Magel2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Magel2
Entrez Gene ID	27385
Full Name	melanoma antigen, family L, 2
Synonyms	Mage-l2,NDNL1,nM15,ns7
General protein information	Preferred Names melanoma antigen, family L, 2 Names MAGE-like protein 2 melanoma antigen-like gene 2 necdin-like 1 protein nS7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 C\|7 34.37 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013779.2	NP_038807.4	MAGE-like protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100684492	XP_003434387.1
Rattus norvegicus (Norway rat)	Magel2	XP_001054803.2
Homo sapiens (human)	MAGEL2	NP_061939.3
	MAGEL2	XP_001114423.2
Mus musculus (house mouse)	Magel2	NP_038807.4
Bos taurus (cattle)	MAGEL2	XP_002696517.1

Gene Ontology
Bibliography

Related articles in PubMed

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways.
Wijesuriya TM, De Ceuninck L, Masschaele D, Sanderson MR, Carias KV, Tavernier J, Wevrick R
Human molecular genetics26(21)4215-4230(2017 Nov)

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty.
Fountain MD, Tao H, Chen CA, Yin J, Schaaf CP
Genes, brain, and behavior16(6)592-600(2017 Jul)

Muscle dysfunction caused by loss of Magel2 in a mouse model of Prader-Willi and Schaaf-Yang syndromes.
Kamaludin AA, Smolarchuk C, Bischof JM, Eggert R, Greer JJ, Ren J, Lee JJ, Yokota T, Berry FB, Wevrick R
Human molecular genetics25(17)3798-3809(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Magel2 knockout mice displayed altered social phenotype and a lack of preference for social novelty.
Title: Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty.

these findings suggest that a loss of Magel2 leads to the disruption of hypothalamic feeding circuits, an effect that appears to be independent of the neurodevelopmental effects of leptin and ghrelin and likely involves a direct neurotrophic effect of Magel2.
Title: Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits.

We detected fundamental deficits in the Magel2-null brain, including global decreases in catecholamine and indolamine pathway biogenic amines, with the catecholamine pathway most affected in the hindbrain and hypothalamus.
Title: Dopamine pathway imbalance in mice lacking Magel2, a Prader-Willi syndrome candidate gene.

Normal leptin responses were found in Magel2-null mice up to 4 weeks of age, but the proportion of leptin-responsive POMC neurons was reduced in 6-week-old Magel2-null mice.
Title: Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in the Magel2-null mouse model of Prader-Willi syndrome.

Magel2 inactivation induces a deficit in social recognition and social interaction and a reduced learning ability in adult male mice.
Title: An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

The following Magel2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Magel2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58564	NM_013779.2 Latest version!	Mus musculus melanoma antigen, family L, 2 (Magel2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$755.30 $1079.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Magel2 ( NM_013779.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038807.4 Mus musculus melanoma antigen, family L, 2 (Magel2), mRNA.

