Dkc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dkc1
Entrez Gene ID	245474
Full Name	dyskeratosis congenita 1, dyskerin
Synonyms	BC068171
General protein information	Preferred Names dyskeratosis congenita 1, dyskerin Names H/ACA ribonucleoprotein complex subunit 4 dyskeratosis congenita 1, dyskerin homolog dyskerin nopp140-associated protein of 57 kDa nucleolar protein NAP57 nucleolar protein family A member 4 snoRNP protein DKC1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A7.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001359412.1	NP_001346341.1	H/ACA ribonucleoprotein complex subunit DKC1 isoform 2
XM_030251338.1	XP_030107198.1	H/ACA ribonucleoprotein complex subunit DKC1 isoform X1
NM_001359411.1	NP_001346340.1	H/ACA ribonucleoprotein complex subunit DKC1 isoform 1
NM_001030307.2	NP_001025478.1	H/ACA ribonucleoprotein complex subunit DKC1 isoform 3
XM_006528023.3	XP_006528086.1	H/ACA ribonucleoprotein complex subunit 4 isoform X1
XM_017318488.1	XP_017173977.1	H/ACA ribonucleoprotein complex subunit 4 isoform X2
NM_001359413.1	NP_001346342.1	H/ACA ribonucleoprotein complex subunit DKC1 isoform 4

Pathways from BioSystems

Homologies

	DKC1	XP_001090867.2
Mus musculus (house mouse)	Dkc1	NP_001025478.1
Gallus gallus (chicken)	DKC1	NP_001026286.1
Caenorhabditis elegans (roundworm)	K01G5.5	NP_499370.1
Magnaporthe oryzae (rice blast fungus)	MGG_07518	XP_003711432.1
Oryza sativa (rice)	Os07g0636000	NP_001060391.1
Rattus norvegicus (Norway rat)	Dkc1	NP_596910.1
Drosophila melanogaster (fruit fly)	Nop60B	NP_001163289.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004739	XP_318082.4
Kluyveromyces lactis	KLLA0D04796g	XP_453273.1
Eremothecium gossypii	AGOS_AAL007C	NP_982535.1
Pan troglodytes (chimpanzee)	DKC1	XP_521345.3
Bos taurus (cattle)	DKC1	NP_001098865.1
Saccharomyces cerevisiae (baker's yeast)	CBF5	NP_013276.1
Neurospora crassa	NCU01290	XP_960827.1
Arabidopsis thaliana (thale cress)	NAP57	NP_191274.1
Xenopus tropicalis (tropical clawed frog)	dkc1	XP_004916830.1
Canis lupus familiaris (dog)	DKC1	XP_549382.2
Danio rerio (zebrafish)	dkc1	NP_001028279.2
Schizosaccharomyces pombe (fission yeast)	cbf5	NP_594878.1
Oryza sativa (rice)	Os03g0370500	NP_001050199.1
Homo sapiens (human)	DKC1	NP_001354.1

Gene Ontology
Bibliography

Related articles in PubMed

Slow growth and unstable ribosomal RNA lacking pseudouridine in mouse embryonic fibroblast cells expressing catalytically inactive dyskerin.
Gu BW, Ge J, Fan JM, Bessler M, Mason PJ
FEBS letters587(14)2112-7(2013 Jul)

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Kappei D, Butter F, Benda C, Scheibe M, Dra?kovi? I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londo?o-Vallejo JA, Mann M, Buchholz F
The EMBO journal32(12)1681-701(2013 Jun)

Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain.
Machado-Pinilla R, Carrillo J, Manguan-Garcia C, Sastre L, Mentzer A, Gu BW, Mason PJ, Perona R
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico14(10)755-63(2012 Oct)

The genetics of dyskeratosis congenita.
Mason PJ, Bessler M
Cancer genetics204(12)635-45(2011 Dec)

Dyskeratosis congenita.
Dokal I
Hematology. American Society of Hematology. Education Program2011480-6(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mouse embryonic fibroblasts cells with no pseudouridylation activity in H/ACA snoRNPs due to lack of Dkc1, can produce mature ribosomes, however, the ribosomes are very unstable and cell growth and division is very slow.
Title: Slow growth and unstable ribosomal RNA lacking pseudouridine in mouse embryonic fibroblast cells expressing catalytically inactive dyskerin.

mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain.
Title: Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain.

A mouse small nucleolar snoRNA microarray was used to monitor changes in abundance of snoRNAs after ablation of dyskerin, an H/ACA snoRNA protein component, from mouse liver, which causes a decrease in ribosome production.
Title: SnoRNA microarray analysis reveals changes in H/ACA and C/D RNA levels caused by dyskerin ablation in mouse liver.

hepatocytes can survive without dyskerin but the role of dyskerin in RNA modification is essential for cellular proliferation.
Title: Dyskerin ablation in mouse liver inhibits rRNA processing and cell division.

dyskerin mutations cause slow growth independently of telomere shortening and this slow growth is the result of the induction of DNA damage. Thus, dyskerin interacts with telomerase and affects telomere maintenance independently of telomere length.
Title: A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice.

