Neu4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Neu4
Entrez Gene ID	241159
Full Name	sialidase 4
Synonyms	9330166I04
General protein information	Preferred Names sialidase 4 Names sialidase-4 N-acetyl-alpha-neuraminidase 4 neuraminidase 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_001310769.1	NP_001297698.1	sialidase-4 isoform 1
NM_173772.3	NP_776133.1	sialidase-4 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NEU4	XP_002686672.1
Rattus norvegicus (Norway rat)	Neu4	NP_001101704.1
Xenopus tropicalis (tropical clawed frog)	LOC100486976	XP_002943103.2
	NEU4	XP_001095081.2
Mus musculus (house mouse)	Neu4	NP_776133.1
Danio rerio (zebrafish)	neu4	NP_001018384.1
Homo sapiens (human)	NEU4	NP_001161071.1
Gallus gallus (chicken)	NEU4	XP_004937059.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.
Pan X, De Arag?o CBP, Velasco-Martin JP, Priestman DA, Wu HY, Takahashi K, Yamaguchi K, Sturiale L, Garozzo D, Platt FM, Lamarche-Vane N, Morales CR, Miyagi T, Pshezhetsky AV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(8)3467-3483(2017 Aug)

Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T
The Journal of biological chemistry287(18)14816-26(2012 Apr)

Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
Seyrantepe V, Lema P, Caqueret A, Dridi L, Bel Hadj S, Carpentier S, Boucher F, Levade T, Carmant L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud JL, Morales CR, Pshezhetsky AV
PLoS genetics6(9)e1001118(2010 Sep)

Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation.
Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H, Miyagi T
The Journal of biological chemistry284(32)21157-64(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results provide the first in vivo evidence that neuraminidases 3 and 4 have important roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin bodies.
Title: Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.

NEU4 is involved in regulation of neuronal function by polySia degradation in mammals.
Title: Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.

Neu4 is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice.
Title: Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.

mouse Neu4 plays an important regulatory role in neurite formation, possibly through desialylation of glycoproteins
Title: Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation.

Neu4 is a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs.
Title: Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.

