 
AATGACATGG ACTTCAGCGT GCAGAATAGC AAGGAAAGAG CAACCACCAA CATCATTCAG 
TCACTGCCCT CTGCGGAGTG GGTTCTGGGA GACTGGTCTG AATGTCCGAG CACGTGCAGA 
GGTAGCTGGC AGCGGCGGAC TGTGGAATGC AGGGACCCCT CAGGTCAGGC CTCTGACACC 
TGTGATGAGG CTCTGAAACC TGAGGATGCC AAGCCCTGTG GAAGCCAGCC GTGTCCCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Adamts8 ( NM_013906.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038934.2 Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20732
Clone ID Related Accession (Same CDS sequence)	NM_013906.3
Accession Version	NM_013906.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2718bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT025653.7 and AK043875.1. On May 13, 2016 this sequence version replaced NM_013906.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF175282.1, SRR1660819.107997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGCTCCGCG ACCCCACCAC CACCGGGTGG CCGCCCCTCC TGCTGCTGCT ATTGCAGCTG 
CCGCCGCCGC CACTCGTCTG CGGCGCCCCG GCGGGGCCGG GAACCGGGGC GCAGGCCTCG 
GAGCTAGTGG TGCCCACGCG GTTGCCCGGC AGCGCGAGCG AGCTCGCCTT CCACCTGTCC 
GCCTTCGGCC AGGGCTTCGT GCTGCGCCTG GCGCCTGACG CCAGCTTCCT GGCGCCGGAA 
TTCAAGATCG AGCGCCTCGG GGGCTCGAGC GCGGCGGCCG GGGGCGAGCC GGGACTGCGT 
GGCTGCTTCT TCTCTGGCAC AGTGAATGGA GAACGGGAGT CGCTGGCGGC GATGAGCCTG 
TGTCGCGGGC TGAGCGGCTC GTTCTTGCTG GCAGGCGAGG AGTTCACCAT CCAGCCACAG 
GGCGCTGGGG ACTCCCTGGA CCAGCCTCAT CGCCTGCAGC GCTGGGGGCC GGGACAGCGC 
CGCGAAGACC CCGGGCTCGC TGCCGCCGAA GTTTTCCCCC TCCCTCAAGG ACTGGAGTGG 
GAGGTGGAGA TGGGTAATGG GCAGGGACAG GAGAGAAGTG ACAACGAAGA GGACAGGAAG 
CAGGACAAGG AGGGGTTGCT CAAAGAGACA GAAGACTCCC GCAAAGTGCC ACCACCCTTC 
GGATCCAAAA CTAGAAGCAA GAGGTTTGTG TCCGAGGCTC GCTTCGTGGA AACACTTCTG 
GTGGCTGATG CGTCCATGGC TGCCTTCTAT GGGACCGACC TGCAGAACCA CATCCTCACG 
GTGATGTCAA TGGCAGCCCG AATCTACAAG CACCCGAGCA TCAGGAACTC CGTCAACCTT 
GTGGTGGTGA AAGTGCTAAT AGTGGAAGAG GAAGGATGGG GCCCGGAGGT GTCGGACAAC 
GGGGGGCTCA CACTGCGCAA CTTCTGCAGC TGGCAACGGC GTTTCAACAA GCCCAGTGAC 
CGCCACCCGG AGCACTATGA CACTGCCATC TTGTTCACCA GACAGAACTT CTGTGGGAAG 
GGAGAGCAGT GTGACACCCT GGGGATGGCA GACGTTGGCA CCATCTGTGA CCCCGACAAG 
AGCTGCTCAG TGATCAAGGA TGAGGGACTG CAGGCAGCCT ACACCCTGGC CCATGAGCTA 
GGGCACGTTC TCAGCATGCC CCATGATGAT TCTAAGCCCT GTGTGAGATT GTTTGGGCCC 
ATGGGCAAGT ACCACATGAT GGCGCCATTC TTCATCCACG TGAACAAGAC GCTGCCCTGG 
TCTCCCTGCA GTGCTGTCTA CCTCACAGAG CTCCTGGATG ATGGTCACGG AGATTGTCTT 
CTGGATGCCC CCACCTCGGT TCTGCCCCTC CCCACAGGCC TCCCGGGCCA CAGCACCCTC 
TACGAGCTGG ACCAGCAGTG CAAGCAGATC TTTGGGCCTG ATTTCCGACA CTGCCCCAAC 
