Mmp17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp17
Entrez Gene ID	23948
Full Name	matrix metallopeptidase 17
Synonyms	MT4-MMP,MT4MMP,MTMMP4
General protein information	Preferred Names matrix metallopeptidase 17 Names matrix metalloproteinase-17 membrane-type matrix metalloproteinase 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 G1.3\|5 68.18 cM
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011846.5	NP_035976.3	matrix metalloproteinase-17 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP17	XP_509485.2
Gallus gallus (chicken)	MMP17	XP_415092.3
Danio rerio (zebrafish)	mmp17a	XP_698601.6
Rattus norvegicus (Norway rat)	Mmp17	NP_001099395.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011870	XP_320653.4
Xenopus tropicalis (tropical clawed frog)	mmp17	NP_001096469.1
Canis lupus familiaris (dog)	MMP17	XP_852332.3
Bos taurus (cattle)	MMP17	XP_002694502.1
Mus musculus (house mouse)	Mmp17	NP_035976.3
Drosophila melanogaster (fruit fly)	Mmp2	NP_995788.1
Homo sapiens (human)	MMP17	NP_057239.4
	LOC100430708	XP_002798895.1
Caenorhabditis elegans (roundworm)	zmp-1	NP_741156.1

Gene Ontology
Bibliography

Related articles in PubMed

Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.
Blanco MJ, Rodr?guez-Mart?n I, Learte AIR, Clemente C, Montalvo MG, Seiki M, Arroyo AG, S?nchez-Camacho C
PloS one12(9)e0184767(2017)

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.
Mart?n-Alonso M, Garc?a-Redondo AB, Guo D, Camafeita E, Mart?nez F, Alfranca A, M?ndez-Barbero N, Poll?n ?, S?nchez-Camacho C, Denhardt DT, Seiki M, V?zquez J, Salaices M, Redondo JM, Milewicz D, Arroyo AG
Circulation research117(2)e13-26(2015 Jul)

Matrix metalloproteinases in tumor invasion.
Johansson N, Ahonen M, K?h?ri VM
Cellular and molecular life sciences : CMLS57(1)5-15(2000 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

while Adam17-deficiency suppresses Ang II-induced SMC remodeling in vitro, in vivo Adam17-deficiency provides only a transient protective effect against Ang II-mediated hypertension and end-organ damage.
Title: Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.

Mmp17-mediated osteopontin cleavage regulated vascular SMC maturation via c-JNK during aorta wall development. Mmp17 proteolytic activity regulates vascular SMC phenotype in the arterial vessel wall. Its absence predisposes to thoracic aortic aneurysm.
Title: Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.

function and expression of MT4-MMP
Title: Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.

MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation
Title: Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture.

MT1-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 at the cell surface.
Title: MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells.

The following Mmp17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08973	NM_011846.5 Latest version!	Mus musculus matrix metallopeptidase 17 (Mmp17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$335.30 $479.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp17 ( NM_011846.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035976.3 Mus musculus matrix metallopeptidase 17 (Mmp17), mRNA.