The following Neu4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Neu4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04156	NM_173772.3 Latest version!	Mus musculus sialidase 4 (Neu4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu74048	NM_001310769.1 Latest version!	Mus musculus sialidase 4 (Neu4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Neu4 ( NM_173772.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_776133.1 Mus musculus sialidase 4 (Neu4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04156
Clone ID Related Accession (Same CDS sequence)	NM_173772.3
Accession Version	NM_173772.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	sialidase-4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070438.1. On May 16, 2004 this sequence version replaced NM_173772.2. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC070438.1, AK034236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCCCA CGCGTGTTCC CAGGAGAACG GTGCTCTTCC AGAGGGAAAG GACGGGCCTG 
ACCTACCGTG TGCCTGCGTT ACTCTGTGTG CCTCCCAGGC CTACTCTGCT GGCCTTCGCG 
GAACAGCGAC TTAGCCCTGA TGACTCCCAT GCCCACCGCC TGGTGCTACG GAGGGGCACG 
CTGACCAGGG GCTCAGTGCG GTGGGGCACT CTGAGTGTAC TGGAGACTGC AGTACTGGAG 
GAGCACAGGT CTATGAACCC TTGCCCGGTG CTGGATGAGC ACTCTGGTAC CATCTTCCTC 
TTCTTCATTG CCGTGCTGGG CCACACACCG GAGGCCGTGC AAATCGCCAC TGGCAAGAAC 
GCTGCTCGCC TCTGCTGTGT GACCAGCTGT GACGCTGGCC TCACCTGGGG CAGTGTTCGA 
GATCTCACTG AGGAAGCCAT TGGTGCTGCA TTGCAGGACT GGGCCACCTT TGCTGTGGGT 
CCGGGCCATG GAGTTCAGCT GCGCTCGGGT CGCCTGCTTG TTCCTGCTTA CACCTATCAT 
GTGGACCGAC GGGAATGTTT TGGCAAGATC TGCTGGACCA GTCCCCACTC CTTGGCATTC 
TACAGTGATG ATCATGGGAT CTCCTGGCAT TGTGGAGGCC TTGTGCCCAA CCTACGCTCT 
GGAGAGTGCC AACTGGCTGC GGTAGATGGA GACTTTCTCT ACTGTAATGC TCGAAGCCCT 
CTGGGTAACC GTGTGCAGGC ACTGAGTGCT GATGAAGGCA CGTCCTTCCT ACCAGGGGAG 
CTGGTGCCTA CATTGGCAGA GACGGCTCGT GGTTGCCAGG GTAGCATTGT GGGCTTCCTA 
GCTCCACCCT CAATCGAGCC TCAGGATGAC CGGTGGACAG GGAGTCCTAG GAACACCCCA 
CATTCCCCAT GCTTCAATCT CAGAGTACAG GAGTCTTCGG GGGAAGGTGC CAGAGGTCTT 
CTTGAACGTT GGATGCCCAG GTTGCCTCTC TGCTACCCAC AGTCCCGGAG CCCAGAGAAT 
CATGGCCTAG AGCCTGGGTC AGATGGAGAT AAGACATCCT GGACTCCGGA ATGTCCTATG 
TCCTCTGATT CCATGCTTCA GAGCCCCACA TGGCTACTAT ATTCCCACCC AGCAGGGCGT 
AGAGCTCGGC TCCACATGGG AATCTACCTG AGCCGATCCC CCTTGGATCC CCACAGCTGG 
ACAGAGCCCT GGGTGATCTA TGAGGGCCCC AGTGGCTACT CTGACCTTGC CTTTCTTGGG 
CCTATGCCTG GGGCATCCCT GGTTTTTGCC TGTCTGTTTG AGAGCGGGAC CAGGACTTCC 
TATGAAGACA TTTCTTTTTG CTTGTTCTCA CTGGCGGATG TCCTGGAGAA TGTGCCCACT 
GGCTTAGAGA TGCTAAGTCT CAGGGATAAG GCTCAGGGGC ATTGCTGGCC CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776133.1
CDS	157..1593
Translation	MGPTRVPRRTVLFQRERTGLTYRVPALLCVPPRPTLLAFAEQRLSPDDSHAHRLVLRRGTLTRGSVRWGTLSVLETAVLEEHRSMNPCPVLDEHSGTIFLFFIAVLGHTPEAVQIATGKNAARLCCVTSCDAGLTWGSVRDLTEEAIGAALQDWATFAVGPGHGVQLRSGRLLVPAYTYHVDRRECFGKICWTSPHSLAFYSDDHGISWHCGGLVPNLRSGECQLAAVDGDFLYCNARSPLGNRVQALSADEGTSFLPGELVPTLAETARGCQGSIVGFLAPPSIEPQDDRWTGSPRNTPHSPCFNLRVQESSGEGARGLLERWMPRLPLCYPQSRSPENHGLEPGSDGDKTSWTPECPMSSDSMLQSPTWLLYSHPAGRRARLHMGIYLSRSPLDPHSWTEPWVIYEGPSGYSDLAFLGPMPGASLVFACLFESGTRTSYEDISFCLFSLADVLENVPTGLEMLSLRDKAQGHCWPS

Target ORF information:

RefSeq Version	NM_173772.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus sialidase 4 (Neu4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173772.3

ORF Insert Sequence:

ATGGGGCCCA CGCGTGTTCC CAGGAGAACG GTGCTCTTCC AGAGGGAAAG GACGGGCCTG 
ACCTACCGTG TGCCTGCGTT ACTCTGTGTG CCTCCCAGGC CTACTCTGCT GGCCTTCGCG 
GAACAGCGAC TTAGCCCTGA TGACTCCCAT GCCCACCGCC TGGTGCTACG GAGGGGCACG 
CTGACCAGGG GCTCAGTGCG GTGGGGCACT CTGAGTGTAC TGGAGACTGC AGTACTGGAG 
GAGCACAGGT CTATGAACCC TTGCCCGGTG CTGGATGAGC ACTCTGGTAC CATCTTCCTC 
TTCTTCATTG CCGTGCTGGG CCACACACCG GAGGCCGTGC AAATCGCCAC TGGCAAGAAC 
GCTGCTCGCC TCTGCTGTGT GACCAGCTGT GACGCTGGCC TCACCTGGGG CAGTGTTCGA 
GATCTCACTG AGGAAGCCAT TGGTGCTGCA TTGCAGGACT GGGCCACCTT TGCTGTGGGT 
CCGGGCCATG GAGTTCAGCT GCGCTCGGGT CGCCTGCTTG TTCCTGCTTA CACCTATCAT 
GTGGACCGAC GGGAATGTTT TGGCAAGATC TGCTGGACCA GTCCCCACTC CTTGGCATTC 
TACAGTGATG ATCATGGGAT CTCCTGGCAT TGTGGAGGCC TTGTGCCCAA CCTACGCTCT 
GGAGAGTGCC AACTGGCTGC GGTAGATGGA GACTTTCTCT ACTGTAATGC TCGAAGCCCT 
CTGGGTAACC GTGTGCAGGC ACTGAGTGCT GATGAAGGCA CGTCCTTCCT ACCAGGGGAG 
CTGGTGCCTA CATTGGCAGA GACGGCTCGT GGTTGCCAGG GTAGCATTGT GGGCTTCCTA 
GCTCCACCCT CAATCGAGCC TCAGGATGAC CGGTGGACAG GGAGTCCTAG GAACACCCCA 
CATTCCCCAT GCTTCAATCT CAGAGTACAG GAGTCTTCGG GGGAAGGTGC CAGAGGTCTT 
CTTGAACGTT GGATGCCCAG GTTGCCTCTC TGCTACCCAC AGTCCCGGAG CCCAGAGAAT 
CATGGCCTAG AGCCTGGGTC AGATGGAGAT AAGACATCCT GGACTCCGGA ATGTCCTATG 
TCCTCTGATT CCATGCTTCA GAGCCCCACA TGGCTACTAT ATTCCCACCC AGCAGGGCGT 
AGAGCTCGGC TCCACATGGG AATCTACCTG AGCCGATCCC CCTTGGATCC CCACAGCTGG 
ACAGAGCCCT GGGTGATCTA TGAGGGCCCC AGTGGCTACT CTGACCTTGC CTTTCTTGGG 
CCTATGCCTG GGGCATCCCT GGTTTTTGCC TGTCTGTTTG AGAGCGGGAC CAGGACTTCC 
TATGAAGACA TTTCTTTTTG CTTGTTCTCA CTGGCGGATG TCCTGGAGAA TGTGCCCACT 
GGCTTAGAGA TGCTAAGTCT CAGGGATAAG GCTCAGGGGC ATTGCTGGCC CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Neu4 ( NM_001310769.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297698.1 Mus musculus sialidase 4 (Neu4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu74048
Clone ID Related Accession (Same CDS sequence)	NM_001310769.1
Accession Version	NM_001310769.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	sialidase-4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB521925.1, AB510404.1 and BC070438.1. On Jul 18, 2015 this sequence version replaced XM_006529593.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AB510404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACTG CTGGAGCTCC CTTCTGCTTC CATGTGGACT CCCTGGTACC TTGCTCCTAC 
