Nlrp10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nlrp10
Entrez Gene ID	244202
Full Name	NLR family, pyrin domain containing 10
Synonyms	6430548I20Rik,Nalp10,Napl10,PAN5,Pynod
General protein information	Preferred Names NLR family, pyrin domain containing 10 Names NACHT, LRR and PYD domains-containing protein 10 NACHT, LRR and PYD containing protein 10 NACHT, leucine rich repeat and PYD containing 10 NACHT/LRR/pyrin domain-containing protein 10 neuronal apoptosis inhibitor protein 10
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_175532.3	NP_780741.1	NACHT, LRR and PYD domains-containing protein 10

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NLRP10	XP_003313013.1
	NLRP10	XP_001098361.1
Canis lupus familiaris (dog)	NLRP10	XP_854074.1
Mus musculus (house mouse)	Nlrp10	NP_780741.1
Homo sapiens (human)	NLRP10	NP_789791.1
Rattus norvegicus (Norway rat)	Nlrp10	NP_001099761.1

Gene Ontology
Bibliography

Related articles in PubMed

An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
Clay GM, Valadares DG, Graff JW, Ulland TK, Davis RE, Scorza BM, Zhanbolat BS, Chen Y, Sutterwala FS, Wilson ME
Journal of immunology (Baltimore, Md. : 1950)199(8)2823-2833(2017 Oct)

Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.
Damm A, Giebeler N, Zamek J, Zigrino P, Kufer TA
European journal of immunology46(8)1959-69(2016 08)

Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, M?ller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC
Proceedings of the National Academy of Sciences of the United States of America112(10)3056-61(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection
Title: An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.

NLRP10 contributes to T-cell-mediated inflammatory responses in the skin
Title: Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.

conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function
Title: Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.

Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review]
Title: Roles of NLRP10 in innate and adaptive immunity.

Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection.
Title: Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.

The following Nlrp10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nlrp10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05527	NM_175532.3 Latest version!	Mus musculus NLR family, pyrin domain containing 10 (Nlrp10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$398.30 $569.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nlrp10 ( NM_175532.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780741.1 Mus musculus NLR family, pyrin domain containing 10 (Nlrp10), mRNA.

