Mrgpra2b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mrgpra2b
Entrez Gene ID	235712
Full Name	MAS-related GPR, member A2B
Synonyms	MrgA2,Mrgpra2
General protein information	Preferred Names MAS-related GPR, member A2B Names mas-related G-protein coupled receptor member A2 G protein-coupled receptor MrgA2 MAS-related GPR, member A2 Mas-related gene A2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_153101.3	NP_694741.2	mas-related G-protein coupled receptor member A2
XM_006540858.2	XP_006540921.1	mas-related G-protein coupled receptor member A2 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mrgpra1	NP_694735.2
Mus musculus (house mouse)	Mrgpra2a	NP_001166059.1
Mus musculus (house mouse)	Mrgpra9	NP_001171037.1
Rattus norvegicus (Norway rat)	Mrgprx3	NP_665730.2
Pan troglodytes (chimpanzee)	MRGPRX3	XP_001172934.1
Homo sapiens (human)	MRGPRX3	NP_473372.3
	MRGPRX3	NP_001035511.1
Mus musculus (house mouse)	Mrgpra2b	NP_694741.2

Gene Ontology
Bibliography

Related articles in PubMed

Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.
Callera GE, Antunes TT, Correa JW, Moorman D, Gutsol A, He Y, Cat AN, Briones AM, Montezano AC, Burns KD, Touyz RM
Bioscience reports36(5)(2016 Oct)

Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism.
Santos SH, Fernandes LR, Mario EG, Ferreira AV, P?rto LC, Alvarez-Leite JI, Botion LM, Bader M, Alenina N, Santos RA
Diabetes57(2)340-7(2008 Feb)

Differential mRNA processing in hematopoietic stem cells.
Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA
Stem cells (Dayton, Ohio)24(3)662-70(2006 Mar)

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Zylka MJ, Dong X, Southwell AL, Anderson DJ
Proceedings of the National Academy of Sciences of the United States of America100(17)10043-8(2003 Aug)

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T
Proceedings of the National Academy of Sciences of the United States of America100(14)8258-63(2003 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage.
Title: Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.

data suggest that members of the Mrgpr family, in particular MrgprC11, may constitute an endogenous inhibitory mechanism for regulating persistent pain in mice
Title: Mas-related G-protein-coupled receptors inhibit pathological pain in mice.

Mas deficiency in FVB/N mice leads to dramatic changes in glucose and lipid metabolisms, inducing a metabolic syndrome-like state.
Title: Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism.

Deletion of the Mas protooncogene abolishes the binding of Ang-(1-7) to mouse kidneys. Mas is a functional receptor for Ang-(1-7)
Title: Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.

The following Mrgpra2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mrgpra2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02291	NM_153101.3 Latest version!	Mus musculus MAS-related GPR, member A2B (Mrgpra2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu38828	XM_006540858.2 Latest version!	Mus musculus MAS-related GPR, member A2B (Mrgpra2b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mrgpra2b ( NM_153101.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694741.2 Mus musculus MAS-related GPR, member A2B (Mrgpra2b), mRNA.

