Grk1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grk1
Entrez Gene ID	24013
Full Name	G protein-coupled receptor kinase 1
Synonyms	Gprk1,Rhok,Rk
General protein information	Preferred Names G protein-coupled receptor kinase 1 Names rhodopsin kinase G-protein receptor kinase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A1.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_011881.3	NP_036011.3	rhodopsin kinase GRK1

Pathways from BioSystems

Homologies

	GRK1	XP_001105738.1
Rattus norvegicus (Norway rat)	Grk1	NP_112358.1
Danio rerio (zebrafish)	grk1a	NP_001029353.2
Pan troglodytes (chimpanzee)	GRK1	XP_003314275.1
Mus musculus (house mouse)	Grk1	NP_036011.3
Homo sapiens (human)	GRK1	NP_002920.1
Canis lupus familiaris (dog)	GRK1	XP_003639862.1
Xenopus tropicalis (tropical clawed frog)	grk1	XP_002937018.2
Bos taurus (cattle)	GRK1	NP_776598.1

Gene Ontology
Bibliography

Related articles in PubMed

A mutagenesis-derived
Charette JR, Earp SE, Bell BA, Ackert-Bicknell CL, Godfrey DA, Rao S, Anand-Apte B, Nishina PM, Peachey NS
Molecular vision23140-148(2017)

Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.
Ronquillo CC, Hanke-Gogokhia C, Revelo MP, Frederick JM, Jiang L, Baehr W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3400-3412(2016 10)

Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.
Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L 4th, Koutalos Y, Kefalov VJ, Cornwall MC
The Journal of general physiology148(1)1-11(2016 Jul)

Mfsd2a Is a Transporter for the Essential ?-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL
The Journal of biological chemistry291(20)10501-14(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We conclude that, in addition to their well-established roles in Meta II inactivation, Grk1 and Arr1 can modulate the kinetics of Meta III decay and rod dark adaptation in vivo.
Title: Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.

Rods and cones share the same isoforms of recoverin and GRK1, and photoactivation also triggers a calcium decline in cones
Title: Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.

The retinal phenotype of Grk1-/- mice is compromised by a Crb1 rd8 mutation.
Title: The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.

Knockout of Unc119 partially reversed the transport defect of GRK1 in cone photoreceptors caused by deletion of Pde6d.
Title: Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.

rhodopsin kinase may modulate the decay of light-activated PDE*, which may be responsible for the quickening of response recovery in background light.
Title: Modulation of mouse rod response decay by rhodopsin kinase and recoverin.

The following Grk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58293	NM_011881.3 Latest version!	Mus musculus G protein-coupled receptor kinase 1 (Grk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grk1 ( NM_011881.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036011.3 Mus musculus G protein-coupled receptor kinase 1 (Grk1), mRNA.