The following Dkc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dkc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu16007	NM_001030307.2 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu56265	NM_001359411.1 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu56265	XM_006528023.3 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu83120	NM_001359413.1 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu83120	XM_017318488.1 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu90396	XM_030251338.1 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu83603	NM_001359412.1 Latest version!	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dkc1 ( NM_001030307.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001025478.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu16007
Clone ID Related Accession (Same CDS sequence)	NM_001030307.2
Accession Version	NM_001030307.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	H/ACA ribonucleoprotein complex subunit DKC1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY126448.1, AK136418.1 and AL808110.7. On Oct 31, 2009 this sequence version replaced NM_001030307.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136418.1, AK167973.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATG CAGAAGTAAT TACATTCCCA AAGAAGCATA AGAAGAAAAA AGACCGGAAG 
CCATTACAAG AAGATGATGT TGCCGAAATA CAACATGCTG AAGAATTTCT TATCAAACCA 
GAATCTAAAG TGGCTCAATT AGACACTTCT CAGTGGCCCT TGTTACTAAA GAATTTTGAT 
AAGCTAAATG TAAGGACAGC ACACTATACA CCTCTTCCTT GTGGTTCAAA TCCTCTGAAG 
AGGGAGATTG GGGACTATAT CAGGACCGGT TTCATTAATC TTGACAAGCC CTCTAACCCC 
TCTTCCCATG AGGTGGTAGC CTGGATCCGA CGAATACTTC GGGTAGAGAA GACTGGCCAC 
AGTGGCACAC TAGATCCCAA AGTGACTGGT TGTTTAATTG TGTGCATTGA ACGAGCCACT 
CGTTTGGTGA AATCACAACA GAGTGCAGGC AAAGAGTATG TTGGAATTGT CCGGCTGCAC 
AATGCTATTG AAGGGGGTAC TCAGCTTTCT AGGGCCCTAG AAACTCTGAC AGGTGCCCTG 
TTTCAGCGAC CCCCACTTAT TGCTGCAGTA AAGAGGCAGC TTCGAGTGAG GACTATCTAC 
GAGAGCAAAA TGATAGAATA TGATCCTGAG AGAAGATTAG GAATCTTTTG GGTAAGCTGT 
GAAGCTGGCA CCTACATTCG GACACTATGC GTACACCTTG GCTTGTTACT GGGAGTTGGT 
GGTCAGATGC AGGAACTTCG GAGGGTGCGT TCTGGAGTCA TGAGTGAAAA GGACCACATG 
GTGACAATGC ATGATGTACT CGATGCTCAG TGGCTGTATG ATAACCATAA GGATGAGAGT 
TACTTGCGGC GTGTTGTTTA CCCTTTGGAA AAGCTGTTGA CATCTCATAA ACGTCTGGTT 
ATGAAAGATA GTGCAGTGAA TGCAATCTGC TATGGGGCCA AGATCATGCT TCCTGGTCTT 
CTTCGATATG AAGATGGCAT TGAGGTCAAC CAGGAGATTG TGGTCATTAC TACTAAGGGG 
GAAGCTATCT GCATGGCAAT TGCATTGATG ACTACAGCAG TGATTTCTAC CTGTGACCAT 
GGTATAGTAG CCAAAATAAA GAGGGTGATC ATGGAGAGAG ACACTTATCC TCGCAAGTGG 
GGTTTAGGTC CAAAGGCAAG TCAGAAGAAG ATGATGATCA AGCAGGGCCT TCTGGACAAG 
CATGGCAAAC CCACAGACAA TACCCCTGCC ACATGGAAAC AGGATTACAT TGACTATAGT 
GATTCTGGCA AGAACACACT GGTTACCGAA GCAGTACAAG CCCCTCAGTT AGCTGCTGAA 
GCAGTAAATG TCATAAAAAG GAAGCGGGAT AGTGAGAGTG AAAGTGATGA GACCCCAACA 
GTTCCCCAGT TGAAGGAAAA GAAGAAGAAG AAGGATAAGA AGCCCAAAAC TGTGCTAGAA 
AGTGGGGGCG AAACTGGAGA TGGGGACAAC GACACCACCA AAAAGAAAAA GAAGAAGAAA 
GTAAAAGTGG TAGAAGAGAT GTCTGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025478.1
CDS	259..1788
Translation	MADAEVITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Target ORF information:

RefSeq Version	NM_001030307.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001030307.2

ORF Insert Sequence:

ATGGCGGATG CAGAAGTAAT TACATTCCCA AAGAAGCATA AGAAGAAAAA AGACCGGAAG 
CCATTACAAG AAGATGATGT TGCCGAAATA CAACATGCTG AAGAATTTCT TATCAAACCA 
GAATCTAAAG TGGCTCAATT AGACACTTCT CAGTGGCCCT TGTTACTAAA GAATTTTGAT 
AAGCTAAATG TAAGGACAGC ACACTATACA CCTCTTCCTT GTGGTTCAAA TCCTCTGAAG 
AGGGAGATTG GGGACTATAT CAGGACCGGT TTCATTAATC TTGACAAGCC CTCTAACCCC 
TCTTCCCATG AGGTGGTAGC CTGGATCCGA CGAATACTTC GGGTAGAGAA GACTGGCCAC 
AGTGGCACAC TAGATCCCAA AGTGACTGGT TGTTTAATTG TGTGCATTGA ACGAGCCACT 
CGTTTGGTGA AATCACAACA GAGTGCAGGC AAAGAGTATG TTGGAATTGT CCGGCTGCAC 
