Kcnh5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnh5
Entrez Gene ID	238271
Full Name	potassium voltage-gated channel, subfamily H (eag-related), member 5
Synonyms	Eag2
General protein information	Preferred Names potassium voltage-gated channel, subfamily H (eag-related), member 5 Names potassium voltage-gated channel subfamily H member 5 ether-a-go-go potassium channel 2 voltage-gated potassium channel subunit Kv10.2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_172805.3	NP_766393.2	potassium voltage-gated channel subfamily H member 5

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KCNH5	XP_421414.2
Xenopus tropicalis (tropical clawed frog)	kcnh5	NP_001120909.1
Mus musculus (house mouse)	Kcnh5	NP_766393.2
Bos taurus (cattle)	KCNH5	NP_001179918.1
Homo sapiens (human)	KCNH5	NP_647479.2
	KCNH5	XP_001100052.1
Canis lupus familiaris (dog)	KCNH5	XP_547846.2
Rattus norvegicus (Norway rat)	Kcnh5	NP_598294.1
Danio rerio (zebrafish)	kcnh5a	NP_001263209.1

Gene Ontology
Bibliography

Related articles in PubMed

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY
Genes & development26(16)1780-96(2012 Aug)

The transcription factor c-Maf controls touch receptor development and function.
Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C
Science (New York, N.Y.)335(6074)1373-6(2012 Mar)

Divalent cations slow activation of EAG family K+ channels through direct binding to S4.
Zhang X, Bursulaya B, Lee CC, Chen B, Pivaroff K, Jegla T
Biophysical journal97(1)110-20(2009 Jul)

Conditional gene targeting on the pure C57BL/6 genetic background.
Mishina M, Sakimura K
Neuroscience research58(2)105-12(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Disruption of EAG2 expression results in G2 arrest and mitotic catastrophe associated with failure of premitotic cytoplasmic condensation
Title: Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Our results suggest close conformational conservation between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels, despite large differences in voltage sensitivity, activation rates, and activation threshold
Title: Divalent cations slow activation of EAG family K+ channels through direct binding to S4.

The following Kcnh5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnh5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04086	NM_172805.3 Latest version!	Mus musculus potassium voltage-gated channel, subfamily H (eag-related), member 5 (Kcnh5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnh5 ( NM_172805.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766393.2 Mus musculus potassium voltage-gated channel, subfamily H (eag-related), member 5 (Kcnh5), mRNA.

