Fxr2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fxr2
Entrez Gene ID	23879
Full Name	fragile X mental retardation, autosomal homolog 2
Synonyms	Fxr2h
General protein information	Preferred Names fragile X mental retardation, autosomal homolog 2 Names fragile X mental retardation syndrome-related protein 2 fragile X mental retardation gene 2, autosomal homolog fragile X mental retardation-related protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B3\|11 42.86 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011814.2	NP_035944.2	fragile X mental retardation syndrome-related protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FXR2	XP_001171317.2
	FXR2	XP_001118084.2
Bos taurus (cattle)	FXR2	NP_001193218.1
Danio rerio (zebrafish)	fxr2	NP_956505.2
Canis lupus familiaris (dog)	FXR2	XP_546596.3
Mus musculus (house mouse)	Fxr2	NP_035944.2
Rattus norvegicus (Norway rat)	Fxr2	NP_001094117.1
Homo sapiens (human)	FXR2	NP_004851.2

Gene Ontology
Bibliography

Related articles in PubMed

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.
Qie S, Majumder M, Mackiewicz K, Howley BV, Peterson YK, Howe PH, Palanisamy V, Diehl JA
Nature communications8(1)1534(2017 Nov)

Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.
Patzlaff NE, Nemec KM, Malone SG, Li Y, Zhao X
Human molecular genetics26(7)1340-1352(2017 04)

Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in
Wang GX, Smith SJ, Mourrain P
eLife5(2016 10)

Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.
Guo W, Polich ED, Su J, Gao Y, Christopher DM, Allan AM, Wang M, Wang F, Wang G, Zhao X
Cell reports11(10)1651-66(2015 Jun)

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.
Fern?ndez E, Li KW, Rajan N, De Rubeis S, Fiers M, Smit AB, Achsel T, Bagni C
The Journal of neuroscience : the official journal of the Society for Neuroscience35(25)9402-8(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We discovered that FXR1P-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P.
Title: Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.

these findings show a coordinated regulation of PSD95/Dlg4 mRNA by FMRP and FXR2P that ultimately affects its fine-tuning during synaptic activity.
Title: FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.

Both Fmr1 and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.
Title: The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice.

Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
Title: RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.

FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.
Title: Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.

The following Fxr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fxr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08908	NM_011814.2 Latest version!	Mus musculus fragile X mental retardation, autosomal homolog 2 (Fxr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$398.30 $569.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fxr2 ( NM_011814.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035944.2 Mus musculus fragile X mental retardation, autosomal homolog 2 (Fxr2), mRNA.

