Fbxo45 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbxo45
Entrez Gene ID	268882
Full Name	F-box protein 45
Synonyms	2610017J04Rik,AI463119,BC026799
General protein information	Preferred Names F-box protein 45 Names F-box/SPRY domain-containing protein 1 F-box only protein 45 fbxo45 mFbxo45
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 B2

mRNA and Protein(s)

mRNA	Protein	Name
NM_173439.2	NP_775615.2	F-box/SPRY domain-containing protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXO45	NP_001099043.1
Drosophila melanogaster (fruit fly)	Fsn	NP_725266.1
Caenorhabditis elegans (roundworm)	fsn-1	NP_498046.1
Mus musculus (house mouse)	Fbxo45	NP_775615.2
Rattus norvegicus (Norway rat)	Fbxo45	XP_006248538.1
Gallus gallus (chicken)	FBXO45	XP_001232841.3
Danio rerio (zebrafish)	fbxo45	NP_956889.1
Canis lupus familiaris (dog)	FBXO45	XP_851899.2
Bos taurus (cattle)	FBXO45	NP_001193687.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012460	XP_309899.3
Xenopus tropicalis (tropical clawed frog)	fbxo45	NP_001135592.1

Gene Ontology
Bibliography

Related articles in PubMed

Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation.
Chung FZ, Sahasrabuddhe AA, Ma K, Chen X, Basrur V, Lim MS, Elenitoba-Johnson KS
The Journal of biological chemistry289(41)28448-59(2014 Oct)

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
Chen X, Sahasrabuddhe AA, Szankasi P, Chung F, Basrur V, Rangnekar VM, Pagano M, Lim MS, Elenitoba-Johnson KS
Cell death and differentiation21(10)1535-45(2014 Oct)

The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.
Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V
The Journal of biological chemistry287(36)30063-72(2012 Aug)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
The Journal of biological chemistry285(6)3840-9(2010 Feb)

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HJ, Okano H, Nakayama KI
Molecular and cellular biology29(13)3529-43(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fbxo45 binds to N-cadherin intracellularly and prevents its degradation thereby playing a key role in promoting N-cadherin-mediated neuronal differentiation.
Title: Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation.

Data suggest that Fbxo45 plays an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse.
Title: Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.

Results suggest that Fbxo45 forms a novel Fbxo45-PAM ubiquitin ligase complex that plays an important role in neural development.
Title: Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.

The following Fbxo45 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbxo45 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04647	NM_173439.2 Latest version!	Mus musculus F-box protein 45 (Fbxo45), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbxo45 ( NM_173439.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_775615.2 Mus musculus F-box protein 45 (Fbxo45), mRNA.

Price & Availability↑

CloneID	OMu04647
Clone ID Related Accession (Same CDS sequence)	NM_173439.2
Accession Version	NM_173439.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	F-box/SPRY domain-containing protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088738.1. On or before May 25, 2005 this sequence version replaced XM_622647.1, NM_173439.1. ##Evidence-Data-START## Transcript exon combination :: BC088738.1, BC026799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGC CGGGCCCGGG GGCTGGGGCA GCCTCGGGCG GCGCTAGTGG TGGCGGCGCC 
GGTGCCGGCG GCGGCGCCAG CGCGGGCTCG GGGTCCTCCG GGGTCGGCGG CCGGTTGCCC 
AGCCGGGTGC TGGAGTTGGT GTTCTCCTAC CTGGAGCTGT CCGAGCTGCG GAGCTGCGCC 
CTGGTTTGCA AGCACTGGTA CCGCTGCCTC CACGGCGACG AGAACAGCGA GGTGTGGCGG 
AGCCTGTGCG CCCGCAGCCT AGCAGAAGAG GCTCTGCGCA CGGACATCCT CTGCAACCTG 
CCCAGCTACA AGGCCAAGGT GCGTGCTTTC CAACATGCCT TCAGCACGAA TGACTGCTCC 
AGGAATGTCT ATATCAAGAA GAATGGTTTT ACATTACATC GGAACCCCAT CGCTCAGAGC 
ACTGATGGTG CAAGGACCAA GATTGGTTTC AGTGAGGGCC GCCACGCCTG GGAAGTGTGG 
TGGGAGGGCC CTTTGGGCAC GGTGGCAGTG ATTGGGATTG CTACGAAACG GGCCCCCATG 
CAGTGCCAAG GTTATGTGGC CTTGCTGGGA AGTGACGACC AGAGCTGGGG CTGGAATCTG 
GTGGACAATA ATCTACTACA TAACGGGGAA GTCAACGGCA GCTTCCCACA GTGCAACAAC 
GCACCAAAGT ATCAGATAGG AGAGAGAATC CGAGTCATCC TGGACATGGA GGATAAGACT 
TTAGCTTTTG AGCGTGGGTA TGAGTTCCTG GGGGTTGCCT TTCGAGGACT TCCAAAAGCC 
TGCTTATACC CAGCTGTCTC TGCAGTATAT GGCAACACAG AAGTGACTTT GGTTTATCTT 
GGAAAACCTC TGGATGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775615.2
CDS	215..1075
Translation	MAAPGPGAGAASGGASGGGAGAGGGASAGSGSSGVGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKVRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKACLYPAVSAVYGNTEVTLVYLGKPLDG