Price & Availability↑

CloneID	OMu58564
Clone ID Related Accession (Same CDS sequence)	NM_013779.2
Accession Version	NM_013779.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	MAGE-like protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC156555.8. On or before Sep 13, 2009 this sequence version replaced XM_622091.3, NM_013779.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK086725.1, AK082944.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 10915770 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGCAGC TAAGTACGAA TCTGGGGGAT TCCAGCCCTC CGGAGTCCCC AGTGCCTGCA 
GTCCATAGCC GCCCTACGGT TCTGATGCGG GCTCCGCCTG CTTCCTCCCG GGCTCCTCCT 
GTCCCCTGGG ATCCACCTCC AGTGGACTTG CAGGCTCCCA TGGCTGCTTG GCAGGCTCCT 
CAACCTGCCT GGGAGGCTCC GGAGGGCCAG CTGCCTGCCC CAGTGGCTCA GCTGGCCCAG 
CCTCCTGGTC TAGGGGCCCC AATGGTCCAG GCTCCACCGC TCGGAGGGGG GATGGCCAAG 
CCTCCAACTC CTGGAGTCTT GATGGTCCAT CAGCCCCCTC CGGGAGCCCC CATGGCCCAG 
TCTTCAACTC CGGGAGTCCT GATGCTACAT CCTTCTGTCA CGGGGGCCCC TTTGGCTCAT 
CCTCCTCCCC CAGGAACCCC GATGACACAC CCTCCCGGGA CCTCGATGGC GCACCCTCCT 
CCTCCTCCTC CTCCCCCTCC TCCTCCTCCT CCTCCTGGGA CCCCAATGAC CCACCCACCT 
CCTCCTGGGA CTCCGATGGG TCACCATCCT CCTCCTGGGA ACCCTATGAC CCATCCTCCA 
CCGGGGAACC CGATGGTGCA TCCTCTCACT CATGGAGCCC CGATGGTCCA TGGGGGACCA 
CATGGAACTC CAATGCCGCA TGTTCCCATT ACGGGGACAC CGATAGCCCA GCAGCCAACT 
CCAGGAGTCC TGATGGCCCA GCAGCTGACA CCGGGAGTCC TGATGGTCCA GCCGCCTGCT 
CCGGGAGCTC CGATGGTCCA GCCACCTCCA CAGGCTGCCT TGATGACCCA GCCTGCACCT 
TCGATTACTC CGATGGCCAA GCCTCCAGGT CCTGGTGTCG TGATGATCCA TCCTCCAGGT 
GCCAGAGGTC CAATCATTCA GACTCCAGTA TCAGGAGCAC CAATGGCTCA GACAGTGCTG 
CCCCCTGGGC AGCCTCTGGC CACTTGGGCC CCACAGGGTC AGCCTTTGAT CCTACAAATC 
CAGTCTCAAG TCATAAGGGC TCCTCCACAG GTTCCCTCTG TACCACAAGC CCCCCAGGTA 
CAGCTGGCCA CACCCCCAGG CTGGCAAGCC ACCACACCCA ACTGGCAGGT GACCCCCCAG 
GGGTGGCCAG CAACGCCTTT GACATGGCAG GCTACACAGG TGACCTGGCA GGCCCCCACA 
ATAGCCTGGC AGGCCACTCA ACCTGGGCGC CAAGGGCACT CAACCATTCG TACTGGTCAC 
ACACCCATTC GACCTGGACC AGCTCCATTG CTTCGCCAGA TACCTCCTAT GATCCGTCAG 
