Leo1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Leo1
Entrez Gene ID	235497
Full Name	Leo1, Paf1/RNA polymerase II complex component
Synonyms	Gm185
General protein information	Preferred Names Leo1, Paf1/RNA polymerase II complex component Names RNA polymerase-associated protein LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 D

mRNA and Protein(s)

mRNA	Protein	Name
XM_017313344.1	XP_017168833.1	RNA polymerase-associated protein LEO1 isoform X1
NM_001039522.1	NP_001034611.1	RNA polymerase-associated protein LEO1
XM_017313344.2	XP_017168833.1	RNA polymerase-associated protein LEO1 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LEO1	XP_535485.2
Rattus norvegicus (Norway rat)	Leo1	NP_001005548.1
Pan troglodytes (chimpanzee)	LEO1	NP_001233372.1
Gallus gallus (chicken)	LEO1	XP_004943851.1
Bos taurus (cattle)	LEO1	NP_001076073.1
Mus musculus (house mouse)	Leo1	NP_001034611.1
Danio rerio (zebrafish)	leo1	NP_996950.1
Homo sapiens (human)	LEO1	NP_620147.1
Xenopus tropicalis (tropical clawed frog)	leo1	XP_002936391.2

Gene Ontology
Bibliography

Related articles in PubMed

Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.
Osipovich AB, Gangula R, Vianna PG, Magnuson MA
Development (Cambridge, England)143(24)4595-4607(2016 12)

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.
Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I
Nature cell biology18(11)1127-1138(2016 Nov)

The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.
Zhang C, Mejia LA, Huang J, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, Rudnicki M, Harper JW, Bonni A
Neuron78(6)986-93(2013 Jun)

Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation.
Vethantham V, Yang Y, Bowman C, Asp P, Lee JH, Skalnik DG, Dynlacht BD
Molecular and cellular biology32(6)1044-55(2012 Mar)

