Ces2c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ces2c
Entrez Gene ID	234671
Full Name	carboxylesterase 2C
Synonyms	ACH M1,CES 2,Ces2,ces2A3
General protein information	Preferred Names carboxylesterase 2C Names acylcarnitine hydrolase acylcarnitine hydrolase M1 carboxylesterase 2 carboxylesterase ML3 peroxisome proliferator-inducible acylcarnitine hydrolase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 D3
Summary	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. The transcription of this gene is regulated by several factors including HNF-4alpha (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1), Sp3 and USF1 (upstream stimulatory factor 1). The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with several family members including a few of pseudogenes and Ces5 on chromosome 8.[provided by RefSeq, Jun 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145603.2	NP_663578.1	acylcarnitine hydrolase precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ces2c	NP_663578.1
Magnaporthe oryzae (rice blast fungus)	MGG_08416	XP_003715641.1
Magnaporthe oryzae (rice blast fungus)	MGG_15428	XP_003720440.1

Gene Ontology
Bibliography

Related articles in PubMed

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH
Proceedings of the National Academy of Sciences of the United States of America114(8)E1432-E1440(2017 02)

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ
Mammalian genome : official journal of the International Mammalian Genome Society21(9-10)427-41(2010 Oct)

Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice.
Ahowesso C, Piccolo E, Li XM, Dulong S, Hossard V, La Sorda R, Filipski E, Tinari N, Delaunay F, Iacobelli S, L?vi F
Toxicology letters192(3)395-401(2010 Feb)

A new class of mammalian carboxylesterase CES6.
Holmes RS, Cox LA, Vandeberg JL
Comparative biochemistry and physiology. Part D, Genomics & proteomics4(3)209-17(2009 Sep)

Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver.
Zhu HJ, Appel DI, Jiang Y, Markowitz JS
Drug metabolism and disposition: the biological fate of chemicals37(9)1819-25(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings show that HNF-4alpha plays an important role in the regulation of mCES2 gene transcription.
Title: Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver.

purified and characterized an acylcarnitine hydrolase (ACH M1) from liver microsomes, cloned the cDNA named mCES2, expressed it in Sf9 cells and characterized it
Title: Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family.

The following Ces2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ces2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11871	NM_145603.2 Latest version!	Mus musculus carboxylesterase 2C (Ces2c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$328.30 $469.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ces2c ( NM_145603.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663578.1 Mus musculus carboxylesterase 2C (Ces2c), mRNA.

