Tlr13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tlr13
Entrez Gene ID	279572
Full Name	toll-like receptor 13
Synonyms	AI666735,Gm713
General protein information	Preferred Names toll-like receptor 13 Names toll-like receptor 13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X D

mRNA and Protein(s)

mRNA	Protein	Name
NM_205820.1	NP_991389.1	toll-like receptor 13 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tlr13	NP_991389.1
Xenopus tropicalis (tropical clawed frog)	LOC100485164	XP_002935047.1
Rattus norvegicus (Norway rat)	Tlr13	XP_006257061.1

Gene Ontology
Bibliography

Related articles in PubMed

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM
The Journal of experimental medicine214(5)1297-1311(2017 May)

Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA.
Wang J, Chai J, Wang H
The FEBS journal283(9)1631-5(2016 05)

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1? Production during Infection.
Mohammadi N, Midiri A, Mancuso G, Patan? F, Venza M, Venza I, Passantino A, Galbo R, Teti G, Beninati C, Biondo C
PloS one11(8)e0160249(2016)

Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13.
Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J, Wang HW, Chai J
Nature structural & molecular biology22(10)782-7(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA has been presented.
Title: Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA.

S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 and subsequently by TLR13 upon internalization.
Title: Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

These data lend support to the conclusion that TLR13 participates in group B streptococcus recognition, although blockade of the function of this receptor can be compensated for by other endosomal toll-like receptors.
Title: Role of Toll-like receptor 13 in innate immune recognition of group B streptococci.

TLR13 expressed by immune cells detects bacterial RNA with exquisite sequence specificity.
Title: Sequence specific detection of bacterial 23S ribosomal RNA by TLR13.

TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA.
Title: Cutting edge: TLR13 is a receptor for bacterial RNA.

The following Tlr13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tlr13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09659	NM_205820.1 Latest version!	Mus musculus toll-like receptor 13 (Tlr13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$580.30 $829.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tlr13 ( NM_205820.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_991389.1 Mus musculus toll-like receptor 13 (Tlr13), mRNA.