A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, de Vries I, Kittler R, Junqueira M, Shevchenko A, Schulz H, Hubner N, Doss MX, Sachinidis A, Hescheler J, Iacone R, Anastassiadis K, Stewart AF, Pisabarro MT, Caldarelli A, Poser I, Theis M, Buchholz F
Cell stem cell4(5)403-15(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Leo1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Leo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu82811	XM_017313344.2 Latest version!	Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu17540	NM_001039522.1 Latest version!	Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OMu82811	XM_017313344.1	Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Leo1 ( XM_017313344.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168833.1 Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu82811
Clone ID Related Accession (Same CDS sequence)	XM_017313344.1 , XM_017313344.2
Accession Version	XM_017313344.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	RNA polymerase-associated protein LEO1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017313344.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACA TGGAGGACCT CTTCGGGAGC GAAGCTGAGA GCGAGGCCGA GCGCAAAGAT 
TCCGAGTCTG AGTCCGACTC GGACTCTGAC CAGGACAACG GCGCTTCTGG CAGCAACGCC 
TCTGGCAGCG AAAGTGATCA GGATGACAGA GGTGACTCCG GACAGCCCAG TAACAAGGAA 
CTGTTCGGGG ACGACAGTGA GGAGGAGGGG GCCTCTCATC ACAGTGGCAG TGACAATCAC 
TCTGAACGGT CAGACAATAG GTCGGAGGCT TCCGAGCGCT CTGACCACGA GGATAATGAG 
CCCTCTGACG AGGACCAGCA CAGTGGCTCT GAAGCCCACA ACGATGACGA CGATGAGGGC 
CACAGGTCGG ACGAAGGGAG CCGTCACTCA GAGGCAGAAG GGTCTGAAAA AGCCCAGTCA 
GATGATGAGA AATGGGATGG AGAGGATAAA AGTGACCAGT CAGATGACGA GAAGCTGCAG 
AACTCTGACG ACGAGGATCG GGAGCAAGGG TCCGATGAGG ATAAGCTGCA GAACTCTGAC 
GACGACGAGG AGAAAATGCA GAACACAGAT GACGAGGACC GGGCCCAGAT TTCTGATGAT 
GACAGACAGC AGCTGTCTGA GGAGGAGAAG GGGAATTCTG ACGATGAGCA TCCAGTAGCT 
TCTGATAATG ACGAGGAGAA GCAGAATTCG GACGATGAGG ACCAGCCGCA GGTGTCCGAT 
GAGGAGAAAA TGCAGAACTC AGACGATGAA AGGCCACAAG TCTCAGATGA AGATGGAAGG 