Price & Availability↑

CloneID	OMu04086
Clone ID Related Accession (Same CDS sequence)	NM_172805.3
Accession Version	NM_172805.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Mus musculus(house mouse)
Product	potassium voltage-gated channel subfamily H member 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110175.14, AK032438.1, CT010432.7 and AC131762.2. On Aug 6, 2009 this sequence version replaced NM_172805.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK032438.1, BC066138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCT CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AAATTGTGGA CTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CCTGCAGTTT TATGTATGGA GAACTGACCG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAGA CTTTTGACAA CTACGAGTCA AACTGTTTTG AAGTTCTTCT GTACAAAAAA 
AACCGTACCC CTGTTTGGTT TTACATGCAA ATCGCACCAA TAAGAAATGA ACACGAGAAG 
GTGGTCTTGT TCCTGTGTAC ATTCAAGGAC ATTACACTGT TCAAACAGCC TATAGAGGAT 
GACTCAACGA AAGGTTGGAC GAAGTTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTAC AGCAGCTTAC ACCAATGAAT AAAACAGAGA CAGTCCACAA GCATTCAAGA 
CTAGCTGAAG TGCTTCAGCT GGGATCAGAC ATCCTTCCTC AGTACAAACA AGAAGCGCCA 
AAGACGCCAC CACATATCAT CTTACACTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATC ATGGTTCCTT ACAATGTTTC TTTCAAAACA 
AAGCAGAACA ATATCGCCTG GCTGGTGCTG GACAGTGTGG TGGACGTGAT TTTTCTGGTG 
GACATTGTTT TAAATTTTCA CACGACTTTT GTGGGGCCGG GTGGAGAGGT CATTTCTGAC 
CCGAAGCTTA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATTGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGCTCTTTAA AGGTGGTGCG CCTTTTACGC CTGGGCCGTG TTGCTAGGAA ACTGGACCAT 
TACCTGGAAT ATGGAGCAGC GGTCCTTGTG CTCCTGGTAT GTGTGTTTGG ACTGGTGGCT 
CACTGGCTGG CTTGCATCTG GTACAGCATT GGAGACTATG AGGTCATTGA TGAAGTCACC 
AACACCATTC AAATAGACAG CTGGCTCTAC CAGTTGGCCT TGAGCATTGG GACCCCATAT 
CGCTACAATA CGAGTGCAGG GATCTGGGAA GGAGGACCCA GCAAGGACTC CCTGTATGTG 
TCCTCCCTCT ACTTCACCAT GACGAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCG 
ACCACAGACG TGGAGAAGAT GTTCTCAGTG GCCATGATGA TGGTCGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACCACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGT 
TACCATGAGA TGCTGAATAA TGTTCGAGAT TTCCTGAAAT TATATCAGGT CCCAAAAGGC 
CTTAGTGAAC GAGTGATGGA TTATATTGTC TCAACATGGT CAATGTCAAA AGGCATCGAC 
ACAGAGAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGACATCTG TGTTCATCTG 
AACCGGAAGG TTTTTAATGA ACATCCTGCA TTCCGATTGG CCAGCGATGG ATGTCTGCGT 
GCCTTGGCAG TGGAGTTCCA AACCATTCAC TGTGCTCCTG GGGACCTGAT TTACCATGCT 
GGAGAGAGTG TGGATGCCCT CTGCTTTGTG GTGTCCGGGT CCTTGGAAGT TATCCAGGAT 
GAGGAGGTGG TGGCCATTTT AGGGAAAGGT GACGTGTTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CTCATGCGTG TGCCAATGTC CGGGCCCTGA CTTACTGTGA TCTGCACATC 
ATCAAGCGAG AAGCCTTGCT CAAGGTCCTT GACTTCTATA CAGCATTTGC AAACTCATTT 
TCCAGGAACC TCACTCTCAC TTGCAATCTA AGGAAGCGGA TCATCTTCCG TAAAATTAGT 
GATGTGAAGA AGGAGGAGGA GGAGCGGCTG CGGCAGAAGA ATGAGGTGAC TCTGAGCATC 
CCCGTGGACC ACCCAGTGAG GAAGCTCTTC CAGAAGTTCA AACAGCAGAA AGAACTGAGG 
ATCCAGGGCT CTGCACAGAG TGATCCTGAG AGGAGCCAGC TTCAGGTAGA GAGCCGCCCT 
TTGCAGAACG GAGCCTCCAT CACAGGTACC AGTGTGGTCA CCGTATCACA GATTACCCCC 
ATCCAGACGT CTCTGGCGTA TGTGAAAACC AGCGAGTCTC TTAAGCAGAA CAACCGCGAT 
GCCATGGAAC TGAAGCCCAA TGGTGGCGCT GAACCCAAAT GTCTCAAGGT CAACAGCCCC 
ATCAGGATGA AAAACGGAAA TGGGAAGGGG TGGCTGAGAC TCAAGAACAA CATGGGGGCT 
CAGGAGGAGA AAAAGGAAGA CTGGAATAAT GTCACCAAAG CCGAGTCGAT GGGGCTCTTG 
TCGGAGGACC CCAAGGGCAG TGACTCAGAG AACAGTGTGA CCAAGAACCC CTTAAGGAAA 
ACGGATTCTT GTGACAGTGG GATTACAAAA AGTGACCTTC GTTTGGATAA AGCCGGTGAG 
GCCCGAAGTC CTCTAGAACA CAGCCCCAGC CAGGCTGATG TCAAGCATTC TTTCTACCCC 
ATCCCCGAGC AGGCCTTACA AACCACACTG CAGGAAGTCA AACATGAACT CAAGGAGGAT 
ATCCAGCTGC TAAGCTGCAG AATGACTGCC CTGGAAAAGC AGGTGGCAGA GATTTTAAAA 
CTACTCTCAG AGAAAAGCGT ACCCCAGACA TCTTCTCCAA AACCCCAAAT TCCACTCCAA 
GTACCTCCCC AAATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA GTCACCCGAA 
TCTGACAAAG ACGAAATCAA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766393.2
CDS	805..3771
Translation	MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRIQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAQEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADVKHSFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKLLSEKSVPQTSSPKPQIPLQVPPQIPCQDIFSVSRPESPESDKDEINF