Price & Availability↑

CloneID	OMu05527
Clone ID Related Accession (Same CDS sequence)	NM_175532.3
Accession Version	NM_175532.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Mus musculus(house mouse)
Product	NACHT, LRR and PYD domains-containing protein 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK028575.1 and AC122046.2. On Jan 13, 2006 this sequence version replaced NM_175532.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ062235.1, AK028802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTGG CACGGGCCAA CAGCCCCCAG GAGGCACTGC TTTGGGCCTT GAATGACCTT 
GAGGAGAACA GTTTCAAGAC GCTGAAGTTC CACTTACGAG ATGTGACCCA ATTTCATCTG 
GCCCGAGGGG AACTGGAGAG TCTGAGTCAG GTGGACCTGG CATCAAAACT GATTTCAATG 
TACGGAGCAC AGGAAGCCGT GAGAGTGGTG AGCAGGAGCT TGCTGGCCAT GAACTTGATG 
GAGCTTGTAG ACTACCTCAA CCAGGTTTGT CTGAATGATT ACAGAGAAAT CTACCGGGAG 
CATGTGCGCT GCTTGGAGGA GAGGCAAGAT TGGGGTGTTA ATAGCAGCCA CAATAAGCTG 
CTCCTGATGG CCACATCCAG TTCAGGGGGT CGCAGATCAC CTTCCTGTTC TGACCTGGAA 
CAGGAGTTGG ATCCTGTCGA TGTGGAGACT TTATTTGCTC CGGAGGCGGA GTCCTACTCA 
ACCCCGCCCA TAGTGGTGAT GCAAGGATCT GCGGGCACTG GAAAGACAAC CCTGGTCAAA 
AAACTGGTGC AGGACTGGTC CAAAGGGAAG CTGTACCCAG GCCAGTTTGA TTATGTTTTC 
TACGTGAGCT GCAGAGAAGT GGTCCTGTTA CCCAAGTGTG ACCTGCCCAA CCTCATCTGC 
TGGTGTTGTG GAGATGATCA AGCCCCAGTC ACAGAGATTC TGCGGCAGCC TGGGCGGCTC 
CTGTTCATCC TGGATGGCTA TGATGAGTTA CAGAAGTCCA GTCGTGCCGA GTGCGTACTT 
CACATTCTGA TGAGGAGAAG GGAGGTACCA TGCTCCCTTC TCATCACCAC GCGGCCTCCA 
GCTTTGCAGA GTCTGGAACC CATGTTGGGT GAACGGCGAC ATGTCCTTGT CTTAGGCTTC 
TCTGAGGAGG AGAGGGAAAC ATATTTCAGC TCCTGTTTTA CGGATAAGGA GCAATTGAAA 
AATGCCCTTG AGTTTGTGCA AAACAATGCT GTTCTCTATA AAGCATGCCA GGTTCCAGGC 
ATTTGCTGGG TGGTCTGCTC CTGGCTGAAG AAGAAGATGG CGAGAGGTCA GGAAGTCTCA 
GAGACACCTA GCAACAGTAC AGACATCTTC ACTGCTTATG TGTCCACCTT TCTGCCCACT 
GATGGCAATG GAGACAGCTC TGAGCTTACC AGGCACAAGG TACTGAAGAG TCTGTGCTCC 
TTGGCTGCGG AGGGGATGCG GCACCAGAGG CTGCTATTTG AAGAAGAGGT CCTCAGAAAG 
CATGGCTTAG ACGGCCCCAG CCTTACTGCT TTCCTGAACT GCATCGACTA CCGAGCGGGG 
CTTGGCATCA AGAAATTCTA CAGCTTTCGC CACATCAGCT TCCAGGAATT TTTCTATGCC 
ATGTCCTTCC TTGTGAAGGA GGACCAGAGT CAGCAGGGAG AGGCCACACA CAAAGAAGTG 
GCAAAGCTGG TGGATCCAGA GAACCATGAA GAGGTGACTC TCAGTTTGCA GTTCTTATTC 
GACATGTTGA AAACAGAGGG CACCTTGAGC TTGGGGCTGA AGTTCTGCTT CAGAATCGCT 
CCTTCGGTAA GGCAGGATCT GAAGCATTTT AAAGAGCAAA TAGAAGCCAT AAAGTACAAA 
AGGTCATGGG ATCTGGAATT CTCTCTCTAT GATTCTAAGA TAAAGAAGCT CACACAAGGT 
ATCCAGATGA AAGATGTCAT TCTCAATGTG CAACATTTGG ATGAAAAGAA ATCTGACAAG 
AAGAAGTCAG TTTCAGTGAC AAGCAGCTTT AGTAGCGGGA AGGTACAAAG TCCATTCTTG 
GGAAATGATA AAAGCACCAG GAAACAAAAG AAGGCATCTA ATGGGAAAAG CAGAGGGGCA 
GAGGAACCAG CCCCGGGGGT TAGAAACCGT AGGCTGGCAA GCAGAGAAAA GGGTCATATG 
GAGATGAATG ATAAGGAGGA TGGTGGGGTG GAGGAACAGG AGGATGAGGA AGGACAGACA 
CTTAAAAAGG ATGGAGAGAT GATAGATAAG ATGAATGGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780741.1
CDS	65..2086
Translation	MALARANSPQEALLWALNDLEENSFKTLKFHLRDVTQFHLARGELESLSQVDLASKLISMYGAQEAVRVVSRSLLAMNLMELVDYLNQVCLNDYREIYREHVRCLEERQDWGVNSSHNKLLLMATSSSGGRRSPSCSDLEQELDPVDVETLFAPEAESYSTPPIVVMQGSAGTGKTTLVKKLVQDWSKGKLYPGQFDYVFYVSCREVVLLPKCDLPNLICWCCGDDQAPVTEILRQPGRLLFILDGYDELQKSSRAECVLHILMRRREVPCSLLITTRPPALQSLEPMLGERRHVLVLGFSEEERETYFSSCFTDKEQLKNALEFVQNNAVLYKACQVPGICWVVCSWLKKKMARGQEVSETPSNSTDIFTAYVSTFLPTDGNGDSSELTRHKVLKSLCSLAAEGMRHQRLLFEEEVLRKHGLDGPSLTAFLNCIDYRAGLGIKKFYSFRHISFQEFFYAMSFLVKEDQSQQGEATHKEVAKLVDPENHEEVTLSLQFLFDMLKTEGTLSLGLKFCFRIAPSVRQDLKHFKEQIEAIKYKRSWDLEFSLYDSKIKKLTQGIQMKDVILNVQHLDEKKSDKKKSVSVTSSFSSGKVQSPFLGNDKSTRKQKKASNGKSRGAEEPAPGVRNRRLASREKGHMEMNDKEDGGVEEQEDEEGQTLKKDGEMIDKMNG

Target ORF information:

RefSeq Version	NM_175532.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus NLR family, pyrin domain containing 10 (Nlrp10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175532.3

ORF Insert Sequence:

ATGGCCTTGG CACGGGCCAA CAGCCCCCAG GAGGCACTGC TTTGGGCCTT GAATGACCTT 
GAGGAGAACA GTTTCAAGAC GCTGAAGTTC CACTTACGAG ATGTGACCCA ATTTCATCTG 
GCCCGAGGGG AACTGGAGAG TCTGAGTCAG GTGGACCTGG CATCAAAACT GATTTCAATG 
TACGGAGCAC AGGAAGCCGT GAGAGTGGTG AGCAGGAGCT TGCTGGCCAT GAACTTGATG 
GAGCTTGTAG ACTACCTCAA CCAGGTTTGT CTGAATGATT ACAGAGAAAT CTACCGGGAG 
CATGTGCGCT GCTTGGAGGA GAGGCAAGAT TGGGGTGTTA ATAGCAGCCA CAATAAGCTG 
CTCCTGATGG CCACATCCAG TTCAGGGGGT CGCAGATCAC CTTCCTGTTC TGACCTGGAA 
CAGGAGTTGG ATCCTGTCGA TGTGGAGACT TTATTTGCTC CGGAGGCGGA GTCCTACTCA 
ACCCCGCCCA TAGTGGTGAT GCAAGGATCT GCGGGCACTG GAAAGACAAC CCTGGTCAAA 
AAACTGGTGC AGGACTGGTC CAAAGGGAAG CTGTACCCAG GCCAGTTTGA TTATGTTTTC 
TACGTGAGCT GCAGAGAAGT GGTCCTGTTA CCCAAGTGTG ACCTGCCCAA CCTCATCTGC 
TGGTGTTGTG GAGATGATCA AGCCCCAGTC ACAGAGATTC TGCGGCAGCC TGGGCGGCTC 
CTGTTCATCC TGGATGGCTA TGATGAGTTA CAGAAGTCCA GTCGTGCCGA GTGCGTACTT 
CACATTCTGA TGAGGAGAAG GGAGGTACCA TGCTCCCTTC TCATCACCAC GCGGCCTCCA 
GCTTTGCAGA GTCTGGAACC CATGTTGGGT GAACGGCGAC ATGTCCTTGT CTTAGGCTTC 
TCTGAGGAGG AGAGGGAAAC ATATTTCAGC TCCTGTTTTA CGGATAAGGA GCAATTGAAA 
AATGCCCTTG AGTTTGTGCA AAACAATGCT GTTCTCTATA AAGCATGCCA GGTTCCAGGC 
ATTTGCTGGG TGGTCTGCTC CTGGCTGAAG AAGAAGATGG CGAGAGGTCA GGAAGTCTCA 
GAGACACCTA GCAACAGTAC AGACATCTTC ACTGCTTATG TGTCCACCTT TCTGCCCACT 
GATGGCAATG GAGACAGCTC TGAGCTTACC AGGCACAAGG TACTGAAGAG TCTGTGCTCC 
TTGGCTGCGG AGGGGATGCG GCACCAGAGG CTGCTATTTG AAGAAGAGGT CCTCAGAAAG 
CATGGCTTAG ACGGCCCCAG CCTTACTGCT TTCCTGAACT GCATCGACTA CCGAGCGGGG 
CTTGGCATCA AGAAATTCTA CAGCTTTCGC CACATCAGCT TCCAGGAATT TTTCTATGCC 
ATGTCCTTCC TTGTGAAGGA GGACCAGAGT CAGCAGGGAG AGGCCACACA CAAAGAAGTG 
GCAAAGCTGG TGGATCCAGA GAACCATGAA GAGGTGACTC TCAGTTTGCA GTTCTTATTC 
GACATGTTGA AAACAGAGGG CACCTTGAGC TTGGGGCTGA AGTTCTGCTT CAGAATCGCT 
CCTTCGGTAA GGCAGGATCT GAAGCATTTT AAAGAGCAAA TAGAAGCCAT AAAGTACAAA 
AGGTCATGGG ATCTGGAATT CTCTCTCTAT GATTCTAAGA TAAAGAAGCT CACACAAGGT 
ATCCAGATGA AAGATGTCAT TCTCAATGTG CAACATTTGG ATGAAAAGAA ATCTGACAAG 
AAGAAGTCAG TTTCAGTGAC AAGCAGCTTT AGTAGCGGGA AGGTACAAAG TCCATTCTTG 
GGAAATGATA AAAGCACCAG GAAACAAAAG AAGGCATCTA ATGGGAAAAG CAGAGGGGCA 
GAGGAACCAG CCCCGGGGGT TAGAAACCGT AGGCTGGCAA GCAGAGAAAA GGGTCATATG 
GAGATGAATG ATAAGGAGGA TGGTGGGGTG GAGGAACAGG AGGATGAGGA AGGACAGACA 
CTTAAAAAGG ATGGAGAGAT GATAGATAAG ATGAATGGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)199(8)2823-2833(2017 Oct)
Clay GM,Valadares DG,Graff JW,Ulland TK,Davis RE,Scorza BM,Zhanbolat BS,Chen Y,Sutterwala FS,Wilson ME

Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.
European journal of immunology46(8)1959-69(2016 08)
Damm A,Giebeler N,Zamek J,Zigrino P,Kufer TA

Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Proceedings of the National Academy of Sciences of the United States of America112(10)3056-61(2015 Mar)
Krishnaswamy JK,Singh A,Gowthaman U,Wu R,Gorrepati P,Sales Nascimento M,Gallman A,Liu D,Rhebergen AM,Calabro S,Xu L,Ranney P,Srivastava A,Ranson M,Gorham JD,McCaw Z,Kleeberger SR,Heinz LX,M?ller AC,Bennett KL,Superti-Furga G,Henao-Mejia J,Sutterwala FS,Williams A,Flavell RA,Eisenbarth SC

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Nlrp10 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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