CGTTCAGACG GTGAGGAGGA GCAAGACCAG AAGTCAGAAT CTGCAAGAGG CAGTGACAGT 
GAAGATGAAG TTTTACGACT GAAGCGCAAG AACGCGATTC CATCGGATTC CGAAGCAGAC 
AGCGACACCG AGGTGCCCAA AGATAATAAT GGAACCATGG ATCTGTTCGG AGGTGCAGAT 
GACATATCTT CAGGGAGTGA TGGAGAAGAT AAGCCCCCAA CTCCAGGACA GCCTGTGGAT 
GAAAATGGCT TGCCCCAGGA TCAGCAGGAG GAAGAGCCCA TACCTGAGAC CAGAATAGAA 
GTGGAGATCC CCAAAGTAAA CACGGACTTG GGCAATGACT TATATTTTGT TAAACTGCCC 
AACTTCCTCA GTGTAGAGCC CAGGCCTTTT GATCCTCAGT ATTATGAAGA TGAATTTGAA 
GATGAGGAGA TGCTGGATGA AGAGGGGAGA ACCAGGTTAA AATTGAAGGT AGAAAACACT 
ATAAGATGGA GGATACGCAG AGATGAAGAA GGAAATGAAA TTAAAGAAAG CAATGCGCGG 
ATCGTCAAGT GGTCAGATGG AAGCATGTCC CTGCATTTAG GGAATGAAGT GTTTGATGTG 
TACAAAGCCC CACTGCAGGG CGACCACAAC CATCTTTTCA TAAGACAAGG TACTGGGCTG 
CAGGGGCAGG CCGTCTTTAA AACGAAGCTC ACCTTCAGGC CTCACTCTAC AGACAGTGCC 
ACACACAGGA AGATGACCCT GTCACTTGCA GATAGATGCT CAAAGACACA GAAGATTCGA 
ATCTTACCAA TGGCTGGCCG TGACCCTGAG TGCCAGCGCA CAGAGATGAT TAAGAAAGAA 
GAAGAACGCC TGAGGGCCTC CATCAGGAGG GAGTCTCAGC AGCGCCGGAT GCGAGAGAAA 
CAGCACCAGC GGGGGCTGAG CGCCAGCTAC CTGGAGCCTG ATCGCTACGA CGAGGAGGAG 
GAAGGCGAGG AGTCCGTCAG CCTGGCTGCC ATTAAAAACC GCTACAAAGG GGGCATCCGC 
GAGGAACGAG CCAGAATCTA CTCCTCGGAC AGTGATGAGG GCTCCGAAGA AGACAAAGCT 
CAAAGGTTAC TCAAAGCAAA GAAGCTCAAC AGTGATGAGG TGAATCTTCT GGAAAGAGGA 
AAGCGGAAGA CGATGACAAA GCGAATAAAA AGCATAAGAA GTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168833.1
CDS	564..2531
Translation	MADMEDLFGSEAESEAERKDSESESDSDSDQDNGASGSNASGSESDQDDRGDSGQPSNKELFGDDSEEEGASHHSGSDNHSERSDNRSEASERSDHEDNEPSDEDQHSGSEAHNDDDDEGHRSDEGSRHSEAEGSEKAQSDDEKWDGEDKSDQSDDEKLQNSDDEDREQGSDEDKLQNSDDDEEKMQNTDDEDRAQISDDDRQQLSEEEKGNSDDEHPVASDNDEEKQNSDDEDQPQVSDEEKMQNSDDERPQVSDEDGRRSDGEEEQDQKSESARGSDSEDEVLRLKRKNAIPSDSEADSDTEVPKDNNGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESVSLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLNSDEVNLLERGKRKTMTKRIKSIRSM

Target ORF information:

RefSeq Version	XM_017313344.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313344.2

ORF Insert Sequence:

ATGGCGGACA TGGAGGACCT CTTCGGGAGC GAAGCTGAGA GCGAGGCCGA GCGCAAAGAT 
TCCGAGTCTG AGTCCGACTC GGACTCTGAC CAGGACAACG GCGCTTCTGG CAGCAACGCC 
TCTGGCAGCG AAAGTGATCA GGATGACAGA GGTGACTCCG GACAGCCCAG TAACAAGGAA 
CTGTTCGGGG ACGACAGTGA GGAGGAGGGG GCCTCTCATC ACAGTGGCAG TGACAATCAC 
TCTGAACGGT CAGACAATAG GTCGGAGGCT TCCGAGCGCT CTGACCACGA GGATAATGAG 
CCCTCTGACG AGGACCAGCA CAGTGGCTCT GAAGCCCACA ACGATGACGA CGATGAGGGC 
CACAGGTCGG ACGAAGGGAG CCGTCACTCA GAGGCAGAAG GGTCTGAAAA AGCCCAGTCA 
GATGATGAGA AATGGGATGG AGAGGATAAA AGTGACCAGT CAGATGACGA GAAGCTGCAG 
AACTCTGACG ACGAGGATCG GGAGCAAGGG TCCGATGAGG ATAAGCTGCA GAACTCTGAC 
GACGACGAGG AGAAAATGCA GAACACAGAT GACGAGGACC GGGCCCAGAT TTCTGATGAT 
GACAGACAGC AGCTGTCTGA GGAGGAGAAG GGGAATTCTG ACGATGAGCA TCCAGTAGCT 
TCTGATAATG ACGAGGAGAA GCAGAATTCG GACGATGAGG ACCAGCCGCA GGTGTCCGAT 
GAGGAGAAAA TGCAGAACTC AGACGATGAA AGGCCACAAG TCTCAGATGA AGATGGAAGG 
CGTTCAGACG GTGAGGAGGA GCAAGACCAG AAGTCAGAAT CTGCAAGAGG CAGTGACAGT 
GAAGATGAAG TTTTACGACT GAAGCGCAAG AACGCGATTC CATCGGATTC CGAAGCAGAC 
AGCGACACCG AGGTGCCCAA AGATAATAAT GGAACCATGG ATCTGTTCGG AGGTGCAGAT 
GACATATCTT CAGGGAGTGA TGGAGAAGAT AAGCCCCCAA CTCCAGGACA GCCTGTGGAT 
GAAAATGGCT TGCCCCAGGA TCAGCAGGAG GAAGAGCCCA TACCTGAGAC CAGAATAGAA 
GTGGAGATCC CCAAAGTAAA CACGGACTTG GGCAATGACT TATATTTTGT TAAACTGCCC 
AACTTCCTCA GTGTAGAGCC CAGGCCTTTT GATCCTCAGT ATTATGAAGA TGAATTTGAA 
GATGAGGAGA TGCTGGATGA AGAGGGGAGA ACCAGGTTAA AATTGAAGGT AGAAAACACT 
ATAAGATGGA GGATACGCAG AGATGAAGAA GGAAATGAAA TTAAAGAAAG CAATGCGCGG 
ATCGTCAAGT GGTCAGATGG AAGCATGTCC CTGCATTTAG GGAATGAAGT GTTTGATGTG 
TACAAAGCCC CACTGCAGGG CGACCACAAC CATCTTTTCA TAAGACAAGG TACTGGGCTG 
CAGGGGCAGG CCGTCTTTAA AACGAAGCTC ACCTTCAGGC CTCACTCTAC AGACAGTGCC 
ACACACAGGA AGATGACCCT GTCACTTGCA GATAGATGCT CAAAGACACA GAAGATTCGA 
ATCTTACCAA TGGCTGGCCG TGACCCTGAG TGCCAGCGCA CAGAGATGAT TAAGAAAGAA 
GAAGAACGCC TGAGGGCCTC CATCAGGAGG GAGTCTCAGC AGCGCCGGAT GCGAGAGAAA 
CAGCACCAGC GGGGGCTGAG CGCCAGCTAC CTGGAGCCTG ATCGCTACGA CGAGGAGGAG 
GAAGGCGAGG AGTCCGTCAG CCTGGCTGCC ATTAAAAACC GCTACAAAGG GGGCATCCGC 
GAGGAACGAG CCAGAATCTA CTCCTCGGAC AGTGATGAGG GCTCCGAAGA AGACAAAGCT 
CAAAGGTTAC TCAAAGCAAA GAAGCTCAAC AGTGATGAGG TGAATCTTCT GGAAAGAGGA 
AAGCGGAAGA CGATGACAAA GCGAATAAAA AGCATAAGAA GTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Leo1 ( NM_001039522.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001034611.1 Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), mRNA.

