Lrrc52 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrc52
Entrez Gene ID	240899
Full Name	leucine rich repeat containing 52
Synonyms	4930413P14Rik
General protein information	Preferred Names leucine rich repeat containing 52 Names leucine-rich repeat-containing protein 52 BK channel auxiliary gamma subunit LRRC52 BK channel auxilliary gamma subunit LRRC52
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H2.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013382.2	NP_001013400.1	leucine-rich repeat-containing protein 52 precursor
NM_001013382.3	NP_001013400.1	leucine-rich repeat-containing protein 52 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	lrrc52	XP_002933819.2
Homo sapiens (human)	LRRC52	NP_001005214.2
Pan troglodytes (chimpanzee)	LRRC52	XP_524946.2
	LOC696905	XP_001085517.2
Canis lupus familiaris (dog)	LRRC52	XP_545788.2
Mus musculus (house mouse)	Lrrc52	NP_001013400.1
Rattus norvegicus (Norway rat)	Lrrc52	NP_001070902.1
Bos taurus (cattle)	LRRC52	NP_001193028.1
Gallus gallus (chicken)	LRRC52	XP_001234094.2

Gene Ontology
Bibliography

Related articles in PubMed

SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.
Zeng XH, Yang C, Xia XM, Liu M, Lingle CJ
Proceedings of the National Academy of Sciences of the United States of America112(8)2599-604(2015 Feb)

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)

LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.
Yang C, Zeng XH, Zhou Y, Xia XM, Lingle CJ
Proceedings of the National Academy of Sciences of the United States of America108(48)19419-24(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.
Title: SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.

LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels.
Title: LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.

The following Lrrc52 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrc52 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11476	NM_001013382.3 Latest version!	Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OMu11476	NM_001013382.2	Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrc52 ( NM_001013382.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001013400.1 Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.

Price & Availability↑

CloneID	OMu11476
Clone ID Related Accession (Same CDS sequence)	NM_001013382.2 , NM_001013382.3
Accession Version	NM_001013382.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat-containing protein 52 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087947.1. On Apr 6, 2007 this sequence version replaced NM_001013382.1. ##Evidence-Data-START## Transcript exon combination :: BC087947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCTTG CTTCAGGCCC TAGCTCCAAG TTGTTACTCT TTTCTCTTGG AATGGGGTTG 
GTATCAGGGT CCAAGTGTCC AAACAAGTGT GTGTGTCAAG ACCAAGAAGT AGCCTGCATA 
GATTTGCACC TAACGGAATA CCCAGCTGAT ATTCCTCTGA ACACCCGGAG ACTATACCTG 
AACAATAACA AAATCACTAG TTTACCAGCT TTGCAGCTGG GATTCCTCAG TGACCTCGTT 
TACTTGGACT GTCAGAACAA CCGGATTCGA GAGGTGATGG ATTATACCTT CATCGGGATC 
TTCAGACTCA TCTACCTTGA CCTCAGCTCC AACAACCTAA CTTCCATCTC CCCTTTCAGC 
TTCTCAGTGC TCACCAACCT GGTGCGGCTG AACATTTCAC ACAACCCTCA CCTGTTGTAT 
CTTGACAAAT ACGTCTTTGC CAACACCACG TCTTTGAGGT ACCTGGACCT CAGAAACACC 
GGATTGCACA TCATCGACCA TAATGGCTTC CACCACCTGG TGGTGCTCCA GACTCTGTAC 
CTAAGTGGGA ACCCCTGGAT ATGCAACTGC TCCTTCCTGG ACTTCACCAT CCACTTATTA 
GTGTCCCATA TGGACCACCC AGATGCCCAG AACGCCACGT GTACGGAGCC TGCTGAGCTG 
AAAGGGTGGC CCATCACGAA GGTGGGGAAT CCACTCCAGT ACATGTGCAT CACACACCTG 
GACCAGCAGG ACTACATCTT CTTACTGCTC ATCGGCTTCT GCATCTTCGC TGCCGGCACG 
GTGGCTGCCT GGCTCACGGG TGTATGTGCT GTGCTGTACC AGAATGCCCT CCGAACGTCG 
AGCGGGGATG ATACCGAAGA TGAAACTGGG AGTAGATTCG CCAACCAGAT TTTTCGAAGC 
AACACACACT TGGGCCCCAT TCGTCGGTTC CCTGAACTGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013400.1
CDS	67..1011
Translation	MSLASGPSSKLLLFSLGMGLVSGSKCPNKCVCQDQEVACIDLHLTEYPADIPLNTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLLVSHMDHPDAQNATCTEPAELKGWPITKVGNPLQYMCITHLDQQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNALRTSSGDDTEDETGSRFANQIFRSNTHLGPIRRFPELI

