Lnpep cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lnpep
Entrez Gene ID	240028
Full Name	leucyl/cystinyl aminopeptidase
Synonyms	2010309L07Rik,4732490P18Rik,CAP,IRAP,PLAP,gp160,vp165
General protein information	Preferred Names leucyl/cystinyl aminopeptidase Names leucyl-cystinyl aminopeptidase OTase cystinyl aminopeptidase oxytocinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_172827.3	NP_766415.1	leucyl-cystinyl aminopeptidase

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LNPEP	XP_002689456.2
Danio rerio (zebrafish)	lnpep	NP_955915.1
Pan troglodytes (chimpanzee)	LNPEP	XP_517842.3
Mus musculus (house mouse)	Lnpep	NP_766415.1
Gallus gallus (chicken)	LNPEP	XP_424862.3
	LNPEP	XP_001092287.2
Homo sapiens (human)	LNPEP	NP_005566.2
Canis lupus familiaris (dog)	LNPEP	XP_005618126.1
Xenopus tropicalis (tropical clawed frog)	lnpep	XP_002933474.1

Gene Ontology
Bibliography

Related articles in PubMed

IRAP
Babdor J, Descamps D, Adiko AC, Tohm? M, Maschalidi S, Evnouchidou I, Vasconcellos LR, De Luca M, Mauvais FX, Garfa-Traore M, Brinkmann MM, Chignard M, Manoury B, Saveanu L
Nature immunology18(5)509-518(2017 May)

Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory.
Yeatman HR, Albiston AL, Burns P, Chai SY
Neurobiology of learning and memory136174-182(2016 Dec)

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle.
Habtemichael EN, Alc?zar-Rom?n A, Rubin BR, Grossi LR, Belman JP, Julca O, L?ffler MG, Li H, Chi NW, Samuel VT, Bogan JS
The Journal of biological chemistry290(23)14454-61(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this paper shows that endosomal retention of TLR9 via the interaction of IRAP with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 in dendritic cells
Title: IRAP

IRAP deficiency may lead to suppression of PAI-1 expression in adipocytes and upregulation of UCP-1-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity.
Title: IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.

IRAP is more highly expressed in pro-inflammatory M1-activated macrophages.
Title: Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages.

The current study demonstrates that deletion of the IRAP gene protects the brain from ischemic damage
Title: Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice.

requirement of IRAP in cross-presentation extends to steady-state conventional dendritic cells (cDCs);data suggest increased recruitment of an IRAP(+)/Rab14(+) compartment to Ag-containing vesicles contributes to cross-presentation efficacy of CD8(+)cDCs
Title: Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation.

The following Lnpep gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lnpep cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04119	NM_172827.3 Latest version!	Mus musculus leucyl/cystinyl aminopeptidase (Lnpep), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$601.30 $859.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lnpep ( NM_172827.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766415.1 Mus musculus leucyl/cystinyl aminopeptidase (Lnpep), mRNA.