ATCCAACCTG TGATGAGGCA AGCCCCACCA CTGATCCGAC AGGTCCCTAT CAGACCAGCT 
CCACATGGCA TAGCAAGCCA GCCTCAGCTG TGGCAGGTCC TGCCACCCCC ACCTCCACTG 
CGGCAGGCTC CACAGGCTCG TCTACTGCTC CCGAGGGTAC CAGGAACAGG CCAGGTGTCT 
ACAGTACCAC CAGTTGCTCA GATACATTTG GTGCCACAGT CAGGCCCACA GGTGCCCCAG 
ACAGTACTGC CAGCCCAACT GTCTATCCCA ATTCCTGTAC CCCAGGCTGC TGCTCAGTCT 
GCTCCCCGGA CTGTGCATTG CCCACCCATC ATCTGGCAGG CCCCCAAAGG CCAGGCCCCG 
GTGCCACAGG AGCTCCCAGT GCCACAGGAG CTCCCGGTGC CACAGGAGCT CCCGGTGCCA 
CAAGAGGTCC CGGTTCCACA GGAGATCCCG GTGCCACAGG AGATCCCGGT GCCACAGGAG 
CTCCCGGTTC CACAGGAGCT CCCGGTGCCA CAGGAGCTCC CAGTGCCACA AGAGCTCCCG 
GTGCCACAGG AGCTCCCAGT GCCACAGGAG CTCCCGGTGC CACAGGAGCT CCCGGTGCCA 
CAGGAGCTCC CGGTGCCATT GGAGTTCCAG GAGGTACAGC AGGCCCAGGC AGTGGGCTGG 
CGGGCACCCA AGGTACCTCC TCACTTCTGG CAGCCTGTGT CTGCCCAGGA GGCCCAGGAG 
CAGGCCACTC AGATCGCCCA TGTGGAGCAG CAGCAGCCCT TTCAGGGAGC TCCAGCCTCC 
TCCAAGGCAC TGCAAACTCA GCTGCCGACC CACCAGGCCC AAGCCTCTGG CTTGCAGGCA 
GAACTGCCTT CAGTGCAGCT GCAGCCTTCT TGGCAAGGCC CACTGCCCAT GTTGCAGGCC 
CAGCCTGGAG CCTCTGCCAC ACTGGCAAAC TTTCCCCGGG GCTCCACTCG ATCACGTATG 
GCTCCATCAG GAGAACCTGG CCCCTCTTCT CTAGAACCTC GGGGCCCTCC TAGGGAACGT 
AGGGCACCTG CAAGGGACAA AAAGGGTCCT CCAAAAGAGC GCATGTTCAT TGGTGCCACT 
TTCTGTGCTC CAAGGGGGGC ATCAGCATCC AGGGCATACG TGCCAACTGC CTGGAAAAAC 
TTGCCTGCCA CATCAGAGAC CTTTCCTGCC ACCTCAAGGG TCTTTCCATC TACCTCTCAT 
TTCCAGCCTG CCTCTTCTAA TGCCTTTAGA GGTCCATCTG CCGCCTCAGA GAGCCCAAAG 
TCACTGCCAT TTGCTCTGCA GGATCCTTAT GCCTGCGTAG AGGCCCTGCC TGCAGTTCCC 
TGGGTTCCGT ATCCAGATGG AAATGCCTCA TCAGCATGTA AGTCAGTGCC TGCCATCTTG 
ATGGTGGCAG CAGCTGCCCC CCAGGCAAGT GCCACTGCTG CAGAGGCCTC TAAGTCTTCA 
GAGCCGCCAA GACGCCCCGG CAAAGCCACC AGGAAGAAGA AGCATCTGGA ACCCAAAGAA 
GACAACTGTG GCCACAGGCT CTCCTCACGT GACTGGCGGG GGCCCCGAAC CTGGGGCAAT 
CCCAGTCATT CTGACTGGGA GATTCAGAGG GCTATGCAGC TCCTGGGGGA CCGGGAATCC 
CTCTACACTC CGCAGGGCCT GAATGACTGG GGGTGCCCCA ACACTTCTAG GATGCCAAGG 
AGCTTGGAGG GCCCTAGCAC TTCACGGGAC CAGGAATTCT GTGGTGACTC GGGTGGGTCT 
CAGACATGGA TGGCTTCTGA GGTCCCAAGC GTCTCTCGGG GATCCAGTGC TGCTCAGGAG 
