Fbxl5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbxl5
Entrez Gene ID	242960
Full Name	F-box and leucine-rich repeat protein 5
Synonyms	Fbl4,Fir4
General protein information	Preferred Names F-box and leucine-rich repeat protein 5 Names F-box/LRR-repeat protein 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001159963.1	NP_001153435.1	F-box/LRR-repeat protein 5 isoform A
NM_178729.4	NP_848844.1	F-box/LRR-repeat protein 5 isoform B

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXL5	NP_036293.1
Danio rerio (zebrafish)	fbxl5	XP_003201304.1
Mus musculus (house mouse)	Fbxl5	NP_001153435.1
Rattus norvegicus (Norway rat)	Fbxl5	NP_001100692.1
	FBXL5	XP_001118937.2
Canis lupus familiaris (dog)	FBXL5	XP_536232.2
Bos taurus (cattle)	FBXL5	NP_001075909.1
Xenopus tropicalis (tropical clawed frog)	fbxl5	NP_001011072.1
Pan troglodytes (chimpanzee)	FBXL5	XP_517113.3
Gallus gallus (chicken)	FBXL5	XP_420776.4

Gene Ontology
Bibliography

Related articles in PubMed

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Muto Y, Nishiyama M, Nita A, Moroishi T, Nakayama KI
Nature communications816114(2017 Jul)

FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI
Molecular and cellular biology37(8)(2017 Apr)

F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.
Ruiz JC, Bruick RK
Journal of inorganic biochemistry13373-7(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FBXL5 contributes to regulation of neural stem progenitor cell proliferation during mammalian brain development.
Title: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.

we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology.
Title: F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.

F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
Title: F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Title: The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

The following Fbxl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbxl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07648	NM_178729.4 Latest version!	Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00
OMu07842	NM_001159963.1 Latest version!	Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$405.30 $579.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbxl5 ( NM_178729.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848844.1 Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu07648
Clone ID Related Accession (Same CDS sequence)	NM_178729.4
Accession Version	NM_178729.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1872bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	F-box/LRR-repeat protein 5 isoform B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY245949.1, AK041497.1 and BC113798.1. On May 7, 2009 this sequence version replaced NM_178729.3. Transcript Variant: This variant (2) has a different 3' terminus, compared to variant 1, which results in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC113798.1, AK029957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCCCT TCCCCGATGA AGTGGACGTC TTCACCGCCC CGCACTGGCG GATGAAGCAG 
