Pla2g10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pla2g10
Entrez Gene ID	26565
Full Name	phospholipase A2, group X
Synonyms	GX sPLA2,PLA2GX,sPLA2-X
General protein information	Preferred Names phospholipase A2, group X Names group 10 secretory phospholipase A2 group X secretory phospholipase A2 phosphatidylcholine 2-acylhydrolase 10
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A1\|16 9.5 cM
Summary	This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017316987.1	XP_017172476.1	group 10 secretory phospholipase A2 isoform X1
XM_017316987.2	XP_017172476.1	group 10 secretory phospholipase A2 isoform X1
NM_011987.4	NP_036117.1	group 10 secretory phospholipase A2 isoform 1 preproprotein
NM_001291009.2	NP_001277938.1	group 10 secretory phospholipase A2 isoform 2 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PLA2G10	NP_003552.1
Pan troglodytes (chimpanzee)	PLA2G10	XP_001143002.1
	LOC717517	XP_001109076.2
Gallus gallus (chicken)	LOC418356	XP_003640502.1
Xenopus tropicalis (tropical clawed frog)	LOC100492785	XP_002935521.1
Canis lupus familiaris (dog)	PLA2G10	XP_005622132.1
Danio rerio (zebrafish)	zgc:92162	NP_001002350.1
Bos taurus (cattle)	PLA2G10	XP_002698051.2
Mus musculus (house mouse)	Pla2g10	NP_036117.1
Rattus norvegicus (Norway rat)	Pla2g10	NP_058872.1
Gallus gallus (chicken)	PLA2G10	NP_001171686.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.
Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, B?ttcher R, van Royen ME, Jeammet L, Payr? C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R
Cell stem cell19(1)38-51(2016 Jul)

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.
Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb MH, Yamamoto K, Murakami M
The Journal of biological chemistry291(30)15588-601(2016 07)

Group X Secreted Phospholipase A2 Releases ?3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.
Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M
The Journal of biological chemistry291(13)6895-911(2016 Mar)

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2? (iPLA2?) and Group X Secreted Phospholipase A2 (sPLA2).
Abi Nahed R, Martinez G, Escoffier J, Yassine S, Karaouz?ne T, Hograindleur JP, Turk J, Kokotos G, Ray PF, Bottari S, Lambeau G, Hennebicq S, Arnoult C
The Journal of biological chemistry291(6)3076-89(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer.
Title: Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

PLA2G10 releases omega-3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility.
Title: Group X Secreted Phospholipase A2 Releases ?3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta) and Group X Secreted Phospholipase A2 (sPLA2).
Title: Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2? (iPLA2?) and Group X Secreted Phospholipase A2 (sPLA2).

GX sPLA2 negatively regulated pancreatic insulin secretion by augmenting COX-2-dependent PGE2 production.
Title: Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.

Authors propose that activation of GX-sPLA2 during H1N1pdm infection is an early step of pulmonary inflammation and its inhibition increases adaptive immunity and improves survival.
Title: Lack of group X secreted phospholipase A? increases survival following pandemic H1N1 influenza infection.

The following Pla2g10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pla2g10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17116	NM_001291009.2 Latest version!	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu14413	NM_011987.4 Latest version!	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu79328	XM_017316987.2 Latest version!	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu79328	XM_017316987.1	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pla2g10 ( NM_001291009.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277938.1 Mus musculus phospholipase A2, group X (Pla2g10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17116
Clone ID Related Accession (Same CDS sequence)	NM_001291009.2
Accession Version	NM_001291009.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	group 10 secretory phospholipase A2 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC154607.2, AK076921.1 and AV075661.1. On Jul 21, 2015 this sequence version replaced NM_001291009.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028879.1, BF584442.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TACTGCTGCT GTTGCTGCTG GGACCTGGAC CCGGATTCAG CGAAGCAACC 
AGGAGGTCAC ATGTATACAA GCGTGGACTC CTGGAGCTGG CAGGGACCTT GGATTGTGTT 
GGGCCTCGAT CTCCGATGGC TTACATGAAC TATGGCTGTT ATTGTGGCCT TGGTGGCCAT 
GGAGAGCCAC GTGACGCCAT TGACTGGTGC TGCTACCACC ACGACTGCTG CTACTCTCGG 
GCTCAGGACG CTGGCTGCAG CCCTAAGTTA GACCGCTACC CATGGAAGTG CATGGACCAT 
CACATCCTGT GTGGTGAGTG CCCTATGCCG TGTGACTTCC CCAAGTGCCC ACTGGACATC 
CTGCAGATCC CAATGGCTCC TGTACCCTTG TGGACCAGCA GAGAACAAAT GCCAAGAACT 
TTTGTGCAGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277938.1
CDS	74..508
Translation	MLLLLLLLLLGPGPGFSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYHHDCCYSRAQDAGCSPKLDRYPWKCMDHHILCGECPMPCDFPKCPLDILQIPMAPVPLWTSREQMPRTFVQV