Target ORF information:

RefSeq Version	NM_172805.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium voltage-gated channel, subfamily H (eag-related), member 5 (Kcnh5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172805.3

ORF Insert Sequence:

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCT CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AAATTGTGGA CTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CCTGCAGTTT TATGTATGGA GAACTGACCG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAGA CTTTTGACAA CTACGAGTCA AACTGTTTTG AAGTTCTTCT GTACAAAAAA 
AACCGTACCC CTGTTTGGTT TTACATGCAA ATCGCACCAA TAAGAAATGA ACACGAGAAG 
GTGGTCTTGT TCCTGTGTAC ATTCAAGGAC ATTACACTGT TCAAACAGCC TATAGAGGAT 
GACTCAACGA AAGGTTGGAC GAAGTTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTAC AGCAGCTTAC ACCAATGAAT AAAACAGAGA CAGTCCACAA GCATTCAAGA 
CTAGCTGAAG TGCTTCAGCT GGGATCAGAC ATCCTTCCTC AGTACAAACA AGAAGCGCCA 
AAGACGCCAC CACATATCAT CTTACACTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATC ATGGTTCCTT ACAATGTTTC TTTCAAAACA 
AAGCAGAACA ATATCGCCTG GCTGGTGCTG GACAGTGTGG TGGACGTGAT TTTTCTGGTG 
GACATTGTTT TAAATTTTCA CACGACTTTT GTGGGGCCGG GTGGAGAGGT CATTTCTGAC 
CCGAAGCTTA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATTGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGCTCTTTAA AGGTGGTGCG CCTTTTACGC CTGGGCCGTG TTGCTAGGAA ACTGGACCAT 
TACCTGGAAT ATGGAGCAGC GGTCCTTGTG CTCCTGGTAT GTGTGTTTGG ACTGGTGGCT 
CACTGGCTGG CTTGCATCTG GTACAGCATT GGAGACTATG AGGTCATTGA TGAAGTCACC 
AACACCATTC AAATAGACAG CTGGCTCTAC CAGTTGGCCT TGAGCATTGG GACCCCATAT 
CGCTACAATA CGAGTGCAGG GATCTGGGAA GGAGGACCCA GCAAGGACTC CCTGTATGTG 
TCCTCCCTCT ACTTCACCAT GACGAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCG 
ACCACAGACG TGGAGAAGAT GTTCTCAGTG GCCATGATGA TGGTCGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACCACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGT 
TACCATGAGA TGCTGAATAA TGTTCGAGAT TTCCTGAAAT TATATCAGGT CCCAAAAGGC 
CTTAGTGAAC GAGTGATGGA TTATATTGTC TCAACATGGT CAATGTCAAA AGGCATCGAC 
ACAGAGAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGACATCTG TGTTCATCTG 
AACCGGAAGG TTTTTAATGA ACATCCTGCA TTCCGATTGG CCAGCGATGG ATGTCTGCGT 
GCCTTGGCAG TGGAGTTCCA AACCATTCAC TGTGCTCCTG GGGACCTGAT TTACCATGCT 
GGAGAGAGTG TGGATGCCCT CTGCTTTGTG GTGTCCGGGT CCTTGGAAGT TATCCAGGAT 
