Spg21 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Spg21
Entrez Gene ID	27965
Full Name	SPG21, maspardin
Synonyms	ACP33,BM-019,C78576,D9Wsu18e,GL010,MAST
General protein information	Preferred Names SPG21, maspardin Names maspardin acid cluster protein 33 spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog spastic paraplegia 21 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 C\|9 35.32 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001357813.1	NP_001344742.1	maspardin
XM_006511222.2	XP_006511285.1	maspardin isoform X1
XM_006511222.3	XP_006511285.1	maspardin isoform X1
XM_030244409.1	XP_030100269.1	maspardin isoform X1
NM_138584.2	NP_613050.1	maspardin

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SPG21	XP_852491.3
Mus musculus (house mouse)	Spg21	NP_613050.1
Arabidopsis thaliana (thale cress)	AT4G12230	NP_192960.1
Oryza sativa (rice)	Os10g0169800	NP_001064230.1
Homo sapiens (human)	SPG21	NP_001121361.1
Pan troglodytes (chimpanzee)	SPG21	XP_510477.3
Rattus norvegicus (Norway rat)	Spg21	NP_001006988.1
	SPG21	XP_001101919.2
Bos taurus (cattle)	SPG21	NP_991341.1
Gallus gallus (chicken)	SPG21	NP_001185532.1
Danio rerio (zebrafish)	spg21	NP_998560.1
Xenopus tropicalis (tropical clawed frog)	spg21	NP_001017126.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons.
Davenport A, Bivona A, Latson W, Lemanski LF, Cheriyath V
Neuro-degenerative diseases16(3-4)260-72(2016)

Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.
Soderblom C, Stadler J, Jupille H, Blackstone C, Shupliakov O, Hanna MC
Neurogenetics11(4)369-78(2010 Oct)

On the integration of alcohol-related quantitative trait loci and gene expression analyses.
Hitzemann R, Reed C, Malmanger B, Lawler M, Hitzemann B, Cunningham B, McWeeney S, Belknap J, Harrington C, Buck K, Phillips T, Crabbe J
Alcoholism, clinical and experimental research28(10)1437-48(2004 Oct)

Cloning of ACP33 as a novel intracellular ligand of CD4.
Zeitlmann L, Sirim P, Kremmer E, Kolanus W
The Journal of biological chemistry276(12)9123-32(2001 Mar)

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
Human molecular genetics7(12)1967-78(1998 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study showed that the loss of maspardin attenuates the growth, maturation, and axonal branching of cortical neurons to promote progressive neuronal dysfunction; impairment of sensory motor neurons in SPG21-/- mice; and that SPG21-/- cortical neurons failed to respond to EGF-induced growth and maturation, which is confirmed by the attenuated expression of a subset of EGFR target genes
Title: Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons.

Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons
Title: Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.

The following Spg21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spg21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu10781	NM_138584.2 Latest version!	Mus musculus SPG21, maspardin (Spg21), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu10781	NM_001357813.1 Latest version!	Mus musculus SPG21, maspardin (Spg21), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu10781	XM_030244409.1 Latest version!	Mus musculus SPG21, maspardin (Spg21), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu10781	XM_006511222.3 Latest version!	Mus musculus spastic paraplegia 21 homolog (human) (Spg21), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu10781	XM_006511222.2	Mus musculus spastic paraplegia 21 homolog (human) (Spg21), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Spg21 ( NM_001357813.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001344742.1 Mus musculus SPG21, maspardin (Spg21), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu10781
Clone ID Related Accession (Same CDS sequence)	NM_001357813.1 , XM_006511222.2 , XM_006511222.3 , XM_030244409.1 , NM_138584.2
Accession Version	NM_001357813.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	maspardin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114645.9. On Nov 10, 2017 this sequence version replaced XM_006511222.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.198509.1, SRR1660817.306695.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001344742.1
CDS	229..1155
Translation	MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP

Target ORF information:

RefSeq Version	NM_001357813.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SPG21, maspardin (Spg21), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001357813.1

ORF Insert Sequence:

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spg21 ( NM_138584.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_613050.1 Mus musculus SPG21, maspardin (Spg21), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10781
Clone ID Related Accession (Same CDS sequence)	NM_001357813.1 , XM_006511222.2 , XM_006511222.3 , XM_030244409.1 , NM_138584.2
Accession Version	NM_138584.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	maspardin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK150215.1 and AK149930.1. On Feb 28, 2006 this sequence version replaced NM_138584.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK149930.1, BC132377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_613050.1
CDS	243..1169
Translation	MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP

Target ORF information:

RefSeq Version	NM_138584.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SPG21, maspardin (Spg21), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138584.2

ORF Insert Sequence:

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spg21 ( XM_006511222.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006511285.1 Mus musculus spastic paraplegia 21 homolog (human) (Spg21), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10781
Clone ID Related Accession (Same CDS sequence)	NM_001357813.1 , XM_006511222.2 , XM_006511222.3 , XM_030244409.1 , NM_138584.2
Accession Version	XM_006511222.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	maspardin isoform X1
Comment