GACCCTGATA GGGAGAGTCA GCCCTTATCT CCCTTAGATG AGAGAGCAAA CGCTTTGGTG 
CAGTTTCTCT TGGTCAAAGA CCAAGCCAAG GTGCCTGTCC AGCTCTCGGA GATGGTAAAT 
GTTGTCATCC GAGAATACAA AGACGACAGC TTAGACATCA TCAACCGTGC CAACACTAAG 
CTGGAGTGCA CCTTTGGTTG TCAACTGAAG GAAGTTGACA CCAAAACCCA CACTTACATC 
ATCGTCAACA AGATGGCGTA CCCTCAGTGT AATTTGCTGG CATCCTATTT AGAGAGGCCA 
AAGTTCAGCC TCCTGATGGT GGTCTTGAGC CTCATCTTTA TGAAAGGCTA CTGTATCAGG 
GAGAATCTGC TCTTTAGTTT TCTGTTCCAG CTAGGGCTGG ATGTCCAGGA GACAAGTGGT 
CTCTTCAGAA TTACAAAGAA GCTCATCACC AGTGTGTTTG TGAGACACAG GTACCTAGAG 
TACAGGCAAA TCCCGTTCAC TGAGCCTGCA GAATACGAGC TTCTCTGGGG GCCCCGGGCA 
TTCCTCGAAA CCAACAGGGT GCACATCTTG AGATTTTTGG CCGCACTCTA CGAGAACCAG 
CCCCAGATCT GGTCATGCCA GTACCTTGAC TCACTGGCAG AGTTAGAATA CAAGGACGCA 
AATGCCGCCG CCGAAGAGTC CCATGACAGC GATGATGATG CCCACGACCC CACCAGCAGT 
CCCCATCCTC ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038807.4
CDS	372..4226
Translation	MSQLSTNLGDSSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQPPGLGAPMVQAPPLGGGMAKPPTPGVLMVHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVHGGPHGTPMPHVPITGTPIAQQPTPGVLMAQQLTPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLPPGQPLATWAPQGQPLILQIQSQVIRAPPQVPSVPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGHTPIRPGPAPLLRQIPPMIRQIQPVMRQAPPLIRQVPIRPAPHGIASQPQLWQVLPPPPPLRQAPQARLLLPRVPGTGQVSTVPPVAQIHLVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVPPHFWQPVSAQEAQEQATQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGPLPMLQAQPGASATLANFPRGSTRSRMAPSGEPGPSSLEPRGPPRERRAPARDKKGPPKERMFIGATFCAPRGASASRAYVPTAWKNLPATSETFPATSRVFPSTSHFQPASSNAFRGPSAASESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPAILMVAAAAPQASATAAEASKSSEPPRRPGKATRKKKHLEPKEDNCGHRLSSRDWRGPRTWGNPSHSDWEIQRAMQLLGDRESLYTPQGLNDWGCPNTSRMPRSLEGPSTSRDQEFCGDSGGSQTWMASEVPSVSRGSSAAQEDPDRESQPLSPLDERANALVQFLLVKDQAKVPVQLSEMVNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDTKTHTYIIVNKMAYPQCNLLASYLERPKFSLLMVVLSLIFMKGYCIRENLLFSFLFQLGLDVQETSGLFRITKKLITSVFVRHRYLEYRQIPFTEPAEYELLWGPRAFLETNRVHILRFLAALYENQPQIWSCQYLDSLAELEYKDANAAAEESHDSDDDAHDPTSSPHPH