TGGAAGGTTA TGGGGCCCAC GCGTGTTCCC AGGAGAACGG TGCTCTTCCA GAGGGAAAGG 
ACGGGCCTGA CCTACCGTGT GCCTGCGTTA CTCTGTGTGC CTCCCAGGCC TACTCTGCTG 
GCCTTCGCGG AACAGCGACT TAGCCCTGAT GACTCCCATG CCCACCGCCT GGTGCTACGG 
AGGGGCACGC TGACCAGGGG CTCAGTGCGG TGGGGCACTC TGAGTGTACT GGAGACTGCA 
GTACTGGAGG AGCACAGGTC TATGAACCCT TGCCCGGTGC TGGATGAGCA CTCTGGTACC 
ATCTTCCTCT TCTTCATTGC CGTGCTGGGC CACACACCGG AGGCCGTGCA AATCGCCACT 
GGCAAGAACG CTGCTCGCCT CTGCTGTGTG ACCAGCTGTG ACGCTGGCCT CACCTGGGGC 
AGTGTTCGAG ATCTCACTGA GGAAGCCATT GGTGCTGCAT TGCAGGACTG GGCCACCTTT 
GCTGTGGGTC CGGGCCATGG AGTTCAGCTG CGCTCGGGTC GCCTGCTTGT TCCTGCTTAC 
ACCTATCATG TGGACCGACG GGAATGTTTT GGCAAGATCT GCTGGACCAG TCCCCACTCC 
TTGGCATTCT ACAGTGATGA TCATGGGATC TCCTGGCATT GTGGAGGCCT TGTGCCCAAC 
CTACGCTCTG GAGAGTGCCA ACTGGCTGCG GTAGATGGAG ACTTTCTCTA CTGTAATGCT 
CGAAGCCCTC TGGGTAACCG TGTGCAGGCA CTGAGTGCTG ATGAAGGCAC GTCCTTCCTA 
CCAGGGGAGC TGGTGCCTAC ATTGGCAGAG ACGGCTCGTG GTTGCCAGGG TAGCATTGTG 
GGCTTCCTAG CTCCACCCTC AATCGAGCCT CAGGATGACC GGTGGACAGG GAGTCCTAGG 
AACACCCCAC ATTCCCCATG CTTCAATCTC AGAGTACAGG AGTCTTCGGG GGAAGGTGCC 
AGAGGTCTTC TTGAACGTTG GATGCCCAGG TTGCCTCTCT GCTACCCACA GTCCCGGAGC 
CCAGAGAATC ATGGCCTAGA GCCTGGGTCA GATGGAGATA AGACATCCTG GACTCCGGAA 
TGTCCTATGT CCTCTGATTC CATGCTTCAG AGCCCCACAT GGCTACTATA TTCCCACCCA 
GCAGGGCGTA GAGCTCGGCT CCACATGGGA ATCTACCTGA GCCGATCCCC CTTGGATCCC 
CACAGCTGGA CAGAGCCCTG GGTGATCTAT GAGGGCCCCA GTGGCTACTC TGACCTTGCC 
TTTCTTGGGC CTATGCCTGG GGCATCCCTG GTTTTTGCCT GTCTGTTTGA GAGCGGGACC 
AGGACTTCCT ATGAAGACAT TTCTTTTTGC TTGTTCTCAC TGGCGGATGT CCTGGAGAAT 
GTGCCCACTG GCTTAGAGAT GCTAAGTCTC AGGGATAAGG CTCAGGGGCA TTGCTGGCCC 
TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297698.1
CDS	172..1677
Translation	METAGAPFCFHVDSLVPCSYWKVMGPTRVPRRTVLFQRERTGLTYRVPALLCVPPRPTLLAFAEQRLSPDDSHAHRLVLRRGTLTRGSVRWGTLSVLETAVLEEHRSMNPCPVLDEHSGTIFLFFIAVLGHTPEAVQIATGKNAARLCCVTSCDAGLTWGSVRDLTEEAIGAALQDWATFAVGPGHGVQLRSGRLLVPAYTYHVDRRECFGKICWTSPHSLAFYSDDHGISWHCGGLVPNLRSGECQLAAVDGDFLYCNARSPLGNRVQALSADEGTSFLPGELVPTLAETARGCQGSIVGFLAPPSIEPQDDRWTGSPRNTPHSPCFNLRVQESSGEGARGLLERWMPRLPLCYPQSRSPENHGLEPGSDGDKTSWTPECPMSSDSMLQSPTWLLYSHPAGRRARLHMGIYLSRSPLDPHSWTEPWVIYEGPSGYSDLAFLGPMPGASLVFACLFESGTRTSYEDISFCLFSLADVLENVPTGLEMLSLRDKAQGHCWPS

