Insl5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Insl5
Entrez Gene ID	23919
Full Name	insulin-like 5
Synonyms	RIF2
General protein information	Preferred Names insulin-like 5 Names insulin-like peptide INSL5 relaxin/insulin-like factor 2 relaxin/insulin-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 C6\|4 47.27 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001290648.2	NP_001277577.1	insulin-like peptide INSL5 isoform 1 precursor
NM_011831.2	NP_035961.1	insulin-like peptide INSL5 isoform 2 precursor
NM_001290648.1	NP_001277577.1	insulin-like peptide INSL5 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	INSL5	XP_001163108.1
Mus musculus (house mouse)	Insl5	NP_035961.1
Homo sapiens (human)	INSL5	NP_005469.2
	INSL5	XP_001093100.1
Bos taurus (cattle)	INSL5	NP_001193060.1

Gene Ontology
Bibliography

Related articles in PubMed

Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.
Kay RG, Galvin S, Larraufie P, Reimann F, Gribble FM
Rapid communications in mass spectrometry : RCM31(23)1963-1973(2017 Dec)

Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production.
Lee YS, De Vadder F, Tremaroli V, Wichmann A, Mithieux G, B?ckhed F
Molecular metabolism5(4)263-70(2016 Apr)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.
Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann F, O'Rahilly S, Gribble FM
Proceedings of the National Academy of Sciences of the United States of America111(30)11133-8(2014 Jul)

INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.
Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H
Biochemical and biophysical research communications432(4)586-92(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation.
Title: Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

INSL5 may be a unique marker of colorectal enteroendocrine cells, and INSL5-RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors.
Title: INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.

Insl5 knockout mice displayed impaired male and female fertility that are due to marked reduction in sperm motility and irregular length of the estrous cycle. Also impaired glucose homeostasis due to glucose intolerance.
Title: INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility.

Insulin-like peptide 5 is expressed in mouse brain and has a role in mobilization of calcium
Title: Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium.

The following Insl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Insl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17076	NM_001290648.2 Latest version!	Mus musculus insulin-like 5 (Insl5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu13944	NM_011831.2 Latest version!	Mus musculus insulin-like 5 (Insl5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu17076	NM_001290648.1	Mus musculus insulin-like 5 (Insl5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Insl5 ( NM_001290648.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277577.1 Mus musculus insulin-like 5 (Insl5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17076
Clone ID Related Accession (Same CDS sequence)	NM_001290648.2 , NM_001290648.1
Accession Version	NM_001290648.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Mus musculus(house mouse)
Product	insulin-like peptide INSL5 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX004765.6 and AL732543.8. On Jun 19, 2019 this sequence version replaced NM_001290648.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.320092.1, SRR6116558.117650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCTTAG TAAACACTGT TAAGATAAGG ATGAAGGGCC CCACTCTTGC TCTGTTTCTC 
CTCTTAGTTC TGTTGGCTGT GGTGGAAGTA AGAAGCAGGC AGACTGTGAA GCTCTGTGGC 
CTGGACTACG TGAGAACAGT TATCTACATC TGTGCCAGCT CACGGTGGAG GAGACATCTG 
GAGGGGCATT TCCACTCTCA ACAAGCTGAG ACAAGAAACT ACCTCCAGCT CCTAGACAGG 
CACGAGCCAT CCAAGAAAAC TCTGGAGCAC AGCCTTCCCA AGACGGATCT CTCAGGACAG 
GAGCTTGTTC GAGATCCACA GGCACCCAAG GAAGGTCTTT GGGAACTGAA GAAGCACTCA 
GTGGTATCCA GACGAGATCT GCAAGCTCTG TGCTGCAGGG AAGGCTGCTC CATGAAGGAA 
CTCAGCACCC TCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277577.1
CDS	430..867
Translation	MCLVNTVKIRMKGPTLALFLLLVLLAVVEVRSRQTVKLCGLDYVRTVIYICASSRWRRHLEGHFHSQQAETRNYLQLLDRHEPSKKTLEHSLPKTDLSGQELVRDPQAPKEGLWELKKHSVVSRRDLQALCCREGCSMKELSTLC

