Cd200r2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd200r2
Entrez Gene ID	271375
Full Name	Cd200 receptor 2
Synonyms	AY230198,Cd200r1l
General protein information	Preferred Names Cd200 receptor 2 Names cell surface glycoprotein CD200 receptor 2 CD200 cell surface glycoprotein receptor CD200 cell surface glycoprotein receptor-like 2 CD200 cell surface glycoprotein receptor-like c CD200 receptor-like 2 CD200RLc cell surface glycoprotein OX2 receptor 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 B4-B5

mRNA and Protein(s)

mRNA	Protein	Name
NM_206535.1	NP_996258.1	cell surface glycoprotein CD200 receptor 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cd200r2	NP_996258.1
	CD200R1	XP_001105278.2
Homo sapiens (human)	CD200R1L	NP_001008784.2
Pan troglodytes (chimpanzee)	CD200R1L	XP_526264.2
Mus musculus (house mouse)	Cd200r4	NP_997127.1
Rattus norvegicus (Norway rat)	Cd200r1l	XP_577181.4

Gene Ontology
Bibliography

Related articles in PubMed

Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-? abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice.
Gorczynski R, Yu K, Chen Z
Transplantation97(1)39-46(2014 Jan)

Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease.
Sato K, Eizumi K, Fukaya T, Fujita S, Sato Y, Takagi H, Yamamoto M, Yamashita N, Hijikata A, Kitamura H, Ohara O, Yamasaki S, Saito T, Sato K
Blood113(19)4780-9(2009 May)

An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells.
Gorczynski R, Khatri I, Lee L, Boudakov I
Journal of immunology (Baltimore, Md. : 1950)180(9)5946-55(2008 May)

Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor.
Hatherley D, Cherwinski HM, Moshref M, Barclay AN
Journal of immunology (Baltimore, Md. : 1950)175(4)2469-74(2005 Aug)

Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.
Gorczynski RM, Chen Z, Clark DA, Kai Y, Lee L, Nachman J, Wong S, Marsden P
American journal of reproductive immunology (New York, N.Y. : 1989)52(2)147-63(2004 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role of mast cells and Tregs.
Title: Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-? abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice.

An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells.
Title: An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells.

The CD200 receptor family consists of both activatory and inhibitory members, like several other paired ligand receptors.
Title: Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor.

The following Cd200r2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd200r2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00060	NM_206535.1 Latest version!	Mus musculus Cd200 receptor 2 (Cd200r2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd200r2 ( NM_206535.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_996258.1 Mus musculus Cd200 receptor 2 (Cd200r2), mRNA.

Price & Availability↑

CloneID	OMu00060
Clone ID Related Accession (Same CDS sequence)	NM_206535.1
Accession Version	NM_206535.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	cell surface glycoprotein CD200 receptor 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY230198.1. On Mar 22, 2004 this sequence version replaced XM_195003.2. ##Evidence-Data-START## Transcript exon combination :: AY230198.1 [ECO:0000332] ##Evidence-Data-END##