Target ORF information:

RefSeq Version	NM_173439.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box protein 45 (Fbxo45), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173439.2

ORF Insert Sequence:

ATGGCGGCGC CGGGCCCGGG GGCTGGGGCA GCCTCGGGCG GCGCTAGTGG TGGCGGCGCC 
GGTGCCGGCG GCGGCGCCAG CGCGGGCTCG GGGTCCTCCG GGGTCGGCGG CCGGTTGCCC 
AGCCGGGTGC TGGAGTTGGT GTTCTCCTAC CTGGAGCTGT CCGAGCTGCG GAGCTGCGCC 
CTGGTTTGCA AGCACTGGTA CCGCTGCCTC CACGGCGACG AGAACAGCGA GGTGTGGCGG 
AGCCTGTGCG CCCGCAGCCT AGCAGAAGAG GCTCTGCGCA CGGACATCCT CTGCAACCTG 
CCCAGCTACA AGGCCAAGGT GCGTGCTTTC CAACATGCCT TCAGCACGAA TGACTGCTCC 
AGGAATGTCT ATATCAAGAA GAATGGTTTT ACATTACATC GGAACCCCAT CGCTCAGAGC 
ACTGATGGTG CAAGGACCAA GATTGGTTTC AGTGAGGGCC GCCACGCCTG GGAAGTGTGG 
TGGGAGGGCC CTTTGGGCAC GGTGGCAGTG ATTGGGATTG CTACGAAACG GGCCCCCATG 
CAGTGCCAAG GTTATGTGGC CTTGCTGGGA AGTGACGACC AGAGCTGGGG CTGGAATCTG 
GTGGACAATA ATCTACTACA TAACGGGGAA GTCAACGGCA GCTTCCCACA GTGCAACAAC 
GCACCAAAGT ATCAGATAGG AGAGAGAATC CGAGTCATCC TGGACATGGA GGATAAGACT 
TTAGCTTTTG AGCGTGGGTA TGAGTTCCTG GGGGTTGCCT TTCGAGGACT TCCAAAAGCC 
TGCTTATACC CAGCTGTCTC TGCAGTATAT GGCAACACAG AAGTGACTTT GGTTTATCTT 
GGAAAACCTC TGGATGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation.
The Journal of biological chemistry289(41)28448-59(2014 Oct)
Chung FZ,Sahasrabuddhe AA,Ma K,Chen X,Basrur V,Lim MS,Elenitoba-Johnson KS

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
Cell death and differentiation21(10)1535-45(2014 Oct)
Chen X,Sahasrabuddhe AA,Szankasi P,Chung F,Basrur V,Rangnekar VM,Pagano M,Lim MS,Elenitoba-Johnson KS

The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.
The Journal of biological chemistry287(36)30063-72(2012 Aug)
Han S,Kim S,Bahl S,Li L,Burande CF,Smith N,James M,Beauchamp RL,Bhide P,DiAntonio A,Ramesh V

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
The Journal of biological chemistry285(6)3840-9(2010 Feb)
Tada H,Okano HJ,Takagi H,Shibata S,Yao I,Matsumoto M,Saiga T,Nakayama KI,Kashima H,Takahashi T,Setou M,Okano H

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Molecular and cellular biology29(13)3529-43(2009 Jul)
Saiga T,Fukuda T,Matsumoto M,Tada H,Okano HJ,Okano H,Nakayama KI

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Fbxo45 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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