Sytl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sytl1
Entrez Gene ID	269589
Full Name	synaptotagmin-like 1
Synonyms	9030417L18,PSGL-1,Slp1
General protein information	Preferred Names synaptotagmin-like 1 Names synaptotagmin-like protein 1 exophilin-7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D2.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_031393.2	NP_113570.2	synaptotagmin-like protein 1
XM_011250265.1	XP_011248567.1	synaptotagmin-like protein 1 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sytl1	NP_113570.2
Danio rerio (zebrafish)	LOC565707	XP_694069.5
	SYTL1	XP_002802304.1
Bos taurus (cattle)	SYTL1	XP_002685738.2
Gallus gallus (chicken)	SYTL1	NP_001074358.1
Pan troglodytes (chimpanzee)	SYTL1	XP_513243.2
Homo sapiens (human)	SYTL1	NP_001180237.1
Canis lupus familiaris (dog)	SYTL1	XP_005617776.1
Rattus norvegicus (Norway rat)	Sytl1	NP_001020822.1
Xenopus tropicalis (tropical clawed frog)	sytl1	NP_001006773.1

Gene Ontology
Bibliography

Related articles in PubMed

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.
Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Sch?fer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M
The Journal of clinical investigation126(11)4125-4139(2016 Nov)

MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.
Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T
The Journal of clinical investigation126(5)1664-78(2016 May)

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Adissu HA, Estabel J, Sunter D, Tuck E, Hooks Y, Carragher DM, Clarke K, Karp NA, , Newbigging S, Jones N, Morikawa L, White JK, McKerlie C
Disease models & mechanisms7(5)515-24(2014 May)

The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Wang H, Ishizaki R, Xu J, Kasai K, Kobayashi E, Gomi H, Izumi T
Molecular biology of the cell24(3)319-30(2013 Feb)

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD
Molecular biology of the cell23(10)1902-16(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
Title: The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.

Expression of Rab27B-binding proteinm Sytl1 in pancreatic acinar cells and its involvement in amylase secretion are reported.
Title: Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion.

These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
Title: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.

Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.

The following Sytl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sytl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08587	NM_031393.2 Latest version!	Mus musculus synaptotagmin-like 1 (Sytl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu08587	XM_011250265.1 Latest version!	Mus musculus synaptotagmin-like 1 (Sytl1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sytl1 ( NM_031393.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_113570.2 Mus musculus synaptotagmin-like 1 (Sytl1), mRNA.