Target ORF information:

RefSeq Version	NM_001290648.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like 5 (Insl5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290648.2

ORF Insert Sequence:

ATGTGCTTAG TAAACACTGT TAAGATAAGG ATGAAGGGCC CCACTCTTGC TCTGTTTCTC 
CTCTTAGTTC TGTTGGCTGT GGTGGAAGTA AGAAGCAGGC AGACTGTGAA GCTCTGTGGC 
CTGGACTACG TGAGAACAGT TATCTACATC TGTGCCAGCT CACGGTGGAG GAGACATCTG 
GAGGGGCATT TCCACTCTCA ACAAGCTGAG ACAAGAAACT ACCTCCAGCT CCTAGACAGG 
CACGAGCCAT CCAAGAAAAC TCTGGAGCAC AGCCTTCCCA AGACGGATCT CTCAGGACAG 
GAGCTTGTTC GAGATCCACA GGCACCCAAG GAAGGTCTTT GGGAACTGAA GAAGCACTCA 
GTGGTATCCA GACGAGATCT GCAAGCTCTG TGCTGCAGGG AAGGCTGCTC CATGAAGGAA 
CTCAGCACCC TCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Insl5 ( NM_001290648.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277577.1 Mus musculus insulin-like 5 (Insl5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17076
Clone ID Related Accession (Same CDS sequence)	NM_001290648.2 , NM_001290648.1
Accession Version	NM_001290648.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Mus musculus(house mouse)
Product	insulin-like peptide INSL5 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX004765.6 and AF133817.1. On Mar 15, 2014 this sequence version replaced XM_006503068.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF054842.1, SRR1660811.320092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCTTAG TAAACACTGT TAAGATAAGG ATGAAGGGCC CCACTCTTGC TCTGTTTCTC 
CTCTTAGTTC TGTTGGCTGT GGTGGAAGTA AGAAGCAGGC AGACTGTGAA GCTCTGTGGC 
CTGGACTACG TGAGAACAGT TATCTACATC TGTGCCAGCT CACGGTGGAG GAGACATCTG 
GAGGGGCATT TCCACTCTCA ACAAGCTGAG ACAAGAAACT ACCTCCAGCT CCTAGACAGG 
CACGAGCCAT CCAAGAAAAC TCTGGAGCAC AGCCTTCCCA AGACGGATCT CTCAGGACAG 
GAGCTTGTTC GAGATCCACA GGCACCCAAG GAAGGTCTTT GGGAACTGAA GAAGCACTCA 
GTGGTATCCA GACGAGATCT GCAAGCTCTG TGCTGCAGGG AAGGCTGCTC CATGAAGGAA 
CTCAGCACCC TCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277577.1
CDS	1..438
Translation	MCLVNTVKIRMKGPTLALFLLLVLLAVVEVRSRQTVKLCGLDYVRTVIYICASSRWRRHLEGHFHSQQAETRNYLQLLDRHEPSKKTLEHSLPKTDLSGQELVRDPQAPKEGLWELKKHSVVSRRDLQALCCREGCSMKELSTLC

Target ORF information:

RefSeq Version	NM_001290648.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like 5 (Insl5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290648.1

ORF Insert Sequence:

ATGTGCTTAG TAAACACTGT TAAGATAAGG ATGAAGGGCC CCACTCTTGC TCTGTTTCTC 
CTCTTAGTTC TGTTGGCTGT GGTGGAAGTA AGAAGCAGGC AGACTGTGAA GCTCTGTGGC 
CTGGACTACG TGAGAACAGT TATCTACATC TGTGCCAGCT CACGGTGGAG GAGACATCTG 
GAGGGGCATT TCCACTCTCA ACAAGCTGAG ACAAGAAACT ACCTCCAGCT CCTAGACAGG 
CACGAGCCAT CCAAGAAAAC TCTGGAGCAC AGCCTTCCCA AGACGGATCT CTCAGGACAG 
GAGCTTGTTC GAGATCCACA GGCACCCAAG GAAGGTCTTT GGGAACTGAA GAAGCACTCA 
GTGGTATCCA GACGAGATCT GCAAGCTCTG TGCTGCAGGG AAGGCTGCTC CATGAAGGAA 
CTCAGCACCC TCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Insl5 ( NM_011831.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035961.1 Mus musculus insulin-like 5 (Insl5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13944
Clone ID Related Accession (Same CDS sequence)	NM_011831.2
Accession Version	NM_011831.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	insulin-like peptide INSL5 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF133817.1. On Apr 5, 2007 this sequence version replaced NM_011831.1. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133817.1, BC010968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGGCC CCACTCTTGC TCTGTTTCTC CTCTTAGTTC TGTTGGCTGT GGTGGAAGTA 
AGAAGCAGGC AGACTGTGAA GCTCTGTGGC CTGGACTACG TGAGAACAGT TATCTACATC 
TGTGCCAGCT CACGGTGGAG GAGACATCTG GAGGGGCATT TCCACTCTCA ACAAGCTGAG 
ACAAGAAACT ACCTCCAGCT CCTAGACAGG CACGAGCCAT CCAAGAAAAC TCTGGAGCAC 
AGCCTTCCCA AGACGGATCT CTCAGGACAG GAGCTTGTTC GAGATCCACA GGCACCCAAG 
GAAGGTCTTT GGGAACTGAA GAAGCACTCA GTGGTATCCA GACGAGATCT GCAAGCTCTG 
TGCTGCAGGG AAGGCTGCTC CATGAAGGAA CTCAGCACCC TCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035961.1
CDS	37..444
Translation	MKGPTLALFLLLVLLAVVEVRSRQTVKLCGLDYVRTVIYICASSRWRRHLEGHFHSQQAETRNYLQLLDRHEPSKKTLEHSLPKTDLSGQELVRDPQAPKEGLWELKKHSVVSRRDLQALCCREGCSMKELSTLC

Target ORF information:

RefSeq Version	NM_011831.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like 5 (Insl5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011831.2

ORF Insert Sequence:

ATGAAGGGCC CCACTCTTGC TCTGTTTCTC CTCTTAGTTC TGTTGGCTGT GGTGGAAGTA 
AGAAGCAGGC AGACTGTGAA GCTCTGTGGC CTGGACTACG TGAGAACAGT TATCTACATC 
TGTGCCAGCT CACGGTGGAG GAGACATCTG GAGGGGCATT TCCACTCTCA ACAAGCTGAG 
ACAAGAAACT ACCTCCAGCT CCTAGACAGG CACGAGCCAT CCAAGAAAAC TCTGGAGCAC 
AGCCTTCCCA AGACGGATCT CTCAGGACAG GAGCTTGTTC GAGATCCACA GGCACCCAAG 
GAAGGTCTTT GGGAACTGAA GAAGCACTCA GTGGTATCCA GACGAGATCT GCAAGCTCTG 
TGCTGCAGGG AAGGCTGCTC CATGAAGGAA CTCAGCACCC TCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.
Rapid communications in mass spectrometry : RCM31(23)1963-1973(2017 Dec)
Kay RG,Galvin S,Larraufie P,Reimann F,Gribble FM

Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production.
Molecular metabolism5(4)263-70(2016 Apr)
Lee YS,De Vadder F,Tremaroli V,Wichmann A,Mithieux G,B?ckhed F

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.
Proceedings of the National Academy of Sciences of the United States of America111(30)11133-8(2014 Jul)
Grosse J,Heffron H,Burling K,Akhter Hossain M,Habib AM,Rogers GJ,Richards P,Larder R,Rimmington D,Adriaenssens AA,Parton L,Powell J,Binda M,Colledge WH,Doran J,Toyoda Y,Wade JD,Aparicio S,Carlton MB,Coll AP,Reimann F,O'Rahilly S,Gribble FM

INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.
Biochemical and biophysical research communications432(4)586-92(2013 Mar)
Mashima H,Ohno H,Yamada Y,Sakai T,Ohnishi H

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Insl5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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