Target ORF information:

RefSeq Version	NM_001013382.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013382.2

ORF Insert Sequence:

ATGTCCCTTG CTTCAGGCCC TAGCTCCAAG TTGTTACTCT TTTCTCTTGG AATGGGGTTG 
GTATCAGGGT CCAAGTGTCC AAACAAGTGT GTGTGTCAAG ACCAAGAAGT AGCCTGCATA 
GATTTGCACC TAACGGAATA CCCAGCTGAT ATTCCTCTGA ACACCCGGAG ACTATACCTG 
AACAATAACA AAATCACTAG TTTACCAGCT TTGCAGCTGG GATTCCTCAG TGACCTCGTT 
TACTTGGACT GTCAGAACAA CCGGATTCGA GAGGTGATGG ATTATACCTT CATCGGGATC 
TTCAGACTCA TCTACCTTGA CCTCAGCTCC AACAACCTAA CTTCCATCTC CCCTTTCAGC 
TTCTCAGTGC TCACCAACCT GGTGCGGCTG AACATTTCAC ACAACCCTCA CCTGTTGTAT 
CTTGACAAAT ACGTCTTTGC CAACACCACG TCTTTGAGGT ACCTGGACCT CAGAAACACC 
GGATTGCACA TCATCGACCA TAATGGCTTC CACCACCTGG TGGTGCTCCA GACTCTGTAC 
CTAAGTGGGA ACCCCTGGAT ATGCAACTGC TCCTTCCTGG ACTTCACCAT CCACTTATTA 
GTGTCCCATA TGGACCACCC AGATGCCCAG AACGCCACGT GTACGGAGCC TGCTGAGCTG 
AAAGGGTGGC CCATCACGAA GGTGGGGAAT CCACTCCAGT ACATGTGCAT CACACACCTG 
GACCAGCAGG ACTACATCTT CTTACTGCTC ATCGGCTTCT GCATCTTCGC TGCCGGCACG 
GTGGCTGCCT GGCTCACGGG TGTATGTGCT GTGCTGTACC AGAATGCCCT CCGAACGTCG 
AGCGGGGATG ATACCGAAGA TGAAACTGGG AGTAGATTCG CCAACCAGAT TTTTCGAAGC 
AACACACACT TGGGCCCCAT TCGTCGGTTC CCTGAACTGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrrc52 ( NM_001013382.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001013400.1 Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.

Price & Availability↑

CloneID	OMu11476
Clone ID Related Accession (Same CDS sequence)	NM_001013382.2 , NM_001013382.3
Accession Version	NM_001013382.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat-containing protein 52 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113970.8. On Aug 22, 2018 this sequence version replaced NM_001013382.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC087947.1, SRR5189685.43431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCTTG CTTCAGGCCC TAGCTCCAAG TTGTTACTCT TTTCTCTTGG AATGGGGTTG 
GTATCAGGGT CCAAGTGTCC AAACAAGTGT GTGTGTCAAG ACCAAGAAGT AGCCTGCATA 
GATTTGCACC TAACGGAATA CCCAGCTGAT ATTCCTCTGA ACACCCGGAG ACTATACCTG 
AACAATAACA AAATCACTAG TTTACCAGCT TTGCAGCTGG GATTCCTCAG TGACCTCGTT 
TACTTGGACT GTCAGAACAA CCGGATTCGA GAGGTGATGG ATTATACCTT CATCGGGATC 
TTCAGACTCA TCTACCTTGA CCTCAGCTCC AACAACCTAA CTTCCATCTC CCCTTTCAGC 
TTCTCAGTGC TCACCAACCT GGTGCGGCTG AACATTTCAC ACAACCCTCA CCTGTTGTAT 
CTTGACAAAT ACGTCTTTGC CAACACCACG TCTTTGAGGT ACCTGGACCT CAGAAACACC 
GGATTGCACA TCATCGACCA TAATGGCTTC CACCACCTGG TGGTGCTCCA GACTCTGTAC 
CTAAGTGGGA ACCCCTGGAT ATGCAACTGC TCCTTCCTGG ACTTCACCAT CCACTTATTA 
GTGTCCCATA TGGACCACCC AGATGCCCAG AACGCCACGT GTACGGAGCC TGCTGAGCTG 
AAAGGGTGGC CCATCACGAA GGTGGGGAAT CCACTCCAGT ACATGTGCAT CACACACCTG 
GACCAGCAGG ACTACATCTT CTTACTGCTC ATCGGCTTCT GCATCTTCGC TGCCGGCACG 
GTGGCTGCCT GGCTCACGGG TGTATGTGCT GTGCTGTACC AGAATGCCCT CCGAACGTCG 
AGCGGGGATG ATACCGAAGA TGAAACTGGG AGTAGATTCG CCAACCAGAT TTTTCGAAGC 
AACACACACT TGGGCCCCAT TCGTCGGTTC CCTGAACTGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013400.1
CDS	67..1011
Translation	MSLASGPSSKLLLFSLGMGLVSGSKCPNKCVCQDQEVACIDLHLTEYPADIPLNTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLLVSHMDHPDAQNATCTEPAELKGWPITKVGNPLQYMCITHLDQQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNALRTSSGDDTEDETGSRFANQIFRSNTHLGPIRRFPELI