AATGCTATTG AAGGGGGTAC TCAGCTTTCT AGGGCCCTAG AAACTCTGAC AGGTGCCCTG 
TTTCAGCGAC CCCCACTTAT TGCTGCAGTA AAGAGGCAGC TTCGAGTGAG GACTATCTAC 
GAGAGCAAAA TGATAGAATA TGATCCTGAG AGAAGATTAG GAATCTTTTG GGTAAGCTGT 
GAAGCTGGCA CCTACATTCG GACACTATGC GTACACCTTG GCTTGTTACT GGGAGTTGGT 
GGTCAGATGC AGGAACTTCG GAGGGTGCGT TCTGGAGTCA TGAGTGAAAA GGACCACATG 
GTGACAATGC ATGATGTACT CGATGCTCAG TGGCTGTATG ATAACCATAA GGATGAGAGT 
TACTTGCGGC GTGTTGTTTA CCCTTTGGAA AAGCTGTTGA CATCTCATAA ACGTCTGGTT 
ATGAAAGATA GTGCAGTGAA TGCAATCTGC TATGGGGCCA AGATCATGCT TCCTGGTCTT 
CTTCGATATG AAGATGGCAT TGAGGTCAAC CAGGAGATTG TGGTCATTAC TACTAAGGGG 
GAAGCTATCT GCATGGCAAT TGCATTGATG ACTACAGCAG TGATTTCTAC CTGTGACCAT 
GGTATAGTAG CCAAAATAAA GAGGGTGATC ATGGAGAGAG ACACTTATCC TCGCAAGTGG 
GGTTTAGGTC CAAAGGCAAG TCAGAAGAAG ATGATGATCA AGCAGGGCCT TCTGGACAAG 
CATGGCAAAC CCACAGACAA TACCCCTGCC ACATGGAAAC AGGATTACAT TGACTATAGT 
GATTCTGGCA AGAACACACT GGTTACCGAA GCAGTACAAG CCCCTCAGTT AGCTGCTGAA 
GCAGTAAATG TCATAAAAAG GAAGCGGGAT AGTGAGAGTG AAAGTGATGA GACCCCAACA 
GTTCCCCAGT TGAAGGAAAA GAAGAAGAAG AAGGATAAGA AGCCCAAAAC TGTGCTAGAA 
AGTGGGGGCG AAACTGGAGA TGGGGACAAC GACACCACCA AAAAGAAAAA GAAGAAGAAA 
GTAAAAGTGG TAGAAGAGAT GTCTGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dkc1 ( NM_001359411.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001346340.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu56265
Clone ID Related Accession (Same CDS sequence)	NM_001359411.1 , XM_006528023.3
Accession Version	NM_001359411.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	H/ACA ribonucleoprotein complex subunit DKC1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL808110.7. On Jan 4, 2018 this sequence version replaced XM_006528023.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.104478.1, SRR1660817.101240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAAGC CACGTGGAGA ACCCGAAGGG AAGCCAACAC GTGCTAGAGT CATTTACCAG 
CCAAGCCATC CTAGTGTTTG GCCTCACAAA CTAATTACAT TCCCAAAGAA GCATAAGAAG 
AAAAAAGACC GGAAGCCATT ACAAGAAGAT GATGTTGCCG AAATACAACA TGCTGAAGAA 
TTTCTTATCA AACCAGAATC TAAAGTGGCT CAATTAGACA CTTCTCAGTG GCCCTTGTTA 
CTAAAGAATT TTGATAAGCT AAATGTAAGG ACAGCACACT ATACACCTCT TCCTTGTGGT 
TCAAATCCTC TGAAGAGGGA GATTGGGGAC TATATCAGGA CCGGTTTCAT TAATCTTGAC 
AAGCCCTCTA ACCCCTCTTC CCATGAGGTG GTAGCCTGGA TCCGACGAAT ACTTCGGGTA 
GAGAAGACTG GCCACAGTGG CACACTAGAT CCCAAAGTGA CTGGTTGTTT AATTGTGTGC 
ATTGAACGAG CCACTCGTTT GGTGAAATCA CAACAGAGTG CAGGCAAAGA GTATGTTGGA 
ATTGTCCGGC TGCACAATGC TATTGAAGGG GGTACTCAGC TTTCTAGGGC CCTAGAAACT 
CTGACAGGTG CCCTGTTTCA GCGACCCCCA CTTATTGCTG CAGTAAAGAG GCAGCTTCGA 
GTGAGGACTA TCTACGAGAG CAAAATGATA GAATATGATC CTGAGAGAAG ATTAGGAATC 
TTTTGGGTAA GCTGTGAAGC TGGCACCTAC ATTCGGACAC TATGCGTACA CCTTGGCTTG 
TTACTGGGAG TTGGTGGTCA GATGCAGGAA CTTCGGAGGG TGCGTTCTGG AGTCATGAGT 
GAAAAGGACC ACATGGTGAC AATGCATGAT GTACTCGATG CTCAGTGGCT GTATGATAAC 
CATAAGGATG AGAGTTACTT GCGGCGTGTT GTTTACCCTT TGGAAAAGCT GTTGACATCT 
CATAAACGTC TGGTTATGAA AGATAGTGCA GTGAATGCAA TCTGCTATGG GGCCAAGATC 
ATGCTTCCTG GTCTTCTTCG ATATGAAGAT GGCATTGAGG TCAACCAGGA GATTGTGGTC 
ATTACTACTA AGGGGGAAGC TATCTGCATG GCAATTGCAT TGATGACTAC AGCAGTGATT 
TCTACCTGTG ACCATGGTAT AGTAGCCAAA ATAAAGAGGG TGATCATGGA GAGAGACACT 
TATCCTCGCA AGTGGGGTTT AGGTCCAAAG GCAAGTCAGA AGAAGATGAT GATCAAGCAG 
GGCCTTCTGG ACAAGCATGG CAAACCCACA GACAATACCC CTGCCACATG GAAACAGGAT 
TACATTGACT ATAGTGATTC TGGCAAGAAC ACACTGGTTA CCGAAGCAGT ACAAGCCCCT 
CAGTTAGCTG CTGAAGCAGT AAATGTCATA AAAAGGAAGC GGGATAGTGA GAGTGAAAGT 
GATGAGACCC CAACAGTTCC CCAGTTGAAG GAAAAGAAGA AGAAGAAGGA TAAGAAGCCC 
AAAACTGTGC TAGAAAGTGG GGGCGAAACT GGAGATGGGG ACAACGACAC CACCAAAAAG 
AAAAAGAAGA AGAAAGTAAA AGTGGTAGAA GAGATGTCTG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346340.1
CDS	266..1870
Translation	MQKPRGEPEGKPTRARVIYQPSHPSVWPHKLITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Target ORF information:

RefSeq Version	NM_001359411.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359411.1

ORF Insert Sequence:

ATGCAGAAGC CACGTGGAGA ACCCGAAGGG AAGCCAACAC GTGCTAGAGT CATTTACCAG 
CCAAGCCATC CTAGTGTTTG GCCTCACAAA CTAATTACAT TCCCAAAGAA GCATAAGAAG 
AAAAAAGACC GGAAGCCATT ACAAGAAGAT GATGTTGCCG AAATACAACA TGCTGAAGAA 
TTTCTTATCA AACCAGAATC TAAAGTGGCT CAATTAGACA CTTCTCAGTG GCCCTTGTTA 
CTAAAGAATT TTGATAAGCT AAATGTAAGG ACAGCACACT ATACACCTCT TCCTTGTGGT 
TCAAATCCTC TGAAGAGGGA GATTGGGGAC TATATCAGGA CCGGTTTCAT TAATCTTGAC 
AAGCCCTCTA ACCCCTCTTC CCATGAGGTG GTAGCCTGGA TCCGACGAAT ACTTCGGGTA 
GAGAAGACTG GCCACAGTGG CACACTAGAT CCCAAAGTGA CTGGTTGTTT AATTGTGTGC 
ATTGAACGAG CCACTCGTTT GGTGAAATCA CAACAGAGTG CAGGCAAAGA GTATGTTGGA 
ATTGTCCGGC TGCACAATGC TATTGAAGGG GGTACTCAGC TTTCTAGGGC CCTAGAAACT 
CTGACAGGTG CCCTGTTTCA GCGACCCCCA CTTATTGCTG CAGTAAAGAG GCAGCTTCGA 
GTGAGGACTA TCTACGAGAG CAAAATGATA GAATATGATC CTGAGAGAAG ATTAGGAATC 
TTTTGGGTAA GCTGTGAAGC TGGCACCTAC ATTCGGACAC TATGCGTACA CCTTGGCTTG 
TTACTGGGAG TTGGTGGTCA GATGCAGGAA CTTCGGAGGG TGCGTTCTGG AGTCATGAGT 
GAAAAGGACC ACATGGTGAC AATGCATGAT GTACTCGATG CTCAGTGGCT GTATGATAAC 
CATAAGGATG AGAGTTACTT GCGGCGTGTT GTTTACCCTT TGGAAAAGCT GTTGACATCT 
CATAAACGTC TGGTTATGAA AGATAGTGCA GTGAATGCAA TCTGCTATGG GGCCAAGATC 
ATGCTTCCTG GTCTTCTTCG ATATGAAGAT GGCATTGAGG TCAACCAGGA GATTGTGGTC 
ATTACTACTA AGGGGGAAGC TATCTGCATG GCAATTGCAT TGATGACTAC AGCAGTGATT 
TCTACCTGTG ACCATGGTAT AGTAGCCAAA ATAAAGAGGG TGATCATGGA GAGAGACACT 
TATCCTCGCA AGTGGGGTTT AGGTCCAAAG GCAAGTCAGA AGAAGATGAT GATCAAGCAG 
GGCCTTCTGG ACAAGCATGG CAAACCCACA GACAATACCC CTGCCACATG GAAACAGGAT 
TACATTGACT ATAGTGATTC TGGCAAGAAC ACACTGGTTA CCGAAGCAGT ACAAGCCCCT 
CAGTTAGCTG CTGAAGCAGT AAATGTCATA AAAAGGAAGC GGGATAGTGA GAGTGAAAGT 
GATGAGACCC CAACAGTTCC CCAGTTGAAG GAAAAGAAGA AGAAGAAGGA TAAGAAGCCC 
AAAACTGTGC TAGAAAGTGG GGGCGAAACT GGAGATGGGG ACAACGACAC CACCAAAAAG 
AAAAAGAAGA AGAAAGTAAA AGTGGTAGAA GAGATGTCTG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dkc1 ( XM_006528023.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006528086.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu56265
Clone ID Related Accession (Same CDS sequence)	NM_001359411.1 , XM_006528023.3
Accession Version	XM_006528023.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	H/ACA ribonucleoprotein complex subunit 4 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006528023.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAAGC CACGTGGAGA ACCCGAAGGG AAGCCAACAC GTGCTAGAGT CATTTACCAG 
CCAAGCCATC CTAGTGTTTG GCCTCACAAA CTAATTACAT TCCCAAAGAA GCATAAGAAG 
AAAAAAGACC GGAAGCCATT ACAAGAAGAT GATGTTGCCG AAATACAACA TGCTGAAGAA 
TTTCTTATCA AACCAGAATC TAAAGTGGCT CAATTAGACA CTTCTCAGTG GCCCTTGTTA 
CTAAAGAATT TTGATAAGCT AAATGTAAGG ACAGCACACT ATACACCTCT TCCTTGTGGT 
TCAAATCCTC TGAAGAGGGA GATTGGGGAC TATATCAGGA CCGGTTTCAT TAATCTTGAC 
AAGCCCTCTA ACCCCTCTTC CCATGAGGTG GTAGCCTGGA TCCGACGAAT ACTTCGGGTA 
GAGAAGACTG GCCACAGTGG CACACTAGAT CCCAAAGTGA CTGGTTGTTT AATTGTGTGC 
ATTGAACGAG CCACTCGTTT GGTGAAATCA CAACAGAGTG CAGGCAAAGA GTATGTTGGA 
ATTGTCCGGC TGCACAATGC TATTGAAGGG GGTACTCAGC TTTCTAGGGC CCTAGAAACT 
CTGACAGGTG CCCTGTTTCA GCGACCCCCA CTTATTGCTG CAGTAAAGAG GCAGCTTCGA 
GTGAGGACTA TCTACGAGAG CAAAATGATA GAATATGATC CTGAGAGAAG ATTAGGAATC 
TTTTGGGTAA GCTGTGAAGC TGGCACCTAC ATTCGGACAC TATGCGTACA CCTTGGCTTG 
TTACTGGGAG TTGGTGGTCA GATGCAGGAA CTTCGGAGGG TGCGTTCTGG AGTCATGAGT 
GAAAAGGACC ACATGGTGAC AATGCATGAT GTACTCGATG CTCAGTGGCT GTATGATAAC 
CATAAGGATG AGAGTTACTT GCGGCGTGTT GTTTACCCTT TGGAAAAGCT GTTGACATCT 
CATAAACGTC TGGTTATGAA AGATAGTGCA GTGAATGCAA TCTGCTATGG GGCCAAGATC 
ATGCTTCCTG GTCTTCTTCG ATATGAAGAT GGCATTGAGG TCAACCAGGA GATTGTGGTC 
ATTACTACTA AGGGGGAAGC TATCTGCATG GCAATTGCAT TGATGACTAC AGCAGTGATT 
TCTACCTGTG ACCATGGTAT AGTAGCCAAA ATAAAGAGGG TGATCATGGA GAGAGACACT 
TATCCTCGCA AGTGGGGTTT AGGTCCAAAG GCAAGTCAGA AGAAGATGAT GATCAAGCAG 
GGCCTTCTGG ACAAGCATGG CAAACCCACA GACAATACCC CTGCCACATG GAAACAGGAT 
TACATTGACT ATAGTGATTC TGGCAAGAAC ACACTGGTTA CCGAAGCAGT ACAAGCCCCT 
CAGTTAGCTG CTGAAGCAGT AAATGTCATA AAAAGGAAGC GGGATAGTGA GAGTGAAAGT 
GATGAGACCC CAACAGTTCC CCAGTTGAAG GAAAAGAAGA AGAAGAAGGA TAAGAAGCCC 
AAAACTGTGC TAGAAAGTGG GGGCGAAACT GGAGATGGGG ACAACGACAC CACCAAAAAG 
AAAAAGAAGA AGAAAGTAAA AGTGGTAGAA GAGATGTCTG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006528086.1
CDS	236..1840
Translation	MQKPRGEPEGKPTRARVIYQPSHPSVWPHKLITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Target ORF information:

RefSeq Version	XM_006528023.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006528023.3

ORF Insert Sequence:

ATGCAGAAGC CACGTGGAGA ACCCGAAGGG AAGCCAACAC GTGCTAGAGT CATTTACCAG 
CCAAGCCATC CTAGTGTTTG GCCTCACAAA CTAATTACAT TCCCAAAGAA GCATAAGAAG 
AAAAAAGACC GGAAGCCATT ACAAGAAGAT GATGTTGCCG AAATACAACA TGCTGAAGAA 
TTTCTTATCA AACCAGAATC TAAAGTGGCT CAATTAGACA CTTCTCAGTG GCCCTTGTTA 
CTAAAGAATT TTGATAAGCT AAATGTAAGG ACAGCACACT ATACACCTCT TCCTTGTGGT 
TCAAATCCTC TGAAGAGGGA GATTGGGGAC TATATCAGGA CCGGTTTCAT TAATCTTGAC 
AAGCCCTCTA ACCCCTCTTC CCATGAGGTG GTAGCCTGGA TCCGACGAAT ACTTCGGGTA 
GAGAAGACTG GCCACAGTGG CACACTAGAT CCCAAAGTGA CTGGTTGTTT AATTGTGTGC 
ATTGAACGAG CCACTCGTTT GGTGAAATCA CAACAGAGTG CAGGCAAAGA GTATGTTGGA 
ATTGTCCGGC TGCACAATGC TATTGAAGGG GGTACTCAGC TTTCTAGGGC CCTAGAAACT 
CTGACAGGTG CCCTGTTTCA GCGACCCCCA CTTATTGCTG CAGTAAAGAG GCAGCTTCGA 
GTGAGGACTA TCTACGAGAG CAAAATGATA GAATATGATC CTGAGAGAAG ATTAGGAATC 
TTTTGGGTAA GCTGTGAAGC TGGCACCTAC ATTCGGACAC TATGCGTACA CCTTGGCTTG 
TTACTGGGAG TTGGTGGTCA GATGCAGGAA CTTCGGAGGG TGCGTTCTGG AGTCATGAGT 
GAAAAGGACC ACATGGTGAC AATGCATGAT GTACTCGATG CTCAGTGGCT GTATGATAAC 
CATAAGGATG AGAGTTACTT GCGGCGTGTT GTTTACCCTT TGGAAAAGCT GTTGACATCT 
CATAAACGTC TGGTTATGAA AGATAGTGCA GTGAATGCAA TCTGCTATGG GGCCAAGATC 
ATGCTTCCTG GTCTTCTTCG ATATGAAGAT GGCATTGAGG TCAACCAGGA GATTGTGGTC 
ATTACTACTA AGGGGGAAGC TATCTGCATG GCAATTGCAT TGATGACTAC AGCAGTGATT 
TCTACCTGTG ACCATGGTAT AGTAGCCAAA ATAAAGAGGG TGATCATGGA GAGAGACACT 
TATCCTCGCA AGTGGGGTTT AGGTCCAAAG GCAAGTCAGA AGAAGATGAT GATCAAGCAG 
GGCCTTCTGG ACAAGCATGG CAAACCCACA GACAATACCC CTGCCACATG GAAACAGGAT 
TACATTGACT ATAGTGATTC TGGCAAGAAC ACACTGGTTA CCGAAGCAGT ACAAGCCCCT 
CAGTTAGCTG CTGAAGCAGT AAATGTCATA AAAAGGAAGC GGGATAGTGA GAGTGAAAGT 
GATGAGACCC CAACAGTTCC CCAGTTGAAG GAAAAGAAGA AGAAGAAGGA TAAGAAGCCC 
AAAACTGTGC TAGAAAGTGG GGGCGAAACT GGAGATGGGG ACAACGACAC CACCAAAAAG 
AAAAAGAAGA AGAAAGTAAA AGTGGTAGAA GAGATGTCTG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dkc1 ( NM_001359413.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001346342.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 4, mRNA.

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CloneID	OMu83120
Clone ID Related Accession (Same CDS sequence)	XM_017318488.1 , NM_001359413.1
Accession Version	NM_001359413.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	H/ACA ribonucleoprotein complex subunit DKC1 isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL808110.7. On Jan 4, 2018 this sequence version replaced XM_017318488.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.109691.1, SRR1660817.157420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATAGAAT ATGATCCTGA GAGAAGATTA GGAATCTTTT GGGTAAGCTG TGAAGCTGGC 
ACCTACATTC GGACACTATG CGTACACCTT GGCTTGTTAC TGGGAGTTGG TGGTCAGATG 
CAGGAACTTC GGAGGGTGCG TTCTGGAGTC ATGAGTGAAA AGGACCACAT GGTGACAATG 
CATGATGTAC TCGATGCTCA GTGGCTGTAT GATAACCATA AGGATGAGAG TTACTTGCGG 
CGTGTTGTTT ACCCTTTGGA AAAGCTGTTG ACATCTCATA AACGTCTGGT TATGAAAGAT 
AGTGCAGTGA ATGCAATCTG CTATGGGGCC AAGATCATGC TTCCTGGTCT TCTTCGATAT 
GAAGATGGCA TTGAGGTCAA CCAGGAGATT GTGGTCATTA CTACTAAGGG GGAAGCTATC 
TGCATGGCAA TTGCATTGAT GACTACAGCA GTGATTTCTA CCTGTGACCA TGGTATAGTA 
GCCAAAATAA AGAGGGTGAT CATGGAGAGA GACACTTATC CTCGCAAGTG GGGTTTAGGT 
CCAAAGGCAA GTCAGAAGAA GATGATGATC AAGCAGGGCC TTCTGGACAA GCATGGCAAA 
CCCACAGACA ATACCCCTGC CACATGGAAA CAGGATTACA TTGACTATAG TGATTCTGGC 
AAGAACACAC TGGTTACCGA AGCAGTACAA GCCCCTCAGT TAGCTGCTGA AGCAGTAAAT 
GTCATAAAAA GGAAGCGGGA TAGTGAGAGT GAAAGTGATG AGACCCCAAC AGTTCCCCAG 
TTGAAGGAAA AGAAGAAGAA GAAGGATAAG AAGCCCAAAA CTGTGCTAGA AAGTGGGGGC 
GAAACTGGAG ATGGGGACAA CGACACCACC AAAAAGAAAA AGAAGAAGAA AGTAAAAGTG 
GTAGAAGAGA TGTCTGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346342.1
CDS	995..1915
Translation	MIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Target ORF information:

RefSeq Version	NM_001359413.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359413.1

ORF Insert Sequence:

ATGATAGAAT ATGATCCTGA GAGAAGATTA GGAATCTTTT GGGTAAGCTG TGAAGCTGGC 
ACCTACATTC GGACACTATG CGTACACCTT GGCTTGTTAC TGGGAGTTGG TGGTCAGATG 
CAGGAACTTC GGAGGGTGCG TTCTGGAGTC ATGAGTGAAA AGGACCACAT GGTGACAATG 
CATGATGTAC TCGATGCTCA GTGGCTGTAT GATAACCATA AGGATGAGAG TTACTTGCGG 
CGTGTTGTTT ACCCTTTGGA AAAGCTGTTG ACATCTCATA AACGTCTGGT TATGAAAGAT 
AGTGCAGTGA ATGCAATCTG CTATGGGGCC AAGATCATGC TTCCTGGTCT TCTTCGATAT 
GAAGATGGCA TTGAGGTCAA CCAGGAGATT GTGGTCATTA CTACTAAGGG GGAAGCTATC 
TGCATGGCAA TTGCATTGAT GACTACAGCA GTGATTTCTA CCTGTGACCA TGGTATAGTA 
GCCAAAATAA AGAGGGTGAT CATGGAGAGA GACACTTATC CTCGCAAGTG GGGTTTAGGT 
CCAAAGGCAA GTCAGAAGAA GATGATGATC AAGCAGGGCC TTCTGGACAA GCATGGCAAA 
CCCACAGACA ATACCCCTGC CACATGGAAA CAGGATTACA TTGACTATAG TGATTCTGGC 
AAGAACACAC TGGTTACCGA AGCAGTACAA GCCCCTCAGT TAGCTGCTGA AGCAGTAAAT 
GTCATAAAAA GGAAGCGGGA TAGTGAGAGT GAAAGTGATG AGACCCCAAC AGTTCCCCAG 
TTGAAGGAAA AGAAGAAGAA GAAGGATAAG AAGCCCAAAA CTGTGCTAGA AAGTGGGGGC 
GAAACTGGAG ATGGGGACAA CGACACCACC AAAAAGAAAA AGAAGAAGAA AGTAAAAGTG 
GTAGAAGAGA TGTCTGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dkc1 ( XM_017318488.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173977.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X2, mRNA.