Target ORF information:

RefSeq Version	NM_001310769.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sialidase 4 (Neu4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310769.1

ORF Insert Sequence:

ATGGAGACTG CTGGAGCTCC CTTCTGCTTC CATGTGGACT CCCTGGTACC TTGCTCCTAC 
TGGAAGGTTA TGGGGCCCAC GCGTGTTCCC AGGAGAACGG TGCTCTTCCA GAGGGAAAGG 
ACGGGCCTGA CCTACCGTGT GCCTGCGTTA CTCTGTGTGC CTCCCAGGCC TACTCTGCTG 
GCCTTCGCGG AACAGCGACT TAGCCCTGAT GACTCCCATG CCCACCGCCT GGTGCTACGG 
AGGGGCACGC TGACCAGGGG CTCAGTGCGG TGGGGCACTC TGAGTGTACT GGAGACTGCA 
GTACTGGAGG AGCACAGGTC TATGAACCCT TGCCCGGTGC TGGATGAGCA CTCTGGTACC 
ATCTTCCTCT TCTTCATTGC CGTGCTGGGC CACACACCGG AGGCCGTGCA AATCGCCACT 
GGCAAGAACG CTGCTCGCCT CTGCTGTGTG ACCAGCTGTG ACGCTGGCCT CACCTGGGGC 
AGTGTTCGAG ATCTCACTGA GGAAGCCATT GGTGCTGCAT TGCAGGACTG GGCCACCTTT 
GCTGTGGGTC CGGGCCATGG AGTTCAGCTG CGCTCGGGTC GCCTGCTTGT TCCTGCTTAC 
ACCTATCATG TGGACCGACG GGAATGTTTT GGCAAGATCT GCTGGACCAG TCCCCACTCC 
TTGGCATTCT ACAGTGATGA TCATGGGATC TCCTGGCATT GTGGAGGCCT TGTGCCCAAC 
CTACGCTCTG GAGAGTGCCA ACTGGCTGCG GTAGATGGAG ACTTTCTCTA CTGTAATGCT 
CGAAGCCCTC TGGGTAACCG TGTGCAGGCA CTGAGTGCTG ATGAAGGCAC GTCCTTCCTA 
CCAGGGGAGC TGGTGCCTAC ATTGGCAGAG ACGGCTCGTG GTTGCCAGGG TAGCATTGTG 
GGCTTCCTAG CTCCACCCTC AATCGAGCCT CAGGATGACC GGTGGACAGG GAGTCCTAGG 
AACACCCCAC ATTCCCCATG CTTCAATCTC AGAGTACAGG AGTCTTCGGG GGAAGGTGCC 
AGAGGTCTTC TTGAACGTTG GATGCCCAGG TTGCCTCTCT GCTACCCACA GTCCCGGAGC 
CCAGAGAATC ATGGCCTAGA GCCTGGGTCA GATGGAGATA AGACATCCTG GACTCCGGAA 
TGTCCTATGT CCTCTGATTC CATGCTTCAG AGCCCCACAT GGCTACTATA TTCCCACCCA 
GCAGGGCGTA GAGCTCGGCT CCACATGGGA ATCTACCTGA GCCGATCCCC CTTGGATCCC 
CACAGCTGGA CAGAGCCCTG GGTGATCTAT GAGGGCCCCA GTGGCTACTC TGACCTTGCC 
TTTCTTGGGC CTATGCCTGG GGCATCCCTG GTTTTTGCCT GTCTGTTTGA GAGCGGGACC 
AGGACTTCCT ATGAAGACAT TTCTTTTTGC TTGTTCTCAC TGGCGGATGT CCTGGAGAAT 
GTGCCCACTG GCTTAGAGAT GCTAAGTCTC AGGGATAAGG CTCAGGGGCA TTGCTGGCCC 
TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(8)3467-3483(2017 Aug)
Pan X,De Arag?o CBP,Velasco-Martin JP,Priestman DA,Wu HY,Takahashi K,Yamaguchi K,Sturiale L,Garozzo D,Platt FM,Lamarche-Vane N,Morales CR,Miyagi T,Pshezhetsky AV

Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
The Journal of biological chemistry287(18)14816-26(2012 Apr)
Takahashi K,Mitoma J,Hosono M,Shiozaki K,Sato C,Yamaguchi K,Kitajima K,Higashi H,Nitta K,Shima H,Miyagi T

Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
PLoS genetics6(9)e1001118(2010 Sep)
Seyrantepe V,Lema P,Caqueret A,Dridi L,Bel Hadj S,Carpentier S,Boucher F,Levade T,Carmant L,Gravel RA,Hamel E,Vachon P,Di Cristo G,Michaud JL,Morales CR,Pshezhetsky AV

Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation.
The Journal of biological chemistry284(32)21157-64(2009 Aug)
Shiozaki K,Koseki K,Yamaguchi K,Shiozaki M,Narimatsu H,Miyagi T

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Neu4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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