Target ORF information:

RefSeq Version	NM_013779.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus melanoma antigen, family L, 2 (Magel2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013779.2

ORF Insert Sequence:

ATGTCGCAGC TAAGTACGAA TCTGGGGGAT TCCAGCCCTC CGGAGTCCCC AGTGCCTGCA 
GTCCATAGCC GCCCTACGGT TCTGATGCGG GCTCCGCCTG CTTCCTCCCG GGCTCCTCCT 
GTCCCCTGGG ATCCACCTCC AGTGGACTTG CAGGCTCCCA TGGCTGCTTG GCAGGCTCCT 
CAACCTGCCT GGGAGGCTCC GGAGGGCCAG CTGCCTGCCC CAGTGGCTCA GCTGGCCCAG 
CCTCCTGGTC TAGGGGCCCC AATGGTCCAG GCTCCACCGC TCGGAGGGGG GATGGCCAAG 
CCTCCAACTC CTGGAGTCTT GATGGTCCAT CAGCCCCCTC CGGGAGCCCC CATGGCCCAG 
TCTTCAACTC CGGGAGTCCT GATGCTACAT CCTTCTGTCA CGGGGGCCCC TTTGGCTCAT 
CCTCCTCCCC CAGGAACCCC GATGACACAC CCTCCCGGGA CCTCGATGGC GCACCCTCCT 
CCTCCTCCTC CTCCCCCTCC TCCTCCTCCT CCTCCTGGGA CCCCAATGAC CCACCCACCT 
CCTCCTGGGA CTCCGATGGG TCACCATCCT CCTCCTGGGA ACCCTATGAC CCATCCTCCA 
CCGGGGAACC CGATGGTGCA TCCTCTCACT CATGGAGCCC CGATGGTCCA TGGGGGACCA 
CATGGAACTC CAATGCCGCA TGTTCCCATT ACGGGGACAC CGATAGCCCA GCAGCCAACT 
CCAGGAGTCC TGATGGCCCA GCAGCTGACA CCGGGAGTCC TGATGGTCCA GCCGCCTGCT 
CCGGGAGCTC CGATGGTCCA GCCACCTCCA CAGGCTGCCT TGATGACCCA GCCTGCACCT 
TCGATTACTC CGATGGCCAA GCCTCCAGGT CCTGGTGTCG TGATGATCCA TCCTCCAGGT 
GCCAGAGGTC CAATCATTCA GACTCCAGTA TCAGGAGCAC CAATGGCTCA GACAGTGCTG 
CCCCCTGGGC AGCCTCTGGC CACTTGGGCC CCACAGGGTC AGCCTTTGAT CCTACAAATC 
CAGTCTCAAG TCATAAGGGC TCCTCCACAG GTTCCCTCTG TACCACAAGC CCCCCAGGTA 
CAGCTGGCCA CACCCCCAGG CTGGCAAGCC ACCACACCCA ACTGGCAGGT GACCCCCCAG 
GGGTGGCCAG CAACGCCTTT GACATGGCAG GCTACACAGG TGACCTGGCA GGCCCCCACA 
ATAGCCTGGC AGGCCACTCA ACCTGGGCGC CAAGGGCACT CAACCATTCG TACTGGTCAC 
ACACCCATTC GACCTGGACC AGCTCCATTG CTTCGCCAGA TACCTCCTAT GATCCGTCAG 
ATCCAACCTG TGATGAGGCA AGCCCCACCA CTGATCCGAC AGGTCCCTAT CAGACCAGCT 
CCACATGGCA TAGCAAGCCA GCCTCAGCTG TGGCAGGTCC TGCCACCCCC ACCTCCACTG 
CGGCAGGCTC CACAGGCTCG TCTACTGCTC CCGAGGGTAC CAGGAACAGG CCAGGTGTCT 
ACAGTACCAC CAGTTGCTCA GATACATTTG GTGCCACAGT CAGGCCCACA GGTGCCCCAG 
ACAGTACTGC CAGCCCAACT GTCTATCCCA ATTCCTGTAC CCCAGGCTGC TGCTCAGTCT 
GCTCCCCGGA CTGTGCATTG CCCACCCATC ATCTGGCAGG CCCCCAAAGG CCAGGCCCCG 
GTGCCACAGG AGCTCCCAGT GCCACAGGAG CTCCCGGTGC CACAGGAGCT CCCGGTGCCA 
CAAGAGGTCC CGGTTCCACA GGAGATCCCG GTGCCACAGG AGATCCCGGT GCCACAGGAG 
CTCCCGGTTC CACAGGAGCT CCCGGTGCCA CAGGAGCTCC CAGTGCCACA AGAGCTCCCG 
GTGCCACAGG AGCTCCCAGT GCCACAGGAG CTCCCGGTGC CACAGGAGCT CCCGGTGCCA 
CAGGAGCTCC CGGTGCCATT GGAGTTCCAG GAGGTACAGC AGGCCCAGGC AGTGGGCTGG 
CGGGCACCCA AGGTACCTCC TCACTTCTGG CAGCCTGTGT CTGCCCAGGA GGCCCAGGAG 
CAGGCCACTC AGATCGCCCA TGTGGAGCAG CAGCAGCCCT TTCAGGGAGC TCCAGCCTCC 
TCCAAGGCAC TGCAAACTCA GCTGCCGACC CACCAGGCCC AAGCCTCTGG CTTGCAGGCA 