Price & Availability↑

CloneID	OMu08908
Clone ID Related Accession (Same CDS sequence)	NM_011814.2
Accession Version	NM_011814.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	fragile X mental retardation syndrome-related protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC062971.1. On Dec 23, 2005 this sequence version replaced NM_011814.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062971.1, AK154243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGCC TGGCCTCTGG GGGGGATGTG GAGCCGGGAC TGCCCGTCGA GGTGCGGGGC 
TCCAACGGGG CCTTCTACAA GGGCTTTGTA AAGGATGTCC ATGAAGACTC TGTCACTATC 
TTCTTTGAGA ACAACTGGCA GAGTGAGAGA CAGATTCCCT TTGGGGATGT CCGACTACCG 
CCTCCAGCTG ACTACAATAA GGAAATCACA GAAGGAGATG AAGTAGAGGT CTATTCGAGA 
GCCAATGAAC AGGAACCTTG TGGCTGGTGG CTGGCCCGGG TGCGGATGAT GAAGGGAGAT 
TTCTATGTCA TTGAGTACGC TGCCTGTGAT GCTACCTACA ATGAGATTGT CACTCTGGAA 
CGACTTCGGC CAGTCAATCC CAGTCCCCTT GCAACCAAAG GCAGCTTCTT CAAGGTTACC 
ATGGCTGTGC CTGAGGACCT CAGGGAGGCC TGCTCCAATG AAAATGTCCA TAAGGAGTTC 
AAGAAAGCAC TGGGAGCCAA CTGCATCTTT CTCAACATCA CAAACAGTGA GCTCTTTATT 
CTGTCAACCA CAGAAGCCCC TGTGAAGAGG GCATCTTTGT TGGGTGATAT GCATTTCCGA 
AGCCTTCGCA CCAAATTGCT GCTCATGTCC CGCAATGAAG AAGCTACTAA GCACCTAGAG 
ACAAGTAAGC AGCTGGCAGC AGCCTTCCAA GAGGAGTTCA CAGTGCGAGA GGACCTGATG 
GGTCTGGCGA TCGGAACGCA CGGTGCCAAC ATCCAGCAGG CTCGGAAAGT GCCCGGAGTG 
ACTGCCATTG AGTTGGGTGA AGAGACCTGC ACTTTCCGAA TCTATGGGGA GACACCAGAG 
GCATGCAGAC AGGCTCGAAG CTACCTTGAA TTTTCCGAGG ACTCTGTACA AGTGCCCAGG 
AACCTGGTTG GCAAAGTGAT CGGAAAGAAC GGGAAAGTGA TTCAGGAGAT TGTGGATAAG 
TCTGGTGTGG TGAGGGTTCG TGTGGAAGGA GATAACGACA AGAAGAACCC CAGGGAGGAG 
GGAATGGTTC CCTTCATATT TGTTGGCACC CGAGAGAACA TCAGCAATGC CCAGGCACTG 
CTTGAGTATC ACCTCTCCTA CCTGCAGGAG GTTGAACAGC TTCGCCTGGA GAGACTGCAG 
ATTGACGAAC AGCTTCGGCA GATTGGGCTG GGCTTTCGCC CTCCTGGGAG TGGACGGGGT 
GGCAGTGGTG GTGGCAGTGA CAAGGCGGGC TATACCACAG ACGAAAGCTC CTCCTCTTCC 
CTGCACACGA CCAGAACCTA TGGGGGCAGC TATGGGGGCC GGGGCCGGGG CCGGAGGACT 
GGTGGTCCTG CCTATGGCCC CAGCTCAGAC CCCTCCACAG CTTCAGAGAC AGAGTCAGAA 
AAGAGAGAGG AGTCTAATCG AGCAGGACCT GGTGACAGAG ATCCCCCAAG CCGTGGAGAA 
GAAAGCAGGA GGCGGCCGAT TGGGGGCCGG GGAAGGGGAC CCCCACCTGT TCCCCGGCCT 
ACCTCAAGAT ATAACTCATC ATCTATTAGC TCAGTGCTAA AGGATCCAGA CAGCAATCCT 
TACAGCCTCT TGGACACATC TGAACCAGAG CCTCCAGTTG ATTCGGAGCC TGGTGAACCT 
CCTCCAGCAA GTGCCCGTCG TCGCCGTTCC CGCCGCCGCC GTACTGATGA AGACAGGACT 
GTCATGGACG GAGGCCTGGA GTCTGATGGT CCTAACATGA CAGAGAATGG CCTGGAAGAT 
GAATCAAGAC CCCAGAGACG AAATCGCAGC CGCCGCCGCC GTAATCGTGG TAACCGGACT 
GATGGGTCCA TCAGTGGAGA CCGCCAACCA GTGACTGTGG CTGACTATAT CTCACGGGCA 
GAGTCTCAGA GCCGCCAGCG GCCCCTGGAA CGCACGAAAC CCTCAGAGGA TTCTCTTTCA 
GGACAGAAGG GTGACTCTGT CAGCAAGCTT CCCAAGGGCC CCTCAGAGAA TGGGGAGCTC 
TCTGCCCCCT TGGAGTTGGG TAGTTTGGTG AATGGAGTTT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035944.2
CDS	348..2372
Translation	MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPSPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSDPSTASETESEKREESNRAGPGDRDPPSRGEESRRRPIGGRGRGPPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS

Target ORF information:

RefSeq Version	NM_011814.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fragile X mental retardation, autosomal homolog 2 (Fxr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011814.2

ORF Insert Sequence:

ATGGGCGGCC TGGCCTCTGG GGGGGATGTG GAGCCGGGAC TGCCCGTCGA GGTGCGGGGC 
TCCAACGGGG CCTTCTACAA GGGCTTTGTA AAGGATGTCC ATGAAGACTC TGTCACTATC 
TTCTTTGAGA ACAACTGGCA GAGTGAGAGA CAGATTCCCT TTGGGGATGT CCGACTACCG 
CCTCCAGCTG ACTACAATAA GGAAATCACA GAAGGAGATG AAGTAGAGGT CTATTCGAGA 
GCCAATGAAC AGGAACCTTG TGGCTGGTGG CTGGCCCGGG TGCGGATGAT GAAGGGAGAT 
TTCTATGTCA TTGAGTACGC TGCCTGTGAT GCTACCTACA ATGAGATTGT CACTCTGGAA 
CGACTTCGGC CAGTCAATCC CAGTCCCCTT GCAACCAAAG GCAGCTTCTT CAAGGTTACC 
ATGGCTGTGC CTGAGGACCT CAGGGAGGCC TGCTCCAATG AAAATGTCCA TAAGGAGTTC 
AAGAAAGCAC TGGGAGCCAA CTGCATCTTT CTCAACATCA CAAACAGTGA GCTCTTTATT 
CTGTCAACCA CAGAAGCCCC TGTGAAGAGG GCATCTTTGT TGGGTGATAT GCATTTCCGA 
AGCCTTCGCA CCAAATTGCT GCTCATGTCC CGCAATGAAG AAGCTACTAA GCACCTAGAG 
ACAAGTAAGC AGCTGGCAGC AGCCTTCCAA GAGGAGTTCA CAGTGCGAGA GGACCTGATG 
GGTCTGGCGA TCGGAACGCA CGGTGCCAAC ATCCAGCAGG CTCGGAAAGT GCCCGGAGTG 
ACTGCCATTG AGTTGGGTGA AGAGACCTGC ACTTTCCGAA TCTATGGGGA GACACCAGAG 
GCATGCAGAC AGGCTCGAAG CTACCTTGAA TTTTCCGAGG ACTCTGTACA AGTGCCCAGG 
AACCTGGTTG GCAAAGTGAT CGGAAAGAAC GGGAAAGTGA TTCAGGAGAT TGTGGATAAG 
TCTGGTGTGG TGAGGGTTCG TGTGGAAGGA GATAACGACA AGAAGAACCC CAGGGAGGAG 
GGAATGGTTC CCTTCATATT TGTTGGCACC CGAGAGAACA TCAGCAATGC CCAGGCACTG 
CTTGAGTATC ACCTCTCCTA CCTGCAGGAG GTTGAACAGC TTCGCCTGGA GAGACTGCAG 
ATTGACGAAC AGCTTCGGCA GATTGGGCTG GGCTTTCGCC CTCCTGGGAG TGGACGGGGT 
GGCAGTGGTG GTGGCAGTGA CAAGGCGGGC TATACCACAG ACGAAAGCTC CTCCTCTTCC 
CTGCACACGA CCAGAACCTA TGGGGGCAGC TATGGGGGCC GGGGCCGGGG CCGGAGGACT 
GGTGGTCCTG CCTATGGCCC CAGCTCAGAC CCCTCCACAG CTTCAGAGAC AGAGTCAGAA 
AAGAGAGAGG AGTCTAATCG AGCAGGACCT GGTGACAGAG ATCCCCCAAG CCGTGGAGAA 
GAAAGCAGGA GGCGGCCGAT TGGGGGCCGG GGAAGGGGAC CCCCACCTGT TCCCCGGCCT 
ACCTCAAGAT ATAACTCATC ATCTATTAGC TCAGTGCTAA AGGATCCAGA CAGCAATCCT 
TACAGCCTCT TGGACACATC TGAACCAGAG CCTCCAGTTG ATTCGGAGCC TGGTGAACCT 
CCTCCAGCAA GTGCCCGTCG TCGCCGTTCC CGCCGCCGCC GTACTGATGA AGACAGGACT 
GTCATGGACG GAGGCCTGGA GTCTGATGGT CCTAACATGA CAGAGAATGG CCTGGAAGAT 
GAATCAAGAC CCCAGAGACG AAATCGCAGC CGCCGCCGCC GTAATCGTGG TAACCGGACT 
GATGGGTCCA TCAGTGGAGA CCGCCAACCA GTGACTGTGG CTGACTATAT CTCACGGGCA 
GAGTCTCAGA GCCGCCAGCG GCCCCTGGAA CGCACGAAAC CCTCAGAGGA TTCTCTTTCA 
GGACAGAAGG GTGACTCTGT CAGCAAGCTT CCCAAGGGCC CCTCAGAGAA TGGGGAGCTC 
TCTGCCCCCT TGGAGTTGGG TAGTTTGGTG AATGGAGTTT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.
Nature communications8(1)1534(2017 Nov)
Qie S,Majumder M,Mackiewicz K,Howley BV,Peterson YK,Howe PH,Palanisamy V,Diehl JA

Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.
Human molecular genetics26(7)1340-1352(2017 04)
Patzlaff NE,Nemec KM,Malone SG,Li Y,Zhao X

Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in
eLife5(2016 10)
Wang GX,Smith SJ,Mourrain P

Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.
Cell reports11(10)1651-66(2015 Jun)
Guo W,Polich ED,Su J,Gao Y,Christopher DM,Allan AM,Wang M,Wang F,Wang G,Zhao X

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(25)9402-8(2015 Jun)
Fern?ndez E,Li KW,Rajan N,De Rubeis S,Fiers M,Smit AB,Achsel T,Bagni C

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Fxr2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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