ACCTCTGTGG AGGACATCTG TGTCCAGCTC TGGTGCCGTC ATCGGGATAG TGATGAGCCC 
ATTTGCCACA CAAAGAATGG TAGCCTGCTC TGGGCTGATG GTACACCCTG TGGCCCTGGG 
CACCTGTGCC TGGATGGTAG CTGTGTACTC AAGGAGGATG TGGAGAATCC CAAGGCTGTG 
GTAGATGGAG ACTGGGGTCC CTGGAGACCC TGGGGACAAT GTTCTCGCAC CTGTGGTGGA 
GGGATACAAT TCTCGAACCG TGAATGTGAT AATCCAATGC CTCAGAATGG AGGAAGATTT 
TGCCTGGGTG AAAGAGTCAA GTACCAATCA TGCAACACAG AGGAATGTCC ACCAAACGGA 
AAAAGCTTCC GGGAGCAGCA GTGTGAGAAA TATAATGCCT ACAACCACAC TGACCTGGAT 
GGGAATTTCC TGCAGTGGGT CCCCAAGTAT TCAGGAGTGT CCCCCCGAGA CCGATGCAAG 
CTGTTTTGCA GAGCCCGTGG GAGGAGTGAG TTCAAAGTGT TTGAAGCTAA GGTGATCGAT 
GGCACTCTGT GTGGACCGGA TACTCTGTCC ATCTGCGTCC GGGGGCAATG TGTTAAGGCT 
GGCTGTGACC ATGTGGTGAA CTCACCTAAG AAGCTGGACA AATGTGGGGT GTGTGGGGGC 
AAAGGCACTG CCTGTAGGAA GATCTCCGGT TCTTTCACCC CCTTCAGTTA TGGCTACAAT 
GACATTGTCA CCATCCCAGC TGGTGCCACA AACATTGATG TGAAACAGCG GAGTCACCCA 
GGGGTCAGGA ACGACGGCAG CTACCTGGCG CTGAAGACAG CCAATGGGCA GTACCTGCTC 
AATGGTAACC TGGCCATCTC TGCCATAGAG CAAGACATCT TGGTGAAGGG GACCATCCTG 
AAGTACAGTG GCTCCATGGC TACCCTGGAG CGGCTGCAGA GCTTCCAGGC CCTGCCTGAG 
CCTCTTACAG TACAGCTCCT GACTGTGTCT GGTGAGGTCT TCCCTCCAAA AGTCAGATAT 
ACCTTCTTTG TCCCCAATGA CATGGACTTC AGCGTGCAGA ATAGCAAGGA AAGAGCAACC 
ACCAACATCA TTCAGTCACT GCCCTCTGCG GAGTGGGTTC TGGGAGACTG GTCTGAATGT 
CCGAGCACGT GCAGAGGTAG CTGGCAGCGG CGGACTGTGG AATGCAGGGA CCCCTCAGGT 
CAGGCCTCTG ACACCTGTGA TGAGGCTCTG AAACCTGAGG ATGCCAAGCC CTGTGGAAGC 
CAGCCGTGTC CCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038934.2
CDS	276..2993
Translation	MLRDPTTTGWPPLLLLLLQLPPPPLVCGAPAGPGTGAQASELVVPTRLPGSASELAFHLSAFGQGFVLRLAPDASFLAPEFKIERLGGSSAAAGGEPGLRGCFFSGTVNGERESLAAMSLCRGLSGSFLLAGEEFTIQPQGAGDSLDQPHRLQRWGPGQRREDPGLAAAEVFPLPQGLEWEVEMGNGQGQERSDNEEDRKQDKEGLLKETEDSRKVPPPFGSKTRSKRFVSEARFVETLLVADASMAAFYGTDLQNHILTVMSMAARIYKHPSIRNSVNLVVVKVLIVEEEGWGPEVSDNGGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTRQNFCGKGEQCDTLGMADVGTICDPDKSCSVIKDEGLQAAYTLAHELGHVLSMPHDDSKPCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPLPTGLPGHSTLYELDQQCKQIFGPDFRHCPNTSVEDICVQLWCRHRDSDEPICHTKNGSLLWADGTPCGPGHLCLDGSCVLKEDVENPKAVVDGDWGPWRPWGQCSRTCGGGIQFSNRECDNPMPQNGGRFCLGERVKYQSCNTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPDTLSICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRKISGSFTPFSYGYNDIVTIPAGATNIDVKQRSHPGVRNDGSYLALKTANGQYLLNGNLAISAIEQDILVKGTILKYSGSMATLERLQSFQALPEPLTVQLLTVSGEVFPPKVRYTFFVPNDMDFSVQNSKERATTNIIQSLPSAEWVLGDWSECPSTCRGSWQRRTVECRDPSGQASDTCDEALKPEDAKPCGSQPCPL