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CloneID	OMu04119
Clone ID Related Accession (Same CDS sequence)	NM_172827.3
Accession Version	NM_172827.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3078bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	leucyl-cystinyl aminopeptidase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC147983.3 and AC121795.3. On May 2, 2007 this sequence version replaced NM_172827.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029094.1, BC120925.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAGTCCT TTACCAATGA TCGGCTTCAG CTTCCAAGGA ATATGATCGA AAACAGCATG 
TTTGAAGAAG AGCCAGATGT GGTAGATTTA GCCAAAGAAC CTTGTTTACA TCCTCTGGAA 
CCCGATGAAG TGGAATATGA GCCCCGAGGT TCGAGGCTTC TGGTGCGAGG TCTTGGTGAG 
CATGAGATGG ACGAGGATGA AGAGGATTAT GAGTCCTCTG CGAAGCTGCT GGGCATGTCC 
TTCATGAACA GAAGCTCAGG CCTGCGGAAC AGTGCAGCAG GCTACAGGCA GAGTCCAGAT 
GGGACTTGTT CATTACCCTC TGCCAGGACC TTAGTGATCT GTGTTTTTGT CATTGTGGTT 
GCGGTCTCTG TAATCATGGT GATTTATCTA CTGCCTAGAT GTACCTTTAC CAAAGAAGGC 
TGCCACAAAA CAAACCAGTC AGCAGAACTC ATCCAGCCAG TTGCTACAAA CGGGAAAGTG 
TTCCCATGGG CTCAAATTAG GCTTCCCACT GCCATTATTC CTCTATGCTA TGAACTTAGC 
CTACATCCAA ACCTAACCTC AATGACATTC AGGGGATCTG TGACAATTTC ACTTCAGGCT 
CTTCAAGACA CACGGGATAT CATTCTCCAT AGCACAGGAC ATAATATTTC AAGAGTGACA 
TTTATGTCAG CAGTTTCAAG TCAAGAAAAA CAAGTTGAAA TTCTGGAATA TCCATATCAT 
GAACAAATCG CCGTTGTTGC CCCGGAACCT CTTCTAACAG GACACAATTA TACCCTGAAG 
ATAGAGTATT CAGCAAATAT ATCTAACTCT TATTATGGGT TTTATGGCAT CACCTACACA 
GATAAAAGTA ATGAGAAAAA GTACTTTGCA GCAACTCAGT TTGAACCTCT GGCAGCAAGA 
TCTGCTTTTC CTTGTTTTGA TGAACCAGCA TTTAAGGCCA CATTTATCAT CAAGATCACA 
AGGAATGAGC ACCATACTGC GTTATCAAAT ATGCCTAAGA AGTCATCGGT CCCTGCAGAA 
GAAGGACTTA TTCAAGATGA GTTTTCTGAA AGTGTGAAAA TGAGCACATA CCTGGTTGCT 
TTCATTGTAG GGGAGATGAG GAACCTGAGT CAGGATGTAA ATGGAACTCT GGTTTCTGTG 
TATGCTGTAC CAGAAAAAAT TGGTCAAGTT CACCATGCCT TGGACACAAC TATAAAGCTT 
CTTGAGTTTT ATCAAACTTA CTTTGAAATT CAGTACCCAC TTAAGAAATT GGATTTGGTG 
GCCATTCCTG ACTTTGAAGC AGGAGCAATG GAAAACTGGG GCCTGCTTAC ATTCCGAGAA 
GAGACTCTTC TGTATGACAA TGCAACTTCT TCAGTAGCAG ACAGAAAACT GGTCACTAAA 
ATCATTGCTC ACGAACTGGC ACATCAGTGG TTTGGAAATC TGGTTACAAT GCAGTGGTGG 
AATGACCTGT GGCTAAATGA AGGCTTTGCC ACTTTCATGG AGTATTTCTC TGTGGAAAAA 
ATATTCAAAG AGCTCAACAG TTATGAAGAC TTCTTAGATG CTCGATTTAA AACCATGAGG 
AAAGATTCCT TGAATTCGTC TCATCCAATA TCATCATCTG TTCAGTCTTC GGAACAAATA 
GAAGAAATGT TTGATTCTCT CTCCTATTTT AAGGGAGCTT CTCTCTTGTT GATGCTGAAA 
AGTTACCTTA GTGAAGATGT ATTTCGGCAT GCTGTCATTC TTTACCTGCA CAATCACAGC 