Price & Availability↑

CloneID	OMu17540
Clone ID Related Accession (Same CDS sequence)	NM_001039522.1
Accession Version	NM_001039522.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2004bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	RNA polymerase-associated protein LEO1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB248994.1, BC083358.1 and BC082540.1. ##Evidence-Data-START## Transcript exon combination :: BC083358.1, SRR1660821.16502.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGACA TGGAGGACCT CTTCGGGAGC GAAGCTGAGA GCGAGGCCGA GCGCAAAGAT 
TCCGAGTCTG AGTCCGACTC GGACTCTGAC CAGGACAACG GCGCTTCTGG CAGCAACGCC 
TCTGGCAGCG AAAGTGATCA GGATGACAGA GGTGACTCCG GACAGCCCAG TAACAAGGAA 
CTGTTCGGGG ACGACAGTGA GGAGGAGGGG GCCTCTCATC ACAGTGGCAG TGACAATCAC 
TCTGAACGGT CAGACAATAG GTCGGAGGCT TCCGAGCGCT CTGACCACGA GGATAATGAG 
CCCTCTGACG AGGACCAGCA CAGTGGCTCT GAAGCCCACA ACGATGACGA CGATGAGGGC 
CACAGGTCGG ACGAAGGGAG CCGTCACTCA GAGGCAGAAG GGTCTGAAAA AGCCCAGTCA 
GATGATGAGA AATGGGATGG AGAGGATAAA AGTGACCAGT CAGATGACGA GAAGCTGCAG 
AACTCTGACG ACGAGGATCG GGAGCAAGGG TCCGATGAGG ATAAGCTGCA GAACTCTGAC 
GACGACGAGG AGAAAATGCA GAACACAGAT GACGAGGACC GGGCCCAGAT TTCTGATGAT 
GACAGACAGC AGCTGTCTGA GGAGGAGAAG GGGAATTCTG ACGATGAGCA TCCAGTAGCT 
TCTGATAATG ACGAGGAGAA GCAGAATTCG GACGATGAGG ACCAGCCGCA GGTGTCCGAT 
GAGGAGAAAA TGCAGAACTC AGACGATGAA AGGCCACAAG TCTCAGATGA AGATGGAAGG 
CGTTCAGACG GTGAGGAGGA GCAAGACCAG AAGTCAGAAT CTGCAAGAGG CAGTGACAGT 
GAAGATGAAG TTTTACGACT GAAGCGCAAG AACGCGATTC CATCGGATTC CGAAGCAGAC 
AGCGACACCG AGGTGCCCAA AGATAATAAT GGAACCATGG ATCTGTTCGG AGGTGCAGAT 
GACATATCTT CAGGGAGTGA TGGAGAAGAT AAGCCCCCAA CTCCAGGACA GCCTGTGGAT 
GAAAATGGCT TGCCCCAGGA TCAGCAGGAG GAAGAGCCCA TACCTGAGAC CAGAATAGAA 
GTGGAGATCC CCAAAGTAAA CACGGACTTG GGCAATGACT TATATTTTGT TAAACTGCCC 
AACTTCCTCA GTGTAGAGCC CAGGCCTTTT GATCCTCAGT ATTATGAAGA TGAATTTGAA 
GATGAGGAGA TGCTGGATGA AGAGGGGAGA ACCAGGTTAA AATTGAAGGT AGAAAACACT 
ATAAGATGGA GGATACGCAG AGATGAAGAA GGAAATGAAA TTAAAGAAAG CAATGCGCGG 
ATCGTCAAGT GGTCAGATGG AAGCATGTCC CTGCATTTAG GGAATGAAGT GTTTGATGTG 
TACAAAGCCC CACTGCAGGG CGACCACAAC CATCTTTTCA TAAGACAAGG TACTGGGCTG 
CAGGGGCAGG CCGTCTTTAA AACGAAGCTC ACCTTCAGGC CTCACTCTAC AGACAGTGCC 
ACACACAGGA AGATGACCCT GTCACTTGCA GATAGATGCT CAAAGACACA GAAGATTCGA 
ATCTTACCAA TGGCTGGCCG TGACCCTGAG TGCCAGCGCA CAGAGATGAT TAAGAAAGAA 
GAAGAACGCC TGAGGGCCTC CATCAGGAGG GAGTCTCAGC AGCGCCGGAT GCGAGAGAAA 
CAGCACCAGC GGGGGCTGAG CGCCAGCTAC CTGGAGCCTG ATCGCTACGA CGAGGAGGAG 
GAAGGCGAGG AGTCCGTCAG CCTGGCTGCC ATTAAAAACC GCTACAAAGG GGGCATCCGC 
GAGGAACGAG CCAGAATCTA CTCCTCGGAC AGTGATGAGG GCTCCGAAGA AGACAAAGCT 
CAAAGGTTAC TCAAAGCAAA GAAGCTCAAC AGTGATGAGG AAGGTGAATC TTCTGGAAAG 
AGGAAAGCGG AAGACGATGA CAAAGCGAAT AAAAAGCATA AGAAGTATGT GATCAGTGAT 
GAAGAAGAAG AAGAAGATGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034611.1
CDS	55..2058
Translation	MADMEDLFGSEAESEAERKDSESESDSDSDQDNGASGSNASGSESDQDDRGDSGQPSNKELFGDDSEEEGASHHSGSDNHSERSDNRSEASERSDHEDNEPSDEDQHSGSEAHNDDDDEGHRSDEGSRHSEAEGSEKAQSDDEKWDGEDKSDQSDDEKLQNSDDEDREQGSDEDKLQNSDDDEEKMQNTDDEDRAQISDDDRQQLSEEEKGNSDDEHPVASDNDEEKQNSDDEDQPQVSDEEKMQNSDDERPQVSDEDGRRSDGEEEQDQKSESARGSDSEDEVLRLKRKNAIPSDSEADSDTEVPKDNNGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESVSLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLNSDEEGESSGKRKAEDDDKANKKHKKYVISDEEEEEDD