Price & Availability↑

CloneID	OMu58293
Clone ID Related Accession (Same CDS sequence)	NM_011881.3
Accession Version	NM_011881.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	rhodopsin kinase GRK1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC096611.1, AC130818.3 and BC030304.1. On Nov 15, 2007 this sequence version replaced NM_011881.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096611.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTTCG GGTCCTTGGA GACCGTGGTG GCCAACTCTG CCTTCATCGC TGCCCGGGGC 
AGTTTTGACG GAAGCAGCAC ACCGTCTTCC CGAGACAAGA AATATCTGGC CAAGCTCCGG 
TTGCCCCCAC TGTCCAAGTG TGAGGGTCTC CGTGACAACC TCAGCTTGGA GTTTGAGAGC 
CTGTGCTCAG AGCAACCCAT CGGCAAGAGG CTCTTCCAAC AGTTCTTGAA GACAGACGAG 
AGACATGTGC CAGCTCTGGA GCTCTGGAAG GACATTGAGG ACTATGACAC TGCTGATGAT 
GACCTGAGGC CACAGAAGGC ACAAGCCATC CTGGCTGAGT ACCTGGACCC ACAGGGCACA 
CTCTTCTGCA ACTTTCTGGA CCAGGGCATG GTGACAAGGG TGAAAGAAGG GCCAACTGGG 
AGCCAGGACG GCCTCTTCCA GCCTTTGCTC CAGGCCACAA TGGAGCACTT GAGCCAGGCG 
CCCTTCCAGG AGTACCTAGA AAGCTTGTAT TTCCTGCGGT TTCTTCAGTG GAAGTGGTTG 
GAAGCCCAGC CCATAGGTGA AGACTGGTTC TTGGACTTCA GGGTCCTGGG AAAGGGGGGC 
TTCGGGGAAG TGTCTGCCTG TCAGATGAAG GCGACTGGCA AGATGTATGC CTGCAAGAAG 
CTCAACAAGA AACGGCTGAA GAAGAGGAAG GGCTACCAGG GCGCCATTGT TGAGAAGAGG 
ATTCTGACTA AAGTACACAG CAGGTTCATT GTGTCTCTGG CCTATGCGTT CGAGACCAAG 
ACGGACCTCT GTCTGGTGAT GACCATCATG AACGGAGGTG ACGTGAGGTA CCACATCTAC 
AATGTGGATG AGGATAACCC CGGCTTCTCA GAACCACGGG CCATCTATTA CACAGCACAG 
ATCATCAGTG GCCTGGAGCA CCTGCATCAG AGACGCATTG TCTACCGTGA CCTCAAGCCA 
GAGAATGTGC TATTGGACAA TGATGGCAAT ATCCGAATTT CTGACCTTGG ACTGGCTGTG 
GAGCTGAAGG AAGGGCAGAA TAAGACCAAG GGCTACGCAG GGACCCCAGG TTTCATGGCC 
CCTGAGCTCC TGCGAGGTGA AGAATACGAC TTCTCTGTGG ACTACTTTGC CCTGGGGGTC 
ACATTGTACG AGATGATCGC AGCCAGAGGA CCCTTCCGAG CCCGAGGAGA GAAGGTAGAG 
AACAAGGAGC TTAAGCAACG TATCATCTCA GAGCCTGTGA AGTACCCAGA GAAGTTCAGC 
CAGGCCAGCA AGGACTTCTG TGAGCAGCTG TTGGAGAAGG ACCCGGAGAA GCGCCTGGGC 
TTCCGGGATG GAACCTGTGA TGCGCTTCGG GCAAACGTCC TCTTCAAAGA TATCAGCTGG 
AGGCAGCTCG AAGCCGGGAT GCTCATTCCT CCATTCATCC CAGACTCTAG GACTGTCTAT 
GCCAAGAACA TTCAGGACGT GGGTGCCTTT TCCACAGTCA AGGGTGTGGT TTTTGACAAA 
GCGGACACAG AGTTCTTCCA AGAATTCGCC TCTGGCAACT GCTCCATTCC CTGGCAGGAG 
GAGATGATCG AGACTGGGCT CTTTGGGGAC CTAAATGTGT GGCGCGCAGA TGGTCAGATG 
CCGGATGACA TGAAGGGAAT CACCACGGAG GAGGCAGCCC CTACAGCCAA GTCGGGAATG 
TGTCTCATCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036011.3
CDS	38..1732
Translation	MDFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCEGLRDNLSLEFESLCSEQPIGKRLFQQFLKTDERHVPALELWKDIEDYDTADDDLRPQKAQAILAEYLDPQGTLFCNFLDQGMVTRVKEGPTGSQDGLFQPLLQATMEHLSQAPFQEYLESLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALRANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGLFGDLNVWRADGQMPDDMKGITTEEAAPTAKSGMCLIS

Target ORF information:

RefSeq Version	NM_011881.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor kinase 1 (Grk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011881.3

ORF Insert Sequence:

ATGGATTTCG GGTCCTTGGA GACCGTGGTG GCCAACTCTG CCTTCATCGC TGCCCGGGGC 
AGTTTTGACG GAAGCAGCAC ACCGTCTTCC CGAGACAAGA AATATCTGGC CAAGCTCCGG 
TTGCCCCCAC TGTCCAAGTG TGAGGGTCTC CGTGACAACC TCAGCTTGGA GTTTGAGAGC 
CTGTGCTCAG AGCAACCCAT CGGCAAGAGG CTCTTCCAAC AGTTCTTGAA GACAGACGAG 
AGACATGTGC CAGCTCTGGA GCTCTGGAAG GACATTGAGG ACTATGACAC TGCTGATGAT 
GACCTGAGGC CACAGAAGGC ACAAGCCATC CTGGCTGAGT ACCTGGACCC ACAGGGCACA 
CTCTTCTGCA ACTTTCTGGA CCAGGGCATG GTGACAAGGG TGAAAGAAGG GCCAACTGGG 
AGCCAGGACG GCCTCTTCCA GCCTTTGCTC CAGGCCACAA TGGAGCACTT GAGCCAGGCG 
CCCTTCCAGG AGTACCTAGA AAGCTTGTAT TTCCTGCGGT TTCTTCAGTG GAAGTGGTTG 
GAAGCCCAGC CCATAGGTGA AGACTGGTTC TTGGACTTCA GGGTCCTGGG AAAGGGGGGC 
TTCGGGGAAG TGTCTGCCTG TCAGATGAAG GCGACTGGCA AGATGTATGC CTGCAAGAAG 
CTCAACAAGA AACGGCTGAA GAAGAGGAAG GGCTACCAGG GCGCCATTGT TGAGAAGAGG 
ATTCTGACTA AAGTACACAG CAGGTTCATT GTGTCTCTGG CCTATGCGTT CGAGACCAAG 
ACGGACCTCT GTCTGGTGAT GACCATCATG AACGGAGGTG ACGTGAGGTA CCACATCTAC 
AATGTGGATG AGGATAACCC CGGCTTCTCA GAACCACGGG CCATCTATTA CACAGCACAG 
ATCATCAGTG GCCTGGAGCA CCTGCATCAG AGACGCATTG TCTACCGTGA CCTCAAGCCA 
GAGAATGTGC TATTGGACAA TGATGGCAAT ATCCGAATTT CTGACCTTGG ACTGGCTGTG 
GAGCTGAAGG AAGGGCAGAA TAAGACCAAG GGCTACGCAG GGACCCCAGG TTTCATGGCC 
CCTGAGCTCC TGCGAGGTGA AGAATACGAC TTCTCTGTGG ACTACTTTGC CCTGGGGGTC 
ACATTGTACG AGATGATCGC AGCCAGAGGA CCCTTCCGAG CCCGAGGAGA GAAGGTAGAG 
AACAAGGAGC TTAAGCAACG TATCATCTCA GAGCCTGTGA AGTACCCAGA GAAGTTCAGC 
CAGGCCAGCA AGGACTTCTG TGAGCAGCTG TTGGAGAAGG ACCCGGAGAA GCGCCTGGGC 
TTCCGGGATG GAACCTGTGA TGCGCTTCGG GCAAACGTCC TCTTCAAAGA TATCAGCTGG 
AGGCAGCTCG AAGCCGGGAT GCTCATTCCT CCATTCATCC CAGACTCTAG GACTGTCTAT 
GCCAAGAACA TTCAGGACGT GGGTGCCTTT TCCACAGTCA AGGGTGTGGT TTTTGACAAA 
GCGGACACAG AGTTCTTCCA AGAATTCGCC TCTGGCAACT GCTCCATTCC CTGGCAGGAG 
GAGATGATCG AGACTGGGCT CTTTGGGGAC CTAAATGTGT GGCGCGCAGA TGGTCAGATG 
CCGGATGACA TGAAGGGAAT CACCACGGAG GAGGCAGCCC CTACAGCCAA GTCGGGAATG 
TGTCTCATCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A mutagenesis-derived
Molecular vision23140-148(2017)
Charette JR,Earp SE,Bell BA,Ackert-Bicknell CL,Godfrey DA,Rao S,Anand-Apte B,Nishina PM,Peachey NS

Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3400-3412(2016 10)
Ronquillo CC,Hanke-Gogokhia C,Revelo MP,Frederick JM,Jiang L,Baehr W

Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.
The Journal of general physiology148(1)1-11(2016 Jul)
Frederiksen R,Nymark S,Kolesnikov AV,Berry JD,Adler L 4th,Koutalos Y,Kefalov VJ,Cornwall MC

Mfsd2a Is a Transporter for the Essential ?-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
The Journal of biological chemistry291(20)10501-14(2016 May)
Wong BH,Chan JP,Cazenave-Gassiot A,Poh RW,Foo JC,Galam DL,Ghosh S,Nguyen LN,Barathi VA,Yeo SW,Luu CD,Wenk MR,Silver DL

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Grk1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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