Price & Availability↑

CloneID	OMu09659
Clone ID Related Accession (Same CDS sequence)	NM_205820.1
Accession Version	NM_205820.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2976bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	toll-like receptor 13 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY510706.1. On Mar 22, 2004 this sequence version replaced XM_205159.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY510706.1, SRR1660815.252928.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGGGC TCTACAGGAT CCTGGTCCAG CTGGAACAAA GTCCATATGT GAAGACCGTG 
CCTTTGAACA TGAGAAGGGA TTTTTTTTTC CTGGTTGTAA CCTGGATGCC TAAGACAGTC 
AAGATGAATG GGAGCAGCTT TGTGCCATCT CTACAGCTCC TGCTCATGTT AGTAGGATTT 
TCTCTGCCGC CTGTGGCAGA GACATATGGG TTCAACAAGT GCACACAGTA TGAATTTGAT 
ATTCACCATG TGCTCTGCAT TAGGAAGAAG ATCACCAACT TGACAGAGGC CATTAGTGAC 
ATACCTAGAT ATACTACTCA CCTTAACCTC ACACACAACG AAATTCAAGT CCTCCCTCCC 
TGGAGTTTTA CCAATCTGTC TGCTCTGGTG GACTTGAGAC TAGAGTGGAA CTCAATTTGG 
AAGATCGACG AAGGTGCCTT TAGGGGACTT GAAAATTTGA CTCTGCTGAA TTTAGTGGAA 
AATAAGATTC AAAGTGTGAA TAACTCCTTT GAGGGCCTGT CCAGCCTGAA GACCCTGCTC 
CTGAGCCATA ATCAGATTAC CCATATTCAC AAAGACGCCT TCACTCCTCT AATCAAATTG 
AAATATTTGA GCCTATCTCG AAACAACATT AGCGATTTTT CTGGTATTCT TGAAGCAGTC 
CAGCATCTTC CATGCCTGGA GCGCCTTGAT CTAACTAACA ACAGCATCAT GTACTTGGAC 
CACAGCCCTA GGTCACTGGT TTCTCTGACC CACCTGAGTT TTGAGGGGAA CAAACTAAGG 
GAGTTAAACT TCTCTGCTTT GTCATTACCT AACTTAACCA ATCTAAGTGC TTCCCGGAAT 
GGCAATAAAG TCATTCAGAA TGTGTATCTT AAAACTCTGC CCCAACTTAA AAGCTTGAAT 
CTGAGTGGAA CGGTGATAAA ATTGGAAAAT CTTTCGGCCA AACACCTGCA GAATCTAAGA 
GCTATGGATC TCAGTAATTG GGAGCTTAGA CATGGTCACT TAGATATGAA AACTGTTTGT 
CACCTGCTCG GAAACCTACC CAAGTTAGAG ACACTGGTTT TTCAGAAAAA TGTCACCAAT 
GCAGAGGGCA TTAAGCAGCT GGCAAAGTGC ACCAGGCTCT TGTTCCTTGA CCTGGGTCAA 
AACAGTGACT TGATTTATCT CAATGACAGC GAGTTCAATG CTCTGCCCAG TCTCCAAAAA 
CTGAATTTGA ACAAGTGCCA GCTCTCCTTC ATCAACAACA GGACCTGGAG TTCCTTGCAG 
AACTTGACCA GCCTAGATCT GAGCCACAAC AAGTTTAAAA GCTTTCCAGA TTTTGCATTT 
TCCCCCTTGA AGCACTTGGA GTTTCTCTCT CTTTCAAGAA ACCCCATCAC AGAACTCAAT 
AATCTGGCCT TTAGTGGGCT ATTTGCACTG AAGGAGCTCA ACTTGGCTGC ATGTTGGATT 
GTAACAATTG ACAGGTATTC CTTTACTCAG TTTCCAAACT TAGAGGTCTT AGATCTTGGA 
GACAACAATA TTCGGACTCT CAACCACGGA ACCTTCCGAC CTCTGAAAAA ACTCCAGTCT 
TTGATTCTTT CCCACAACTG CCTAAAAATC CTGGAGCCAA ATTCGTTTTC TGGTCTCACT 
AACCTACGTT CCCTTGACCT GATGTACAAC AGCTTGTCAT ATTTTCATGA ACACCTTTTC 
TCGGGCCTTG AAAAGCTTCT GATTTTGAAA CTTGGTTTTA ATAAGATCAC ATATGAAACT 
ACTAGGACCC TTCAGTATCC TCCATTTATA AAGCTCAAGT CTTTGAAACA GCTTAACCTA 
GAAGGACAAA GACACGGGAT TCAGGTTGTT CCGAGCAACT TTTTCCAAGG ATTGGGTAGT 
TTGCAGGAGT TACTCTTAGG AAAAAATCCC TCTGTATTCC TGGACCACCA CCAATTTGAC 
CCTCTGATTA ACCTCACAAA GTTGGATATC TCAGGAACAA AAGATGGAGA TCGAAGCCTC 
TATTTAAATG CTTCCTTATT CCAAAACCTC AAAAGGCTAA AGATCCTCCG CCTTGAAAAT 
AACAACTTAG AGTCACTGGT TCCTGACATG TTCTCCAGCT TACAGAGCCT CCAGGTCTTT 
TCTTTAAGAT TCAACAACTT GAAGGTCATT AATCAAAGTC ATCTGAAGAA TCTGAAATCA 
CTGATGTTTT TTGATGTCTA TGGGAACAAA CTTCAGTGCA CCTGTGACAA TTTGTGGTTC 
AAGAACTGGT CAATGAACAC AGAGGAGGTC CACATCCCCT TCCTCCGGAG CTATCCCTGT 
CAGCAGCCAG GCAGCCAGAG TTTACTTATA GATTTTGATG ATGCCATGTG TAATTTTGAC 
TTGGGAAAGG TCTACTTCTT ATGTTCCTTC AGTATGGTCC TCAGCACCAT GGTCTTCTCT 
TGGTTCAGTA CCAAGATGAT TGCATCTCTG TGGTATGGTT TGTACATATG TAGGGCCTGG 
TACCTCACTA AATGGCACAA AACGGAGAAG AAGTTCTTAT ATGATGCGTT TGTCTCTTTC 
TCGGCCACTG ATGAGGCATG GGTATACAAA GAGCTTGTTC CAGCCCTAGA ACAAGGCAGC 
CAGACCACCT TTAAACTCTG TCTTCACCAA CGGGATTTTG AACCAGGCAT TGATATCTTC 
GAGAACATCC AGAATGCTAT TAACACAAGC AGGAAAACCT TGTGCGTAGT CAGTAACCAC 
TACCTACACA GTGAATGGTG CCGACTTGAA GTCCAGCTGG CTAGCATGAA GATGTTTTAT 
GAGCACAAGG ATGTCATTAT CTTGATCTTC CTTGAAGAGA TTCCGAACTA TAAGCTGTCC 
AGCTACCACC GACTCAGGAA ACTCATAAAC AAACAGACGT TTATCACTTG GCCGGACAGT 
GTTCACCAGC AGCCACTTTT CTGGGCTCGC ATCAGAAATG CGTTGGGCAA GGAGACTGTG 
GAGAAAGAAA ATACACATCT AATTGTTGTT GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_991389.1
CDS	180..3155
Translation	MSGLYRILVQLEQSPYVKTVPLNMRRDFFFLVVTWMPKTVKMNGSSFVPSLQLLLMLVGFSLPPVAETYGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIPRYTTHLNLTHNEIQVLPPWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQSVNNSFEGLSSLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKLRELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLENLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKLLILKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGLGSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQNLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYFLCSFSMVLSTMVFSWFSTKMIASLWYGLYICRAWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPALEQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQLASMKMFYEHKDVIILIFLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNALGKETVEKENTHLIVVE

Target ORF information:

RefSeq Version	NM_205820.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus toll-like receptor 13 (Tlr13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205820.1

ORF Insert Sequence:

ATGAGTGGGC TCTACAGGAT CCTGGTCCAG CTGGAACAAA GTCCATATGT GAAGACCGTG 
CCTTTGAACA TGAGAAGGGA TTTTTTTTTC CTGGTTGTAA CCTGGATGCC TAAGACAGTC 
AAGATGAATG GGAGCAGCTT TGTGCCATCT CTACAGCTCC TGCTCATGTT AGTAGGATTT 
TCTCTGCCGC CTGTGGCAGA GACATATGGG TTCAACAAGT GCACACAGTA TGAATTTGAT 
ATTCACCATG TGCTCTGCAT TAGGAAGAAG ATCACCAACT TGACAGAGGC CATTAGTGAC 
ATACCTAGAT ATACTACTCA CCTTAACCTC ACACACAACG AAATTCAAGT CCTCCCTCCC 
TGGAGTTTTA CCAATCTGTC TGCTCTGGTG GACTTGAGAC TAGAGTGGAA CTCAATTTGG 
AAGATCGACG AAGGTGCCTT TAGGGGACTT GAAAATTTGA CTCTGCTGAA TTTAGTGGAA 
AATAAGATTC AAAGTGTGAA TAACTCCTTT GAGGGCCTGT CCAGCCTGAA GACCCTGCTC 
CTGAGCCATA ATCAGATTAC CCATATTCAC AAAGACGCCT TCACTCCTCT AATCAAATTG 
AAATATTTGA GCCTATCTCG AAACAACATT AGCGATTTTT CTGGTATTCT TGAAGCAGTC 
CAGCATCTTC CATGCCTGGA GCGCCTTGAT CTAACTAACA ACAGCATCAT GTACTTGGAC 
CACAGCCCTA GGTCACTGGT TTCTCTGACC CACCTGAGTT TTGAGGGGAA CAAACTAAGG 
GAGTTAAACT TCTCTGCTTT GTCATTACCT AACTTAACCA ATCTAAGTGC TTCCCGGAAT 
GGCAATAAAG TCATTCAGAA TGTGTATCTT AAAACTCTGC CCCAACTTAA AAGCTTGAAT 
CTGAGTGGAA CGGTGATAAA ATTGGAAAAT CTTTCGGCCA AACACCTGCA GAATCTAAGA 
GCTATGGATC TCAGTAATTG GGAGCTTAGA CATGGTCACT TAGATATGAA AACTGTTTGT 
CACCTGCTCG GAAACCTACC CAAGTTAGAG ACACTGGTTT TTCAGAAAAA TGTCACCAAT 
GCAGAGGGCA TTAAGCAGCT GGCAAAGTGC ACCAGGCTCT TGTTCCTTGA CCTGGGTCAA 
AACAGTGACT TGATTTATCT CAATGACAGC GAGTTCAATG CTCTGCCCAG TCTCCAAAAA 
CTGAATTTGA ACAAGTGCCA GCTCTCCTTC ATCAACAACA GGACCTGGAG TTCCTTGCAG 
AACTTGACCA GCCTAGATCT GAGCCACAAC AAGTTTAAAA GCTTTCCAGA TTTTGCATTT 
TCCCCCTTGA AGCACTTGGA GTTTCTCTCT CTTTCAAGAA ACCCCATCAC AGAACTCAAT 
AATCTGGCCT TTAGTGGGCT ATTTGCACTG AAGGAGCTCA ACTTGGCTGC ATGTTGGATT 
GTAACAATTG ACAGGTATTC CTTTACTCAG TTTCCAAACT TAGAGGTCTT AGATCTTGGA 
GACAACAATA TTCGGACTCT CAACCACGGA ACCTTCCGAC CTCTGAAAAA ACTCCAGTCT 
TTGATTCTTT CCCACAACTG CCTAAAAATC CTGGAGCCAA ATTCGTTTTC TGGTCTCACT 
AACCTACGTT CCCTTGACCT GATGTACAAC AGCTTGTCAT ATTTTCATGA ACACCTTTTC 
TCGGGCCTTG AAAAGCTTCT GATTTTGAAA CTTGGTTTTA ATAAGATCAC ATATGAAACT 
ACTAGGACCC TTCAGTATCC TCCATTTATA AAGCTCAAGT CTTTGAAACA GCTTAACCTA 