Target ORF information:

RefSeq Version	NM_001039522.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039522.1

ORF Insert Sequence:

ATGGCGGACA TGGAGGACCT CTTCGGGAGC GAAGCTGAGA GCGAGGCCGA GCGCAAAGAT 
TCCGAGTCTG AGTCCGACTC GGACTCTGAC CAGGACAACG GCGCTTCTGG CAGCAACGCC 
TCTGGCAGCG AAAGTGATCA GGATGACAGA GGTGACTCCG GACAGCCCAG TAACAAGGAA 
CTGTTCGGGG ACGACAGTGA GGAGGAGGGG GCCTCTCATC ACAGTGGCAG TGACAATCAC 
TCTGAACGGT CAGACAATAG GTCGGAGGCT TCCGAGCGCT CTGACCACGA GGATAATGAG 
CCCTCTGACG AGGACCAGCA CAGTGGCTCT GAAGCCCACA ACGATGACGA CGATGAGGGC 
CACAGGTCGG ACGAAGGGAG CCGTCACTCA GAGGCAGAAG GGTCTGAAAA AGCCCAGTCA 
GATGATGAGA AATGGGATGG AGAGGATAAA AGTGACCAGT CAGATGACGA GAAGCTGCAG 
AACTCTGACG ACGAGGATCG GGAGCAAGGG TCCGATGAGG ATAAGCTGCA GAACTCTGAC 
GACGACGAGG AGAAAATGCA GAACACAGAT GACGAGGACC GGGCCCAGAT TTCTGATGAT 
GACAGACAGC AGCTGTCTGA GGAGGAGAAG GGGAATTCTG ACGATGAGCA TCCAGTAGCT 
TCTGATAATG ACGAGGAGAA GCAGAATTCG GACGATGAGG ACCAGCCGCA GGTGTCCGAT 
GAGGAGAAAA TGCAGAACTC AGACGATGAA AGGCCACAAG TCTCAGATGA AGATGGAAGG 
CGTTCAGACG GTGAGGAGGA GCAAGACCAG AAGTCAGAAT CTGCAAGAGG CAGTGACAGT 
GAAGATGAAG TTTTACGACT GAAGCGCAAG AACGCGATTC CATCGGATTC CGAAGCAGAC 
AGCGACACCG AGGTGCCCAA AGATAATAAT GGAACCATGG ATCTGTTCGG AGGTGCAGAT 
GACATATCTT CAGGGAGTGA TGGAGAAGAT AAGCCCCCAA CTCCAGGACA GCCTGTGGAT 
GAAAATGGCT TGCCCCAGGA TCAGCAGGAG GAAGAGCCCA TACCTGAGAC CAGAATAGAA 
GTGGAGATCC CCAAAGTAAA CACGGACTTG GGCAATGACT TATATTTTGT TAAACTGCCC 
AACTTCCTCA GTGTAGAGCC CAGGCCTTTT GATCCTCAGT ATTATGAAGA TGAATTTGAA 
GATGAGGAGA TGCTGGATGA AGAGGGGAGA ACCAGGTTAA AATTGAAGGT AGAAAACACT 
ATAAGATGGA GGATACGCAG AGATGAAGAA GGAAATGAAA TTAAAGAAAG CAATGCGCGG 
ATCGTCAAGT GGTCAGATGG AAGCATGTCC CTGCATTTAG GGAATGAAGT GTTTGATGTG 
TACAAAGCCC CACTGCAGGG CGACCACAAC CATCTTTTCA TAAGACAAGG TACTGGGCTG 
CAGGGGCAGG CCGTCTTTAA AACGAAGCTC ACCTTCAGGC CTCACTCTAC AGACAGTGCC 
ACACACAGGA AGATGACCCT GTCACTTGCA GATAGATGCT CAAAGACACA GAAGATTCGA 
ATCTTACCAA TGGCTGGCCG TGACCCTGAG TGCCAGCGCA CAGAGATGAT TAAGAAAGAA 
GAAGAACGCC TGAGGGCCTC CATCAGGAGG GAGTCTCAGC AGCGCCGGAT GCGAGAGAAA 
CAGCACCAGC GGGGGCTGAG CGCCAGCTAC CTGGAGCCTG ATCGCTACGA CGAGGAGGAG 
GAAGGCGAGG AGTCCGTCAG CCTGGCTGCC ATTAAAAACC GCTACAAAGG GGGCATCCGC 
GAGGAACGAG CCAGAATCTA CTCCTCGGAC AGTGATGAGG GCTCCGAAGA AGACAAAGCT 
CAAAGGTTAC TCAAAGCAAA GAAGCTCAAC AGTGATGAGG AAGGTGAATC TTCTGGAAAG 
AGGAAAGCGG AAGACGATGA CAAAGCGAAT AAAAAGCATA AGAAGTATGT GATCAGTGAT 
GAAGAAGAAG AAGAAGATGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Leo1 ( XM_017313344.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168833.1 Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu82811
Clone ID Related Accession (Same CDS sequence)	XM_017313344.1 , XM_017313344.2
Accession Version	XM_017313344.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	RNA polymerase-associated protein LEO1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACA TGGAGGACCT CTTCGGGAGC GAAGCTGAGA GCGAGGCCGA GCGCAAAGAT 