TATGCAGCTA TCCAAAGTGA TGATCTCTGG GACAGCTTCA ATGAGGTCAC AGACAAAACT 
CTAGATGTAA AGAAAATGAT GAAAACCTGG ACCCTACAGA AAGGATTCCC GTTAGTGACA 
GTCCAGAGGA AGGGGACTGA GCTTCTTCTA CAACAGGAAA GATTTTTTCT ACGCATGCAA 
CCAGAAAGTC AGCCTTCAGA TACAAGCCAC CTTTGGCATA TTCCAATATC CTATGTCACT 
GATGGAAGAA ACTATTCAGA ATATCGATCA GTTTCACTAC TGGACAAGAA ATCAGATGTC 
ATCAATCTTA CAGAACAAGT GCAGTGGGTC AAAGTCAATT CAAACATGAC TGGCTATTAC 
ATTGTTCACT ATGCTCATGA TGACTGGACA GCTCTAATCA ATCAGTTAAA AAGAAACCCT 
TATGTTCTGA GTGACAAAGA CCGAGCCAAC CTGATCAATA ACATCTTTGA ACTTGCAGGT 
CTTGGCAAAG TGCCTCTTCG GATGGCATTT GATTTGATTG ACTATCTTAA AAATGAGACC 
CACACTGCAC CGATCACTGA AGCCCTGTTC CAGACAAACC TTATCTATAA TCTCCTAGAA 
AAACTGGGGC ACATGGACCT GTCCTCAAGA TTGGTGGCCA GAGTACATAA ATTGCTCCAG 
AACCAAATCC AGCAGCAGAC TTGGACAGAT GAAGGCACAC CATCCATGCG AGAGCTTCGG 
TCAGCCTTGC TGGAATTTGC CTGTGCCCAC AGCCTAGAGA ACTGTACCAC TATGGCCACA 
AATCTGTTTG ACAGTTGGAT GGCATCAAAT GGAACTCAGA GCCTGCCTAC TGATGTCATG 
GTCACTGTGT TCAAGGTGGG AGCGAGAACC GAGAAAGGCT GGTTGTTCCT CTTTAGCATG 
TATTCCTCCA TGGGCTCTGA AGCAGAAAAG AATAAAATTC TTGAAGCTCT TGCCAGCTCA 
GAGGATGTAC ATAAACTTTA CTGGTTAATG AAAAGTAGCC TTGATGGTGA CATCATCCGA 
ACACAGAAGT TGTCACTTAT CATTAGAACA GTGGGCAGAC ATTTTCCTGG ACACTTGCTG 
GCTTGGGATT TTGTTAAAGA AAACTGGAAT AAGCTTGTAC ATAAGTTCCA TCTGGGCTCC 
TATACCATAC AAAGTATTGT TGCTGGATCT ACTCACTTAT TTTCAACAAA GACACATTTA 
TCTGAGGTCC AGGCATTCTT TGAAAATCAG TCAGAGGCAA CCTTGAAGCT TCGGTGTGTT 
CAGGAGGCTT TGGAAGTGAT TCAGCTGAAT ATCCAGTGGA TGGTCAGGAA TCTGAAAACG 
CTCTCCCAGT GGCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766415.1
CDS	78..3155
Translation	MESFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSAAGYRQSPDGTCSLPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPVATNGKVFPWAQIRLPTAIIPLCYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISRVTFMSAVSSQEKQVEILEYPYHEQIAVVAPEPLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKITRNEHHTALSNMPKKSSVPAEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIGQVHHALDTTIKLLEFYQTYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFRHAVILYLHNHSYAAIQSDDLWDSFNEVTDKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFLRMQPESQPSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNSNMTGYYIVHYAHDDWTALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLRMAFDLIDYLKNETHTAPITEALFQTNLIYNLLEKLGHMDLSSRLVARVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATNLFDSWMASNGTQSLPTDVMVTVFKVGARTEKGWLFLFSMYSSMGSEAEKNKILEALASSEDVHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRHFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQAFFENQSEATLKLRCVQEALEVIQLNIQWMVRNLKTLSQWL