Target ORF information:

RefSeq Version	NM_013906.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013906.3

ORF Insert Sequence:

ATGCTCCGCG ACCCCACCAC CACCGGGTGG CCGCCCCTCC TGCTGCTGCT ATTGCAGCTG 
CCGCCGCCGC CACTCGTCTG CGGCGCCCCG GCGGGGCCGG GAACCGGGGC GCAGGCCTCG 
GAGCTAGTGG TGCCCACGCG GTTGCCCGGC AGCGCGAGCG AGCTCGCCTT CCACCTGTCC 
GCCTTCGGCC AGGGCTTCGT GCTGCGCCTG GCGCCTGACG CCAGCTTCCT GGCGCCGGAA 
TTCAAGATCG AGCGCCTCGG GGGCTCGAGC GCGGCGGCCG GGGGCGAGCC GGGACTGCGT 
GGCTGCTTCT TCTCTGGCAC AGTGAATGGA GAACGGGAGT CGCTGGCGGC GATGAGCCTG 
TGTCGCGGGC TGAGCGGCTC GTTCTTGCTG GCAGGCGAGG AGTTCACCAT CCAGCCACAG 
GGCGCTGGGG ACTCCCTGGA CCAGCCTCAT CGCCTGCAGC GCTGGGGGCC GGGACAGCGC 
CGCGAAGACC CCGGGCTCGC TGCCGCCGAA GTTTTCCCCC TCCCTCAAGG ACTGGAGTGG 
GAGGTGGAGA TGGGTAATGG GCAGGGACAG GAGAGAAGTG ACAACGAAGA GGACAGGAAG 
CAGGACAAGG AGGGGTTGCT CAAAGAGACA GAAGACTCCC GCAAAGTGCC ACCACCCTTC 
GGATCCAAAA CTAGAAGCAA GAGGTTTGTG TCCGAGGCTC GCTTCGTGGA AACACTTCTG 
GTGGCTGATG CGTCCATGGC TGCCTTCTAT GGGACCGACC TGCAGAACCA CATCCTCACG 
GTGATGTCAA TGGCAGCCCG AATCTACAAG CACCCGAGCA TCAGGAACTC CGTCAACCTT 
GTGGTGGTGA AAGTGCTAAT AGTGGAAGAG GAAGGATGGG GCCCGGAGGT GTCGGACAAC 
GGGGGGCTCA CACTGCGCAA CTTCTGCAGC TGGCAACGGC GTTTCAACAA GCCCAGTGAC 
CGCCACCCGG AGCACTATGA CACTGCCATC TTGTTCACCA GACAGAACTT CTGTGGGAAG 
GGAGAGCAGT GTGACACCCT GGGGATGGCA GACGTTGGCA CCATCTGTGA CCCCGACAAG 
AGCTGCTCAG TGATCAAGGA TGAGGGACTG CAGGCAGCCT ACACCCTGGC CCATGAGCTA 
GGGCACGTTC TCAGCATGCC CCATGATGAT TCTAAGCCCT GTGTGAGATT GTTTGGGCCC 
ATGGGCAAGT ACCACATGAT GGCGCCATTC TTCATCCACG TGAACAAGAC GCTGCCCTGG 
TCTCCCTGCA GTGCTGTCTA CCTCACAGAG CTCCTGGATG ATGGTCACGG AGATTGTCTT 
CTGGATGCCC CCACCTCGGT TCTGCCCCTC CCCACAGGCC TCCCGGGCCA CAGCACCCTC 
TACGAGCTGG ACCAGCAGTG CAAGCAGATC TTTGGGCCTG ATTTCCGACA CTGCCCCAAC 
ACCTCTGTGG AGGACATCTG TGTCCAGCTC TGGTGCCGTC ATCGGGATAG TGATGAGCCC 
ATTTGCCACA CAAAGAATGG TAGCCTGCTC TGGGCTGATG GTACACCCTG TGGCCCTGGG 
CACCTGTGCC TGGATGGTAG CTGTGTACTC AAGGAGGATG TGGAGAATCC CAAGGCTGTG 
GTAGATGGAG ACTGGGGTCC CTGGAGACCC TGGGGACAAT GTTCTCGCAC CTGTGGTGGA 
GGGATACAAT TCTCGAACCG TGAATGTGAT AATCCAATGC CTCAGAATGG AGGAAGATTT 
TGCCTGGGTG AAAGAGTCAA GTACCAATCA TGCAACACAG AGGAATGTCC ACCAAACGGA 
