Slc27a5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc27a5
Entrez Gene ID	26459
Full Name	solute carrier family 27 (fatty acid transporter), member 5
Synonyms	FACVL3,FATP5,VLCS-H2,VLCSH2,Vlacsr
General protein information	Preferred Names solute carrier family 27 (fatty acid transporter), member 5 Names bile acyl-CoA synthetase BA-CoA ligase BACS BAL FATP-5 VLACS-related bile acid-CoA ligase cholate--CoA ligase fatty acid transport protein 5 solute carrier family 27 member 5 very long-chain acyl-CoA synthetase-related protein very long-chain acyl-Coenzyme A dehydrogenase synthase related
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009512.2	NP_033538.2	bile acyl-CoA synthetase precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC27A5	NP_001096743.1
Mus musculus (house mouse)	Slc27a5	NP_033538.2
Homo sapiens (human)	SLC27A5	NP_036386.1
Pan troglodytes (chimpanzee)	SLC27A5	XP_001148729.1
	LOC713713	XP_001103163.2
Rattus norvegicus (Norway rat)	Slc27a5	NP_077057.1

Gene Ontology
Bibliography

Related articles in PubMed

ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).
Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kuklin NA, Mitnaul LJ
Lipids46(11)991-1003(2011 Nov)

Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.
Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L
Journal of proteome research10(10)4683-91(2011 Oct)

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
Mishima T, Miner JH, Morizane M, Stahl A, Sadovsky Y
PloS one6(10)e25865(2011)

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.
Doege H, Grimm D, Falcon A, Tsang B, Storm TA, Xu H, Ortegon AM, Kazantzis M, Kay MA, Stahl A
The Journal of biological chemistry283(32)22186-92(2008 Aug)

Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.
Schaiff WT, Knapp FF Jr, Barak Y, Biron-Shental T, Nelson DM, Sadovsky Y
Endocrinology148(8)3625-34(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fatp5 knockdown lead to a 100-fold increase in ratio of unconjugated to conjugated bile acids in ApoB defficient mice
Title: ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).

Slc27a5, also known as fatty acid transport protein 5 (FATP5), is the hepatic BA-CoA ligase involved in reconjugating BAs during enterohepatic BA recycling
Title: Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.

continued activity of hepatic fatty acid transport protein 5 is required to sustain caloric uptake and fatty acid flux into the liver during high fat feeding
Title: Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.

Efficient hepatocellular uptake of long-chain fatty acids, and thus liver lipid homeostasis in general, is largely protein-mediated process requiring fatty acid transport protein 5 (FATP5).
Title: Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis.

Important role for fatty acid transport protein 5(FATP5) in bile acid conjugation in vivo and an unexpected function in body weight homeostasis.
Title: Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity.

The following Slc27a5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc27a5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04315	NM_009512.2 Latest version!	Mus musculus solute carrier family 27 (fatty acid transporter), member 5 (Slc27a5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$405.30 $579.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc27a5 ( NM_009512.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033538.2 Mus musculus solute carrier family 27 (fatty acid transporter), member 5 (Slc27a5), mRNA.

