Sgcb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sgcb
Entrez Gene ID	24051
Full Name	sarcoglycan, beta (dystrophin-associated glycoprotein)
Synonyms	43kDa,AI747103,AI844814,beta-SG
General protein information	Preferred Names sarcoglycan, beta (dystrophin-associated glycoprotein) Names beta-sarcoglycan 43 kDa dystrophin-associated glycoprotein 43DAG sarcoglycan, beta (43kD dystrophin-associated glycoprotein)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 C3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_011890.5	NP_036020.1	beta-sarcoglycan
NM_011890.4	NP_036020.1	beta-sarcoglycan

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sgcb	NP_001177997.1
Gallus gallus (chicken)	SGCB	NP_001026326.1
Homo sapiens (human)	SGCB	NP_000223.1
Pan troglodytes (chimpanzee)	SGCB	XP_517299.2
Canis lupus familiaris (dog)	SGCB	XP_853790.1
Xenopus tropicalis (tropical clawed frog)	sgcb	NP_001135484.1
Bos taurus (cattle)	SGCB	NP_001095658.1
Danio rerio (zebrafish)	sgcb	NP_001030145.1
	SGCB	XP_001090970.1
Mus musculus (house mouse)	Sgcb	NP_036020.1

Gene Ontology
Bibliography

Related articles in PubMed

?-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice.
Murugesan V, Degerman E, Holmen-P?lbrink AK, Duner P, Knutsson A, Hultg?rdh-Nilsson A, Rauch U
Journal of vascular research54(4)235-245(2017)

Independent variability of microtubule perturbations associated with dystrophinopathy.
Belanto JJ, Olthoff JT, Mader TL, Chamberlain CM, Nelson DM, McCourt PM, Talsness DM, Gundersen GG, Lowe DA, Ervasti JM
Human molecular genetics25(22)4951-4961(2016 11)

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
Quattrocelli M, Swinnen M, Giacomazzi G, Camps J, Barth?lemy I, Ceccarelli G, Caluw? E, Grosemans H, Thorrez L, Pelizzo G, Muijtjens M, Verfaillie CM, Blot S, Janssens S, Sampaolesi M
The Journal of clinical investigation125(12)4463-82(2015 Dec)

Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse.
Gibertini S, Zanotti S, Savadori P, Curcio M, Saredi S, Salerno F, Andreetta F, Bernasconi P, Mantegazza R, Mora M
Cell and tissue research356(2)427-43(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

beta-Sarcoglycan deficiency reduces atherosclerotic plaque formation in ApoE-knockout mouse model.
Title: ?-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice.

In Sgcb-null mice, severe morphological disruption was present from 4 weeks in both quadriceps and diaphragm, and included conspicuous deposition of extracellular matrix components.
Title: Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse.

Aging leads to changes in expression of beta-sarcoglycan in aged affected muscles (diaphragm and limb).
Title: Age-related changes in dystrophin-glycoprotein complex and in utrophin are not correlated with intrinsic laryngeal muscles protection in mdx mice.

Data demonstrate a novel function of the sarcoglycan complex in whole body glucose homeostasis and skeletal muscle metabolism, suggesting that the impairment of the skeletal muscle metabolism influences the pathogenesis of muscular dystrophy.
Title: Sarcoglycan complex: implications for metabolic defects in muscular dystrophies.

Sarcoglycan beta missense mutations affect sarcoglycan complex assembly and/or localization to the cell surface and provide information on the molecular mechanisms underlying the effects of various sarcoglycan mutations in muscular dystrophies.
Title: Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting.

The following Sgcb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sgcb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu16531	NM_011890.5 Latest version!	Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein) (Sgcb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00
View Old Accession Versions >>
OMu16531	NM_011890.4	Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein) (Sgcb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sgcb ( NM_011890.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036020.1 Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein) (Sgcb), mRNA.