Price & Availability↑

CloneID	OMu08587
Clone ID Related Accession (Same CDS sequence)	NM_031393.2 , XM_011250265.1
Accession Version	NM_031393.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	synaptotagmin-like protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA856092.1, AK131162.1 and AI553427.1. On Oct 31, 2007 this sequence version replaced NM_031393.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154176.1, AK078868.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCCCCAGA GAGGCCACCC ATCTCAGGAG AGGCTTTGGG CCCTGCCCTC CCTCCCCATG 
GCACATGGAC CAGGATCTGA AGCTGAGGGG TTGCTGGACC TCAGCTTCCT GACAGAGGAG 
GAACAGGAGG CCATCTCTGA TGTCCTCAAA CGAGATGCCC ACCTGCGCCA GCTGGAGGAA 
GGGCGGGTCA GCAAGCTCCG GGCCTCCCTG GAAGACCCCT GGCAGCTGAA GATCCTGACA 
GGGGACTGGT TCCAAGAAGC GCGTTCCCAG AGGCACCATC ACGCCCATTT TGGTTCTGAC 
CTCGTCCGGG CTTCTATCCG AAGGAAGAAG AGCCCAAAGG GGGACCAGGC TCTGGGGAGT 
GATGGTGAAG CAGAGGCTGC TGGGGAAAAC ACCATTGAAG GAGAGCCGGA GTCCAGGGTC 
TCCATAGAGG TGGCAGCTCC AGAGAGAAAC ACTGAGACCC AAGGGCCTGA TTTGTTCTCA 
CCATATGTAC CCTCAAAGGC TTCCGAAGGT CAGGAGGAGG AGCCCCAGGA CCAGGAATGT 
GAGCTGGAGG CCCCTGGCGA AGGGGGTGTG CAGGTGGCAG AGGCGGACCC AGAGCTGGAT 
CCTGAGCAGA AGGCGGAGCA GGAGTCCCAG CCAACTCCAG CCCAGTCCAA GGCGACCTCC 
AAGATCCTGG AGAATGGAGA AGAGGCCCCG GGGCTCGGCC CCTCTCTTGA CCGCATGCTC 
AGCAGCAGCT CCTCTGTGTC CAGCCTCAAT TCCTCTACGC TGAGCGGCAG CCTGATGAGC 
CTATCCGGGG AGGCAGAGGC AGGCACGGTG CAGGTGCGAG GCTCCGTGCT CTTCTCGCTG 
CGCTACGAGC CTGGCACCTC TGAGCTGCGA GTACAGGTGA TCCAGTGCCA GGGCCTGGCC 
GCTGCCCGGC GACGCCGCTC CGATCCCTAC GTGAAAAGCT ACCTCCTCCC GGATAAGCAG 
AGCAAGCGTA AGACGTCAGT GAAGAAACGG AATCTGAACC CGATCTTCAA CGAGACTCTG 
CGGCACTCTG TCCAGCAGGC TGATCTCCCA GGCCGCGTGC TGAGCCTGTC CGTGTGGCAC 
CGGGAAAGTC TGGGTCGCAA CATCTTCCTG GGAGAAGTAG AAGTGCCCCT AGACACATGG 
AACTGGGACT CTGAGGCTAC CTGGCTCCCC CTGCAGCCTC GGGTTCCTCC ATCTCCAGAT 
GAGCTTCCCA GCCGTGGACT GCTGTCTCTG TCCCTTAAGT ATGTCCCTGC CGGCTCAGAG 
GGAGGAGGAC AGCCTCAGAG TGGGGAGTTA CACTTCTGGG TAAAGGAAGC TCAGAGCCTG 
GTACCACTGC GACCAGGATC CCTGGACACT TACATTCAAT GCTCAGTGCT GCCTGATGAC 
AGTCGGGCCA GCCGCCAACG CACAAGAGTG GTTCGAAGAA GTCTCAGCCC TGTGTTCAAC 
CACACCATGG TTTATGACGG CTTCGGGCCT GCTGACCTAC GCCAGGCCTG TGCCGAGCTC 
TCCCTGTGGG ACCATGGGGC CCTGGCCAGT CGCCAGCTGG GGGGCACACG CCTCAGCCTT 
GGTACAGGCA GCAGTTATGG GCTTCAGGTG CCCTGGATGG ATTCCACACC GGAGGAGAAG 
CAGCTGTGGC AGACACTCCT GGAGCGGCCC TGTGAGTGGG TGGATGGCCT TCTGCCCCTC 
AGAACCAACC TGGTCCCCAG GGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113570.2
CDS	140..1846
Translation	MPQRGHPSQERLWALPSLPMAHGPGSEAEGLLDLSFLTEEEQEAISDVLKRDAHLRQLEEGRVSKLRASLEDPWQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKSPKGDQALGSDGEAEAAGENTIEGEPESRVSIEVAAPERNTETQGPDLFSPYVPSKASEGQEEEPQDQECELEAPGEGGVQVAEADPELDPEQKAEQESQPTPAQSKATSKILENGEEAPGLGPSLDRMLSSSSSVSSLNSSTLSGSLMSLSGEAEAGTVQVRGSVLFSLRYEPGTSELRVQVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTSVKKRNLNPIFNETLRHSVQQADLPGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNWDSEATWLPLQPRVPPSPDELPSRGLLSLSLKYVPAGSEGGGQPQSGELHFWVKEAQSLVPLRPGSLDTYIQCSVLPDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALASRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQTLLERPCEWVDGLLPLRTNLVPRA