GAAGGACAAA GACACGGGAT TCAGGTTGTT CCGAGCAACT TTTTCCAAGG ATTGGGTAGT 
TTGCAGGAGT TACTCTTAGG AAAAAATCCC TCTGTATTCC TGGACCACCA CCAATTTGAC 
CCTCTGATTA ACCTCACAAA GTTGGATATC TCAGGAACAA AAGATGGAGA TCGAAGCCTC 
TATTTAAATG CTTCCTTATT CCAAAACCTC AAAAGGCTAA AGATCCTCCG CCTTGAAAAT 
AACAACTTAG AGTCACTGGT TCCTGACATG TTCTCCAGCT TACAGAGCCT CCAGGTCTTT 
TCTTTAAGAT TCAACAACTT GAAGGTCATT AATCAAAGTC ATCTGAAGAA TCTGAAATCA 
CTGATGTTTT TTGATGTCTA TGGGAACAAA CTTCAGTGCA CCTGTGACAA TTTGTGGTTC 
AAGAACTGGT CAATGAACAC AGAGGAGGTC CACATCCCCT TCCTCCGGAG CTATCCCTGT 
CAGCAGCCAG GCAGCCAGAG TTTACTTATA GATTTTGATG ATGCCATGTG TAATTTTGAC 
TTGGGAAAGG TCTACTTCTT ATGTTCCTTC AGTATGGTCC TCAGCACCAT GGTCTTCTCT 
TGGTTCAGTA CCAAGATGAT TGCATCTCTG TGGTATGGTT TGTACATATG TAGGGCCTGG 
TACCTCACTA AATGGCACAA AACGGAGAAG AAGTTCTTAT ATGATGCGTT TGTCTCTTTC 
TCGGCCACTG ATGAGGCATG GGTATACAAA GAGCTTGTTC CAGCCCTAGA ACAAGGCAGC 
CAGACCACCT TTAAACTCTG TCTTCACCAA CGGGATTTTG AACCAGGCAT TGATATCTTC 
GAGAACATCC AGAATGCTAT TAACACAAGC AGGAAAACCT TGTGCGTAGT CAGTAACCAC 
TACCTACACA GTGAATGGTG CCGACTTGAA GTCCAGCTGG CTAGCATGAA GATGTTTTAT 
GAGCACAAGG ATGTCATTAT CTTGATCTTC CTTGAAGAGA TTCCGAACTA TAAGCTGTCC 
AGCTACCACC GACTCAGGAA ACTCATAAAC AAACAGACGT TTATCACTTG GCCGGACAGT 
GTTCACCAGC AGCCACTTTT CTGGGCTCGC ATCAGAAATG CGTTGGGCAA GGAGACTGTG 
GAGAAAGAAA ATACACATCT AATTGTTGTT GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
The Journal of experimental medicine214(5)1297-1311(2017 May)
Choo MK,Sano Y,Kim C,Yasuda K,Li XD,Lin X,Stenzel-Poore M,Alexopoulou L,Ghosh S,Latz E,Rifkin IR,Chen ZJ,Stewart GC,Chong H,Park JM

Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA.
The FEBS journal283(9)1631-5(2016 05)
Wang J,Chai J,Wang H

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1? Production during Infection.
PloS one11(8)e0160249(2016)
Mohammadi N,Midiri A,Mancuso G,Patan? F,Venza M,Venza I,Passantino A,Galbo R,Teti G,Beninati C,Biondo C

Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13.
Nature structural & molecular biology22(10)782-7(2015 Oct)
Song W,Wang J,Han Z,Zhang Y,Zhang H,Wang W,Chang J,Xia B,Fan S,Zhang D,Wang J,Wang HW,Chai J

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Tlr13 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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