Target ORF information:

RefSeq Version	NM_172827.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucyl/cystinyl aminopeptidase (Lnpep), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172827.3

ORF Insert Sequence:

ATGGAGTCCT TTACCAATGA TCGGCTTCAG CTTCCAAGGA ATATGATCGA AAACAGCATG 
TTTGAAGAAG AGCCAGATGT GGTAGATTTA GCCAAAGAAC CTTGTTTACA TCCTCTGGAA 
CCCGATGAAG TGGAATATGA GCCCCGAGGT TCGAGGCTTC TGGTGCGAGG TCTTGGTGAG 
CATGAGATGG ACGAGGATGA AGAGGATTAT GAGTCCTCTG CGAAGCTGCT GGGCATGTCC 
TTCATGAACA GAAGCTCAGG CCTGCGGAAC AGTGCAGCAG GCTACAGGCA GAGTCCAGAT 
GGGACTTGTT CATTACCCTC TGCCAGGACC TTAGTGATCT GTGTTTTTGT CATTGTGGTT 
GCGGTCTCTG TAATCATGGT GATTTATCTA CTGCCTAGAT GTACCTTTAC CAAAGAAGGC 
TGCCACAAAA CAAACCAGTC AGCAGAACTC ATCCAGCCAG TTGCTACAAA CGGGAAAGTG 
TTCCCATGGG CTCAAATTAG GCTTCCCACT GCCATTATTC CTCTATGCTA TGAACTTAGC 
CTACATCCAA ACCTAACCTC AATGACATTC AGGGGATCTG TGACAATTTC ACTTCAGGCT 
CTTCAAGACA CACGGGATAT CATTCTCCAT AGCACAGGAC ATAATATTTC AAGAGTGACA 
TTTATGTCAG CAGTTTCAAG TCAAGAAAAA CAAGTTGAAA TTCTGGAATA TCCATATCAT 
GAACAAATCG CCGTTGTTGC CCCGGAACCT CTTCTAACAG GACACAATTA TACCCTGAAG 
ATAGAGTATT CAGCAAATAT ATCTAACTCT TATTATGGGT TTTATGGCAT CACCTACACA 
GATAAAAGTA ATGAGAAAAA GTACTTTGCA GCAACTCAGT TTGAACCTCT GGCAGCAAGA 
TCTGCTTTTC CTTGTTTTGA TGAACCAGCA TTTAAGGCCA CATTTATCAT CAAGATCACA 
AGGAATGAGC ACCATACTGC GTTATCAAAT ATGCCTAAGA AGTCATCGGT CCCTGCAGAA 
GAAGGACTTA TTCAAGATGA GTTTTCTGAA AGTGTGAAAA TGAGCACATA CCTGGTTGCT 
TTCATTGTAG GGGAGATGAG GAACCTGAGT CAGGATGTAA ATGGAACTCT GGTTTCTGTG 
TATGCTGTAC CAGAAAAAAT TGGTCAAGTT CACCATGCCT TGGACACAAC TATAAAGCTT 
CTTGAGTTTT ATCAAACTTA CTTTGAAATT CAGTACCCAC TTAAGAAATT GGATTTGGTG 
GCCATTCCTG ACTTTGAAGC AGGAGCAATG GAAAACTGGG GCCTGCTTAC ATTCCGAGAA 
GAGACTCTTC TGTATGACAA TGCAACTTCT TCAGTAGCAG ACAGAAAACT GGTCACTAAA 
ATCATTGCTC ACGAACTGGC ACATCAGTGG TTTGGAAATC TGGTTACAAT GCAGTGGTGG 
AATGACCTGT GGCTAAATGA AGGCTTTGCC ACTTTCATGG AGTATTTCTC TGTGGAAAAA 
ATATTCAAAG AGCTCAACAG TTATGAAGAC TTCTTAGATG CTCGATTTAA AACCATGAGG 
AAAGATTCCT TGAATTCGTC TCATCCAATA TCATCATCTG TTCAGTCTTC GGAACAAATA 
GAAGAAATGT TTGATTCTCT CTCCTATTTT AAGGGAGCTT CTCTCTTGTT GATGCTGAAA 
AGTTACCTTA GTGAAGATGT ATTTCGGCAT GCTGTCATTC TTTACCTGCA CAATCACAGC 
TATGCAGCTA TCCAAAGTGA TGATCTCTGG GACAGCTTCA ATGAGGTCAC AGACAAAACT 
