Rab39 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab39
Entrez Gene ID	270160
Full Name	RAB39, member RAS oncogene family
Synonyms	C230094F14Rik,Rab39a
General protein information	Preferred Names RAB39, member RAS oncogene family Names ras-related protein Rab-39A rab-39
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A5.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_175562.3	NP_780771.1	ras-related protein Rab-39A

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RAB39	XP_005619887.1
Homo sapiens (human)	RAB39A	NP_059986.1
	RAB39	XP_001103335.1
Pan troglodytes (chimpanzee)	RAB39A	XP_001136512.2
Rattus norvegicus (Norway rat)	Rab39a	NP_001101618.1
Mus musculus (house mouse)	Rab39	NP_780771.1
Bos taurus (cattle)	RAB39	NP_001179759.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.
Mori Y, Matsui T, Omote D, Fukuda M
Biochemical and biophysical research communications435(1)113-9(2013 May)

Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
Seto S, Sugaya K, Tsujimura K, Nagata T, Horii T, Koide Y
PloS one8(12)e83324(2013)

Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
Giannandrea M, Bianchi V, Mignogna ML, Sirri A, Carrabino S, D'Elia E, Vecellio M, Russo S, Cogliati F, Larizza L, Ropers HH, Tzschach A, Kalscheuer V, Oehl-Jaschkowitz B, Skinner C, Schwartz CE, Gecz J, Van Esch H, Raynaud M, Chelly J, de Brouwer AP, Toniolo D, D'Adamo P
American journal of human genetics86(2)185-95(2010 Feb)

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Itoh T, Satoh M, Kanno E, Fukuda M
Genes to cells : devoted to molecular & cellular mechanisms11(9)1023-37(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate that UACA functions as a Rab39A effector in the retinoic acid-induced differentiation of Neuro2A cells.
Title: Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.

These results suggest that Rab39a negatively regulates the LPS-induced autophagy in macrophages
Title: Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.

The following Rab39 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab39 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05574	NM_175562.3 Latest version!	Mus musculus RAB39, member RAS oncogene family (Rab39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab39 ( NM_175562.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780771.1 Mus musculus RAB39, member RAS oncogene family (Rab39), mRNA.

Price & Availability↑

CloneID	OMu05574
Clone ID Related Accession (Same CDS sequence)	NM_175562.3
Accession Version	NM_175562.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	ras-related protein Rab-39A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC158384.2. On Mar 21, 2007 this sequence version replaced NM_175562.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK049038.1, BC049787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACTA TTTGGATCTA TCAGTTCCGC CTTATTGTGA TCGGAGACTC CACGGTGGGC 
AAGTCGTGCC TTCTGCACCG CTTCACCCAG GGCCGCTTCC CAGGGCTGCA CTCCCCCGCC 
TGCGACCCCA CAGTCGGCGT GGACTTCTTC TCGCGCCTGC TGGAGATTGA GCCGGGCAAG 
AGGATCAAGC TGCAGCTCTG GGACACGGCG GGGCAGGAGC GCTTCAGATC AATAACTCGA 
TCCTATTACC GCAACTCAGT TGGAGGATTT TTAGTGTTTG ACATTACTAA CCGACGGTCT 
TTTGAACATG TGAAAGATTG GCTAGAAGAA GCAAAAATGC ATGTACAGCC TTTTCAGATT 
GTATTTCTAC TGGTGGGACA TAAATGTGAC CTGGCTTCGC AACGCCAGGT TTCAAGGGAA 
GAAGCTGAAA GACTGTCAAC AGACTGTGGA ATGAAGTACA TAGAGACCTC AGCCAAGGAC 
GCGACAAACG TTGAAGAGTC CTTTACAATC CTGACAAGAG ACATATATGA GCTTATCAAA 
AAAGGAGAGA TTTGTATTCA GGATGGATGG GAAGGGGTTA AAAGTGGTTT CGTTCCAAAT 
ACTGTGCATT CTTCTGAGGA AGCAGTCAAG CCCAGAAAAG AGTGCTTCTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780771.1
CDS	118..771
Translation	METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLHSPACDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMHVQPFQIVFLLVGHKCDLASQRQVSREEAERLSTDCGMKYIETSAKDATNVEESFTILTRDIYELIKKGEICIQDGWEGVKSGFVPNTVHSSEEAVKPRKECFC

Target ORF information:

RefSeq Version	NM_175562.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAB39, member RAS oncogene family (Rab39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175562.3

ORF Insert Sequence:

ATGGAGACTA TTTGGATCTA TCAGTTCCGC CTTATTGTGA TCGGAGACTC CACGGTGGGC 
AAGTCGTGCC TTCTGCACCG CTTCACCCAG GGCCGCTTCC CAGGGCTGCA CTCCCCCGCC 
TGCGACCCCA CAGTCGGCGT GGACTTCTTC TCGCGCCTGC TGGAGATTGA GCCGGGCAAG 
AGGATCAAGC TGCAGCTCTG GGACACGGCG GGGCAGGAGC GCTTCAGATC AATAACTCGA 
TCCTATTACC GCAACTCAGT TGGAGGATTT TTAGTGTTTG ACATTACTAA CCGACGGTCT 
TTTGAACATG TGAAAGATTG GCTAGAAGAA GCAAAAATGC ATGTACAGCC TTTTCAGATT 
GTATTTCTAC TGGTGGGACA TAAATGTGAC CTGGCTTCGC AACGCCAGGT TTCAAGGGAA 
GAAGCTGAAA GACTGTCAAC AGACTGTGGA ATGAAGTACA TAGAGACCTC AGCCAAGGAC 
GCGACAAACG TTGAAGAGTC CTTTACAATC CTGACAAGAG ACATATATGA GCTTATCAAA 
AAAGGAGAGA TTTGTATTCA GGATGGATGG GAAGGGGTTA AAAGTGGTTT CGTTCCAAAT 
ACTGTGCATT CTTCTGAGGA AGCAGTCAAG CCCAGAAAAG AGTGCTTCTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.
Biochemical and biophysical research communications435(1)113-9(2013 May)
Mori Y,Matsui T,Omote D,Fukuda M

Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
PloS one8(12)e83324(2013)
Seto S,Sugaya K,Tsujimura K,Nagata T,Horii T,Koide Y

Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
American journal of human genetics86(2)185-95(2010 Feb)
Giannandrea M,Bianchi V,Mignogna ML,Sirri A,Carrabino S,D'Elia E,Vecellio M,Russo S,Cogliati F,Larizza L,Ropers HH,Tzschach A,Kalscheuer V,Oehl-Jaschkowitz B,Skinner C,Schwartz CE,Gecz J,Van Esch H,Raynaud M,Chelly J,de Brouwer AP,Toniolo D,D'Adamo P

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Genes to cells : devoted to molecular & cellular mechanisms11(9)1023-37(2006 Sep)
Itoh T,Satoh M,Kanno E,Fukuda M

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Rab39 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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