Price & Availability↑

CloneID	OMu04315
Clone ID Related Accession (Same CDS sequence)	NM_009512.2
Accession Version	NM_009512.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	bile acyl-CoA synthetase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK144301.1, BC145825.1 and AI173562.1. On Apr 29, 2009 this sequence version replaced NM_009512.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013272.1, AJ223959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTATTT GGAAGAAACT AACCTTACTG CTGTTGCTGC TTCTGCTGGT TGGCCTGGGG 
CAGCCCCCAT GGCCAGCAGC TATGGCTCTG GCCCTGCGTT GGTTCCTGGG AGACCCCACA 
TGCCTTGTGC TGCTTGGCTT GGCATTGCTG GGCAGACCCT GGATCAGCTC CTGGATGCCC 
CACTGGCTGA GCCTGGTAGG AGCAGCTCTT ACCTTATTCC TATTGCCTCT ACAGCCACCC 
CCAGGGCTAC GCTGGCTGCA TAAAGATGTG GCTTTCACCT TCAAGATGCT TTTCTATGGC 
CTAAAGTTCA GGCGACGCCT TAACAAACAT CCTCCAGAGA CCTTTGTGGA TGCTTTAGAG 
CGGCAAGCAC TGGCATGGCC TGACCGGGTG GCCTTGGTGT GTACTGGGTC TGAGGGCTCC 
TCAATCACAA ATAGCCAGCT GGATGCCAGG TCCTGTCAGG CAGCATGGGT CCTGAAAGCA 
AAGCTGAAGG ATGCCGTAAT CCAGAACACA AGAGATGCTG CTGCTATCTT AGTTCTCCCG 
TCCAAGACCA TTTCTGCTTT GAGTGTGTTT CTGGGGTTGG CCAAGTTGGG CTGCCCTGTG 
GCCTGGATCA ATCCACACAG CCGAGGGATG CCCTTGCTAC ACTCTGTACG GAGCTCTGGG 
GCCAGTGTGC TGATTGTGGA TCCAGACCTC CAGGAGAACC TGGAAGAAGT CCTTCCCAAG 
CTGCTAGCTG AGAACATTCA CTGCTTCTAC CTTGGCCACA GCTCACCCAC CCCGGGAGTA 
GAGGCTCTGG GAGCTTCCCT GGATGCTGCA CCTTCTGACC CAGTACCTGC CAGCCTTCGA 
GCTACGATTA AGTGGAAATC TCCTGCCATA TTCATCTTTA CTTCAGGGAC CACTGGACTC 
CCAAAGCCAG CCATCTTATC ACATGAGCGG GTCATACAAG TGAGCAACGT GCTGTCCTTC 
TGTGGATGCA GAGCTGATGA TGTGGTCTAT GACGTCCTAC CTCTGTACCA TACGATAGGG 
CTTGTCCTTG GATTCCTTGG CTGCTTACAA GTTGGAGCCA CCTGTGTCCT GGCCCCCAAG 
TTCTCTGCCT CCCGATTCTG GGCTGAGTGC CGGCAGCATG GCGTAACAGT GATCTTGTAT 
GTGGGTGAAA TCCTGCGGTA CTTGTGTAAC GTCCCTGAGC AACCAGAAGA CAAGATACAT 