Target ORF information:

RefSeq Version	NM_031393.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus synaptotagmin-like 1 (Sytl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031393.2

ORF Insert Sequence:

ATGCCCCAGA GAGGCCACCC ATCTCAGGAG AGGCTTTGGG CCCTGCCCTC CCTCCCCATG 
GCACATGGAC CAGGATCTGA AGCTGAGGGG TTGCTGGACC TCAGCTTCCT GACAGAGGAG 
GAACAGGAGG CCATCTCTGA TGTCCTCAAA CGAGATGCCC ACCTGCGCCA GCTGGAGGAA 
GGGCGGGTCA GCAAGCTCCG GGCCTCCCTG GAAGACCCCT GGCAGCTGAA GATCCTGACA 
GGGGACTGGT TCCAAGAAGC GCGTTCCCAG AGGCACCATC ACGCCCATTT TGGTTCTGAC 
CTCGTCCGGG CTTCTATCCG AAGGAAGAAG AGCCCAAAGG GGGACCAGGC TCTGGGGAGT 
GATGGTGAAG CAGAGGCTGC TGGGGAAAAC ACCATTGAAG GAGAGCCGGA GTCCAGGGTC 
TCCATAGAGG TGGCAGCTCC AGAGAGAAAC ACTGAGACCC AAGGGCCTGA TTTGTTCTCA 
CCATATGTAC CCTCAAAGGC TTCCGAAGGT CAGGAGGAGG AGCCCCAGGA CCAGGAATGT 
GAGCTGGAGG CCCCTGGCGA AGGGGGTGTG CAGGTGGCAG AGGCGGACCC AGAGCTGGAT 
CCTGAGCAGA AGGCGGAGCA GGAGTCCCAG CCAACTCCAG CCCAGTCCAA GGCGACCTCC 
AAGATCCTGG AGAATGGAGA AGAGGCCCCG GGGCTCGGCC CCTCTCTTGA CCGCATGCTC 
AGCAGCAGCT CCTCTGTGTC CAGCCTCAAT TCCTCTACGC TGAGCGGCAG CCTGATGAGC 
CTATCCGGGG AGGCAGAGGC AGGCACGGTG CAGGTGCGAG GCTCCGTGCT CTTCTCGCTG 
CGCTACGAGC CTGGCACCTC TGAGCTGCGA GTACAGGTGA TCCAGTGCCA GGGCCTGGCC 
GCTGCCCGGC GACGCCGCTC CGATCCCTAC GTGAAAAGCT ACCTCCTCCC GGATAAGCAG 
AGCAAGCGTA AGACGTCAGT GAAGAAACGG AATCTGAACC CGATCTTCAA CGAGACTCTG 
CGGCACTCTG TCCAGCAGGC TGATCTCCCA GGCCGCGTGC TGAGCCTGTC CGTGTGGCAC 
CGGGAAAGTC TGGGTCGCAA CATCTTCCTG GGAGAAGTAG AAGTGCCCCT AGACACATGG 
AACTGGGACT CTGAGGCTAC CTGGCTCCCC CTGCAGCCTC GGGTTCCTCC ATCTCCAGAT 
GAGCTTCCCA GCCGTGGACT GCTGTCTCTG TCCCTTAAGT ATGTCCCTGC CGGCTCAGAG 
GGAGGAGGAC AGCCTCAGAG TGGGGAGTTA CACTTCTGGG TAAAGGAAGC TCAGAGCCTG 
GTACCACTGC GACCAGGATC CCTGGACACT TACATTCAAT GCTCAGTGCT GCCTGATGAC 