CTGGTGGGGC GCTACTGCGA CAAGCTTTCT AAAACCAACT TTTCCAACAA CAATGACTTC 
CGTGCTCTTC TCCAGTCTTT ATATGCTACT TTCAAGGAGT TTAAAATGCA TGAACAAATT 
GAAAATGAAT ACATTATCGG TTTACTTCAG CAGCGCAGTC AGACCATATA TAATGTACAC 
TCTGACAATA AGCTCTCCGA GATGCTGAGT CTCTTTGAAA AGGGGCTGAA GAATGTCAAG 
AATGAGTACG AACAGTTAAA TTATGCAAAA CAGCTGAAAG AGAGATTGGA GGCTTTTACA 
AGAGATTTTC TTCCTCACAT GAAAGAGGAA GAAGAGGTTT TTCAGCCCAT GTTAATGGAA 
TATTTTACCT ACGAGGAGCT TAAAGATATC AAAAAGAAAG TGATTGCACA GCACTGCTCA 
CAGAAGGACA CGGCAGAGCT CCTCAGAGGG CTCAGTCTGT GGAACCAAGC TGAGGAGCGA 
CAGAAAGTTC TCAAGTACTC TGTGGATGAG AAGGCAGATA CAGAAGCGGA AGTGTCAGAA 
CACTCCACAG GTATAACCCA TCTTCCTCCT GAGGTAATGC TGTCCATTTT CAGTTACCTT 
AATCCTCAAG AATTGTGTCG GTGTAGTCAA GTCAGTACTA AGTGGTCTCA GCTGGCAAAA 
ACAGGATCTT TGTGGAAACA TCTTTACCCT GTTCATTGGG CAAGAGGTGA CTGGTATAGT 
GGTCCTGCCA CTGAACTTGA TACTGAGCCT GATGAGGAAT GGGTGAGAAA TAGGAAAGAT 
GAAAGTCGTG CTTTCCAGGA GTGGGATGAA GATGCCGATA TAGATGAATC TGAAGAGTCT 
GCAGAGGAAT CGGTTGCTAT CAGCATTGCA CAAATGGAAA AACGTGTACT CCATGGCTTA 
ATTCATAATG TTCTGCCATA TGTTGGTACC TCTGTAAAAA CTTTAGTGTT AGCGTACAGC 
TCTGCAGTCT CCAGCAAAAT GGTTAGGCAG ATTTTAGAGC TTTGTCCTAA CCTGGAACAT 
CTGGATCTTA CCCAGACCGA CATTTCTGAT TCTGCATTTG ACAGTTGGTC TTGGCTCGGT 
TGCTGCCAGA GTCTTCGGCA TCTTGATCTG TCTGGATGTG AAAAAATCAC AGACATGGCT 
CTAGAGAAGA TTTCTAGAGC TCTTGGAGTT CTGACATCTC ATCAGAGTGG CTTTCTGAAA 
AGTGCAGGCA AGGCTGCTTC AACTCCATGG ACAAGTAAAG ACATTACCAT GCCATCCACC 
ACGCAGTATG CCTGTTTGCA CAATTTAACT GACAAAGGCA TTGGTGAAGA AATAGACAAC 
GAGCACTCTT GGACTGAACC TGTGTCTTCT GAAAGTTTGA CTTCTCCTTA TGTGTGGATG 
CTAGATGCTG AAGATTTGGC TGATATTGAA GATGCTGTAG AGTGGAGACA CAGAAATGTT 
GAGAGTCTCT GTGTGATGGA AACAGCCTCC AACTTTGGTT GTTCCTCATC TGGTTGTTAC 
AGTAAGGACA TTGTGGGATT AAGGACTAGT GTCTGTTGGC AGCAGCATTG TGCTTCTCCA 
GCCTTTGCAT ATTGTGGTCA TTCATTCTGT TGTACAGGGA CAGCTTTAAG AACTATGACT 
ACACTCCCAG CGACTTCTGC AATGTGTAGA AAAGCATTAA GGACTACATT GCCCAGGGGG 
AAAGACTTAA TTTATTTTGG GAGTGAAAAG TCTGACCAAG AGACTGGACG AGTACTTTTG 
TTCCTCAGTC TGTCTGGATG TTACCAGATC ACAGACCATG GTCTCAGGTG GGTGATCAGC 
CCTAGTTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848844.1
CDS	102..1973
Translation	MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVLKYSVDEKADTEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRNRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGFLKSAGKAASTPWTSKDITMPSTTQYACLHNLTDKGIGEEIDNEHSWTEPVSSESLTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMTTLPATSAMCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRWVISPSC

Target ORF information:

RefSeq Version	NM_178729.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178729.4

ORF Insert Sequence:

ATGGCGCCCT TCCCCGATGA AGTGGACGTC TTCACCGCCC CGCACTGGCG GATGAAGCAG 
CTGGTGGGGC GCTACTGCGA CAAGCTTTCT AAAACCAACT TTTCCAACAA CAATGACTTC 
CGTGCTCTTC TCCAGTCTTT ATATGCTACT TTCAAGGAGT TTAAAATGCA TGAACAAATT 
GAAAATGAAT ACATTATCGG TTTACTTCAG CAGCGCAGTC AGACCATATA TAATGTACAC 
TCTGACAATA AGCTCTCCGA GATGCTGAGT CTCTTTGAAA AGGGGCTGAA GAATGTCAAG 
AATGAGTACG AACAGTTAAA TTATGCAAAA CAGCTGAAAG AGAGATTGGA GGCTTTTACA 
AGAGATTTTC TTCCTCACAT GAAAGAGGAA GAAGAGGTTT TTCAGCCCAT GTTAATGGAA 
TATTTTACCT ACGAGGAGCT TAAAGATATC AAAAAGAAAG TGATTGCACA GCACTGCTCA 
CAGAAGGACA CGGCAGAGCT CCTCAGAGGG CTCAGTCTGT GGAACCAAGC TGAGGAGCGA 
CAGAAAGTTC TCAAGTACTC TGTGGATGAG AAGGCAGATA CAGAAGCGGA AGTGTCAGAA 
CACTCCACAG GTATAACCCA TCTTCCTCCT GAGGTAATGC TGTCCATTTT CAGTTACCTT 
AATCCTCAAG AATTGTGTCG GTGTAGTCAA GTCAGTACTA AGTGGTCTCA GCTGGCAAAA 
ACAGGATCTT TGTGGAAACA TCTTTACCCT GTTCATTGGG CAAGAGGTGA CTGGTATAGT 
GGTCCTGCCA CTGAACTTGA TACTGAGCCT GATGAGGAAT GGGTGAGAAA TAGGAAAGAT 
GAAAGTCGTG CTTTCCAGGA GTGGGATGAA GATGCCGATA TAGATGAATC TGAAGAGTCT 
GCAGAGGAAT CGGTTGCTAT CAGCATTGCA CAAATGGAAA AACGTGTACT CCATGGCTTA 
ATTCATAATG TTCTGCCATA TGTTGGTACC TCTGTAAAAA CTTTAGTGTT AGCGTACAGC 
TCTGCAGTCT CCAGCAAAAT GGTTAGGCAG ATTTTAGAGC TTTGTCCTAA CCTGGAACAT 
CTGGATCTTA CCCAGACCGA CATTTCTGAT TCTGCATTTG ACAGTTGGTC TTGGCTCGGT 
TGCTGCCAGA GTCTTCGGCA TCTTGATCTG TCTGGATGTG AAAAAATCAC AGACATGGCT 
CTAGAGAAGA TTTCTAGAGC TCTTGGAGTT CTGACATCTC ATCAGAGTGG CTTTCTGAAA 
AGTGCAGGCA AGGCTGCTTC AACTCCATGG ACAAGTAAAG ACATTACCAT GCCATCCACC 
ACGCAGTATG CCTGTTTGCA CAATTTAACT GACAAAGGCA TTGGTGAAGA AATAGACAAC 
GAGCACTCTT GGACTGAACC TGTGTCTTCT GAAAGTTTGA CTTCTCCTTA TGTGTGGATG 
CTAGATGCTG AAGATTTGGC TGATATTGAA GATGCTGTAG AGTGGAGACA CAGAAATGTT 
GAGAGTCTCT GTGTGATGGA AACAGCCTCC AACTTTGGTT GTTCCTCATC TGGTTGTTAC 
AGTAAGGACA TTGTGGGATT AAGGACTAGT GTCTGTTGGC AGCAGCATTG TGCTTCTCCA 
GCCTTTGCAT ATTGTGGTCA TTCATTCTGT TGTACAGGGA CAGCTTTAAG AACTATGACT 
ACACTCCCAG CGACTTCTGC AATGTGTAGA AAAGCATTAA GGACTACATT GCCCAGGGGG 
AAAGACTTAA TTTATTTTGG GAGTGAAAAG TCTGACCAAG AGACTGGACG AGTACTTTTG 
TTCCTCAGTC TGTCTGGATG TTACCAGATC ACAGACCATG GTCTCAGGTG GGTGATCAGC 
CCTAGTTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbxl5 ( NM_001159963.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001153435.1 Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07842
Clone ID Related Accession (Same CDS sequence)	NM_001159963.1
Accession Version	NM_001159963.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2073bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	F-box/LRR-repeat protein 5 isoform A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY245949.1, AK159744.1 and AK150664.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085100.1, AK159744.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCCCT TCCCCGATGA AGTGGACGTC TTCACCGCCC CGCACTGGCG GATGAAGCAG 