TCCGAGTCTG AGTCCGACTC GGACTCTGAC CAGGACAACG GCGCTTCTGG CAGCAACGCC 
TCTGGCAGCG AAAGTGATCA GGATGACAGA GGTGACTCCG GACAGCCCAG TAACAAGGAA 
CTGTTCGGGG ACGACAGTGA GGAGGAGGGG GCCTCTCATC ACAGTGGCAG TGACAATCAC 
TCTGAACGGT CAGACAATAG GTCGGAGGCT TCCGAGCGCT CTGACCACGA GGATAATGAG 
CCCTCTGACG AGGACCAGCA CAGTGGCTCT GAAGCCCACA ACGATGACGA CGATGAGGGC 
CACAGGTCGG ACGAAGGGAG CCGTCACTCA GAGGCAGAAG GGTCTGAAAA AGCCCAGTCA 
GATGATGAGA AATGGGATGG AGAGGATAAA AGTGACCAGT CAGATGACGA GAAGCTGCAG 
AACTCTGACG ACGAGGATCG GGAGCAAGGG TCCGATGAGG ATAAGCTGCA GAACTCTGAC 
GACGACGAGG AGAAAATGCA GAACACAGAT GACGAGGACC GGGCCCAGAT TTCTGATGAT 
GACAGACAGC AGCTGTCTGA GGAGGAGAAG GGGAATTCTG ACGATGAGCA TCCAGTAGCT 
TCTGATAATG ACGAGGAGAA GCAGAATTCG GACGATGAGG ACCAGCCGCA GGTGTCCGAT 
GAGGAGAAAA TGCAGAACTC AGACGATGAA AGGCCACAAG TCTCAGATGA AGATGGAAGG 
CGTTCAGACG GTGAGGAGGA GCAAGACCAG AAGTCAGAAT CTGCAAGAGG CAGTGACAGT 
GAAGATGAAG TTTTACGACT GAAGCGCAAG AACGCGATTC CATCGGATTC CGAAGCAGAC 
AGCGACACCG AGGTGCCCAA AGATAATAAT GGAACCATGG ATCTGTTCGG AGGTGCAGAT 
GACATATCTT CAGGGAGTGA TGGAGAAGAT AAGCCCCCAA CTCCAGGACA GCCTGTGGAT 
GAAAATGGCT TGCCCCAGGA TCAGCAGGAG GAAGAGCCCA TACCTGAGAC CAGAATAGAA 
GTGGAGATCC CCAAAGTAAA CACGGACTTG GGCAATGACT TATATTTTGT TAAACTGCCC 
AACTTCCTCA GTGTAGAGCC CAGGCCTTTT GATCCTCAGT ATTATGAAGA TGAATTTGAA 
GATGAGGAGA TGCTGGATGA AGAGGGGAGA ACCAGGTTAA AATTGAAGGT AGAAAACACT 
ATAAGATGGA GGATACGCAG AGATGAAGAA GGAAATGAAA TTAAAGAAAG CAATGCGCGG 
ATCGTCAAGT GGTCAGATGG AAGCATGTCC CTGCATTTAG GGAATGAAGT GTTTGATGTG 
TACAAAGCCC CACTGCAGGG CGACCACAAC CATCTTTTCA TAAGACAAGG TACTGGGCTG 
CAGGGGCAGG CCGTCTTTAA AACGAAGCTC ACCTTCAGGC CTCACTCTAC AGACAGTGCC 
ACACACAGGA AGATGACCCT GTCACTTGCA GATAGATGCT CAAAGACACA GAAGATTCGA 
ATCTTACCAA TGGCTGGCCG TGACCCTGAG TGCCAGCGCA CAGAGATGAT TAAGAAAGAA 
GAAGAACGCC TGAGGGCCTC CATCAGGAGG GAGTCTCAGC AGCGCCGGAT GCGAGAGAAA 
CAGCACCAGC GGGGGCTGAG CGCCAGCTAC CTGGAGCCTG ATCGCTACGA CGAGGAGGAG 
GAAGGCGAGG AGTCCGTCAG CCTGGCTGCC ATTAAAAACC GCTACAAAGG GGGCATCCGC 
GAGGAACGAG CCAGAATCTA CTCCTCGGAC AGTGATGAGG GCTCCGAAGA AGACAAAGCT 
CAAAGGTTAC TCAAAGCAAA GAAGCTCAAC AGTGATGAGG TGAATCTTCT GGAAAGAGGA 
AAGCGGAAGA CGATGACAAA GCGAATAAAA AGCATAAGAA GTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168833.1
CDS	565..2532
Translation	MADMEDLFGSEAESEAERKDSESESDSDSDQDNGASGSNASGSESDQDDRGDSGQPSNKELFGDDSEEEGASHHSGSDNHSERSDNRSEASERSDHEDNEPSDEDQHSGSEAHNDDDDEGHRSDEGSRHSEAEGSEKAQSDDEKWDGEDKSDQSDDEKLQNSDDEDREQGSDEDKLQNSDDDEEKMQNTDDEDRAQISDDDRQQLSEEEKGNSDDEHPVASDNDEEKQNSDDEDQPQVSDEEKMQNSDDERPQVSDEDGRRSDGEEEQDQKSESARGSDSEDEVLRLKRKNAIPSDSEADSDTEVPKDNNGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESVSLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLNSDEVNLLERGKRKTMTKRIKSIRSM