Target ORF information:

RefSeq Version	NM_001013382.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013382.3

ORF Insert Sequence:

ATGTCCCTTG CTTCAGGCCC TAGCTCCAAG TTGTTACTCT TTTCTCTTGG AATGGGGTTG 
GTATCAGGGT CCAAGTGTCC AAACAAGTGT GTGTGTCAAG ACCAAGAAGT AGCCTGCATA 
GATTTGCACC TAACGGAATA CCCAGCTGAT ATTCCTCTGA ACACCCGGAG ACTATACCTG 
AACAATAACA AAATCACTAG TTTACCAGCT TTGCAGCTGG GATTCCTCAG TGACCTCGTT 
TACTTGGACT GTCAGAACAA CCGGATTCGA GAGGTGATGG ATTATACCTT CATCGGGATC 
TTCAGACTCA TCTACCTTGA CCTCAGCTCC AACAACCTAA CTTCCATCTC CCCTTTCAGC 
TTCTCAGTGC TCACCAACCT GGTGCGGCTG AACATTTCAC ACAACCCTCA CCTGTTGTAT 
CTTGACAAAT ACGTCTTTGC CAACACCACG TCTTTGAGGT ACCTGGACCT CAGAAACACC 
GGATTGCACA TCATCGACCA TAATGGCTTC CACCACCTGG TGGTGCTCCA GACTCTGTAC 
CTAAGTGGGA ACCCCTGGAT ATGCAACTGC TCCTTCCTGG ACTTCACCAT CCACTTATTA 
GTGTCCCATA TGGACCACCC AGATGCCCAG AACGCCACGT GTACGGAGCC TGCTGAGCTG 
AAAGGGTGGC CCATCACGAA GGTGGGGAAT CCACTCCAGT ACATGTGCAT CACACACCTG 
GACCAGCAGG ACTACATCTT CTTACTGCTC ATCGGCTTCT GCATCTTCGC TGCCGGCACG 
GTGGCTGCCT GGCTCACGGG TGTATGTGCT GTGCTGTACC AGAATGCCCT CCGAACGTCG 
AGCGGGGATG ATACCGAAGA TGAAACTGGG AGTAGATTCG CCAACCAGAT TTTTCGAAGC 
AACACACACT TGGGCCCCAT TCGTCGGTTC CCTGAACTGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.
Proceedings of the National Academy of Sciences of the United States of America112(8)2599-604(2015 Feb)
Zeng XH,Yang C,Xia XM,Liu M,Lingle CJ

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)
Gineste C,De Winter JM,Kohl C,Witt CC,Giannesini B,Brohm K,Le Fur Y,Gretz N,Vilmen C,Pecchi E,Jubeau M,Cozzone PJ,Stienen GJ,Granzier H,Labeit S,Ottenheijm CA,Bendahan D,Gondin J

LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.
Proceedings of the National Academy of Sciences of the United States of America108(48)19419-24(2011 Nov)
Yang C,Zeng XH,Zhou Y,Xia XM,Lingle CJ

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Lrrc52 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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