Price & Availability↑

CloneID	OMu08973
Clone ID Related Accession (Same CDS sequence)	NM_011846.5
Accession Version	NM_011846.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1737bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-17 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114657.9, BC051917.1 and AK079221.1. On Feb 13, 2016 this sequence version replaced NM_011846.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051917.1, AK143521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGACGCC GCCCGCGGGG ACCTGGGTCC CCCCGGGGAC CTGGCCCTCC ACGCCCCGGG 
CCGGGGCTGC CACCACTGCT GCTTGTACTG GCGCTGGCGG CCCATGGGGG CTGCGCAGCG 
CCCGCGCCCC GCGCGGAGGA CCTCAGCCTC GGGGTGGAGT GGCTAAGCAG GTTTGGCTAC 
CTGCCGCCTG CAGATCCGGC ATCAGGGCAG CTACAGACCC AGGAGGAACT GTCCAAAGCG 
ATTACTGCCA TGCAGCAGTT TGGTGGTCTG GAGACCACTG GCATCCTAGA TGAGGCCACT 
CTGGCCCTGA TGAAAACCCC TCGATGCTCC CTTCCGGACC TGCCCCCTGG GGCCCAATCG 
AGAAGGAAGC GGCAGACTCC ACCCCCAACC AAATGGAGCA AGAGGAACCT TTCTTGGAGG 
GTCCGGACAT TCCCACGGGA CTCACCCCTG GGCCGGGATA CTGTGCGTGC ACTCATGTAC 
TACGCCCTCA AAGTCTGGAG TGACATCACA CCCTTGAACT TCCACGAGGT AGCGGGCAAC 
GCGGCGGACA TCCAGATCGA CTTCTCCAAG GCCGACCACA ATGACGGCTA CCCCTTCGAT 
GGCCCTGGTG GCACGGTGGC CCACGCATTC TTCCCTGGTG ACCACCACAC GGCAGGGGAC 
ACCCACTTTG ATGACGATGA GCCATGGACC TTCCGTTCCT CAGATGCCCA CGGGATGGAC 
CTGTTTGCAG TGGCCGTCCA TGAGTTTGGT CATGCCATTG GTCTGAGCCA TGTTGCCGCC 
CCAAGCTCCA TCATGCAACC GTACTACCAG GGCCCCGTGG GTGACCCGCT ACGCTATGGA 
CTTCCCTATG AGGACAGGGT GCGTGTCTGG CAGTTGTACG GTGTGCGGGA ATCCGTGTCC 
CCTACTGCCC AGCTGGATAC CCCAGAGCCC GAGGAGCCAC CCCTCCTGCC AGAGCCCCCC 
AACAATCGGT CTAGCACTCC GCCCCAGAAG GACGTGCCTC ACAGGTGCAC TGCCCACTTT 
GATGCTGTGG CCCAGATTCG AGGCGAAGCA TTCTTTTTCA AAGGCAAGTA TTTCTGGAGG 
CTGACCCGGG ACCGACACTT GGTGTCGCTG CAGCCGGCTC AAATGCATCG CTTCTGGCGG 
GGCCTGCCGC TGCACCTGGA CAGTGTGGAC GCCGTGTATG AGCGTACCAG TGACCACAAG 
ATTGTCTTCT TCAAAGGAGA CAGATACTGG GTGTTTAAGG ACAACAACGT AGAGGAAGGG 
TACCCGCGAC CTGTCTCCGA CTTCAGCCTC CCGCCAGGTG GCATCGATGC TGTCTTCTCC 
TGGGCCCACA ATGACAGGAC TTATTTCTTT AAGGACCAGC TGTACTGGCG CTATGATGAC 
CACACACGGC GCATGGACCC TGGCTACCCT GCCCAGGGAC CCCTGTGGAG AGGTGTCCCC 
AGCATGTTGG ATGATGCCAT GCGCTGGTCT GATGGTGCAT CCTATTTCTT CCGAGGCCAG 
GAGTACTGGA AAGTGCTGGA TGGCGAGCTG GAAGCAGCCC CCGGGTACCC ACAGTCTACA 
GCCCGCGACT GGCTGGTATG CGGTGAGCCG CTGGCGGATG CGGAGGATGT AGGGCCTGGA 
CCCCAGGGCC GCAGTGGGGC CCAAGATGGT CTGGCAGTAT GTTCCTGCAC TTCAGACGCA 
CACAGGTTGG CACTGCCATC TCTGCTGCTT CTGACTCCAC TGCTGTGGGG CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035976.3
CDS	125..1861
Translation	MGRRPRGPGSPRGPGPPRPGPGLPPLLLVLALAAHGGCAAPAPRAEDLSLGVEWLSRFGYLPPADPASGQLQTQEELSKAITAMQQFGGLETTGILDEATLALMKTPRCSLPDLPPGAQSRRKRQTPPPTKWSKRNLSWRVRTFPRDSPLGRDTVRALMYYALKVWSDITPLNFHEVAGNAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDDEPWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQPYYQGPVGDPLRYGLPYEDRVRVWQLYGVRESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRCTAHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAVFSWAHNDRTYFFKDQLYWRYDDHTRRMDPGYPAQGPLWRGVPSMLDDAMRWSDGASYFFRGQEYWKVLDGELEAAPGYPQSTARDWLVCGEPLADAEDVGPGPQGRSGAQDGLAVCSCTSDAHRLALPSLLLLTPLLWGL

Target ORF information:

RefSeq Version	NM_011846.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 17 (Mmp17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011846.5

ORF Insert Sequence:

ATGGGACGCC GCCCGCGGGG ACCTGGGTCC CCCCGGGGAC CTGGCCCTCC ACGCCCCGGG 
CCGGGGCTGC CACCACTGCT GCTTGTACTG GCGCTGGCGG CCCATGGGGG CTGCGCAGCG 
CCCGCGCCCC GCGCGGAGGA CCTCAGCCTC GGGGTGGAGT GGCTAAGCAG GTTTGGCTAC 
CTGCCGCCTG CAGATCCGGC ATCAGGGCAG CTACAGACCC AGGAGGAACT GTCCAAAGCG 
ATTACTGCCA TGCAGCAGTT TGGTGGTCTG GAGACCACTG GCATCCTAGA TGAGGCCACT 
CTGGCCCTGA TGAAAACCCC TCGATGCTCC CTTCCGGACC TGCCCCCTGG GGCCCAATCG 
AGAAGGAAGC GGCAGACTCC ACCCCCAACC AAATGGAGCA AGAGGAACCT TTCTTGGAGG 
GTCCGGACAT TCCCACGGGA CTCACCCCTG GGCCGGGATA CTGTGCGTGC ACTCATGTAC 
TACGCCCTCA AAGTCTGGAG TGACATCACA CCCTTGAACT TCCACGAGGT AGCGGGCAAC 
GCGGCGGACA TCCAGATCGA CTTCTCCAAG GCCGACCACA ATGACGGCTA CCCCTTCGAT 
GGCCCTGGTG GCACGGTGGC CCACGCATTC TTCCCTGGTG ACCACCACAC GGCAGGGGAC 
ACCCACTTTG ATGACGATGA GCCATGGACC TTCCGTTCCT CAGATGCCCA CGGGATGGAC 
CTGTTTGCAG TGGCCGTCCA TGAGTTTGGT CATGCCATTG GTCTGAGCCA TGTTGCCGCC 
CCAAGCTCCA TCATGCAACC GTACTACCAG GGCCCCGTGG GTGACCCGCT ACGCTATGGA 
CTTCCCTATG AGGACAGGGT GCGTGTCTGG CAGTTGTACG GTGTGCGGGA ATCCGTGTCC 
CCTACTGCCC AGCTGGATAC CCCAGAGCCC GAGGAGCCAC CCCTCCTGCC AGAGCCCCCC 
AACAATCGGT CTAGCACTCC GCCCCAGAAG GACGTGCCTC ACAGGTGCAC TGCCCACTTT 
GATGCTGTGG CCCAGATTCG AGGCGAAGCA TTCTTTTTCA AAGGCAAGTA TTTCTGGAGG 
CTGACCCGGG ACCGACACTT GGTGTCGCTG CAGCCGGCTC AAATGCATCG CTTCTGGCGG 
GGCCTGCCGC TGCACCTGGA CAGTGTGGAC GCCGTGTATG AGCGTACCAG TGACCACAAG 
ATTGTCTTCT TCAAAGGAGA CAGATACTGG GTGTTTAAGG ACAACAACGT AGAGGAAGGG 
TACCCGCGAC CTGTCTCCGA CTTCAGCCTC CCGCCAGGTG GCATCGATGC TGTCTTCTCC 
TGGGCCCACA ATGACAGGAC TTATTTCTTT AAGGACCAGC TGTACTGGCG CTATGATGAC 
CACACACGGC GCATGGACCC TGGCTACCCT GCCCAGGGAC CCCTGTGGAG AGGTGTCCCC 
AGCATGTTGG ATGATGCCAT GCGCTGGTCT GATGGTGCAT CCTATTTCTT CCGAGGCCAG 
GAGTACTGGA AAGTGCTGGA TGGCGAGCTG GAAGCAGCCC CCGGGTACCC ACAGTCTACA 
GCCCGCGACT GGCTGGTATG CGGTGAGCCG CTGGCGGATG CGGAGGATGT AGGGCCTGGA 
CCCCAGGGCC GCAGTGGGGC CCAAGATGGT CTGGCAGTAT GTTCCTGCAC TTCAGACGCA 
CACAGGTTGG CACTGCCATC TCTGCTGCTT CTGACTCCAC TGCTGTGGGG CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.
PloS one12(9)e0184767(2017)
Blanco MJ,Rodr?guez-Mart?n I,Learte AIR,Clemente C,Montalvo MG,Seiki M,Arroyo AG,S?nchez-Camacho C

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.
Circulation research117(2)e13-26(2015 Jul)
Mart?n-Alonso M,Garc?a-Redondo AB,Guo D,Camafeita E,Mart?nez F,Alfranca A,M?ndez-Barbero N,Poll?n ?,S?nchez-Camacho C,Denhardt DT,Seiki M,V?zquez J,Salaices M,Redondo JM,Milewicz D,Arroyo AG

Matrix metalloproteinases in tumor invasion.
Cellular and molecular life sciences : CMLS57(1)5-15(2000 Jan)
Johansson N,Ahonen M,K?h?ri VM

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Mmp17 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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