AAAAGCTTCC GGGAGCAGCA GTGTGAGAAA TATAATGCCT ACAACCACAC TGACCTGGAT 
GGGAATTTCC TGCAGTGGGT CCCCAAGTAT TCAGGAGTGT CCCCCCGAGA CCGATGCAAG 
CTGTTTTGCA GAGCCCGTGG GAGGAGTGAG TTCAAAGTGT TTGAAGCTAA GGTGATCGAT 
GGCACTCTGT GTGGACCGGA TACTCTGTCC ATCTGCGTCC GGGGGCAATG TGTTAAGGCT 
GGCTGTGACC ATGTGGTGAA CTCACCTAAG AAGCTGGACA AATGTGGGGT GTGTGGGGGC 
AAAGGCACTG CCTGTAGGAA GATCTCCGGT TCTTTCACCC CCTTCAGTTA TGGCTACAAT 
GACATTGTCA CCATCCCAGC TGGTGCCACA AACATTGATG TGAAACAGCG GAGTCACCCA 
GGGGTCAGGA ACGACGGCAG CTACCTGGCG CTGAAGACAG CCAATGGGCA GTACCTGCTC 
AATGGTAACC TGGCCATCTC TGCCATAGAG CAAGACATCT TGGTGAAGGG GACCATCCTG 
AAGTACAGTG GCTCCATGGC TACCCTGGAG CGGCTGCAGA GCTTCCAGGC CCTGCCTGAG 
CCTCTTACAG TACAGCTCCT GACTGTGTCT GGTGAGGTCT TCCCTCCAAA AGTCAGATAT 
ACCTTCTTTG TCCCCAATGA CATGGACTTC AGCGTGCAGA ATAGCAAGGA AAGAGCAACC 
ACCAACATCA TTCAGTCACT GCCCTCTGCG GAGTGGGTTC TGGGAGACTG GTCTGAATGT 
CCGAGCACGT GCAGAGGTAG CTGGCAGCGG CGGACTGTGG AATGCAGGGA CCCCTCAGGT 
CAGGCCTCTG ACACCTGTGA TGAGGCTCTG AAACCTGAGG ATGCCAAGCC CTGTGGAAGC 
CAGCCGTGTC CCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Developmental dynamics : an official publication of the American Association of Anatomists245(5)614-26(2016 May)
Gurdziel K,Vogt KR,Walton KD,Schneider GK,Gumucio DL

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.
American journal of reproductive immunology (New York, N.Y. : 1989)74(3)237-57(2015 Sep)
Pan J,Mor G,Ju W,Zhong J,Luo X,Aldo PB,Zhong M,Yu Y,Jenkins EC,Brown WT,Zhong N

Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
Molecular psychiatry20(2)154-61(2015 Feb)
Rossier J,Bernard A,Cabungcal JH,Perrenoud Q,Savoye A,Gallopin T,Hawrylycz M,Cu?nod M,Do K,Urban A,Lein ES

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
Developmental biology346(1)25-38(2010 Oct)
Du J,Takeuchi H,Leonhard-Melief C,Shroyer KR,Dlugosz M,Haltiwanger RS,Holdener BC

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.
Developmental cell17(5)687-98(2009 Nov)
McCulloch DR,Nelson CM,Dixon LJ,Silver DL,Wylie JD,Lindner V,Sasaki T,Cooley MA,Argraves WS,Apte SS

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Adamts8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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