Price & Availability↑

CloneID	OMu16531
Clone ID Related Accession (Same CDS sequence)	NM_011890.5 , NM_011890.4
Accession Version	NM_011890.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	beta-sarcoglycan
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY133708.1 and AK169403.1. On May 12, 2018 this sequence version replaced NM_011890.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK169403.1, AK132306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG CGGCGGCGGC GGCGGCAGCG ACCGAGCAGC AAGGGTCCAA CGGGCCAGTG 
AAGAAATCCA TGCGGGAGAA GGCTGTGGAG CGGAGGAATG TTAACAAAGA GCACAACAGC 
AATTTCAAAG CTGGATATAT CCCCATCGAT GAGGACCGGC TCCATAAGAC TGGGCTGAGG 
GGGCGAAAGG GCAACTTAGC CATCTGCGTG ATCGTCCTCC TGTTTATCCT GGCCGTCATC 
AATCTACTCA TTACACTTGT CATCTGGGCG GTGATCCGCA TTGGGCCAAA TGGGTGTGAT 
AGCATGGAGT TCCACGAGAG CGGTCTGCTG AGGTTCAAGC AAGTGTCTGA CATGGGCGTC 
ATCCACCCGC TTTATAAGAG CACGGTGGGA GGACGGCGGA ATGAAAACCT GGTCATCACT 
GGCAACAACC AGCCAATTGT CTTCCAGCAA GGGACGACCA AGCTGAGTGT TGAAAAGAAC 
AAGACCTCCA TCACCAGCGA CATCGGGATG CAGTTTTTTG ACCCAAGGAC ACACAATATC 
CTGTTCAGCA CGGACTATGA GACGCACGAG TTTCATCTGC CAAGTGGGGT GAAAAGTTTG 
AACGTTCAGA AAGCATCGAC TGAAAGGATT ACCAGCAATG CTACCAGTGA CTTAAACATC 
AAAGTCGATG GGCGTGCAAT TGTGCGAGGC AACGAAGGCG TCTTCATCAT GGGCAAAACC 
ATTGAATTTC ACATGGGAGG AGATGTGGAG TTAAAAGCTG AAAACAGCAT CATCCTCAAC 
GGCACGGTGA TGGTCAGCCC TACGCGCCTG CCCAGTTCCT CCAGCGGGGA CCAGTCAGGG 
AGTGGTGACT GGGTGCGCTA CAAGCTCTGC ATGTGTGCAG ATGGCACACT CTTCAAAGTA 
CAAGTAACAG GTCACAACAT GGGCTGCCAG GTCTCAGACA ACCCTTGTGG GAACACTCAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036020.1
CDS	25..987
Translation	MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKNKTSITSDIGMQFFDPRTHNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGDVELKAENSIILNGTVMVSPTRLPSSSSGDQSGSGDWVRYKLCMCADGTLFKVQVTGHNMGCQVSDNPCGNTH

Target ORF information:

RefSeq Version	NM_011890.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein) (Sgcb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011890.5

ORF Insert Sequence:

ATGGCGGCAG CGGCGGCGGC GGCGGCAGCG ACCGAGCAGC AAGGGTCCAA CGGGCCAGTG 
AAGAAATCCA TGCGGGAGAA GGCTGTGGAG CGGAGGAATG TTAACAAAGA GCACAACAGC 
AATTTCAAAG CTGGATATAT CCCCATCGAT GAGGACCGGC TCCATAAGAC TGGGCTGAGG 
GGGCGAAAGG GCAACTTAGC CATCTGCGTG ATCGTCCTCC TGTTTATCCT GGCCGTCATC 
AATCTACTCA TTACACTTGT CATCTGGGCG GTGATCCGCA TTGGGCCAAA TGGGTGTGAT 
AGCATGGAGT TCCACGAGAG CGGTCTGCTG AGGTTCAAGC AAGTGTCTGA CATGGGCGTC 
ATCCACCCGC TTTATAAGAG CACGGTGGGA GGACGGCGGA ATGAAAACCT GGTCATCACT 
GGCAACAACC AGCCAATTGT CTTCCAGCAA GGGACGACCA AGCTGAGTGT TGAAAAGAAC 
AAGACCTCCA TCACCAGCGA CATCGGGATG CAGTTTTTTG ACCCAAGGAC ACACAATATC 
CTGTTCAGCA CGGACTATGA GACGCACGAG TTTCATCTGC CAAGTGGGGT GAAAAGTTTG 
AACGTTCAGA AAGCATCGAC TGAAAGGATT ACCAGCAATG CTACCAGTGA CTTAAACATC 
AAAGTCGATG GGCGTGCAAT TGTGCGAGGC AACGAAGGCG TCTTCATCAT GGGCAAAACC 
ATTGAATTTC ACATGGGAGG AGATGTGGAG TTAAAAGCTG AAAACAGCAT CATCCTCAAC 
GGCACGGTGA TGGTCAGCCC TACGCGCCTG CCCAGTTCCT CCAGCGGGGA CCAGTCAGGG 
AGTGGTGACT GGGTGCGCTA CAAGCTCTGC ATGTGTGCAG ATGGCACACT CTTCAAAGTA 
CAAGTAACAG GTCACAACAT GGGCTGCCAG GTCTCAGACA ACCCTTGTGG GAACACTCAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sgcb ( NM_011890.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036020.1 Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein) (Sgcb), mRNA.

Price & Availability↑

CloneID	OMu16531
Clone ID Related Accession (Same CDS sequence)	NM_011890.5 , NM_011890.4
Accession Version	NM_011890.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Mus musculus(house mouse)
Product	beta-sarcoglycan
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK169403.1. On Apr 5, 2007 this sequence version replaced NM_011890.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK169403.1, AK132306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCAG CGGCGGCGGC GGCGGCAGCG ACCGAGCAGC AAGGGTCCAA CGGGCCAGTG 
AAGAAATCCA TGCGGGAGAA GGCTGTGGAG CGGAGGAATG TTAACAAAGA GCACAACAGC 
AATTTCAAAG CTGGATATAT CCCCATCGAT GAGGACCGGC TCCATAAGAC TGGGCTGAGG 
GGGCGAAAGG GCAACTTAGC CATCTGCGTG ATCGTCCTCC TGTTTATCCT GGCCGTCATC 
AATCTACTCA TTACACTTGT CATCTGGGCG GTGATCCGCA TTGGGCCAAA TGGGTGTGAT 
AGCATGGAGT TCCACGAGAG CGGTCTGCTG AGGTTCAAGC AAGTGTCTGA CATGGGCGTC 
ATCCACCCGC TTTATAAGAG CACGGTGGGA GGACGGCGGA ATGAAAACCT GGTCATCACT 
GGCAACAACC AGCCAATTGT CTTCCAGCAA GGGACGACCA AGCTGAGTGT TGAAAAGAAC 
AAGACCTCCA TCACCAGCGA CATCGGGATG CAGTTTTTTG ACCCAAGGAC ACACAATATC 
CTGTTCAGCA CGGACTATGA GACGCACGAG TTTCATCTGC CAAGTGGGGT GAAAAGTTTG 
AACGTTCAGA AAGCATCGAC TGAAAGGATT ACCAGCAATG CTACCAGTGA CTTAAACATC 
AAAGTCGATG GGCGTGCAAT TGTGCGAGGC AACGAAGGCG TCTTCATCAT GGGCAAAACC 
ATTGAATTTC ACATGGGAGG AGATGTGGAG TTAAAAGCTG AAAACAGCAT CATCCTCAAC 
GGCACGGTGA TGGTCAGCCC TACGCGCCTG CCCAGTTCCT CCAGCGGGGA CCAGTCAGGG 
AGTGGTGACT GGGTGCGCTA CAAGCTCTGC ATGTGTGCAG ATGGCACACT CTTCAAAGTA 
CAAGTAACAG GTCACAACAT GGGCTGCCAG GTCTCAGACA ACCCTTGTGG GAACACTCAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036020.1
CDS	19..981
Translation	MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKNKTSITSDIGMQFFDPRTHNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGDVELKAENSIILNGTVMVSPTRLPSSSSGDQSGSGDWVRYKLCMCADGTLFKVQVTGHNMGCQVSDNPCGNTH

