Cops6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cops6
Entrez Gene ID	26893
Full Name	COP9 signalosome subunit 6
Synonyms	Sgn3,VIP/MOV34
General protein information	Preferred Names COP9 signalosome subunit 6 Names COP9 signalosome complex subunit 6 COP9 (constitutive photomorphogenic) homolog, subunit 6 COP9 (constitutive photomorphogenic), subunit 6 COP9 complex S6 JAB1-containing signalosome subunit 6 SGN6 signalosome subunit 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_012002.3	NP_036132.1	COP9 signalosome complex subunit 6

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cops6	NP_001017768.1
Drosophila melanogaster (fruit fly)	CSN6	NP_524451.1
Magnaporthe oryzae (rice blast fungus)	MGG_01432	XP_003714381.1
Neurospora crassa	NCU07019	XP_961840.1
Arabidopsis thaliana (thale cress)	CSN6A	NP_568839.1
Arabidopsis thaliana (thale cress)	CSN6B	NP_567746.1
Xenopus tropicalis (tropical clawed frog)	cops6	NP_001006723.1
Pan troglodytes (chimpanzee)	COPS6	XP_001146264.1
Caenorhabditis elegans (roundworm)	csn-6	NP_001255725.1
Homo sapiens (human)	COPS6	NP_006824.2
Rattus norvegicus (Norway rat)	Cops6	NP_001100599.1
	LOC710667	XP_001100125.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008156	XP_317307.4
Canis lupus familiaris (dog)	COPS6	XP_536866.3
Bos taurus (cattle)	COPS6	NP_001095433.1
Mus musculus (house mouse)	Cops6	NP_036132.1
Oryza sativa (rice)	Os08g0500000	NP_001062152.2

Gene Ontology
Bibliography

Related articles in PubMed

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.
Dai N, Zhao L, Wrighting D, Kr?mer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J
Cell metabolism21(4)609-21(2015 Apr)

CSN6 drives carcinogenesis by positively regulating Myc stability.
Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH
Nature communications55384(2014 Nov)

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH
The Journal of clinical investigation121(3)851-65(2011 Mar)

Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS biology2(9)E247(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results define a mechanism for the regulation of Myc stability through the CSN-Cullin-Fbxw7 axis and provide insights into the correlation of CSN6 overexpression with Myc stabilization/activation during tumorigenesis
Title: CSN6 drives carcinogenesis by positively regulating Myc stability.

loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway
Title: Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.

The following Cops6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cops6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09305	NM_012002.3 Latest version!	Mus musculus COP9 signalosome subunit 6 (Cops6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cops6 ( NM_012002.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036132.1 Mus musculus COP9 signalosome subunit 6 (Cops6), mRNA.

Price & Availability↑

CloneID	OMu09305
Clone ID Related Accession (Same CDS sequence)	NM_012002.3
Accession Version	NM_012002.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 975bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	COP9 signalosome complex subunit 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC151719.3. On Apr 28, 2007 this sequence version replaced NM_012002.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC004664.1, AK146775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG CAGCTGCGGC GGGGGCGAAT GGGAGCGGAG GCAGCAGCGG CATGGAAGTG 
GATGCAGCAG TCCCCAGCGT GATGGCCTCC GGAGTGACTG GGAGTGTTTC CGTCGCTCTT 
CATCCCCTTG TCATCCTTAA CATCTCAGAC CATTGGATCC GCATGCGCTC CCAGGAGGGG 
CGGCCTATGC AGGTGATTGG GGCTCTGATC GGGAAGCAGG AGGGGCGAAA TATCGAAGTG 
ATGAACTCCT TTGAGCTGCT GTCCCACACC GTGGAAGAGA AGATTATCAT TGACAAAGAA 
TATTATTACA CCAAGGAGGA GCAGTTTAAA CAGGTTTTCA AGGAGCTGGA GTTTCTGGGT 
TGGTATACCA CAGGGGGGCC ACCTGACCCC TCAGACATCC ACGTCCATAA GCAGGTGTGT 
GAGATAATTG AGAGTCCGCT CTTTCTGAAG TTGAACCCTA TGACCAAGCA CACAGATCTT 
CCTGTCAGCG TTTTTGAGTC TGTCATCGAT ATAATCAATG GAGAGGCCAC AATGCTGTTT 
GCTGAGCTCA CTTACACTCT GGCCACTGAG GAAGCTGAAC GGATCGGTGT AGACCACGTG 
GCCCGGATGA CAGCAACAGG CAGTGGGGAG AACTCCACTG TGGCTGAACA CCTGATAGCT 
CAGCATAGTG CCATCAAGAT GCTGCACAGC CGTGTGAAGC TCATTTTAGA ATATGTCAAG 
GCCTCTGAAG CAGGAGAGGT TCCCTTCAAC CATGAGATCC TGCGGGAGGC CTATGCCCTA 
TGTCACTGTC TTCCAGTTCT CAGCACTGAC AAGTTCAAGA CAGACTTTTA TGATCAATGC 
AATGACGTGG GGCTCATGGC CTACCTCGGC ACCATCACCA AAACGTGCAA CACAATGAAC 
CAGTTTGTGA ACAAGTTCAA CGTCCTCTAC GACCGACAAG GCATTGGCCG GCGAATGCGG 
GGACTGTTTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036132.1
CDS	12..986
Translation	MAAAAAAGANGSGGSSGMEVDAAVPSVMASGVTGSVSVALHPLVILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF

Target ORF information:

RefSeq Version	NM_012002.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus COP9 signalosome subunit 6 (Cops6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012002.3

ORF Insert Sequence:

ATGGCGGCGG CAGCTGCGGC GGGGGCGAAT GGGAGCGGAG GCAGCAGCGG CATGGAAGTG 
GATGCAGCAG TCCCCAGCGT GATGGCCTCC GGAGTGACTG GGAGTGTTTC CGTCGCTCTT 
CATCCCCTTG TCATCCTTAA CATCTCAGAC CATTGGATCC GCATGCGCTC CCAGGAGGGG 
CGGCCTATGC AGGTGATTGG GGCTCTGATC GGGAAGCAGG AGGGGCGAAA TATCGAAGTG 
ATGAACTCCT TTGAGCTGCT GTCCCACACC GTGGAAGAGA AGATTATCAT TGACAAAGAA 
TATTATTACA CCAAGGAGGA GCAGTTTAAA CAGGTTTTCA AGGAGCTGGA GTTTCTGGGT 
TGGTATACCA CAGGGGGGCC ACCTGACCCC TCAGACATCC ACGTCCATAA GCAGGTGTGT 
GAGATAATTG AGAGTCCGCT CTTTCTGAAG TTGAACCCTA TGACCAAGCA CACAGATCTT 
CCTGTCAGCG TTTTTGAGTC TGTCATCGAT ATAATCAATG GAGAGGCCAC AATGCTGTTT 
GCTGAGCTCA CTTACACTCT GGCCACTGAG GAAGCTGAAC GGATCGGTGT AGACCACGTG 
GCCCGGATGA CAGCAACAGG CAGTGGGGAG AACTCCACTG TGGCTGAACA CCTGATAGCT 
CAGCATAGTG CCATCAAGAT GCTGCACAGC CGTGTGAAGC TCATTTTAGA ATATGTCAAG 
GCCTCTGAAG CAGGAGAGGT TCCCTTCAAC CATGAGATCC TGCGGGAGGC CTATGCCCTA 
TGTCACTGTC TTCCAGTTCT CAGCACTGAC AAGTTCAAGA CAGACTTTTA TGATCAATGC 
AATGACGTGG GGCTCATGGC CTACCTCGGC ACCATCACCA AAACGTGCAA CACAATGAAC 
CAGTTTGTGA ACAAGTTCAA CGTCCTCTAC GACCGACAAG GCATTGGCCG GCGAATGCGG 
GGACTGTTTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.
Cell metabolism21(4)609-21(2015 Apr)
Dai N,Zhao L,Wrighting D,Kr?mer D,Majithia A,Wang Y,Cracan V,Borges-Rivera D,Mootha VK,Nahrendorf M,Thorburn DR,Minichiello L,Altshuler D,Avruch J

CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications55384(2014 Nov)
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
The Journal of clinical investigation121(3)851-65(2011 Mar)
Zhao R,Yeung SC,Chen J,Iwakuma T,Su CH,Chen B,Qu C,Zhang F,Chen YT,Lin YL,Lee DF,Jin F,Zhu R,Shaikenov T,Sarbassov D,Sahin A,Wang H,Wang H,Lai CC,Tsai FJ,Lozano G,Lee MH

Genomic analysis of mouse retinal development.
PLoS biology2(9)E247(2004 Sep)
Blackshaw S,Harpavat S,Trimarchi J,Cai L,Huang H,Kuo WP,Weber G,Lee K,Fraioli RE,Cho SH,Yung R,Asch E,Ohno-Machado L,Wong WH,Cepko CL

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Cops6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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