Usp18 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Usp18
Entrez Gene ID	24110
Full Name	ubiquitin specific peptidase 18
Synonyms	1110058H21Rik,AW047653,UBP43,Ubp15
General protein information	Preferred Names ubiquitin specific peptidase 18 Names ubl carboxyl-terminal hydrolase 18 43 kDa ISG15-specific protease ISG15-specific-processing protease ubiquitin specific protease 15 ubiquitin specific protease 18 ubl thioesterase 18 ubl thiolesterase 18
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F1\|6 57.17 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011909.2	NP_036039.2	ubl carboxyl-terminal hydrolase 18

Pathways from BioSystems

Homologies

Homo sapiens (human)	USP18	NP_059110.2
Pan troglodytes (chimpanzee)	USP18	XP_001164261.1
Canis lupus familiaris (dog)	USP18	XP_005637457.1
Mus musculus (house mouse)	Usp18	NP_036039.2
Rattus norvegicus (Norway rat)	Usp18	NP_001014080.1
Gallus gallus (chicken)	USP18	XP_004938016.1
	USP18	XP_001111984.2
Bos taurus (cattle)	USP18	NP_001017940.1
Xenopus tropicalis (tropical clawed frog)	usp18	XP_004912550.1
Danio rerio (zebrafish)	LOC100334535	XP_002661398.1

Gene Ontology
Bibliography

Related articles in PubMed

USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity.
An S, Zhao LP, Shen LJ, Wang S, Zhang K, Qi Y, Zheng J, Zhang XJ, Zhu XY, Bao R, Yang L, Lu YX, She ZG, Tang YD
Hepatology (Baltimore, Md.)66(6)1866-1884(2017 Dec)

Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells.
Lai KP, Cheung AHY, Tse WKF
Cell biology international41(8)914-921(2017 Aug)

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.
Mustachio LM, Lu Y, Tafe LJ, Memoli V, Rodriguez-Canales J, Mino B, Villalobos PA, Wistuba I, Katayama H, Hanash SM, Roszik J, Kawakami M, Cho KJ, Hancock JF, Chinyengetere F, Hu S, Liu X, Freemantle SJ, Dmitrovsky E
Molecular cancer research : MCR15(7)905-914(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

associates with and deubiquitinates TAK1 to protect against hepatic steatosis, insulin resistance, and the inflammatory response
Title: USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity.

USP18's ISG15 specificity is mediated by a small interaction interface.
Title: Structural basis of the specificity of USP18 toward ISG15.

USP18 has a protective role in pathological cardiac remodeling in mouse.
Title: Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling.

findings show that multiple inflammatory stimuli can modulate interferon stimulated gene expression and thus inhibit hepatocyte interferon signaling via USP18 induction
Title: Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression.

this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling
Title: Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.

The following Usp18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Usp18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21471	NM_011909.2 Latest version!	Mus musculus ubiquitin specific peptidase 18 (Usp18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Usp18 ( NM_011909.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036039.2 Mus musculus ubiquitin specific peptidase 18 (Usp18), mRNA.

Price & Availability↑

CloneID	OMu21471
Clone ID Related Accession (Same CDS sequence)	NM_011909.2
Accession Version	NM_011909.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	ubl carboxyl-terminal hydrolase 18
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK151260.1, AK153312.1 and AA286391.1. On May 14, 2008 this sequence version replaced NM_011909.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF069502.1, AK151011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAGG GGTTTGGGCT CCTGAGGAAA CCCTGCCAGT CAGTTGTGGC TGAGCCGCAG 
CAGTACTCAG CGCTGGAGGA AGAGAGGACC ATGAAGAGGA AGAGAGTGCT GTCTAGAGAC 
CTCTGCAGTG CCTGGGACAG CCCTCATGGT CTGGTTGGTT TACACAACAT CGGACAGACG 
TGTTGCCTTA ACTCCTTGCT TCAAGTGTTC ATGATGAACA TGGACTTCAG AATGATATTG 
AAGAGGATAA CAGTGCCTCG GAGTGCAGAA GAGAGGAAGA GAAGTGTCCC CTTCCAGCTG 
CTTTTGCTGC TGGAGAAGAT GCAGGACAGT CGACAGAAAG CCGTGCTGCC CACGGAGCTC 
GTTCAGTGCC TGCAGAAATA CAACGTGCCG TTGTTTGTCC AGCACGATGC TGCTCAACTC 
TACCTTACAA TCTGGAACCT GACTAAGGAC CAGATCACGG ACACAGACTT GACAGAGCGG 
CTGCAGGGTC TGTTCACCAT CTGGACGCAG GAGTCCCTGA TTTGCGTGGG CTGTACAGCA 
GAGAGCAGCA GGAGGAGCAA ACTGCTCACA CTCTCTCTTC CTCTTTTTGA TAAGGACGCA 
AAGCCTCTGA AAACCCTGGA GGATGCCTTG AGATGTTTCG TCCAGCCCAA AGAGTTAGCA 
AGCTCCGACA TGTGCTGCGA GAGCTGTGGG GAGAAGACGC CTTGGAAACA GGTTCTGAAG 
CTGACTCATC TGCCCCAAAC CTTGACCATT CACCTCATGA GATTCTCTGC CAGGAACTCG 
AGGACGGAAA AGATCTGTCA CTCAGTTAAT TTCCCTCAGA GCTTGGATTT CAGTCAGGTT 
CTGCCAACCG AGGAAGACCT CGGTGATACC AAGGAACAGT CTGAAATACA CTATGAACTC 
TTTGCCGTGA TTGCCCACGT TGGGATGGCT GACTTTGGTC ATTACTGTGC CTACATCCGG 
AATCCCGTGG ATGGAAAGTG GTTCTGCTTC AATGACTCAC ATGTTTGTTG GGTCACCTGG 
AAGGATGTCC AGTGTACCTA TGGGAACCAC AGATACCGCT GGCGGGAAAC GGCCTATCTC 
TTGGTTTACA CGAAGACTGG ATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036039.2
CDS	265..1371
Translation	MGKGFGLLRKPCQSVVAEPQQYSALEEERTMKRKRVLSRDLCSAWDSPHGLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVPLFVQHDAAQLYLTIWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDAKPLKTLEDALRCFVQPKELASSDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKICHSVNFPQSLDFSQVLPTEEDLGDTKEQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQCTYGNHRYRWRETAYLLVYTKTGS