Target ORF information:

RefSeq Version	NM_011890.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein) (Sgcb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011890.4

ORF Insert Sequence:

ATGGCGGCAG CGGCGGCGGC GGCGGCAGCG ACCGAGCAGC AAGGGTCCAA CGGGCCAGTG 
AAGAAATCCA TGCGGGAGAA GGCTGTGGAG CGGAGGAATG TTAACAAAGA GCACAACAGC 
AATTTCAAAG CTGGATATAT CCCCATCGAT GAGGACCGGC TCCATAAGAC TGGGCTGAGG 
GGGCGAAAGG GCAACTTAGC CATCTGCGTG ATCGTCCTCC TGTTTATCCT GGCCGTCATC 
AATCTACTCA TTACACTTGT CATCTGGGCG GTGATCCGCA TTGGGCCAAA TGGGTGTGAT 
AGCATGGAGT TCCACGAGAG CGGTCTGCTG AGGTTCAAGC AAGTGTCTGA CATGGGCGTC 
ATCCACCCGC TTTATAAGAG CACGGTGGGA GGACGGCGGA ATGAAAACCT GGTCATCACT 
GGCAACAACC AGCCAATTGT CTTCCAGCAA GGGACGACCA AGCTGAGTGT TGAAAAGAAC 
AAGACCTCCA TCACCAGCGA CATCGGGATG CAGTTTTTTG ACCCAAGGAC ACACAATATC 
CTGTTCAGCA CGGACTATGA GACGCACGAG TTTCATCTGC CAAGTGGGGT GAAAAGTTTG 
AACGTTCAGA AAGCATCGAC TGAAAGGATT ACCAGCAATG CTACCAGTGA CTTAAACATC 
AAAGTCGATG GGCGTGCAAT TGTGCGAGGC AACGAAGGCG TCTTCATCAT GGGCAAAACC 
ATTGAATTTC ACATGGGAGG AGATGTGGAG TTAAAAGCTG AAAACAGCAT CATCCTCAAC 
GGCACGGTGA TGGTCAGCCC TACGCGCCTG CCCAGTTCCT CCAGCGGGGA CCAGTCAGGG 
AGTGGTGACT GGGTGCGCTA CAAGCTCTGC ATGTGTGCAG ATGGCACACT CTTCAAAGTA 
CAAGTAACAG GTCACAACAT GGGCTGCCAG GTCTCAGACA ACCCTTGTGG GAACACTCAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice.
Journal of vascular research54(4)235-245(2017)
Murugesan V,Degerman E,Holmen-P?lbrink AK,Duner P,Knutsson A,Hultg?rdh-Nilsson A,Rauch U

Independent variability of microtubule perturbations associated with dystrophinopathy.
Human molecular genetics25(22)4951-4961(2016 11)
Belanto JJ,Olthoff JT,Mader TL,Chamberlain CM,Nelson DM,McCourt PM,Talsness DM,Gundersen GG,Lowe DA,Ervasti JM

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
The Journal of clinical investigation125(12)4463-82(2015 Dec)
Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barth?lemy I,Ceccarelli G,Caluw? E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M

Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse.
Cell and tissue research356(2)427-43(2014 May)
Gibertini S,Zanotti S,Savadori P,Curcio M,Saredi S,Salerno F,Andreetta F,Bernasconi P,Mantegazza R,Mora M

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Sgcb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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