AGTCGGGCCA GCCGCCAACG CACAAGAGTG GTTCGAAGAA GTCTCAGCCC TGTGTTCAAC 
CACACCATGG TTTATGACGG CTTCGGGCCT GCTGACCTAC GCCAGGCCTG TGCCGAGCTC 
TCCCTGTGGG ACCATGGGGC CCTGGCCAGT CGCCAGCTGG GGGGCACACG CCTCAGCCTT 
GGTACAGGCA GCAGTTATGG GCTTCAGGTG CCCTGGATGG ATTCCACACC GGAGGAGAAG 
CAGCTGTGGC AGACACTCCT GGAGCGGCCC TGTGAGTGGG TGGATGGCCT TCTGCCCCTC 
AGAACCAACC TGGTCCCCAG GGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sytl1 ( XM_011250265.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011248567.1 Mus musculus synaptotagmin-like 1 (Sytl1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu08587
Clone ID Related Accession (Same CDS sequence)	NM_031393.2 , XM_011250265.1
Accession Version	XM_011250265.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	synaptotagmin-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCAGA GAGGCCACCC ATCTCAGGAG AGGCTTTGGG CCCTGCCCTC CCTCCCCATG 
GCACATGGAC CAGGATCTGA AGCTGAGGGG TTGCTGGACC TCAGCTTCCT GACAGAGGAG 
GAACAGGAGG CCATCTCTGA TGTCCTCAAA CGAGATGCCC ACCTGCGCCA GCTGGAGGAA 
GGGCGGGTCA GCAAGCTCCG GGCCTCCCTG GAAGACCCCT GGCAGCTGAA GATCCTGACA 
GGGGACTGGT TCCAAGAAGC GCGTTCCCAG AGGCACCATC ACGCCCATTT TGGTTCTGAC 
CTCGTCCGGG CTTCTATCCG AAGGAAGAAG AGCCCAAAGG GGGACCAGGC TCTGGGGAGT 
GATGGTGAAG CAGAGGCTGC TGGGGAAAAC ACCATTGAAG GAGAGCCGGA GTCCAGGGTC 
TCCATAGAGG TGGCAGCTCC AGAGAGAAAC ACTGAGACCC AAGGGCCTGA TTTGTTCTCA 
CCATATGTAC CCTCAAAGGC TTCCGAAGGT CAGGAGGAGG AGCCCCAGGA CCAGGAATGT 
GAGCTGGAGG CCCCTGGCGA AGGGGGTGTG CAGGTGGCAG AGGCGGACCC AGAGCTGGAT 
CCTGAGCAGA AGGCGGAGCA GGAGTCCCAG CCAACTCCAG CCCAGTCCAA GGCGACCTCC 
AAGATCCTGG AGAATGGAGA AGAGGCCCCG GGGCTCGGCC CCTCTCTTGA CCGCATGCTC 
AGCAGCAGCT CCTCTGTGTC CAGCCTCAAT TCCTCTACGC TGAGCGGCAG CCTGATGAGC 
CTATCCGGGG AGGCAGAGGC AGGCACGGTG CAGGTGCGAG GCTCCGTGCT CTTCTCGCTG 