Target ORF information:

RefSeq Version	NM_001291009.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291009.2

ORF Insert Sequence:

ATGCTGCTGC TACTGCTGCT GTTGCTGCTG GGACCTGGAC CCGGATTCAG CGAAGCAACC 
AGGAGGTCAC ATGTATACAA GCGTGGACTC CTGGAGCTGG CAGGGACCTT GGATTGTGTT 
GGGCCTCGAT CTCCGATGGC TTACATGAAC TATGGCTGTT ATTGTGGCCT TGGTGGCCAT 
GGAGAGCCAC GTGACGCCAT TGACTGGTGC TGCTACCACC ACGACTGCTG CTACTCTCGG 
GCTCAGGACG CTGGCTGCAG CCCTAAGTTA GACCGCTACC CATGGAAGTG CATGGACCAT 
CACATCCTGT GTGGTGAGTG CCCTATGCCG TGTGACTTCC CCAAGTGCCC ACTGGACATC 
CTGCAGATCC CAATGGCTCC TGTACCCTTG TGGACCAGCA GAGAACAAAT GCCAAGAACT 
TTTGTGCAGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pla2g10 ( NM_011987.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036117.1 Mus musculus phospholipase A2, group X (Pla2g10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu14413
Clone ID Related Accession (Same CDS sequence)	NM_011987.4
Accession Version	NM_011987.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	group 10 secretory phospholipase A2 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC154607.2, AK076921.1 and AV075661.1. On Jul 21, 2015 this sequence version replaced NM_011987.3. Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF892392.1, AF166097.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TACTGCTGCT GTTGCTGCTG GGACCTGGAC CCGGATTCAG CGAAGCAACC 
AGGAGGTCAC ATGTATACAA GCGTGGACTC CTGGAGCTGG CAGGGACCTT GGATTGTGTT 
GGGCCTCGAT CTCCGATGGC TTACATGAAC TATGGCTGTT ATTGTGGCCT TGGTGGCCAT 
GGAGAGCCAC GTGACGCCAT TGACTGGTGC TGCTACCACC ACGACTGCTG CTACTCTCGG 
GCTCAGGACG CTGGCTGCAG CCCTAAGTTA GACCGCTACC CATGGAAGTG CATGGACCAT 
CACATCCTGT GTGGACCAGC AGAGAACAAA TGCCAAGAAC TTTTGTGCAG GTGTGACGAG 
GAGCTGGCTT ACTGCCTGGC AGGGACCGAG TACCACCTGA AATACCTCTT CTTCCCCTCC 
ATTTTATGTG AGAAGGACTC TCCCAAGTGC AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036117.1
CDS	74..529
Translation	MLLLLLLLLLGPGPGFSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYHHDCCYSRAQDAGCSPKLDRYPWKCMDHHILCGPAENKCQELLCRCDEELAYCLAGTEYHLKYLFFPSILCEKDSPKCN

Target ORF information:

RefSeq Version	NM_011987.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011987.4

ORF Insert Sequence:

ATGCTGCTGC TACTGCTGCT GTTGCTGCTG GGACCTGGAC CCGGATTCAG CGAAGCAACC 
AGGAGGTCAC ATGTATACAA GCGTGGACTC CTGGAGCTGG CAGGGACCTT GGATTGTGTT 
GGGCCTCGAT CTCCGATGGC TTACATGAAC TATGGCTGTT ATTGTGGCCT TGGTGGCCAT 
GGAGAGCCAC GTGACGCCAT TGACTGGTGC TGCTACCACC ACGACTGCTG CTACTCTCGG 
GCTCAGGACG CTGGCTGCAG CCCTAAGTTA GACCGCTACC CATGGAAGTG CATGGACCAT 
CACATCCTGT GTGGACCAGC AGAGAACAAA TGCCAAGAAC TTTTGTGCAG GTGTGACGAG 
GAGCTGGCTT ACTGCCTGGC AGGGACCGAG TACCACCTGA AATACCTCTT CTTCCCCTCC 
ATTTTATGTG AGAAGGACTC TCCCAAGTGC AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pla2g10 ( XM_017316987.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017172476.1 Mus musculus phospholipase A2, group X (Pla2g10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu79328
Clone ID Related Accession (Same CDS sequence)	XM_017316987.1 , XM_017316987.2
Accession Version	XM_017316987.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	group 10 secretory phospholipase A2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTACA TGAACTATGG CTGTTATTGT GGCCTTGGTG GCCATGGAGA GCCACGTGAC 
GCCATTGACT GGTGCTGCTA CCACCACGAC TGCTGCTACT CTCGGGCTCA GGACGCTGGC 
TGCAGCCCTA AGTTAGACCG CTACCCATGG AAGTGCATGG ACCATCACAT CCTGTGTGGA 
CCAGCAGAGA ACAAATGCCA AGAACTTTTG TGCAGGTGTG ACGAGGAGCT GGCTTACTGC 
CTGGCAGGGA CCGAGTACCA CCTGAAATAC CTCTTCTTCC CCTCCATTTT ATGTGAGAAG 
GACTCTCCCA AGTGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017172476.1
CDS	568..888
Translation	MAYMNYGCYCGLGGHGEPRDAIDWCCYHHDCCYSRAQDAGCSPKLDRYPWKCMDHHILCGPAENKCQELLCRCDEELAYCLAGTEYHLKYLFFPSILCEKDSPKCN