GAGGAGGTGG TGGCCATTTT AGGGAAAGGT GACGTGTTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CTCATGCGTG TGCCAATGTC CGGGCCCTGA CTTACTGTGA TCTGCACATC 
ATCAAGCGAG AAGCCTTGCT CAAGGTCCTT GACTTCTATA CAGCATTTGC AAACTCATTT 
TCCAGGAACC TCACTCTCAC TTGCAATCTA AGGAAGCGGA TCATCTTCCG TAAAATTAGT 
GATGTGAAGA AGGAGGAGGA GGAGCGGCTG CGGCAGAAGA ATGAGGTGAC TCTGAGCATC 
CCCGTGGACC ACCCAGTGAG GAAGCTCTTC CAGAAGTTCA AACAGCAGAA AGAACTGAGG 
ATCCAGGGCT CTGCACAGAG TGATCCTGAG AGGAGCCAGC TTCAGGTAGA GAGCCGCCCT 
TTGCAGAACG GAGCCTCCAT CACAGGTACC AGTGTGGTCA CCGTATCACA GATTACCCCC 
ATCCAGACGT CTCTGGCGTA TGTGAAAACC AGCGAGTCTC TTAAGCAGAA CAACCGCGAT 
GCCATGGAAC TGAAGCCCAA TGGTGGCGCT GAACCCAAAT GTCTCAAGGT CAACAGCCCC 
ATCAGGATGA AAAACGGAAA TGGGAAGGGG TGGCTGAGAC TCAAGAACAA CATGGGGGCT 
CAGGAGGAGA AAAAGGAAGA CTGGAATAAT GTCACCAAAG CCGAGTCGAT GGGGCTCTTG 
TCGGAGGACC CCAAGGGCAG TGACTCAGAG AACAGTGTGA CCAAGAACCC CTTAAGGAAA 
ACGGATTCTT GTGACAGTGG GATTACAAAA AGTGACCTTC GTTTGGATAA AGCCGGTGAG 
GCCCGAAGTC CTCTAGAACA CAGCCCCAGC CAGGCTGATG TCAAGCATTC TTTCTACCCC 
ATCCCCGAGC AGGCCTTACA AACCACACTG CAGGAAGTCA AACATGAACT CAAGGAGGAT 
ATCCAGCTGC TAAGCTGCAG AATGACTGCC CTGGAAAAGC AGGTGGCAGA GATTTTAAAA 
CTACTCTCAG AGAAAAGCGT ACCCCAGACA TCTTCTCCAA AACCCCAAAT TCCACTCCAA 
GTACCTCCCC AAATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA GTCACCCGAA 
TCTGACAAAG ACGAAATCAA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development26(16)1780-96(2012 Aug)
Huang X,Dubuc AM,Hashizume R,Berg J,He Y,Wang J,Chiang C,Cooper MK,Northcott PA,Taylor MD,Barnes MJ,Tihan T,Chen J,Hackett CS,Weiss WA,James CD,Rowitch DH,Shuman MA,Jan YN,Jan LY

The transcription factor c-Maf controls touch receptor development and function.
Science (New York, N.Y.)335(6074)1373-6(2012 Mar)
Wende H,Lechner SG,Cheret C,Bourane S,Kolanczyk ME,Pattyn A,Reuter K,Munier FL,Carroll P,Lewin GR,Birchmeier C

Divalent cations slow activation of EAG family K+ channels through direct binding to S4.
Biophysical journal97(1)110-20(2009 Jul)
Zhang X,Bursulaya B,Lee CC,Chen B,Pivaroff K,Jegla T

Conditional gene targeting on the pure C57BL/6 genetic background.
Neuroscience research58(2)105-12(2007 Jun)
Mishina M,Sakimura K

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Kcnh5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報