Igfbp7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp7
Entrez Gene ID	29817
Full Name	insulin-like growth factor binding protein 7
Synonyms	AGM,Fstl2,Mac25
General protein information	Preferred Names insulin-like growth factor binding protein 7 Names insulin-like growth factor-binding protein 7 IBP-7 IGF-binding protein 7 IGFBP-7 angiomodulin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 C3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_008048.3	NP_032074.3	insulin-like growth factor-binding protein 7 isoform 2 precursor
NM_001159518.1	NP_001152990.1	insulin-like growth factor-binding protein 7 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IGFBP7	XP_517274.3
Canis lupus familiaris (dog)	IGFBP7	XP_850270.1
Danio rerio (zebrafish)	igfbp7	NP_998089.1
Gallus gallus (chicken)	IGFBP7	XP_420577.3
Bos taurus (cattle)	IGFBP7	NP_001095770.1
Rattus norvegicus (Norway rat)	Igfbp7	NP_001013066.1
Homo sapiens (human)	IGFBP7	NP_001544.1
	IGFBP7	XP_001083041.1
Mus musculus (house mouse)	Igfbp7	NP_032074.3

Gene Ontology
Bibliography

Related articles in PubMed

Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.
Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, Konishi H, Masuda A, Imagama S, Kiyama H, Ishiguro N, Ohno K
Scientific reports8(1)434(2018 Jan)

IGFBP7 Deletion Promotes Hepatocellular Carcinoma.
Akiel M, Guo C, Li X, Rajasekaran D, Mendoza RG, Robertson CL, Jariwala N, Yuan F, Subler MA, Windle J, Garcia DK, Lai Z, Chen HH, Chen Y, Giashuddin S, Fisher PB, Wang XY, Sarkar D
Cancer research77(15)4014-4025(2017 Aug)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma
Title: IGFBP7 Deletion Promotes Hepatocellular Carcinoma.

Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC)-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells.
Title: Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression.

data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases
Title: Insulin-like growth factor-binding protein 7 is up-regulated during EAE and inhibits the differentiation of oligodendrocyte precursor cells.

Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals.
Title: Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland.

Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs) and its regulation depends on TAp63 isoform.
Title: Angiomodulin is required for cardiogenesis of embryonic stem cells and is maintained by a feedback loop network of p63 and Activin-A.

The following Igfbp7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13123	NM_008048.3 Latest version!	Mus musculus insulin-like growth factor binding protein 7 (Igfbp7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
OMu13126	NM_001159518.1 Latest version!	Mus musculus insulin-like growth factor binding protein 7 (Igfbp7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp7 ( NM_008048.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032074.3 Mus musculus insulin-like growth factor binding protein 7 (Igfbp7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13123
Clone ID Related Accession (Same CDS sequence)	NM_008048.3
Accession Version	NM_008048.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	insulin-like growth factor-binding protein 7 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB012886.1 and AA200937.1. On Apr 18, 2009 this sequence version replaced NM_008048.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156315.1, AB012886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGAGC GGCCGCCGCG CGCCCTGCTG CTGGGTGCAG CCGGACTGCT GCTCCTGCTC 
CTGCCCCTCT CCTCTTCCTC CTCTTCGGAT GCCTGCGGCC CGTGCGTGCC GGCCTCCTGC 
CCCGCGCTGC CCCGGCTCGG CTGCCCGCTG GGTGAGACCC GCGACGCGTG CGGGTGCTGC 
CCGGTGTGTG CTCGCGGCGA GGGTGAGCCG TGCGGGGGCG GCGCGGCCGG CAGGGGGCAC 
TGCGCGCCGG GCATGGAGTG CGTGAAGAGC CGCAAGAGGC GGAAGGGTAA AGCCGGGGCA 
GCAGCCGGCG GTCCCGCGAC CCTCGCCGTG TGCGTGTGCA AGAGCCGCTA CCCGGTGTGC 
GGCAGCAACG GCATCACCTA CCCCAGCGGC TGCCAGCTGC GCGCTGCCAG CCTGCGCGCC 
GAGAGCCGCG GGGAGAAGGC CATCACCCAG GTCAGCAAGG GCACCTGCGA GCAAGGTCCT 
TCCATAGTGA CGCCCCCCAA GGACATCTGG AACGTCACTG GTGCCAAGGT GTTCTTGAGC 
TGTGAGGTCA TCGGGATCCC AACCCCTGTC CTCATCTGGA ACAAGGTAAA AAGGGATCAC 
TCTGGAGTTC AGCGGACAGA ACTCTTGCCT GGTGACCGGG AAAATCTGGC CATTCAGACC 
CGGGGTGGTC CAGAAAAGCA TGAAGTAACG GGCTGGGTGC TGGTATCTCC TCTAAGTAAG 
GAGGACGCTG GAGAGTATGA GTGCCACGCA TCCAACTCCC AAGGGCAGGC TTCCGCGGCA 
GCCAAAATTA CAGTGGTTGA TGCCCTCCAT GAAATACCAC TGAAAAAAGG TGAAGGTGCT 
CAGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032074.3
CDS	32..880
Translation	MMERPPRALLLGAAGLLLLLLPLSSSSSSDACGPCVPASCPALPRLGCPLGETRDACGCCPVCARGEGEPCGGGAAGRGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVVDALHEIPLKKGEGAQL

Target ORF information:

RefSeq Version	NM_008048.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like growth factor binding protein 7 (Igfbp7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008048.3

ORF Insert Sequence:

ATGATGGAGC GGCCGCCGCG CGCCCTGCTG CTGGGTGCAG CCGGACTGCT GCTCCTGCTC 
CTGCCCCTCT CCTCTTCCTC CTCTTCGGAT GCCTGCGGCC CGTGCGTGCC GGCCTCCTGC 
CCCGCGCTGC CCCGGCTCGG CTGCCCGCTG GGTGAGACCC GCGACGCGTG CGGGTGCTGC 
CCGGTGTGTG CTCGCGGCGA GGGTGAGCCG TGCGGGGGCG GCGCGGCCGG CAGGGGGCAC 
TGCGCGCCGG GCATGGAGTG CGTGAAGAGC CGCAAGAGGC GGAAGGGTAA AGCCGGGGCA 
GCAGCCGGCG GTCCCGCGAC CCTCGCCGTG TGCGTGTGCA AGAGCCGCTA CCCGGTGTGC 
GGCAGCAACG GCATCACCTA CCCCAGCGGC TGCCAGCTGC GCGCTGCCAG CCTGCGCGCC 
GAGAGCCGCG GGGAGAAGGC CATCACCCAG GTCAGCAAGG GCACCTGCGA GCAAGGTCCT 
TCCATAGTGA CGCCCCCCAA GGACATCTGG AACGTCACTG GTGCCAAGGT GTTCTTGAGC 
TGTGAGGTCA TCGGGATCCC AACCCCTGTC CTCATCTGGA ACAAGGTAAA AAGGGATCAC 
TCTGGAGTTC AGCGGACAGA ACTCTTGCCT GGTGACCGGG AAAATCTGGC CATTCAGACC 
CGGGGTGGTC CAGAAAAGCA TGAAGTAACG GGCTGGGTGC TGGTATCTCC TCTAAGTAAG 
GAGGACGCTG GAGAGTATGA GTGCCACGCA TCCAACTCCC AAGGGCAGGC TTCCGCGGCA 
GCCAAAATTA CAGTGGTTGA TGCCCTCCAT GAAATACCAC TGAAAAAAGG TGAAGGTGCT 
CAGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Igfbp7 ( NM_001159518.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001152990.1 Mus musculus insulin-like growth factor binding protein 7 (Igfbp7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13126
Clone ID Related Accession (Same CDS sequence)	NM_001159518.1
Accession Version	NM_001159518.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Mus musculus(house mouse)
Product	insulin-like growth factor-binding protein 7 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB869840.1, AW318969.1, BF471478.1, CK622921.1 and AA200937.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF471478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGAGC GGCCGCCGCG CGCCCTGCTG CTGGGTGCAG CCGGACTGCT GCTCCTGCTC 
CTGCCCCTCT CCTCTTCCTC CTCTTCGGAT GCCTGCGGCC CGTGCGTGCC GGCCTCCTGC 
CCCGCGCTGC CCCGGCTCGG CTGCCCGCTG GGTGAGACCC GCGACGCGTG CGGGTGCTGC 
CCGGTGTGTG CTCGCGGCGA GGGTGAGCCG TGCGGGGGCG GCGCGGCCGG CAGGGGGCAC 
TGCGCGCCGG GCATGGAGTG CGTGAAGAGC CGCAAGAGGC GGAAGGGTAA AGCCGGGGCA 
GCAGCCGGCG GTCCCGCGAC CCTCGCCGTG TGCGTGTGCA AGAGCCGCTA CCCGGTGTGC 
GGCAGCAACG GCATCACCTA CCCCAGCGGC TGCCAGCTGC GCGCTGCCAG CCTGCGCGCC 
GAGAGCCGCG GGGAGAAGGC CATCACCCAG GTCAGCAAGG GCACCTGCGA GCAAGGGTCT 
CTGATATGGG ACACCCAACC AGCCCAAAGG AGTCACAACC CACAGGTTGA GAACCGCTGT 
TTTAGAGACA AGCACTCCAG AGAACAAGGT CCTTCCATAG TGACGCCCCC CAAGGACATC 
TGGAACGTCA CTGGTGCCAA GGTGTTCTTG AGCTGTGAGG TCATCGGGAT CCCAACCCCT 
GTCCTCATCT GGAACAAGGT AAAAAGGGAT CACTCTGGAG TTCAGCGGAC AGAACTCTTG 
CCTGGTGACC GGGAAAATCT GGCCATTCAG ACCCGGGGTG GTCCAGAAAA GCATGAAGTA 
ACGGGCTGGG TGCTGGTATC TCCTCTAAGT AAGGAGGACG CTGGAGAGTA TGAGTGCCAC 
GCATCCAACT CCCAAGGGCA GGCTTCCGCG GCAGCCAAAA TTACAGTGGT TGATGCCCTC 
CATGAAATAC CACTGAAAAA AGGTGAAGGT GCTCAGTTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001152990.1
CDS	32..973
Translation	MMERPPRALLLGAAGLLLLLLPLSSSSSSDACGPCVPASCPALPRLGCPLGETRDACGCCPVCARGEGEPCGGGAAGRGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGSLIWDTQPAQRSHNPQVENRCFRDKHSREQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVVDALHEIPLKKGEGAQL

Target ORF information:

RefSeq Version	NM_001159518.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like growth factor binding protein 7 (Igfbp7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159518.1

ORF Insert Sequence:

ATGATGGAGC GGCCGCCGCG CGCCCTGCTG CTGGGTGCAG CCGGACTGCT GCTCCTGCTC 
CTGCCCCTCT CCTCTTCCTC CTCTTCGGAT GCCTGCGGCC CGTGCGTGCC GGCCTCCTGC 
CCCGCGCTGC CCCGGCTCGG CTGCCCGCTG GGTGAGACCC GCGACGCGTG CGGGTGCTGC 
CCGGTGTGTG CTCGCGGCGA GGGTGAGCCG TGCGGGGGCG GCGCGGCCGG CAGGGGGCAC 
TGCGCGCCGG GCATGGAGTG CGTGAAGAGC CGCAAGAGGC GGAAGGGTAA AGCCGGGGCA 
GCAGCCGGCG GTCCCGCGAC CCTCGCCGTG TGCGTGTGCA AGAGCCGCTA CCCGGTGTGC 
GGCAGCAACG GCATCACCTA CCCCAGCGGC TGCCAGCTGC GCGCTGCCAG CCTGCGCGCC 
GAGAGCCGCG GGGAGAAGGC CATCACCCAG GTCAGCAAGG GCACCTGCGA GCAAGGGTCT 
CTGATATGGG ACACCCAACC AGCCCAAAGG AGTCACAACC CACAGGTTGA GAACCGCTGT 
TTTAGAGACA AGCACTCCAG AGAACAAGGT CCTTCCATAG TGACGCCCCC CAAGGACATC 
TGGAACGTCA CTGGTGCCAA GGTGTTCTTG AGCTGTGAGG TCATCGGGAT CCCAACCCCT 
GTCCTCATCT GGAACAAGGT AAAAAGGGAT CACTCTGGAG TTCAGCGGAC AGAACTCTTG 
CCTGGTGACC GGGAAAATCT GGCCATTCAG ACCCGGGGTG GTCCAGAAAA GCATGAAGTA 
ACGGGCTGGG TGCTGGTATC TCCTCTAAGT AAGGAGGACG CTGGAGAGTA TGAGTGCCAC 
GCATCCAACT CCCAAGGGCA GGCTTCCGCG GCAGCCAAAA TTACAGTGGT TGATGCCCTC 
CATGAAATAC CACTGAAAAA AGGTGAAGGT GCTCAGTTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.
Scientific reports8(1)434(2018 Jan)
Ito K,Ohkawara B,Yagi H,Nakashima H,Tsushima M,Ota K,Konishi H,Masuda A,Imagama S,Kiyama H,Ishiguro N,Ohno K

IGFBP7 Deletion Promotes Hepatocellular Carcinoma.
Cancer research77(15)4014-4025(2017 Aug)
Akiel M,Guo C,Li X,Rajasekaran D,Mendoza RG,Robertson CL,Jariwala N,Yuan F,Subler MA,Windle J,Garcia DK,Lai Z,Chen HH,Chen Y,Giashuddin S,Fisher PB,Wang XY,Sarkar D

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

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Igfbp7 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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