Price & Availability↑

CloneID	OMu02291
Clone ID Related Accession (Same CDS sequence)	NM_153101.3
Accession Version	NM_153101.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	mas-related G-protein coupled receptor member A2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DY245072.1, AY042192.1 and DY243808.1. On May 17, 2008 this sequence version replaced NM_153101.2. CCDS Note: The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. ##Evidence-Data-START## Transcript exon combination :: AY042192.1, AK156116.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849390 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAAA GCAATGGTGA AGCATTTCTT GCCTTTAAGA CCTCAGCCTC ACCAACAGCA 
CCAGTGACAA CAAATCCAAT GGACGAAACC CTCCCTGGAA GTATCAACAT TAGGATTCTG 
ATCCCAAAAT TGATGATCAT CATCTTCGGA CTGGTCGGAC TGATGGGAAA CGCCATTGTG 
TTCTGGCTCC TGGGCTTCCA CTTGCGCAGG AATGCCTTCT CAGTCTACAT CCTAAACTTG 
GCCCTGGCTG ACTTCCTTTT CCTCCTCAGT AGTATCATAG CTTCCACCCT GTTTCTTCTC 
AAAGTTTCCT ACCTCAGCAT CATCTTTCAC TTGTGCTTTA ACACCATTAT GATGGTTGTC 
TACATCACAG GGATAAGCAT GCTCAGTGCC ATCAGCACTG AGTGCTGCCT GTCTGTCCTG 
TGCCCCACCT GGTATCGCTG CCACCGTCCA GTACATACAT CAACTGTCAT GTGTGCTGTG 
ATCTGGGTCC TATCCCTGTT GATCTGCATT CTGAATAGCT ATTTCTGTGC TGTCTTACAT 
ACCAGATATG ATAATGACAA TGAGTGTCTG GCAACTAACA TCTTTACCGC CTCGTACATG 
ATATTTTTGC TTGTGGTCCT CTGTCTGTCC AGCCTGGCTC TGCTGGCCAG GTTGTTCTGT 
GGCGCTGGGC AGATGAAGCT TACCAGATTT CATGTGACCA TCTTGCTGAC CCTTTTGGTT 
TTTCTCCTCT GCGGGTTGCC CTTTGTCATC TACTGCATCC TGTTATTCAA GATTAAGGAT 
GATTTCCATG TATTAGATGT TAATCTTTAT CTAGCATTAG AAGTCCTGAC TGCTATTAAC 
AGCTGTGCCA ACCCCATCAT CTACTTCTTC GTGGGCTCTT TCAGACATCA GTTGAAGCAC 
CAGACCCTCA AAATGGTTCT CCAGAGTGCA CTGCAGGACA CTCCTGAGAC AGCTGAAAAC 
ATGGTAGAGA TGTCAAGTAA CAAAGCAGAG CCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694741.2
CDS	85..1080
Translation	MGESNGEAFLAFKTSASPTAPVTTNPMDETLPGSINIRILIPKLMIIIFGLVGLMGNAIVFWLLGFHLRRNAFSVYILNLALADFLFLLSSIIASTLFLLKVSYLSIIFHLCFNTIMMVVYITGISMLSAISTECCLSVLCPTWYRCHRPVHTSTVMCAVIWVLSLLICILNSYFCAVLHTRYDNDNECLATNIFTASYMIFLLVVLCLSSLALLARLFCGAGQMKLTRFHVTILLTLLVFLLCGLPFVIYCILLFKIKDDFHVLDVNLYLALEVLTAINSCANPIIYFFVGSFRHQLKHQTLKMVLQSALQDTPETAENMVEMSSNKAEP

Target ORF information:

RefSeq Version	NM_153101.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAS-related GPR, member A2B (Mrgpra2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153101.3

ORF Insert Sequence:

ATGGGGGAAA GCAATGGTGA AGCATTTCTT GCCTTTAAGA CCTCAGCCTC ACCAACAGCA 
CCAGTGACAA CAAATCCAAT GGACGAAACC CTCCCTGGAA GTATCAACAT TAGGATTCTG 
ATCCCAAAAT TGATGATCAT CATCTTCGGA CTGGTCGGAC TGATGGGAAA CGCCATTGTG 
TTCTGGCTCC TGGGCTTCCA CTTGCGCAGG AATGCCTTCT CAGTCTACAT CCTAAACTTG 
GCCCTGGCTG ACTTCCTTTT CCTCCTCAGT AGTATCATAG CTTCCACCCT GTTTCTTCTC 
AAAGTTTCCT ACCTCAGCAT CATCTTTCAC TTGTGCTTTA ACACCATTAT GATGGTTGTC 
TACATCACAG GGATAAGCAT GCTCAGTGCC ATCAGCACTG AGTGCTGCCT GTCTGTCCTG 
TGCCCCACCT GGTATCGCTG CCACCGTCCA GTACATACAT CAACTGTCAT GTGTGCTGTG 
ATCTGGGTCC TATCCCTGTT GATCTGCATT CTGAATAGCT ATTTCTGTGC TGTCTTACAT 
ACCAGATATG ATAATGACAA TGAGTGTCTG GCAACTAACA TCTTTACCGC CTCGTACATG 
ATATTTTTGC TTGTGGTCCT CTGTCTGTCC AGCCTGGCTC TGCTGGCCAG GTTGTTCTGT 
GGCGCTGGGC AGATGAAGCT TACCAGATTT CATGTGACCA TCTTGCTGAC CCTTTTGGTT 
TTTCTCCTCT GCGGGTTGCC CTTTGTCATC TACTGCATCC TGTTATTCAA GATTAAGGAT 
GATTTCCATG TATTAGATGT TAATCTTTAT CTAGCATTAG AAGTCCTGAC TGCTATTAAC 
AGCTGTGCCA ACCCCATCAT CTACTTCTTC GTGGGCTCTT TCAGACATCA GTTGAAGCAC 
CAGACCCTCA AAATGGTTCT CCAGAGTGCA CTGCAGGACA CTCCTGAGAC AGCTGAAAAC 
ATGGTAGAGA TGTCAAGTAA CAAAGCAGAG CCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mrgpra2b ( XM_006540858.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540921.1 Mus musculus MAS-related GPR, member A2B (Mrgpra2b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu38828
Clone ID Related Accession (Same CDS sequence)	XM_006540858.2
Accession Version	XM_006540858.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	mas-related G-protein coupled receptor member A2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006540858.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAAA GCAGCAATGG TGAAGCATTT CTTGCCTTTA AGACCTCAGC CTCACCAACA 
GCACCAGTGA CAACAAATCC AATGGACGAA ACCCTCCCTG GAAGTATCAA CATTAGGATT 
CTGATCCCAA AATTGATGAT CATCATCTTC GGACTGGTCG GACTGATGGG AAACGCCATT 
GTGTTCTGGC TCCTGGGCTT CCACTTGCGC AGGAATGCCT TCTCAGTCTA CATCCTAAAC 
TTGGCCCTGG CTGACTTCCT TTTCCTCCTC AGTAGTATCA TAGCTTCCAC CCTGTTTCTT 
CTCAAAGTTT CCTACCTCAG CATCATCTTT CACTTGTGCT TTAACACCAT TATGATGGTT 
GTCTACATCA CAGGGATAAG CATGCTCAGT GCCATCAGCA CTGAGTGCTG CCTGTCTGTC 
CTGTGCCCCA CCTGGTATCG CTGCCACCGT CCAGTACATA CATCAACTGT CATGTGTGCT 
GTGATCTGGG TCCTATCCCT GTTGATCTGC ATTCTGAATA GCTATTTCTG TGCTGTCTTA 
CATACCAGAT ATGATAATGA CAATGAGTGT CTGGCAACTA ACATCTTTAC CGCCTCGTAC 
ATGATATTTT TGCTTGTGGT CCTCTGTCTG TCCAGCCTGG CTCTGCTGGC CAGGTTGTTC 
TGTGGCGCTG GGCAGATGAA GCTTACCAGA TTTCATGTGA CCATCTTGCT GACCCTTTTG 
GTTTTTCTCC TCTGCGGGTT GCCCTTTGTC ATCTACTGCA TCCTGTTATT CAAGATTAAG 
GATGATTTCC ATGTATTAGA TGTTAATCTT TATCTAGCAT TAGAAGTCCT GACTGCTATT 
AACAGCTGTG CCAACCCCAT CATCTACTTC TTCGTGGGCT CTTTCAGACA TCAGTTGAAG 
CACCAGACCC TCAAAATGGT TCTCCAGAGT GCACTGCAGG ACACTCCTGA GACAGCTGAA 
AACATGGTAG AGATGTCAAG TAACAAAGCA GAGCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540921.1
CDS	88..1086
Translation	MGESSNGEAFLAFKTSASPTAPVTTNPMDETLPGSINIRILIPKLMIIIFGLVGLMGNAIVFWLLGFHLRRNAFSVYILNLALADFLFLLSSIIASTLFLLKVSYLSIIFHLCFNTIMMVVYITGISMLSAISTECCLSVLCPTWYRCHRPVHTSTVMCAVIWVLSLLICILNSYFCAVLHTRYDNDNECLATNIFTASYMIFLLVVLCLSSLALLARLFCGAGQMKLTRFHVTILLTLLVFLLCGLPFVIYCILLFKIKDDFHVLDVNLYLALEVLTAINSCANPIIYFFVGSFRHQLKHQTLKMVLQSALQDTPETAENMVEMSSNKAEP