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006511285.1
Translation	MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP

Target ORF information:

RefSeq Version	XM_006511222.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus spastic paraplegia 21 homolog (human) (Spg21), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006511222.2

ORF Insert Sequence:

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spg21 ( XM_006511222.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006511285.1 Mus musculus spastic paraplegia 21 homolog (human) (Spg21), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10781
Clone ID Related Accession (Same CDS sequence)	NM_001357813.1 , XM_006511222.2 , XM_006511222.3 , XM_030244409.1 , NM_138584.2
Accession Version	XM_006511222.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	maspardin isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006511222.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006511285.1
CDS	224..1150
Translation	MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP

Target ORF information:

RefSeq Version	XM_006511222.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus spastic paraplegia 21 homolog (human) (Spg21), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006511222.3

ORF Insert Sequence:

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spg21 ( XM_030244409.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030100269.1 Mus musculus SPG21, maspardin (Spg21), transcript variant X1, mRNA.

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CloneID	OMu10781
Clone ID Related Accession (Same CDS sequence)	NM_001357813.1 , XM_006511222.2 , XM_006511222.3 , XM_030244409.1 , NM_138584.2
Accession Version	XM_030244409.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	maspardin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030100269.1
CDS	1729..2655
Translation	MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP

Target ORF information:

RefSeq Version	XM_030244409.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SPG21, maspardin (Spg21), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030244409.1

ORF Insert Sequence:

ATGGGAGAGA TCAAAGTCTC TCCAGATTAT AATTGGTTTA GAAGTACTGT TCCCCTGAAA 
AAGATAATCG TGGATGACGA TGACAGTAAG ATCTGGTCGC TCTACGACGC TGGCCCCAGA 
AGCATCAGGT GTCCTCTCAT CTTTCTTCCT CCTGTCAGCG GAACTGCAGA TGTGTTTTTC 
CAGCAGATTC TGGCTTTGAC TGGATGGGGT TACCGGGTTA TAGCTTTGCA GTATCCAGTT 
TATTGGGACC ATCTTGAATT CTGTGATGGA TTCAGAAAAC TTTTAGACCA CTTACAACTG 
GATAAAGTTC ATCTGTTTGG GGCATCTTTG GGAGGCTTTT TGGCTCAAAA ATTTGCTGAA 
TACACTCACA AGTCTCCCAG GGTACACTCC CTCATCCTGT GCAATGCCTT CAGTGACACG 
TCTATCTTCA ACCAAACATG GACTGCAAAT AGCTTCTGGT TGATGCCAGC GTTTATGCTC 
AAGAAAATCG TTTTGGGGAA CTTTTCCTCT GGCCCAGTAG ACCCGATGAT GGCTGATGCC 
ATTGATTTCA TGGTGGACAG GCTGGAGAGT TTGGGTCAAA GTGAACTGGC TTCAAGGCTA 
ACTCTCAACT GTCAGAATTC CTATGTGGAG CCACATAAGA TCCGGGACAT CCCCGTCACC 
ATCATGGATG TGTTTGACCA GAGTGCGCTG TCAACAGAAG CCAAGGAAGA AATGTACAAA 
CTGTACCCTA ATGCGCGGAG AGCCCACCTT AAGACAGGAG GCAATTTTCC CTACCTGTGC 
AGGAGTGCAG AGGTCAATCT TTATGTGCAG ATACATCTGC TGCAGTTCCA TGGAACCAAG 
TACGCTGCCA TCGATCCGTC AGTGGTCAGT GCGGAGGAGC TAGAGGTGCA GAAAGGCCGC 
CTCGGCCTCA GCCAGGAAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons.
Neuro-degenerative diseases16(3-4)260-72(2016)
Davenport A,Bivona A,Latson W,Lemanski LF,Cheriyath V

Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.
Neurogenetics11(4)369-78(2010 Oct)
Soderblom C,Stadler J,Jupille H,Blackstone C,Shupliakov O,Hanna MC

On the integration of alcohol-related quantitative trait loci and gene expression analyses.
Alcoholism, clinical and experimental research28(10)1437-48(2004 Oct)
Hitzemann R,Reed C,Malmanger B,Lawler M,Hitzemann B,Cunningham B,McWeeney S,Belknap J,Harrington C,Buck K,Phillips T,Crabbe J

Cloning of ACP33 as a novel intracellular ligand of CD4.
The Journal of biological chemistry276(12)9123-32(2001 Mar)
Zeitlmann L,Sirim P,Kremmer E,Kolanus W

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Human molecular genetics7(12)1967-78(1998 Nov)
Ko MS,Threat TA,Wang X,Horton JH,Cui Y,Wang X,Pryor E,Paris J,Wells-Smith J,Kitchen JR,Rowe LB,Eppig J,Satoh T,Brant L,Fujiwara H,Yotsumoto S,Nakashima H

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Spg21 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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