ACAGTGCGCT TGGCCATGGG CAATGGACTT CGGGCAAATG TGTGGAAAAA CTTCCAGCAA 
CGCTTTGGTC CCATTCGGAT CTGGGAATTC TACGGATCCA CAGAGGGCAA TGTGGGCTTA 
ATGAACTATG TGGGCCACTG CGGGGCTGTG GGAAGGACCA GCTGCATCCT TCGAATGCTG 
ACTCCCTTTG AGCTTGTACA GTTCGACATA GAGACAGCAG AGCCTCTGAG GGACAAACAG 
GGTTTTTGCA TTCCTGTGGA GCCAGGAAAG CCAGGACTTC TTTTGACCAA GGTTCGAAAG 
AACCAACCCT TCCTGGGCTA CCGTGGTTCC CAGGCCGAGT CCAATCGGAA ACTTGTTGCG 
AATGTACGAC GCGTAGGAGA CCTGTACTTC AACACTGGGG ACGTGCTGAC CTTGGACCAG 
GAAGGCTTCT TCTACTTTCA AGACCGCCTT GGTGACACCT TCCGGTGGAA GGGCGAAAAC 
GTATCTACTG GAGAGGTGGA GTGTGTTTTG TCTAGCCTAG ACTTCCTAGA GGAAGTCAAT 
GTCTATGGTG TGCCTGTGCC AGGGTGTGAG GGTAAGGTTG GCATGGCTGC TGTGAAACTG 
GCTCCTGGGA AGACTTTTGA TGGGCAGAAG CTATACCAGC ATGTCCGCTC CTGGCTCCCT 
GCCTATGCCA CACCTCATTT CATCCGTATC CAGGATTCCC TGGAGATCAC AAACACCTAC 
AAGCTGGTAA AGTCACGGCT GGTGCGTGAG GGTTTTGATG TGGGGATCAT TGCTGACCCC 
CTCTACATAC TGGACAACAA GGCCCAGACC TTCCGGAGTC TGATGCCAGA TGTGTACCAG 
GCTGTGTGTG AAGGAACCTG GAATCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033538.2
CDS	131..2200
Translation	MGIWKKLTLLLLLLLLVGLGQPPWPAAMALALRWFLGDPTCLVLLGLALLGRPWISSWMPHWLSLVGAALTLFLLPLQPPPGLRWLHKDVAFTFKMLFYGLKFRRRLNKHPPETFVDALERQALAWPDRVALVCTGSEGSSITNSQLDARSCQAAWVLKAKLKDAVIQNTRDAAAILVLPSKTISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVRSSGASVLIVDPDLQENLEEVLPKLLAENIHCFYLGHSSPTPGVEALGASLDAAPSDPVPASLRATIKWKSPAIFIFTSGTTGLPKPAILSHERVIQVSNVLSFCGCRADDVVYDVLPLYHTIGLVLGFLGCLQVGATCVLAPKFSASRFWAECRQHGVTVILYVGEILRYLCNVPEQPEDKIHTVRLAMGNGLRANVWKNFQQRFGPIRIWEFYGSTEGNVGLMNYVGHCGAVGRTSCILRMLTPFELVQFDIETAEPLRDKQGFCIPVEPGKPGLLLTKVRKNQPFLGYRGSQAESNRKLVANVRRVGDLYFNTGDVLTLDQEGFFYFQDRLGDTFRWKGENVSTGEVECVLSSLDFLEEVNVYGVPVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYATPHFIRIQDSLEITNTYKLVKSRLVREGFDVGIIADPLYILDNKAQTFRSLMPDVYQAVCEGTWNL