GAACTGCCTT CAGTGCAGCT GCAGCCTTCT TGGCAAGGCC CACTGCCCAT GTTGCAGGCC 
CAGCCTGGAG CCTCTGCCAC ACTGGCAAAC TTTCCCCGGG GCTCCACTCG ATCACGTATG 
GCTCCATCAG GAGAACCTGG CCCCTCTTCT CTAGAACCTC GGGGCCCTCC TAGGGAACGT 
AGGGCACCTG CAAGGGACAA AAAGGGTCCT CCAAAAGAGC GCATGTTCAT TGGTGCCACT 
TTCTGTGCTC CAAGGGGGGC ATCAGCATCC AGGGCATACG TGCCAACTGC CTGGAAAAAC 
TTGCCTGCCA CATCAGAGAC CTTTCCTGCC ACCTCAAGGG TCTTTCCATC TACCTCTCAT 
TTCCAGCCTG CCTCTTCTAA TGCCTTTAGA GGTCCATCTG CCGCCTCAGA GAGCCCAAAG 
TCACTGCCAT TTGCTCTGCA GGATCCTTAT GCCTGCGTAG AGGCCCTGCC TGCAGTTCCC 
TGGGTTCCGT ATCCAGATGG AAATGCCTCA TCAGCATGTA AGTCAGTGCC TGCCATCTTG 
ATGGTGGCAG CAGCTGCCCC CCAGGCAAGT GCCACTGCTG CAGAGGCCTC TAAGTCTTCA 
GAGCCGCCAA GACGCCCCGG CAAAGCCACC AGGAAGAAGA AGCATCTGGA ACCCAAAGAA 
GACAACTGTG GCCACAGGCT CTCCTCACGT GACTGGCGGG GGCCCCGAAC CTGGGGCAAT 
CCCAGTCATT CTGACTGGGA GATTCAGAGG GCTATGCAGC TCCTGGGGGA CCGGGAATCC 
CTCTACACTC CGCAGGGCCT GAATGACTGG GGGTGCCCCA ACACTTCTAG GATGCCAAGG 
AGCTTGGAGG GCCCTAGCAC TTCACGGGAC CAGGAATTCT GTGGTGACTC GGGTGGGTCT 
CAGACATGGA TGGCTTCTGA GGTCCCAAGC GTCTCTCGGG GATCCAGTGC TGCTCAGGAG 
GACCCTGATA GGGAGAGTCA GCCCTTATCT CCCTTAGATG AGAGAGCAAA CGCTTTGGTG 
CAGTTTCTCT TGGTCAAAGA CCAAGCCAAG GTGCCTGTCC AGCTCTCGGA GATGGTAAAT 
GTTGTCATCC GAGAATACAA AGACGACAGC TTAGACATCA TCAACCGTGC CAACACTAAG 
CTGGAGTGCA CCTTTGGTTG TCAACTGAAG GAAGTTGACA CCAAAACCCA CACTTACATC 
ATCGTCAACA AGATGGCGTA CCCTCAGTGT AATTTGCTGG CATCCTATTT AGAGAGGCCA 
AAGTTCAGCC TCCTGATGGT GGTCTTGAGC CTCATCTTTA TGAAAGGCTA CTGTATCAGG 
GAGAATCTGC TCTTTAGTTT TCTGTTCCAG CTAGGGCTGG ATGTCCAGGA GACAAGTGGT 
CTCTTCAGAA TTACAAAGAA GCTCATCACC AGTGTGTTTG TGAGACACAG GTACCTAGAG 
TACAGGCAAA TCCCGTTCAC TGAGCCTGCA GAATACGAGC TTCTCTGGGG GCCCCGGGCA 
TTCCTCGAAA CCAACAGGGT GCACATCTTG AGATTTTTGG CCGCACTCTA CGAGAACCAG 
CCCCAGATCT GGTCATGCCA GTACCTTGAC TCACTGGCAG AGTTAGAATA CAAGGACGCA 
AATGCCGCCG CCGAAGAGTC CCATGACAGC GATGATGATG CCCACGACCC CACCAGCAGT 
CCCCATCCTC ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways.
Human molecular genetics26(21)4215-4230(2017 Nov)
Wijesuriya TM,De Ceuninck L,Masschaele D,Sanderson MR,Carias KV,Tavernier J,Wevrick R

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty.
Genes, brain, and behavior16(6)592-600(2017 Jul)
Fountain MD,Tao H,Chen CA,Yin J,Schaaf CP

Muscle dysfunction caused by loss of Magel2 in a mouse model of Prader-Willi and Schaaf-Yang syndromes.
Human molecular genetics25(17)3798-3809(2016 09)
Kamaludin AA,Smolarchuk C,Bischof JM,Eggert R,Greer JJ,Ren J,Lee JJ,Yokota T,Berry FB,Wevrick R

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Magel2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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