CTAGATGTAA AGAAAATGAT GAAAACCTGG ACCCTACAGA AAGGATTCCC GTTAGTGACA 
GTCCAGAGGA AGGGGACTGA GCTTCTTCTA CAACAGGAAA GATTTTTTCT ACGCATGCAA 
CCAGAAAGTC AGCCTTCAGA TACAAGCCAC CTTTGGCATA TTCCAATATC CTATGTCACT 
GATGGAAGAA ACTATTCAGA ATATCGATCA GTTTCACTAC TGGACAAGAA ATCAGATGTC 
ATCAATCTTA CAGAACAAGT GCAGTGGGTC AAAGTCAATT CAAACATGAC TGGCTATTAC 
ATTGTTCACT ATGCTCATGA TGACTGGACA GCTCTAATCA ATCAGTTAAA AAGAAACCCT 
TATGTTCTGA GTGACAAAGA CCGAGCCAAC CTGATCAATA ACATCTTTGA ACTTGCAGGT 
CTTGGCAAAG TGCCTCTTCG GATGGCATTT GATTTGATTG ACTATCTTAA AAATGAGACC 
CACACTGCAC CGATCACTGA AGCCCTGTTC CAGACAAACC TTATCTATAA TCTCCTAGAA 
AAACTGGGGC ACATGGACCT GTCCTCAAGA TTGGTGGCCA GAGTACATAA ATTGCTCCAG 
AACCAAATCC AGCAGCAGAC TTGGACAGAT GAAGGCACAC CATCCATGCG AGAGCTTCGG 
TCAGCCTTGC TGGAATTTGC CTGTGCCCAC AGCCTAGAGA ACTGTACCAC TATGGCCACA 
AATCTGTTTG ACAGTTGGAT GGCATCAAAT GGAACTCAGA GCCTGCCTAC TGATGTCATG 
GTCACTGTGT TCAAGGTGGG AGCGAGAACC GAGAAAGGCT GGTTGTTCCT CTTTAGCATG 
TATTCCTCCA TGGGCTCTGA AGCAGAAAAG AATAAAATTC TTGAAGCTCT TGCCAGCTCA 
GAGGATGTAC ATAAACTTTA CTGGTTAATG AAAAGTAGCC TTGATGGTGA CATCATCCGA 
ACACAGAAGT TGTCACTTAT CATTAGAACA GTGGGCAGAC ATTTTCCTGG ACACTTGCTG 
GCTTGGGATT TTGTTAAAGA AAACTGGAAT AAGCTTGTAC ATAAGTTCCA TCTGGGCTCC 
TATACCATAC AAAGTATTGT TGCTGGATCT ACTCACTTAT TTTCAACAAA GACACATTTA 
TCTGAGGTCC AGGCATTCTT TGAAAATCAG TCAGAGGCAA CCTTGAAGCT TCGGTGTGTT 
CAGGAGGCTT TGGAAGTGAT TCAGCTGAAT ATCCAGTGGA TGGTCAGGAA TCTGAAAACG 
CTCTCCCAGT GGCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IRAP
Nature immunology18(5)509-518(2017 May)
Babdor J,Descamps D,Adiko AC,Tohm? M,Maschalidi S,Evnouchidou I,Vasconcellos LR,De Luca M,Mauvais FX,Garfa-Traore M,Brinkmann MM,Chignard M,Manoury B,Saveanu L

Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory.
Neurobiology of learning and memory136174-182(2016 Dec)
Yeatman HR,Albiston AL,Burns P,Chai SY

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle.
The Journal of biological chemistry290(23)14454-61(2015 Jun)
Habtemichael EN,Alc?zar-Rom?n A,Rubin BR,Grossi LR,Belman JP,Julca O,L?ffler MG,Li H,Chi NW,Samuel VT,Bogan JS

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Lnpep cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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