CGCTACGAGC CTGGCACCTC TGAGCTGCGA GTACAGGTGA TCCAGTGCCA GGGCCTGGCC 
GCTGCCCGGC GACGCCGCTC CGATCCCTAC GTGAAAAGCT ACCTCCTCCC GGATAAGCAG 
AGCAAGCGTA AGACGTCAGT GAAGAAACGG AATCTGAACC CGATCTTCAA CGAGACTCTG 
CGGCACTCTG TCCAGCAGGC TGATCTCCCA GGCCGCGTGC TGAGCCTGTC CGTGTGGCAC 
CGGGAAAGTC TGGGTCGCAA CATCTTCCTG GGAGAAGTAG AAGTGCCCCT AGACACATGG 
AACTGGGACT CTGAGGCTAC CTGGCTCCCC CTGCAGCCTC GGGTTCCTCC ATCTCCAGAT 
GAGCTTCCCA GCCGTGGACT GCTGTCTCTG TCCCTTAAGT ATGTCCCTGC CGGCTCAGAG 
GGAGGAGGAC AGCCTCAGAG TGGGGAGTTA CACTTCTGGG TAAAGGAAGC TCAGAGCCTG 
GTACCACTGC GACCAGGATC CCTGGACACT TACATTCAAT GCTCAGTGCT GCCTGATGAC 
AGTCGGGCCA GCCGCCAACG CACAAGAGTG GTTCGAAGAA GTCTCAGCCC TGTGTTCAAC 
CACACCATGG TTTATGACGG CTTCGGGCCT GCTGACCTAC GCCAGGCCTG TGCCGAGCTC 
TCCCTGTGGG ACCATGGGGC CCTGGCCAGT CGCCAGCTGG GGGGCACACG CCTCAGCCTT 
GGTACAGGCA GCAGTTATGG GCTTCAGGTG CCCTGGATGG ATTCCACACC GGAGGAGAAG 
CAGCTGTGGC AGACACTCCT GGAGCGGCCC TGTGAGTGGG TGGATGGCCT TCTGCCCCTC 
AGAACCAACC TGGTCCCCAG GGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011248567.1
CDS	62..1768
Translation	MPQRGHPSQERLWALPSLPMAHGPGSEAEGLLDLSFLTEEEQEAISDVLKRDAHLRQLEEGRVSKLRASLEDPWQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKSPKGDQALGSDGEAEAAGENTIEGEPESRVSIEVAAPERNTETQGPDLFSPYVPSKASEGQEEEPQDQECELEAPGEGGVQVAEADPELDPEQKAEQESQPTPAQSKATSKILENGEEAPGLGPSLDRMLSSSSSVSSLNSSTLSGSLMSLSGEAEAGTVQVRGSVLFSLRYEPGTSELRVQVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTSVKKRNLNPIFNETLRHSVQQADLPGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNWDSEATWLPLQPRVPPSPDELPSRGLLSLSLKYVPAGSEGGGQPQSGELHFWVKEAQSLVPLRPGSLDTYIQCSVLPDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALASRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQTLLERPCEWVDGLLPLRTNLVPRA