Target ORF information:

RefSeq Version	NM_011909.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin specific peptidase 18 (Usp18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011909.2

ORF Insert Sequence:

ATGGGCAAGG GGTTTGGGCT CCTGAGGAAA CCCTGCCAGT CAGTTGTGGC TGAGCCGCAG 
CAGTACTCAG CGCTGGAGGA AGAGAGGACC ATGAAGAGGA AGAGAGTGCT GTCTAGAGAC 
CTCTGCAGTG CCTGGGACAG CCCTCATGGT CTGGTTGGTT TACACAACAT CGGACAGACG 
TGTTGCCTTA ACTCCTTGCT TCAAGTGTTC ATGATGAACA TGGACTTCAG AATGATATTG 
AAGAGGATAA CAGTGCCTCG GAGTGCAGAA GAGAGGAAGA GAAGTGTCCC CTTCCAGCTG 
CTTTTGCTGC TGGAGAAGAT GCAGGACAGT CGACAGAAAG CCGTGCTGCC CACGGAGCTC 
GTTCAGTGCC TGCAGAAATA CAACGTGCCG TTGTTTGTCC AGCACGATGC TGCTCAACTC 
TACCTTACAA TCTGGAACCT GACTAAGGAC CAGATCACGG ACACAGACTT GACAGAGCGG 
CTGCAGGGTC TGTTCACCAT CTGGACGCAG GAGTCCCTGA TTTGCGTGGG CTGTACAGCA 
GAGAGCAGCA GGAGGAGCAA ACTGCTCACA CTCTCTCTTC CTCTTTTTGA TAAGGACGCA 
AAGCCTCTGA AAACCCTGGA GGATGCCTTG AGATGTTTCG TCCAGCCCAA AGAGTTAGCA 
AGCTCCGACA TGTGCTGCGA GAGCTGTGGG GAGAAGACGC CTTGGAAACA GGTTCTGAAG 
CTGACTCATC TGCCCCAAAC CTTGACCATT CACCTCATGA GATTCTCTGC CAGGAACTCG 
AGGACGGAAA AGATCTGTCA CTCAGTTAAT TTCCCTCAGA GCTTGGATTT CAGTCAGGTT 
CTGCCAACCG AGGAAGACCT CGGTGATACC AAGGAACAGT CTGAAATACA CTATGAACTC 
TTTGCCGTGA TTGCCCACGT TGGGATGGCT GACTTTGGTC ATTACTGTGC CTACATCCGG 
AATCCCGTGG ATGGAAAGTG GTTCTGCTTC AATGACTCAC ATGTTTGTTG GGTCACCTGG 
AAGGATGTCC AGTGTACCTA TGGGAACCAC AGATACCGCT GGCGGGAAAC GGCCTATCTC 
TTGGTTTACA CGAAGACTGG ATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity.
Hepatology (Baltimore, Md.)66(6)1866-1884(2017 Dec)
An S,Zhao LP,Shen LJ,Wang S,Zhang K,Qi Y,Zheng J,Zhang XJ,Zhu XY,Bao R,Yang L,Lu YX,She ZG,Tang YD

Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells.
Cell biology international41(8)914-921(2017 Aug)
Lai KP,Cheung AHY,Tse WKF

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.
Molecular cancer research : MCR15(7)905-914(2017 Jul)
Mustachio LM,Lu Y,Tafe LJ,Memoli V,Rodriguez-Canales J,Mino B,Villalobos PA,Wistuba I,Katayama H,Hanash SM,Roszik J,Kawakami M,Cho KJ,Hancock JF,Chinyengetere F,Hu S,Liu X,Freemantle SJ,Dmitrovsky E

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Usp18 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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