Target ORF information:

RefSeq Version	XM_017316987.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017316987.1

ORF Insert Sequence:

ATGGCTTACA TGAACTATGG CTGTTATTGT GGCCTTGGTG GCCATGGAGA GCCACGTGAC 
GCCATTGACT GGTGCTGCTA CCACCACGAC TGCTGCTACT CTCGGGCTCA GGACGCTGGC 
TGCAGCCCTA AGTTAGACCG CTACCCATGG AAGTGCATGG ACCATCACAT CCTGTGTGGA 
CCAGCAGAGA ACAAATGCCA AGAACTTTTG TGCAGGTGTG ACGAGGAGCT GGCTTACTGC 
CTGGCAGGGA CCGAGTACCA CCTGAAATAC CTCTTCTTCC CCTCCATTTT ATGTGAGAAG 
GACTCTCCCA AGTGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pla2g10 ( XM_017316987.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017172476.1 Mus musculus phospholipase A2, group X (Pla2g10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu79328
Clone ID Related Accession (Same CDS sequence)	XM_017316987.1 , XM_017316987.2
Accession Version	XM_017316987.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	group 10 secretory phospholipase A2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017316987.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTACA TGAACTATGG CTGTTATTGT GGCCTTGGTG GCCATGGAGA GCCACGTGAC 
GCCATTGACT GGTGCTGCTA CCACCACGAC TGCTGCTACT CTCGGGCTCA GGACGCTGGC 
TGCAGCCCTA AGTTAGACCG CTACCCATGG AAGTGCATGG ACCATCACAT CCTGTGTGGA 
CCAGCAGAGA ACAAATGCCA AGAACTTTTG TGCAGGTGTG ACGAGGAGCT GGCTTACTGC 
CTGGCAGGGA CCGAGTACCA CCTGAAATAC CTCTTCTTCC CCTCCATTTT ATGTGAGAAG 
GACTCTCCCA AGTGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017172476.1
CDS	644..964
Translation	MAYMNYGCYCGLGGHGEPRDAIDWCCYHHDCCYSRAQDAGCSPKLDRYPWKCMDHHILCGPAENKCQELLCRCDEELAYCLAGTEYHLKYLFFPSILCEKDSPKCN

Target ORF information:

RefSeq Version	XM_017316987.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase A2, group X (Pla2g10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017316987.2

ORF Insert Sequence:

ATGGCTTACA TGAACTATGG CTGTTATTGT GGCCTTGGTG GCCATGGAGA GCCACGTGAC 
GCCATTGACT GGTGCTGCTA CCACCACGAC TGCTGCTACT CTCGGGCTCA GGACGCTGGC 
TGCAGCCCTA AGTTAGACCG CTACCCATGG AAGTGCATGG ACCATCACAT CCTGTGTGGA 
CCAGCAGAGA ACAAATGCCA AGAACTTTTG TGCAGGTGTG ACGAGGAGCT GGCTTACTGC 
CTGGCAGGGA CCGAGTACCA CCTGAAATAC CTCTTCTTCC CCTCCATTTT ATGTGAGAAG 
GACTCTCCCA AGTGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.
Cell stem cell19(1)38-51(2016 Jul)
Schewe M,Franken PF,Sacchetti A,Schmitt M,Joosten R,B?ttcher R,van Royen ME,Jeammet L,Payr? C,Scott PM,Webb NR,Gelb M,Cormier RT,Lambeau G,Fodde R

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.
The Journal of biological chemistry291(30)15588-601(2016 07)
Miki Y,Kidoguchi Y,Sato M,Taketomi Y,Taya C,Muramatsu K,Gelb MH,Yamamoto K,Murakami M

Group X Secreted Phospholipase A2 Releases ?3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.
The Journal of biological chemistry291(13)6895-911(2016 Mar)
Murase R,Sato H,Yamamoto K,Ushida A,Nishito Y,Ikeda K,Kobayashi T,Yamamoto T,Taketomi Y,Murakami M

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2? (iPLA2?) and Group X Secreted Phospholipase A2 (sPLA2).
The Journal of biological chemistry291(6)3076-89(2016 Feb)
Abi Nahed R,Martinez G,Escoffier J,Yassine S,Karaouz?ne T,Hograindleur JP,Turk J,Kokotos G,Ray PF,Bottari S,Lambeau G,Hennebicq S,Arnoult C

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Pla2g10 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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