CTGGTGGGGC GCTACTGCGA CAAGCTTTCT AAAACCAACT TTTCCAACAA CAATGACTTC 
CGTGCTCTTC TCCAGTCTTT ATATGCTACT TTCAAGGAGT TTAAAATGCA TGAACAAATT 
GAAAATGAAT ACATTATCGG TTTACTTCAG CAGCGCAGTC AGACCATATA TAATGTACAC 
TCTGACAATA AGCTCTCCGA GATGCTGAGT CTCTTTGAAA AGGGGCTGAA GAATGTCAAG 
AATGAGTACG AACAGTTAAA TTATGCAAAA CAGCTGAAAG AGAGATTGGA GGCTTTTACA 
AGAGATTTTC TTCCTCACAT GAAAGAGGAA GAAGAGGTTT TTCAGCCCAT GTTAATGGAA 
TATTTTACCT ACGAGGAGCT TAAAGATATC AAAAAGAAAG TGATTGCACA GCACTGCTCA 
CAGAAGGACA CGGCAGAGCT CCTCAGAGGG CTCAGTCTGT GGAACCAAGC TGAGGAGCGA 
CAGAAAGTTC TCAAGTACTC TGTGGATGAG AAGGCAGATA CAGAAGCGGA AGTGTCAGAA 
CACTCCACAG GTATAACCCA TCTTCCTCCT GAGGTAATGC TGTCCATTTT CAGTTACCTT 
AATCCTCAAG AATTGTGTCG GTGTAGTCAA GTCAGTACTA AGTGGTCTCA GCTGGCAAAA 
ACAGGATCTT TGTGGAAACA TCTTTACCCT GTTCATTGGG CAAGAGGTGA CTGGTATAGT 
GGTCCTGCCA CTGAACTTGA TACTGAGCCT GATGAGGAAT GGGTGAGAAA TAGGAAAGAT 
GAAAGTCGTG CTTTCCAGGA GTGGGATGAA GATGCCGATA TAGATGAATC TGAAGAGTCT 
GCAGAGGAAT CGGTTGCTAT CAGCATTGCA CAAATGGAAA AACGTGTACT CCATGGCTTA 
ATTCATAATG TTCTGCCATA TGTTGGTACC TCTGTAAAAA CTTTAGTGTT AGCGTACAGC 
TCTGCAGTCT CCAGCAAAAT GGTTAGGCAG ATTTTAGAGC TTTGTCCTAA CCTGGAACAT 
CTGGATCTTA CCCAGACCGA CATTTCTGAT TCTGCATTTG ACAGTTGGTC TTGGCTCGGT 
TGCTGCCAGA GTCTTCGGCA TCTTGATCTG TCTGGATGTG AAAAAATCAC AGACATGGCT 
CTAGAGAAGA TTTCTAGAGC TCTTGGAGTT CTGACATCTC ATCAGAGTGG CTTTCTGAAA 
AGTGCAGGCA AGGCTGCTTC AACTCCATGG ACAAGTAAAG ACATTACCAT GCCATCCACC 
ACGCAGTATG CCTGTTTGCA CAATTTAACT GACAAAGGCA TTGGTGAAGA AATAGACAAC 
GAGCACTCTT GGACTGAACC TGTGTCTTCT GAAAGTTTGA CTTCTCCTTA TGTGTGGATG 
CTAGATGCTG AAGATTTGGC TGATATTGAA GATGCTGTAG AGTGGAGACA CAGAAATGTT 
GAGAGTCTCT GTGTGATGGA AACAGCCTCC AACTTTGGTT GTTCCTCATC TGGTTGTTAC 
AGTAAGGACA TTGTGGGATT AAGGACTAGT GTCTGTTGGC AGCAGCATTG TGCTTCTCCA 
GCCTTTGCAT ATTGTGGTCA TTCATTCTGT TGTACAGGGA CAGCTTTAAG AACTATGACT 
ACACTCCCAG CGACTTCTGC AATGTGTAGA AAAGCATTAA GGACTACATT GCCCAGGGGG 
AAAGACTTAA TTTATTTTGG GAGTGAAAAG TCTGACCAAG AGACTGGACG AGTACTTTTG 
TTCCTCAGTC TGTCTGGATG TTACCAGATC ACAGACCATG GTCTCAGGGC TCTGACTCTG 
GGAGGAGGGC TGCCTTACCT GGAGCACCTG AATCTCTCTG GCTGTCTGAC TGTAACTGGT 
GCAGGGCTGC AGGATTTGGT CTCAGCGTGT CCTTCCCTAA ATGACGAATA CTTTTACTAC 
TGTGACAACA TTAACGGTCC TCATGCTGAC ACCGCCAGTG GATGCCAGAA TTTGCAGTGT 
GGTTTTCGAG CCTGCTGCCG CTCTGGCGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153435.1
CDS	102..2174
Translation	MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVLKYSVDEKADTEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRNRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGFLKSAGKAASTPWTSKDITMPSTTQYACLHNLTDKGIGEEIDNEHSWTEPVSSESLTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMTTLPATSAMCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRALTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE

Target ORF information:

RefSeq Version	NM_001159963.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159963.1

ORF Insert Sequence:

ATGGCGCCCT TCCCCGATGA AGTGGACGTC TTCACCGCCC CGCACTGGCG GATGAAGCAG 
CTGGTGGGGC GCTACTGCGA CAAGCTTTCT AAAACCAACT TTTCCAACAA CAATGACTTC 
CGTGCTCTTC TCCAGTCTTT ATATGCTACT TTCAAGGAGT TTAAAATGCA TGAACAAATT 
GAAAATGAAT ACATTATCGG TTTACTTCAG CAGCGCAGTC AGACCATATA TAATGTACAC 
TCTGACAATA AGCTCTCCGA GATGCTGAGT CTCTTTGAAA AGGGGCTGAA GAATGTCAAG 
AATGAGTACG AACAGTTAAA TTATGCAAAA CAGCTGAAAG AGAGATTGGA GGCTTTTACA 
AGAGATTTTC TTCCTCACAT GAAAGAGGAA GAAGAGGTTT TTCAGCCCAT GTTAATGGAA 
TATTTTACCT ACGAGGAGCT TAAAGATATC AAAAAGAAAG TGATTGCACA GCACTGCTCA 
CAGAAGGACA CGGCAGAGCT CCTCAGAGGG CTCAGTCTGT GGAACCAAGC TGAGGAGCGA 
CAGAAAGTTC TCAAGTACTC TGTGGATGAG AAGGCAGATA CAGAAGCGGA AGTGTCAGAA 
CACTCCACAG GTATAACCCA TCTTCCTCCT GAGGTAATGC TGTCCATTTT CAGTTACCTT 
AATCCTCAAG AATTGTGTCG GTGTAGTCAA GTCAGTACTA AGTGGTCTCA GCTGGCAAAA 
ACAGGATCTT TGTGGAAACA TCTTTACCCT GTTCATTGGG CAAGAGGTGA CTGGTATAGT 
GGTCCTGCCA CTGAACTTGA TACTGAGCCT GATGAGGAAT GGGTGAGAAA TAGGAAAGAT 
GAAAGTCGTG CTTTCCAGGA GTGGGATGAA GATGCCGATA TAGATGAATC TGAAGAGTCT 
GCAGAGGAAT CGGTTGCTAT CAGCATTGCA CAAATGGAAA AACGTGTACT CCATGGCTTA 
ATTCATAATG TTCTGCCATA TGTTGGTACC TCTGTAAAAA CTTTAGTGTT AGCGTACAGC 
TCTGCAGTCT CCAGCAAAAT GGTTAGGCAG ATTTTAGAGC TTTGTCCTAA CCTGGAACAT 
CTGGATCTTA CCCAGACCGA CATTTCTGAT TCTGCATTTG ACAGTTGGTC TTGGCTCGGT 
TGCTGCCAGA GTCTTCGGCA TCTTGATCTG TCTGGATGTG AAAAAATCAC AGACATGGCT 
CTAGAGAAGA TTTCTAGAGC TCTTGGAGTT CTGACATCTC ATCAGAGTGG CTTTCTGAAA 
AGTGCAGGCA AGGCTGCTTC AACTCCATGG ACAAGTAAAG ACATTACCAT GCCATCCACC 
ACGCAGTATG CCTGTTTGCA CAATTTAACT GACAAAGGCA TTGGTGAAGA AATAGACAAC 
GAGCACTCTT GGACTGAACC TGTGTCTTCT GAAAGTTTGA CTTCTCCTTA TGTGTGGATG 
CTAGATGCTG AAGATTTGGC TGATATTGAA GATGCTGTAG AGTGGAGACA CAGAAATGTT 
GAGAGTCTCT GTGTGATGGA AACAGCCTCC AACTTTGGTT GTTCCTCATC TGGTTGTTAC 
AGTAAGGACA TTGTGGGATT AAGGACTAGT GTCTGTTGGC AGCAGCATTG TGCTTCTCCA 
GCCTTTGCAT ATTGTGGTCA TTCATTCTGT TGTACAGGGA CAGCTTTAAG AACTATGACT 
ACACTCCCAG CGACTTCTGC AATGTGTAGA AAAGCATTAA GGACTACATT GCCCAGGGGG 
AAAGACTTAA TTTATTTTGG GAGTGAAAAG TCTGACCAAG AGACTGGACG AGTACTTTTG 
TTCCTCAGTC TGTCTGGATG TTACCAGATC ACAGACCATG GTCTCAGGGC TCTGACTCTG 
GGAGGAGGGC TGCCTTACCT GGAGCACCTG AATCTCTCTG GCTGTCTGAC TGTAACTGGT 
GCAGGGCTGC AGGATTTGGT CTCAGCGTGT CCTTCCCTAA ATGACGAATA CTTTTACTAC 
TGTGACAACA TTAACGGTCC TCATGCTGAC ACCGCCAGTG GATGCCAGAA TTTGCAGTGT 
GGTTTTCGAG CCTGCTGCCG CTCTGGCGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature communications816114(2017 Jul)
Muto Y,Nishiyama M,Nita A,Moroishi T,Nakayama KI

FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Molecular and cellular biology37(8)(2017 Apr)
Yamauchi T,Nishiyama M,Moroishi T,Kawamura A,Nakayama KI

F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.
Journal of inorganic biochemistry13373-7(2014 Apr)
Ruiz JC,Bruick RK

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Fbxl5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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