Target ORF information:

RefSeq Version	XM_017313344.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313344.1

ORF Insert Sequence:

ATGGCGGACA TGGAGGACCT CTTCGGGAGC GAAGCTGAGA GCGAGGCCGA GCGCAAAGAT 
TCCGAGTCTG AGTCCGACTC GGACTCTGAC CAGGACAACG GCGCTTCTGG CAGCAACGCC 
TCTGGCAGCG AAAGTGATCA GGATGACAGA GGTGACTCCG GACAGCCCAG TAACAAGGAA 
CTGTTCGGGG ACGACAGTGA GGAGGAGGGG GCCTCTCATC ACAGTGGCAG TGACAATCAC 
TCTGAACGGT CAGACAATAG GTCGGAGGCT TCCGAGCGCT CTGACCACGA GGATAATGAG 
CCCTCTGACG AGGACCAGCA CAGTGGCTCT GAAGCCCACA ACGATGACGA CGATGAGGGC 
CACAGGTCGG ACGAAGGGAG CCGTCACTCA GAGGCAGAAG GGTCTGAAAA AGCCCAGTCA 
GATGATGAGA AATGGGATGG AGAGGATAAA AGTGACCAGT CAGATGACGA GAAGCTGCAG 
AACTCTGACG ACGAGGATCG GGAGCAAGGG TCCGATGAGG ATAAGCTGCA GAACTCTGAC 
GACGACGAGG AGAAAATGCA GAACACAGAT GACGAGGACC GGGCCCAGAT TTCTGATGAT 
GACAGACAGC AGCTGTCTGA GGAGGAGAAG GGGAATTCTG ACGATGAGCA TCCAGTAGCT 
TCTGATAATG ACGAGGAGAA GCAGAATTCG GACGATGAGG ACCAGCCGCA GGTGTCCGAT 
GAGGAGAAAA TGCAGAACTC AGACGATGAA AGGCCACAAG TCTCAGATGA AGATGGAAGG 
CGTTCAGACG GTGAGGAGGA GCAAGACCAG AAGTCAGAAT CTGCAAGAGG CAGTGACAGT 
GAAGATGAAG TTTTACGACT GAAGCGCAAG AACGCGATTC CATCGGATTC CGAAGCAGAC 
AGCGACACCG AGGTGCCCAA AGATAATAAT GGAACCATGG ATCTGTTCGG AGGTGCAGAT 
GACATATCTT CAGGGAGTGA TGGAGAAGAT AAGCCCCCAA CTCCAGGACA GCCTGTGGAT 
GAAAATGGCT TGCCCCAGGA TCAGCAGGAG GAAGAGCCCA TACCTGAGAC CAGAATAGAA 
GTGGAGATCC CCAAAGTAAA CACGGACTTG GGCAATGACT TATATTTTGT TAAACTGCCC 
AACTTCCTCA GTGTAGAGCC CAGGCCTTTT GATCCTCAGT ATTATGAAGA TGAATTTGAA 
GATGAGGAGA TGCTGGATGA AGAGGGGAGA ACCAGGTTAA AATTGAAGGT AGAAAACACT 
ATAAGATGGA GGATACGCAG AGATGAAGAA GGAAATGAAA TTAAAGAAAG CAATGCGCGG 
ATCGTCAAGT GGTCAGATGG AAGCATGTCC CTGCATTTAG GGAATGAAGT GTTTGATGTG 
TACAAAGCCC CACTGCAGGG CGACCACAAC CATCTTTTCA TAAGACAAGG TACTGGGCTG 
CAGGGGCAGG CCGTCTTTAA AACGAAGCTC ACCTTCAGGC CTCACTCTAC AGACAGTGCC 
ACACACAGGA AGATGACCCT GTCACTTGCA GATAGATGCT CAAAGACACA GAAGATTCGA 
ATCTTACCAA TGGCTGGCCG TGACCCTGAG TGCCAGCGCA CAGAGATGAT TAAGAAAGAA 
GAAGAACGCC TGAGGGCCTC CATCAGGAGG GAGTCTCAGC AGCGCCGGAT GCGAGAGAAA 
CAGCACCAGC GGGGGCTGAG CGCCAGCTAC CTGGAGCCTG ATCGCTACGA CGAGGAGGAG 
GAAGGCGAGG AGTCCGTCAG CCTGGCTGCC ATTAAAAACC GCTACAAAGG GGGCATCCGC 
GAGGAACGAG CCAGAATCTA CTCCTCGGAC AGTGATGAGG GCTCCGAAGA AGACAAAGCT 
CAAAGGTTAC TCAAAGCAAA GAAGCTCAAC AGTGATGAGG TGAATCTTCT GGAAAGAGGA 
AAGCGGAAGA CGATGACAAA GCGAATAAAA AGCATAAGAA GTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.
Development (Cambridge, England)143(24)4595-4607(2016 12)
Osipovich AB,Gangula R,Vianna PG,Magnuson MA

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.
Nature cell biology18(11)1127-1138(2016 Nov)
Strikoudis A,Lazaris C,Trimarchi T,Galvao Neto AL,Yang Y,Ntziachristos P,Rothbart S,Buckley S,Dolgalev I,Stadtfeld M,Strahl BD,Dynlacht BD,Tsirigos A,Aifantis I

The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.
Neuron78(6)986-93(2013 Jun)
Zhang C,Mejia LA,Huang J,Valnegri P,Bennett EJ,Anckar J,Jahani-Asl A,Gallardo G,Ikeuchi Y,Yamada T,Rudnicki M,Harper JW,Bonni A

Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation.
Molecular and cellular biology32(6)1044-55(2012 Mar)
Vethantham V,Yang Y,Bowman C,Asp P,Lee JH,Skalnik DG,Dynlacht BD

A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Cell stem cell4(5)403-15(2009 May)
Ding L,Paszkowski-Rogacz M,Nitzsche A,Slabicki MM,Heninger AK,de Vries I,Kittler R,Junqueira M,Shevchenko A,Schulz H,Hubner N,Doss MX,Sachinidis A,Hescheler J,Iacone R,Anastassiadis K,Stewart AF,Pisabarro MT,Caldarelli A,Poser I,Theis M,Buchholz F

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Leo1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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