ATGCATGCTT TGGGGAGGAC TCCGGCTTTG ACTTTGCTGA TCTTCATCTA TAATTTTGTG 
TCTGTGTACA CCATAGTGTC TGTACAGATG GGTACAAAGG CTCGGCTCTG CTGCCGTTCT 
ATTCCACTGA CAAAAGCAGT ATTAATCACA TGGATAATAA AGCCCAGAGG CCAGCCTTCC 
TGCATAATGG CCTACAAAGT AGAAACAAAG GAGACCAATG AAACCTGCTT GGGCAGGAAC 
ATCACCTGGG CCTCCACACC TGACCACATT CCTGACCTTC AGATCAGTGC GGTGGCCCTC 
CAGCATGAGG GGAATTACTT ATGTGAGATA ACAACACCTG AAGGGAATTT CCATAAAGTC 
TATGACCTCC AAGTGCTGGT GCCCCCTGAA GTAACCTACT TTCTCGGGGA AAATAGAACT 
GCAGTTTGTG AGGCAATGGC AGGCAAGCCT GCTGCACAGA TCTCTTGGAC TCCAGATGGG 
GACTGTGTCA CTAAGAGTGA GTCACACAGC AATGGCACTG TGACTGTCAG GAGCACTTGC 
CACTGGGAGC AGAACAATGT GTCTGCTGTG TCCTGCATTG TCTCTCATTC GACTGGTAAT 
CAGTCTCTGT CCATAGAACT GAGTAGAGGT ACCACCAGCA CCACCCCTTC CTTGCTGACC 
ATTCTCTACG TGAAAATGGT CCTTTTGGGG ATTATTCTTC TTAAAGTGGG ATTTGCTTTC 
TTCCAGAAGA GAAATGTTAC CAGAACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996258.1
CDS	214..963
Translation	MHALGRTPALTLLIFIYNFVSVYTIVSVQMGTKARLCCRSIPLTKAVLITWIIKPRGQPSCIMAYKVETKETNETCLGRNITWASTPDHIPDLQISAVALQHEGNYLCEITTPEGNFHKVYDLQVLVPPEVTYFLGENRTAVCEAMAGKPAAQISWTPDGDCVTKSESHSNGTVTVRSTCHWEQNNVSAVSCIVSHSTGNQSLSIELSRGTTSTTPSLLTILYVKMVLLGIILLKVGFAFFQKRNVTRT

Target ORF information:

RefSeq Version	NM_206535.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Cd200 receptor 2 (Cd200r2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206535.1

ORF Insert Sequence:

ATGCATGCTT TGGGGAGGAC TCCGGCTTTG ACTTTGCTGA TCTTCATCTA TAATTTTGTG 
TCTGTGTACA CCATAGTGTC TGTACAGATG GGTACAAAGG CTCGGCTCTG CTGCCGTTCT 
ATTCCACTGA CAAAAGCAGT ATTAATCACA TGGATAATAA AGCCCAGAGG CCAGCCTTCC 
TGCATAATGG CCTACAAAGT AGAAACAAAG GAGACCAATG AAACCTGCTT GGGCAGGAAC 
ATCACCTGGG CCTCCACACC TGACCACATT CCTGACCTTC AGATCAGTGC GGTGGCCCTC 
CAGCATGAGG GGAATTACTT ATGTGAGATA ACAACACCTG AAGGGAATTT CCATAAAGTC 
TATGACCTCC AAGTGCTGGT GCCCCCTGAA GTAACCTACT TTCTCGGGGA AAATAGAACT 
GCAGTTTGTG AGGCAATGGC AGGCAAGCCT GCTGCACAGA TCTCTTGGAC TCCAGATGGG 
GACTGTGTCA CTAAGAGTGA GTCACACAGC AATGGCACTG TGACTGTCAG GAGCACTTGC 
CACTGGGAGC AGAACAATGT GTCTGCTGTG TCCTGCATTG TCTCTCATTC GACTGGTAAT 
CAGTCTCTGT CCATAGAACT GAGTAGAGGT ACCACCAGCA CCACCCCTTC CTTGCTGACC 
ATTCTCTACG TGAAAATGGT CCTTTTGGGG ATTATTCTTC TTAAAGTGGG ATTTGCTTTC 
TTCCAGAAGA GAAATGTTAC CAGAACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-? abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice.
Transplantation97(1)39-46(2014 Jan)
Gorczynski R,Yu K,Chen Z

Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease.
Blood113(19)4780-9(2009 May)
Sato K,Eizumi K,Fukaya T,Fujita S,Sato Y,Takagi H,Yamamoto M,Yamashita N,Hijikata A,Kitamura H,Ohara O,Yamasaki S,Saito T,Sato K

An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)180(9)5946-55(2008 May)
Gorczynski R,Khatri I,Lee L,Boudakov I

Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor.
Journal of immunology (Baltimore, Md. : 1950)175(4)2469-74(2005 Aug)
Hatherley D,Cherwinski HM,Moshref M,Barclay AN

Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.
American journal of reproductive immunology (New York, N.Y. : 1989)52(2)147-63(2004 Aug)
Gorczynski RM,Chen Z,Clark DA,Kai Y,Lee L,Nachman J,Wong S,Marsden P