Price & Availability↑

CloneID	OMu11871
Clone ID Related Accession (Same CDS sequence)	NM_145603.2
Accession Version	NM_145603.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	acylcarnitine hydrolase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB110073.1 and AI255649.1. On Jun 13, 2010 this sequence version replaced NM_145603.1. ##Evidence-Data-START## Transcript exon combination :: AB110073.1, AK136411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACACGGA ACCAACTACA TAACTGGCTG AATGCTGGGT TCTTCGGGCT GCTGCTTCTT 
CTTATCCATG TGCAGGGTCA GGACTCACCA GAGGCCAACC CCATCAGAAA CACACATACA 
GGACAGATCC AAGGCAGCCT TATCCACGTG AAGGACACTA AAGCTGGTGT CCACACCTTC 
CTGGGAATCC CCTTTGCCAA ACCTCCTGTA GGACCACTGC GATTTGCACC TCCTGAGGCC 
CCTGAACCAT GGAGTGGTGT GAGAGATGGA ACTGCACATC CGGCCATGTG TCTGCAAAAT 
CTTGACATGC TGAATGAAGC AGGCCTGCCA GATATGAAAA TGATGCTGTC TTCCTTCCCT 
ATGTCTGAGG ACTGCCTGTA TCTCAACATC TACACCCCAG CCCATGCCCA TGAGGGCTCT 
AACCTGCCTG TGATGGTGTG GATCCATGGA GGTGCACTGG TTATAGGAAT GGCTTCCATG 
TTTGATGGAT CTCTATTGAC AGTCAATGAG GACTTGGTGG TTGTTACTAT CCAGTATCGT 
CTGGGTGTCC TGGGCTTTTT CAGCACTGGA GACCAGCATG CCAGAGGCAA CTGGGGATAC 
CTGGACCAAG CAGCTGCCCT ACGCTGGGTC CAGCAGAACA TCGCTCACTT TGGAGGCAAC 
CCTGACCGGG TCACTATTTT TGGCGAGTCT GCAGGTGGCA CAAGTGTGTC TTCACATGTT 
GTGTCCCCCA TGTCCCAAGG GCTCTTCCAT GGTGCCATCA TGGAGAGTGG GGTGGCCCTG 
CTTCCTGACC TTATCTCTGA AACCTCTGAG ATGGTTTCCA CTACGGTGGC CAAGCTTTCT 
GGATGTGAGG CTATGGATTC CCAGGCCCTG GTGCGCTGTC TGAGAGGCAA AAGTGAAGCA 
GAGATTCTGG CTATTAACAA GGTCTTCAAG ATGATCCCTG CTGTGGTGGA TGGGGAGTTC 
TTCCCCAGGC ATCCCAAAGA GTTGTTGGCA TCTGAGGATT TTCACCCTGT CCCCAGCATC 
ATTGGTGTCA ACAATGATGA GTTTGGCTGG TCCATTCCTG TGGTCATGGG CTCTGCTCAG 
ATGATAAAAG GAATAACCAG AGAGAACCTG CAGGCTGTTC TGAAGGATAC AGCAGTACAA 
ATGATGCTGC CTCCTGAGTG TAGTGACCTG CTAATGGAAG AGTACATGGG GGACACTGAG 
GATGCCCAGA CCCTCCAAAT ACAGTTCACA GAGATGATGG GAGATTTCAT GTTTGTGATC 
CCTGCACTCC AAGTAGCACA TTTTCAACGC TCCCATGCCC CTGTCTACTT CTATGAGTTC 
CAACATCCAC CCAGCTACTT CAAGGATGTC AGACCACCCC ACGTGAAGGC TGACCATGCT 
GATGAGATTC CTTTTGTCTT TGCGTCCTTC TTCTGGGGCA TGAAACTTGA CTTCACTGAG 
GAGGAGGAGC TGCTGAGCAG GAGGATGATG AAGTACTGGG CCAACTTTGC ACGACATGGG 
AACCCCAACA GTGAGGGTCT ACCCTACTGG CCTGTGATGG ACCATGATGA GCAGTACCTG 
CAACTGGACA TCCAGCCTGC TGTGGGTCGA GCCCTGAAGG CTGGAAGGCT GCAGTTCTGG 
ACCAAGACTC TGCCCCAGAA GATCCAGGAG CTAAAGGCTT CTCAGGACAA GCACAGGGAG 
CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663578.1
CDS	66..1751
Translation	MTRNQLHNWLNAGFFGLLLLLIHVQGQDSPEANPIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASMFDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDSQALVRCLRGKSEAEILAINKVFKMIPAVVDGEFFPRHPKELLASEDFHPVPSIIGVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKDTAVQMMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMGDFMFVIPALQVAHFQRSHAPVYFYEFQHPPSYFKDVRPPHVKADHADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDIQPAVGRALKAGRLQFWTKTLPQKIQELKASQDKHREL

Target ORF information:

RefSeq Version	NM_145603.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus carboxylesterase 2C (Ces2c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145603.2

ORF Insert Sequence:

ATGACACGGA ACCAACTACA TAACTGGCTG AATGCTGGGT TCTTCGGGCT GCTGCTTCTT 
CTTATCCATG TGCAGGGTCA GGACTCACCA GAGGCCAACC CCATCAGAAA CACACATACA 
GGACAGATCC AAGGCAGCCT TATCCACGTG AAGGACACTA AAGCTGGTGT CCACACCTTC 
CTGGGAATCC CCTTTGCCAA ACCTCCTGTA GGACCACTGC GATTTGCACC TCCTGAGGCC 
CCTGAACCAT GGAGTGGTGT GAGAGATGGA ACTGCACATC CGGCCATGTG TCTGCAAAAT 
CTTGACATGC TGAATGAAGC AGGCCTGCCA GATATGAAAA TGATGCTGTC TTCCTTCCCT 
ATGTCTGAGG ACTGCCTGTA TCTCAACATC TACACCCCAG CCCATGCCCA TGAGGGCTCT 
AACCTGCCTG TGATGGTGTG GATCCATGGA GGTGCACTGG TTATAGGAAT GGCTTCCATG 
TTTGATGGAT CTCTATTGAC AGTCAATGAG GACTTGGTGG TTGTTACTAT CCAGTATCGT 
CTGGGTGTCC TGGGCTTTTT CAGCACTGGA GACCAGCATG CCAGAGGCAA CTGGGGATAC 
CTGGACCAAG CAGCTGCCCT ACGCTGGGTC CAGCAGAACA TCGCTCACTT TGGAGGCAAC 
CCTGACCGGG TCACTATTTT TGGCGAGTCT GCAGGTGGCA CAAGTGTGTC TTCACATGTT 
GTGTCCCCCA TGTCCCAAGG GCTCTTCCAT GGTGCCATCA TGGAGAGTGG GGTGGCCCTG 
CTTCCTGACC TTATCTCTGA AACCTCTGAG ATGGTTTCCA CTACGGTGGC CAAGCTTTCT 
GGATGTGAGG CTATGGATTC CCAGGCCCTG GTGCGCTGTC TGAGAGGCAA AAGTGAAGCA 
GAGATTCTGG CTATTAACAA GGTCTTCAAG ATGATCCCTG CTGTGGTGGA TGGGGAGTTC 
TTCCCCAGGC ATCCCAAAGA GTTGTTGGCA TCTGAGGATT TTCACCCTGT CCCCAGCATC 
ATTGGTGTCA ACAATGATGA GTTTGGCTGG TCCATTCCTG TGGTCATGGG CTCTGCTCAG 
ATGATAAAAG GAATAACCAG AGAGAACCTG CAGGCTGTTC TGAAGGATAC AGCAGTACAA 
ATGATGCTGC CTCCTGAGTG TAGTGACCTG CTAATGGAAG AGTACATGGG GGACACTGAG 
GATGCCCAGA CCCTCCAAAT ACAGTTCACA GAGATGATGG GAGATTTCAT GTTTGTGATC 
CCTGCACTCC AAGTAGCACA TTTTCAACGC TCCCATGCCC CTGTCTACTT CTATGAGTTC 
CAACATCCAC CCAGCTACTT CAAGGATGTC AGACCACCCC ACGTGAAGGC TGACCATGCT 
GATGAGATTC CTTTTGTCTT TGCGTCCTTC TTCTGGGGCA TGAAACTTGA CTTCACTGAG 
GAGGAGGAGC TGCTGAGCAG GAGGATGATG AAGTACTGGG CCAACTTTGC ACGACATGGG 
AACCCCAACA GTGAGGGTCT ACCCTACTGG CCTGTGATGG ACCATGATGA GCAGTACCTG 
CAACTGGACA TCCAGCCTGC TGTGGGTCGA GCCCTGAAGG CTGGAAGGCT GCAGTTCTGG 
ACCAAGACTC TGCCCCAGAA GATCCAGGAG CTAAAGGCTT CTCAGGACAA GCACAGGGAG 
CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
Proceedings of the National Academy of Sciences of the United States of America114(8)E1432-E1440(2017 02)
Chen S,Lu W,Yueh MF,Rettenmeier E,Liu M,Auwerx J,Yu RT,Evans RM,Wang K,Karin M,Tukey RH

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
Mammalian genome : official journal of the International Mammalian Genome Society21(9-10)427-41(2010 Oct)
Holmes RS,Wright MW,Laulederkind SJ,Cox LA,Hosokawa M,Imai T,Ishibashi S,Lehner R,Miyazaki M,Perkins EJ,Potter PM,Redinbo MR,Robert J,Satoh T,Yamashita T,Yan B,Yokoi T,Zechner R,Maltais LJ

Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice.
Toxicology letters192(3)395-401(2010 Feb)
Ahowesso C,Piccolo E,Li XM,Dulong S,Hossard V,La Sorda R,Filipski E,Tinari N,Delaunay F,Iacobelli S,L?vi F

A new class of mammalian carboxylesterase CES6.
Comparative biochemistry and physiology. Part D, Genomics & proteomics4(3)209-17(2009 Sep)
Holmes RS,Cox LA,Vandeberg JL

Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver.
Drug metabolism and disposition: the biological fate of chemicals37(9)1819-25(2009 Sep)
Zhu HJ,Appel DI,Jiang Y,Markowitz JS

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Ces2c cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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