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CloneID	OMu83120
Clone ID Related Accession (Same CDS sequence)	XM_017318488.1 , NM_001359413.1
Accession Version	XM_017318488.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	H/ACA ribonucleoprotein complex subunit 4 isoform X2
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATAGAAT ATGATCCTGA GAGAAGATTA GGAATCTTTT GGGTAAGCTG TGAAGCTGGC 
ACCTACATTC GGACACTATG CGTACACCTT GGCTTGTTAC TGGGAGTTGG TGGTCAGATG 
CAGGAACTTC GGAGGGTGCG TTCTGGAGTC ATGAGTGAAA AGGACCACAT GGTGACAATG 
CATGATGTAC TCGATGCTCA GTGGCTGTAT GATAACCATA AGGATGAGAG TTACTTGCGG 
CGTGTTGTTT ACCCTTTGGA AAAGCTGTTG ACATCTCATA AACGTCTGGT TATGAAAGAT 
AGTGCAGTGA ATGCAATCTG CTATGGGGCC AAGATCATGC TTCCTGGTCT TCTTCGATAT 
GAAGATGGCA TTGAGGTCAA CCAGGAGATT GTGGTCATTA CTACTAAGGG GGAAGCTATC 
TGCATGGCAA TTGCATTGAT GACTACAGCA GTGATTTCTA CCTGTGACCA TGGTATAGTA 
GCCAAAATAA AGAGGGTGAT CATGGAGAGA GACACTTATC CTCGCAAGTG GGGTTTAGGT 
CCAAAGGCAA GTCAGAAGAA GATGATGATC AAGCAGGGCC TTCTGGACAA GCATGGCAAA 
CCCACAGACA ATACCCCTGC CACATGGAAA CAGGATTACA TTGACTATAG TGATTCTGGC 
AAGAACACAC TGGTTACCGA AGCAGTACAA GCCCCTCAGT TAGCTGCTGA AGCAGTAAAT 
GTCATAAAAA GGAAGCGGGA TAGTGAGAGT GAAAGTGATG AGACCCCAAC AGTTCCCCAG 
TTGAAGGAAA AGAAGAAGAA GAAGGATAAG AAGCCCAAAA CTGTGCTAGA AAGTGGGGGC 
GAAACTGGAG ATGGGGACAA CGACACCACC AAAAAGAAAA AGAAGAAGAA AGTAAAAGTG 
GTAGAAGAGA TGTCTGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173977.1
CDS	939..1859
Translation	MIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Target ORF information:

RefSeq Version	XM_017318488.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017318488.1

ORF Insert Sequence:

ATGATAGAAT ATGATCCTGA GAGAAGATTA GGAATCTTTT GGGTAAGCTG TGAAGCTGGC 
ACCTACATTC GGACACTATG CGTACACCTT GGCTTGTTAC TGGGAGTTGG TGGTCAGATG 
CAGGAACTTC GGAGGGTGCG TTCTGGAGTC ATGAGTGAAA AGGACCACAT GGTGACAATG 
CATGATGTAC TCGATGCTCA GTGGCTGTAT GATAACCATA AGGATGAGAG TTACTTGCGG 
CGTGTTGTTT ACCCTTTGGA AAAGCTGTTG ACATCTCATA AACGTCTGGT TATGAAAGAT 
AGTGCAGTGA ATGCAATCTG CTATGGGGCC AAGATCATGC TTCCTGGTCT TCTTCGATAT 
GAAGATGGCA TTGAGGTCAA CCAGGAGATT GTGGTCATTA CTACTAAGGG GGAAGCTATC 
TGCATGGCAA TTGCATTGAT GACTACAGCA GTGATTTCTA CCTGTGACCA TGGTATAGTA 
GCCAAAATAA AGAGGGTGAT CATGGAGAGA GACACTTATC CTCGCAAGTG GGGTTTAGGT 
CCAAAGGCAA GTCAGAAGAA GATGATGATC AAGCAGGGCC TTCTGGACAA GCATGGCAAA 
CCCACAGACA ATACCCCTGC CACATGGAAA CAGGATTACA TTGACTATAG TGATTCTGGC 
AAGAACACAC TGGTTACCGA AGCAGTACAA GCCCCTCAGT TAGCTGCTGA AGCAGTAAAT 
GTCATAAAAA GGAAGCGGGA TAGTGAGAGT GAAAGTGATG AGACCCCAAC AGTTCCCCAG 
TTGAAGGAAA AGAAGAAGAA GAAGGATAAG AAGCCCAAAA CTGTGCTAGA AAGTGGGGGC 
GAAACTGGAG ATGGGGACAA CGACACCACC AAAAAGAAAA AGAAGAAGAA AGTAAAAGTG 
GTAGAAGAGA TGTCTGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dkc1 ( XM_030251338.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030107198.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu90396
Clone ID Related Accession (Same CDS sequence)	XM_030251338.1
Accession Version	XM_030251338.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	H/ACA ribonucleoprotein complex subunit DKC1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGATG CAGAAGTAAT TACATTCCCA AAGAAGCATA AGAAGAAAAA AGACCGGAAG 
CCATTACAAG AAGATGATGT TGCCGAAATA CAACATGCTG AAGAATTTCT TATCAAACCA 
GAATCTAAAG TGGCTCAATT AGACACTTCT CAGTGGCCCT TGTTACTAAA GAATTTTGAT 
AAGCTAAATG TAAGGACAGC ACACTATACA CCTCTTCCTT GTGGTTCAAA TCCTCTGAAG 
AGGGAGATTG GGGACTATAT CAGGACCGGT TTCATTAATC TTGACAAGCC CTCTAACCCC 
TCTTCCCATG AGGTGGTAGC CTGGATCCGA CGAATACTTC GGGTAGAGAA GACTGGCCAC 
AGTGGCACAC TAGATCCCAA AGTGACTGGT TGTTTAATTG TGTGCATTGA ACGAGCCACT 
CGTTTGGTGA AATCACAACA GAGTGCAGGC AAAGAGTATG TTGGAATTGT CCGGCTGCAC 
AATGCTATTG AAGGGGGTAC TCAGCTTTCT AGGGCCCTAG AAACTCTGAC AGGTGCCCTG 
TTTCAGCGAC CCCCACTTAT TGCTGCAGTA AAGAGGCAGC TTCGAGTGAG GACTATCTAC 
GAGAGCAAAA TGATAGAATA TGATCCTGAG AGAAGATTAG GAATCTTTTG GGTAAGCTGT 
GAAGCTGGCA CCTACATTCG GACACTATGC GTACACCTTG GCTTGTTACT GGGAGTTGGT 
GGTCAGATGC AGGAACTTCG GAGGGTGCGT TCTGGAGTCA TGAGTGAAAA GGACCACATG 
GTGACAATGC ATGATGTACT CGATGCTCAG TGGCTGTATG ATAACCATAA GGATGAGAGT 
TACTTGCGGC GTGTTGTTTA CCCTTTGGAA AAGCTGTTGA CATCTCATAA ACGTCTGGTT 
ATGAAAGATA GTGCAGTGAA TGCAATCTGC TATGGGGCCA AGATCATGCT TCCTGGTCTT 
CTTCGATATG AAGATGGCAT TGAGGTCAAC CAGGAGATTG TGGTCATTAC TACTAAGGGG 
GAAGCTATCT GCATGGCAAT TGCATTGATG ACTACAGCAG TGATTTCTAC CTGTGACCAT 
GGTATAGTAG CCAAAATAAA GAGGGTGATC ATGGAGAGAG ACACTTATCC TCGCAAGTGG 
GGTTTAGGTC CAAAGGCAAG TCAGAAGAAG ATGATGATCA AGCAGGGCCT TCTGGACAAG 
CATGGCAAAC CCACAGACAA TACCCCTGCC ACATGGAAAC AGGATTACAT TGACTATAGG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030107198.1
CDS	259..1521
Translation	MADAEVITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYR

Target ORF information:

RefSeq Version	XM_030251338.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030251338.1

ORF Insert Sequence:

ATGGCGGATG CAGAAGTAAT TACATTCCCA AAGAAGCATA AGAAGAAAAA AGACCGGAAG 
CCATTACAAG AAGATGATGT TGCCGAAATA CAACATGCTG AAGAATTTCT TATCAAACCA 
GAATCTAAAG TGGCTCAATT AGACACTTCT CAGTGGCCCT TGTTACTAAA GAATTTTGAT 
AAGCTAAATG TAAGGACAGC ACACTATACA CCTCTTCCTT GTGGTTCAAA TCCTCTGAAG 
AGGGAGATTG GGGACTATAT CAGGACCGGT TTCATTAATC TTGACAAGCC CTCTAACCCC 
TCTTCCCATG AGGTGGTAGC CTGGATCCGA CGAATACTTC GGGTAGAGAA GACTGGCCAC 
AGTGGCACAC TAGATCCCAA AGTGACTGGT TGTTTAATTG TGTGCATTGA ACGAGCCACT 
CGTTTGGTGA AATCACAACA GAGTGCAGGC AAAGAGTATG TTGGAATTGT CCGGCTGCAC 
AATGCTATTG AAGGGGGTAC TCAGCTTTCT AGGGCCCTAG AAACTCTGAC AGGTGCCCTG 
TTTCAGCGAC CCCCACTTAT TGCTGCAGTA AAGAGGCAGC TTCGAGTGAG GACTATCTAC 
GAGAGCAAAA TGATAGAATA TGATCCTGAG AGAAGATTAG GAATCTTTTG GGTAAGCTGT 
GAAGCTGGCA CCTACATTCG GACACTATGC GTACACCTTG GCTTGTTACT GGGAGTTGGT 
GGTCAGATGC AGGAACTTCG GAGGGTGCGT TCTGGAGTCA TGAGTGAAAA GGACCACATG 
GTGACAATGC ATGATGTACT CGATGCTCAG TGGCTGTATG ATAACCATAA GGATGAGAGT 
TACTTGCGGC GTGTTGTTTA CCCTTTGGAA AAGCTGTTGA CATCTCATAA ACGTCTGGTT 
ATGAAAGATA GTGCAGTGAA TGCAATCTGC TATGGGGCCA AGATCATGCT TCCTGGTCTT 
CTTCGATATG AAGATGGCAT TGAGGTCAAC CAGGAGATTG TGGTCATTAC TACTAAGGGG 
GAAGCTATCT GCATGGCAAT TGCATTGATG ACTACAGCAG TGATTTCTAC CTGTGACCAT 
GGTATAGTAG CCAAAATAAA GAGGGTGATC ATGGAGAGAG ACACTTATCC TCGCAAGTGG 
GGTTTAGGTC CAAAGGCAAG TCAGAAGAAG ATGATGATCA AGCAGGGCCT TCTGGACAAG 
CATGGCAAAC CCACAGACAA TACCCCTGCC ACATGGAAAC AGGATTACAT TGACTATAGG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dkc1 ( NM_001359412.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001346341.1 Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 2, mRNA.

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CloneID	OMu83603
Clone ID Related Accession (Same CDS sequence)	NM_001359412.1
Accession Version	NM_001359412.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	H/ACA ribonucleoprotein complex subunit DKC1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL808110.7. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR6116558.172625.1, SRR7345562.4192132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATG CAGAAGTAAT TACATTCCCA AAGAAGCATA AGAAGAAAAA AGACCGGAAG 
CCATTACAAG AAGATGATGT TGCCGCATGC ACTTCCAAAA TTAAGCTGAG AAATGTTTCT 
GCTCTATTGA AGGAAATACA ACATGCTGAA GAATTTCTTA TCAAACCAGA ATCTAAAGTG 
GCTCAATTAG ACACTTCTCA GTGGCCCTTG TTACTAAAGA ATTTTGATAA GCTAAATGTA 
AGGACAGCAC ACTATACACC TCTTCCTTGT GGTTCAAATC CTCTGAAGAG GGAGATTGGG 
GACTATATCA GGACCGGTTT CATTAATCTT GACAAGCCCT CTAACCCCTC TTCCCATGAG 
GTGGTAGCCT GGATCCGACG AATACTTCGG GTAGAGAAGA CTGGCCACAG TGGCACACTA 
GATCCCAAAG TGACTGGTTG TTTAATTGTG TGCATTGAAC GAGCCACTCG TTTGGTGAAA 
TCACAACAGA GTGCAGGCAA AGAGTATGTT GGAATTGTCC GGCTGCACAA TGCTATTGAA 
GGGGGTACTC AGCTTTCTAG GGCCCTAGAA ACTCTGACAG GTGCCCTGTT TCAGCGACCC 
CCACTTATTG CTGCAGTAAA GAGGCAGCTT CGAGTGAGGA CTATCTACGA GAGCAAAATG 
ATAGAATATG ATCCTGAGAG AAGATTAGGA ATCTTTTGGG TAAGCTGTGA AGCTGGCACC 
TACATTCGGA CACTATGCGT ACACCTTGGC TTGTTACTGG GAGTTGGTGG TCAGATGCAG 
GAACTTCGGA GGGTGCGTTC TGGAGTCATG AGTGAAAAGG ACCACATGGT GACAATGCAT 
GATGTACTCG ATGCTCAGTG GCTGTATGAT AACCATAAGG ATGAGAGTTA CTTGCGGCGT 
GTTGTTTACC CTTTGGAAAA GCTGTTGACA TCTCATAAAC GTCTGGTTAT GAAAGATAGT 
GCAGTGAATG CAATCTGCTA TGGGGCCAAG ATCATGCTTC CTGGTCTTCT TCGATATGAA 
GATGGCATTG AGGTCAACCA GGAGATTGTG GTCATTACTA CTAAGGGGGA AGCTATCTGC 
ATGGCAATTG CATTGATGAC TACAGCAGTG ATTTCTACCT GTGACCATGG TATAGTAGCC 
AAAATAAAGA GGGTGATCAT GGAGAGAGAC ACTTATCCTC GCAAGTGGGG TTTAGGTCCA 
AAGGCAAGTC AGAAGAAGAT GATGATCAAG CAGGGCCTTC TGGACAAGCA TGGCAAACCC 
ACAGACAATA CCCCTGCCAC ATGGAAACAG GATTACATTG ACTATAGTGA TTCTGGCAAG 
AACACACTGG TTACCGAAGC AGTACAAGCC CCTCAGTTAG CTGCTGAAGC AGTAAATGTC 
ATAAAAAGGA AGCGGGATAG TGAGAGTGAA AGTGATGAGA CCCCAACAGT TCCCCAGTTG 
AAGGAAAAGA AGAAGAAGAA GGATAAGAAG CCCAAAACTG TGCTAGAAAG TGGGGGCGAA 
ACTGGAGATG GGGACAACGA CACCACCAAA AAGAAAAAGA AGAAGAAAGT AAAAGTGGTA 
GAAGAGATGT CTGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346341.1
CDS	259..1836
Translation	MADAEVITFPKKHKKKKDRKPLQEDDVAACTSKIKLRNVSALLKEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Target ORF information:

RefSeq Version	NM_001359412.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dyskeratosis congenita 1, dyskerin (Dkc1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359412.1

ORF Insert Sequence:

ATGGCGGATG CAGAAGTAAT TACATTCCCA AAGAAGCATA AGAAGAAAAA AGACCGGAAG 
CCATTACAAG AAGATGATGT TGCCGCATGC ACTTCCAAAA TTAAGCTGAG AAATGTTTCT 
GCTCTATTGA AGGAAATACA ACATGCTGAA GAATTTCTTA TCAAACCAGA ATCTAAAGTG 
GCTCAATTAG ACACTTCTCA GTGGCCCTTG TTACTAAAGA ATTTTGATAA GCTAAATGTA 
AGGACAGCAC ACTATACACC TCTTCCTTGT GGTTCAAATC CTCTGAAGAG GGAGATTGGG 
GACTATATCA GGACCGGTTT CATTAATCTT GACAAGCCCT CTAACCCCTC TTCCCATGAG 
GTGGTAGCCT GGATCCGACG AATACTTCGG GTAGAGAAGA CTGGCCACAG TGGCACACTA 
GATCCCAAAG TGACTGGTTG TTTAATTGTG TGCATTGAAC GAGCCACTCG TTTGGTGAAA 
TCACAACAGA GTGCAGGCAA AGAGTATGTT GGAATTGTCC GGCTGCACAA TGCTATTGAA 
GGGGGTACTC AGCTTTCTAG GGCCCTAGAA ACTCTGACAG GTGCCCTGTT TCAGCGACCC 
CCACTTATTG CTGCAGTAAA GAGGCAGCTT CGAGTGAGGA CTATCTACGA GAGCAAAATG 
ATAGAATATG ATCCTGAGAG AAGATTAGGA ATCTTTTGGG TAAGCTGTGA AGCTGGCACC 
TACATTCGGA CACTATGCGT ACACCTTGGC TTGTTACTGG GAGTTGGTGG TCAGATGCAG 
GAACTTCGGA GGGTGCGTTC TGGAGTCATG AGTGAAAAGG ACCACATGGT GACAATGCAT 
GATGTACTCG ATGCTCAGTG GCTGTATGAT AACCATAAGG ATGAGAGTTA CTTGCGGCGT 
GTTGTTTACC CTTTGGAAAA GCTGTTGACA TCTCATAAAC GTCTGGTTAT GAAAGATAGT 
GCAGTGAATG CAATCTGCTA TGGGGCCAAG ATCATGCTTC CTGGTCTTCT TCGATATGAA 
GATGGCATTG AGGTCAACCA GGAGATTGTG GTCATTACTA CTAAGGGGGA AGCTATCTGC 
ATGGCAATTG CATTGATGAC TACAGCAGTG ATTTCTACCT GTGACCATGG TATAGTAGCC 
AAAATAAAGA GGGTGATCAT GGAGAGAGAC ACTTATCCTC GCAAGTGGGG TTTAGGTCCA 
AAGGCAAGTC AGAAGAAGAT GATGATCAAG CAGGGCCTTC TGGACAAGCA TGGCAAACCC 
ACAGACAATA CCCCTGCCAC ATGGAAACAG GATTACATTG ACTATAGTGA TTCTGGCAAG 
AACACACTGG TTACCGAAGC AGTACAAGCC CCTCAGTTAG CTGCTGAAGC AGTAAATGTC 
ATAAAAAGGA AGCGGGATAG TGAGAGTGAA AGTGATGAGA CCCCAACAGT TCCCCAGTTG 
AAGGAAAAGA AGAAGAAGAA GGATAAGAAG CCCAAAACTG TGCTAGAAAG TGGGGGCGAA 
ACTGGAGATG GGGACAACGA CACCACCAAA AAGAAAAAGA AGAAGAAAGT AAAAGTGGTA 
GAAGAGATGT CTGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Slow growth and unstable ribosomal RNA lacking pseudouridine in mouse embryonic fibroblast cells expressing catalytically inactive dyskerin.
FEBS letters587(14)2112-7(2013 Jul)
Gu BW,Ge J,Fan JM,Bessler M,Mason PJ

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
The EMBO journal32(12)1681-701(2013 Jun)
Kappei D,Butter F,Benda C,Scheibe M,Dra?kovi? I,Stevense M,Novo CL,Basquin C,Araki M,Araki K,Krastev DB,Kittler R,Jessberger R,Londo?o-Vallejo JA,Mann M,Buchholz F

Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico14(10)755-63(2012 Oct)
Machado-Pinilla R,Carrillo J,Manguan-Garcia C,Sastre L,Mentzer A,Gu BW,Mason PJ,Perona R

The genetics of dyskeratosis congenita.
Cancer genetics204(12)635-45(2011 Dec)
Mason PJ,Bessler M

Dyskeratosis congenita.
Hematology. American Society of Hematology. Education Program2011480-6(2011)
Dokal I

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Dkc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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