Target ORF information:

RefSeq Version	XM_011250265.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus synaptotagmin-like 1 (Sytl1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250265.1

ORF Insert Sequence:

ATGCCCCAGA GAGGCCACCC ATCTCAGGAG AGGCTTTGGG CCCTGCCCTC CCTCCCCATG 
GCACATGGAC CAGGATCTGA AGCTGAGGGG TTGCTGGACC TCAGCTTCCT GACAGAGGAG 
GAACAGGAGG CCATCTCTGA TGTCCTCAAA CGAGATGCCC ACCTGCGCCA GCTGGAGGAA 
GGGCGGGTCA GCAAGCTCCG GGCCTCCCTG GAAGACCCCT GGCAGCTGAA GATCCTGACA 
GGGGACTGGT TCCAAGAAGC GCGTTCCCAG AGGCACCATC ACGCCCATTT TGGTTCTGAC 
CTCGTCCGGG CTTCTATCCG AAGGAAGAAG AGCCCAAAGG GGGACCAGGC TCTGGGGAGT 
GATGGTGAAG CAGAGGCTGC TGGGGAAAAC ACCATTGAAG GAGAGCCGGA GTCCAGGGTC 
TCCATAGAGG TGGCAGCTCC AGAGAGAAAC ACTGAGACCC AAGGGCCTGA TTTGTTCTCA 
CCATATGTAC CCTCAAAGGC TTCCGAAGGT CAGGAGGAGG AGCCCCAGGA CCAGGAATGT 
GAGCTGGAGG CCCCTGGCGA AGGGGGTGTG CAGGTGGCAG AGGCGGACCC AGAGCTGGAT 
CCTGAGCAGA AGGCGGAGCA GGAGTCCCAG CCAACTCCAG CCCAGTCCAA GGCGACCTCC 
AAGATCCTGG AGAATGGAGA AGAGGCCCCG GGGCTCGGCC CCTCTCTTGA CCGCATGCTC 
AGCAGCAGCT CCTCTGTGTC CAGCCTCAAT TCCTCTACGC TGAGCGGCAG CCTGATGAGC 
CTATCCGGGG AGGCAGAGGC AGGCACGGTG CAGGTGCGAG GCTCCGTGCT CTTCTCGCTG 
CGCTACGAGC CTGGCACCTC TGAGCTGCGA GTACAGGTGA TCCAGTGCCA GGGCCTGGCC 
GCTGCCCGGC GACGCCGCTC CGATCCCTAC GTGAAAAGCT ACCTCCTCCC GGATAAGCAG 
AGCAAGCGTA AGACGTCAGT GAAGAAACGG AATCTGAACC CGATCTTCAA CGAGACTCTG 
CGGCACTCTG TCCAGCAGGC TGATCTCCCA GGCCGCGTGC TGAGCCTGTC CGTGTGGCAC 
CGGGAAAGTC TGGGTCGCAA CATCTTCCTG GGAGAAGTAG AAGTGCCCCT AGACACATGG 
AACTGGGACT CTGAGGCTAC CTGGCTCCCC CTGCAGCCTC GGGTTCCTCC ATCTCCAGAT 
GAGCTTCCCA GCCGTGGACT GCTGTCTCTG TCCCTTAAGT ATGTCCCTGC CGGCTCAGAG 
GGAGGAGGAC AGCCTCAGAG TGGGGAGTTA CACTTCTGGG TAAAGGAAGC TCAGAGCCTG 
GTACCACTGC GACCAGGATC CCTGGACACT TACATTCAAT GCTCAGTGCT GCCTGATGAC 
AGTCGGGCCA GCCGCCAACG CACAAGAGTG GTTCGAAGAA GTCTCAGCCC TGTGTTCAAC 
CACACCATGG TTTATGACGG CTTCGGGCCT GCTGACCTAC GCCAGGCCTG TGCCGAGCTC 
TCCCTGTGGG ACCATGGGGC CCTGGCCAGT CGCCAGCTGG GGGGCACACG CCTCAGCCTT 
GGTACAGGCA GCAGTTATGG GCTTCAGGTG CCCTGGATGG ATTCCACACC GGAGGAGAAG 
CAGCTGTGGC AGACACTCCT GGAGCGGCCC TGTGAGTGGG TGGATGGCCT TCTGCCCCTC 
AGAACCAACC TGGTCCCCAG GGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.
The Journal of clinical investigation126(11)4125-4139(2016 Nov)
Kurz AR,Pruenster M,Rohwedder I,Ramadass M,Sch?fer K,Harrison U,Gouveia G,Nussbaum C,Immler R,Wiessner JR,Margraf A,Lim DS,Walzog B,Dietzel S,Moser M,Klein C,Vestweber D,Haas R,Catz SD,Sperandio M

MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.
The Journal of clinical investigation126(5)1664-78(2016 May)
Yokoyama T,Nakatake M,Kuwata T,Couzinet A,Goitsuka R,Tsutsumi S,Aburatani H,Valk PJ,Delwel R,Nakamura T

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Disease models & mechanisms7(5)515-24(2014 May)
Adissu HA,Estabel J,Sunter D,Tuck E,Hooks Y,Carragher DM,Clarke K,Karp NA,,Newbigging S,Jones N,Morikawa L,White JK,McKerlie C

The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Molecular biology of the cell24(3)319-30(2013 Feb)
Wang H,Ishizaki R,Xu J,Kasai K,Kobayashi E,Gomi H,Izumi T

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Molecular biology of the cell23(10)1902-16(2012 May)
Johnson JL,Monfregola J,Napolitano G,Kiosses WB,Catz SD

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Sytl1 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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