Target ORF information:

RefSeq Version	XM_006540858.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAS-related GPR, member A2B (Mrgpra2b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540858.2

ORF Insert Sequence:

ATGGGGGAAA GCAGCAATGG TGAAGCATTT CTTGCCTTTA AGACCTCAGC CTCACCAACA 
GCACCAGTGA CAACAAATCC AATGGACGAA ACCCTCCCTG GAAGTATCAA CATTAGGATT 
CTGATCCCAA AATTGATGAT CATCATCTTC GGACTGGTCG GACTGATGGG AAACGCCATT 
GTGTTCTGGC TCCTGGGCTT CCACTTGCGC AGGAATGCCT TCTCAGTCTA CATCCTAAAC 
TTGGCCCTGG CTGACTTCCT TTTCCTCCTC AGTAGTATCA TAGCTTCCAC CCTGTTTCTT 
CTCAAAGTTT CCTACCTCAG CATCATCTTT CACTTGTGCT TTAACACCAT TATGATGGTT 
GTCTACATCA CAGGGATAAG CATGCTCAGT GCCATCAGCA CTGAGTGCTG CCTGTCTGTC 
CTGTGCCCCA CCTGGTATCG CTGCCACCGT CCAGTACATA CATCAACTGT CATGTGTGCT 
GTGATCTGGG TCCTATCCCT GTTGATCTGC ATTCTGAATA GCTATTTCTG TGCTGTCTTA 
CATACCAGAT ATGATAATGA CAATGAGTGT CTGGCAACTA ACATCTTTAC CGCCTCGTAC 
ATGATATTTT TGCTTGTGGT CCTCTGTCTG TCCAGCCTGG CTCTGCTGGC CAGGTTGTTC 
TGTGGCGCTG GGCAGATGAA GCTTACCAGA TTTCATGTGA CCATCTTGCT GACCCTTTTG 
GTTTTTCTCC TCTGCGGGTT GCCCTTTGTC ATCTACTGCA TCCTGTTATT CAAGATTAAG 
GATGATTTCC ATGTATTAGA TGTTAATCTT TATCTAGCAT TAGAAGTCCT GACTGCTATT 
AACAGCTGTG CCAACCCCAT CATCTACTTC TTCGTGGGCT CTTTCAGACA TCAGTTGAAG 
CACCAGACCC TCAAAATGGT TCTCCAGAGT GCACTGCAGG ACACTCCTGA GACAGCTGAA 
AACATGGTAG AGATGTCAAG TAACAAAGCA GAGCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.
Bioscience reports36(5)(2016 Oct)
Callera GE,Antunes TT,Correa JW,Moorman D,Gutsol A,He Y,Cat AN,Briones AM,Montezano AC,Burns KD,Touyz RM

Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism.
Diabetes57(2)340-7(2008 Feb)
Santos SH,Fernandes LR,Mario EG,Ferreira AV,P?rto LC,Alvarez-Leite JI,Botion LM,Bader M,Alenina N,Santos RA

Differential mRNA processing in hematopoietic stem cells.
Stem cells (Dayton, Ohio)24(3)662-70(2006 Mar)
Bowman TV,McCooey AJ,Merchant AA,Ramos CA,Fonseca P,Poindexter A,Bradfute SB,Oliveira DM,Green R,Zheng Y,Jackson KA,Chambers SM,McKinney-Freeman SL,Norwood KG,Darlington G,Gunaratne PH,Steffen D,Goodell MA

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Proceedings of the National Academy of Sciences of the United States of America100(17)10043-8(2003 Aug)
Zylka MJ,Dong X,Southwell AL,Anderson DJ

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Proceedings of the National Academy of Sciences of the United States of America100(14)8258-63(2003 Jul)
Santos RA,Simoes e Silva AC,Maric C,Silva DM,Machado RP,de Buhr I,Heringer-Walther S,Pinheiro SV,Lopes MT,Bader M,Mendes EP,Lemos VS,Campagnole-Santos MJ,Schultheiss HP,Speth R,Walther T

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Mrgpra2b cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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