Target ORF information:

RefSeq Version	NM_009512.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 27 (fatty acid transporter), member 5 (Slc27a5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009512.2

ORF Insert Sequence:

ATGGGTATTT GGAAGAAACT AACCTTACTG CTGTTGCTGC TTCTGCTGGT TGGCCTGGGG 
CAGCCCCCAT GGCCAGCAGC TATGGCTCTG GCCCTGCGTT GGTTCCTGGG AGACCCCACA 
TGCCTTGTGC TGCTTGGCTT GGCATTGCTG GGCAGACCCT GGATCAGCTC CTGGATGCCC 
CACTGGCTGA GCCTGGTAGG AGCAGCTCTT ACCTTATTCC TATTGCCTCT ACAGCCACCC 
CCAGGGCTAC GCTGGCTGCA TAAAGATGTG GCTTTCACCT TCAAGATGCT TTTCTATGGC 
CTAAAGTTCA GGCGACGCCT TAACAAACAT CCTCCAGAGA CCTTTGTGGA TGCTTTAGAG 
CGGCAAGCAC TGGCATGGCC TGACCGGGTG GCCTTGGTGT GTACTGGGTC TGAGGGCTCC 
TCAATCACAA ATAGCCAGCT GGATGCCAGG TCCTGTCAGG CAGCATGGGT CCTGAAAGCA 
AAGCTGAAGG ATGCCGTAAT CCAGAACACA AGAGATGCTG CTGCTATCTT AGTTCTCCCG 
TCCAAGACCA TTTCTGCTTT GAGTGTGTTT CTGGGGTTGG CCAAGTTGGG CTGCCCTGTG 
GCCTGGATCA ATCCACACAG CCGAGGGATG CCCTTGCTAC ACTCTGTACG GAGCTCTGGG 
GCCAGTGTGC TGATTGTGGA TCCAGACCTC CAGGAGAACC TGGAAGAAGT CCTTCCCAAG 
CTGCTAGCTG AGAACATTCA CTGCTTCTAC CTTGGCCACA GCTCACCCAC CCCGGGAGTA 
GAGGCTCTGG GAGCTTCCCT GGATGCTGCA CCTTCTGACC CAGTACCTGC CAGCCTTCGA 
GCTACGATTA AGTGGAAATC TCCTGCCATA TTCATCTTTA CTTCAGGGAC CACTGGACTC 
CCAAAGCCAG CCATCTTATC ACATGAGCGG GTCATACAAG TGAGCAACGT GCTGTCCTTC 
TGTGGATGCA GAGCTGATGA TGTGGTCTAT GACGTCCTAC CTCTGTACCA TACGATAGGG 
CTTGTCCTTG GATTCCTTGG CTGCTTACAA GTTGGAGCCA CCTGTGTCCT GGCCCCCAAG 
TTCTCTGCCT CCCGATTCTG GGCTGAGTGC CGGCAGCATG GCGTAACAGT GATCTTGTAT 
GTGGGTGAAA TCCTGCGGTA CTTGTGTAAC GTCCCTGAGC AACCAGAAGA CAAGATACAT 
ACAGTGCGCT TGGCCATGGG CAATGGACTT CGGGCAAATG TGTGGAAAAA CTTCCAGCAA 
CGCTTTGGTC CCATTCGGAT CTGGGAATTC TACGGATCCA CAGAGGGCAA TGTGGGCTTA 
ATGAACTATG TGGGCCACTG CGGGGCTGTG GGAAGGACCA GCTGCATCCT TCGAATGCTG 
ACTCCCTTTG AGCTTGTACA GTTCGACATA GAGACAGCAG AGCCTCTGAG GGACAAACAG 
GGTTTTTGCA TTCCTGTGGA GCCAGGAAAG CCAGGACTTC TTTTGACCAA GGTTCGAAAG 
AACCAACCCT TCCTGGGCTA CCGTGGTTCC CAGGCCGAGT CCAATCGGAA ACTTGTTGCG 
AATGTACGAC GCGTAGGAGA CCTGTACTTC AACACTGGGG ACGTGCTGAC CTTGGACCAG 
GAAGGCTTCT TCTACTTTCA AGACCGCCTT GGTGACACCT TCCGGTGGAA GGGCGAAAAC 
GTATCTACTG GAGAGGTGGA GTGTGTTTTG TCTAGCCTAG ACTTCCTAGA GGAAGTCAAT 
GTCTATGGTG TGCCTGTGCC AGGGTGTGAG GGTAAGGTTG GCATGGCTGC TGTGAAACTG 
GCTCCTGGGA AGACTTTTGA TGGGCAGAAG CTATACCAGC ATGTCCGCTC CTGGCTCCCT 
GCCTATGCCA CACCTCATTT CATCCGTATC CAGGATTCCC TGGAGATCAC AAACACCTAC 
AAGCTGGTAA AGTCACGGCT GGTGCGTGAG GGTTTTGATG TGGGGATCAT TGCTGACCCC 
CTCTACATAC TGGACAACAA GGCCCAGACC TTCCGGAGTC TGATGCCAGA TGTGTACCAG 
GCTGTGTGTG AAGGAACCTG GAATCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).
Lipids46(11)991-1003(2011 Nov)
Ason B,Castro-Perez J,Tep S,Stefanni A,Tadin-Strapps M,Roddy T,Hankemeier T,Hubbard B,Sachs AB,Michael Flanagan W,Kuklin NA,Mitnaul LJ

Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.
Journal of proteome research10(10)4683-91(2011 Oct)
Castro-Perez JM,Roddy TP,Shah V,Wang SP,Ouyang X,Ogawa A,McLaren DG,Tadin-Strapps M,Robinson MJ,Bartz SR,Ason B,Chen Y,Previs SF,Wong KK,Vreeken RJ,Johns DG,Hubbard BK,Hankemeier T,Mitnaul L

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
PloS one6(10)e25865(2011)
Mishima T,Miner JH,Morizane M,Stahl A,Sadovsky Y

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.
The Journal of biological chemistry283(32)22186-92(2008 Aug)
Doege H,Grimm D,Falcon A,Tsang B,Storm TA,Xu H,Ortegon AM,Kazantzis M,Kay MA,Stahl A

Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.
Endocrinology148(8)3625-34(2007 Aug)
Schaiff WT,Knapp FF Jr,Barak Y,Biron-Shental T,Nelson DM,Sadovsky Y

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Slc27a5 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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