Neil3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Neil3
Entrez Gene ID	234258
Full Name	nei like 3 (E. coli)
Synonyms	AI449477,BC034753,C85903
General protein information	Preferred Names nei like 3 (E. coli) Names endonuclease 8-like 3 DNA glycosylase FPG2 DNA glycosylase/AP lyase Neil3 endonuclease VIII-like 3 nei endonuclease VIII-like 3 nei-like protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 B1.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_146208.2	NP_666320.1	endonuclease 8-like 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NEIL3	XP_526741.2
Mus musculus (house mouse)	Neil3	NP_666320.1
Canis lupus familiaris (dog)	NEIL3	XP_532852.3
Danio rerio (zebrafish)	neil3	NP_001007336.1
Gallus gallus (chicken)	NEIL3	XP_426306.3
Homo sapiens (human)	NEIL3	NP_060718.2
	NEIL3	XP_001090459.1
Bos taurus (cattle)	NEIL3	NP_001029662.1
Rattus norvegicus (Norway rat)	Neil3	NP_001163817.1
Xenopus tropicalis (tropical clawed frog)	neil3	NP_001017201.1

Gene Ontology
Bibliography

Related articles in PubMed

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, ?gaard JDS, Ohm IK, Slupphaug G, Ku?nierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, ?stlie I, Klungland A, Christensen G, Sjaastad I, S?trom P, Yndestad A, Aukrust P, Bj?r?s M, Finsen AV
Cell reports18(1)82-92(2017 01)

Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Jalland CM, Scheffler K, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bj?r?s M, Tranulis MA
Scientific reports637844(2016 Nov)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
Massaad MJ, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, Glauzy S, Olson BG, Morbach H, Ohsumi TK, Schmitz K, Kyriacos M, Kane J, Torisu K, Nakabeppu Y, Notarangelo LD, Chouery E, Megarbane A, Kang PB, Al-Idrissi E, Aldhekri H, Meffre E, Mizui M, Tsokos GC, Manis JP, Al-Herz W, Wallace SS, Geha RS
The Journal of clinical investigation126(11)4219-4236(2016 Nov)

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, ?stlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bj?rndal B, Svardal AM, Iversen PO, Hedin U, Nyg?rd S, Olstad OK, Krohg-S?rensen K, Slupphaug G, Eide L, Ku?nierczyk A, Folkersen L, Ueland T, Berge RK, Hansson GK, Biessen EA, Halvorsen B, Bj?r?s M, Aukrust P
Scientific reports628337(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NEIL3-dependent modulation of DNA methylation regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction.
Title: NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.

These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity.
Title: Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

one role for Neil3 and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.
Title: Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.

Our data support the involvement of Neil3 in removal of replication blocks in proliferating cells.
Title: Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress.

Structural insight into the substrate specificity and marked preference of Neil3 for ssDNA.
Title: Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA.

The following Neil3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Neil3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12321	NM_146208.2 Latest version!	Mus musculus nei like 3 (E. coli) (Neil3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$356.30 $509.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Neil3 ( NM_146208.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666320.1 Mus musculus nei like 3 (E. coli) (Neil3), mRNA.

Price & Availability↑

CloneID	OMu12321
Clone ID Related Accession (Same CDS sequence)	NM_146208.2
Accession Version	NM_146208.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Mus musculus(house mouse)
Product	endonuclease 8-like 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC108413.4, AK031027.1, DV646606.1, AI510383.1, BF714694.1 and BF714693.1. On Aug 25, 2009 this sequence version replaced NM_146208.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034753.1, AB072931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGAAG GGCCAGGGTG TACACTGAAT GGAGAGAAGA TCCGGGCACG AGTGCTACCG 
GGGCAGGCGG TGACTGGTGT GCGGGGCACA GCTCTGCAGA GCCTCCTGGG CCCTGCCATG 
TCCCCTGCCG CCTCCCTGGC TGATGTCGCT ACCTCGGCTG CTCCAATGAA TGCTAAGGAT 
TCTGGCTGGA AACTCTTGAG ACTGTTTAAT GGATATGTTT ACAGTGGCGT GGAAACCTTA 
GGGAAGGAGC TGTTTATGTA CTTTGGCCCC AGAGCTTTAC GGATTCATTT CGGAATGAAA 
GGCTCCATCT TGATTAACCC ACGGGAGGGT GAGAACAGAG CTGGGGCTTC TCCAGCCTTG 
GCGGTGCAGC TCACCAGAGA CTTGATCTGC TTCTATGACT CTTCAGTAGA ACTCAGAAAT 
TCGGTGGAAA GCCAACAGAG AGTCAGAGTG ATGGAAGAGT TGGATATATG TTCACCAAAG 
TTCAGTTTCT CAAGAGCAGA GAGTGAAGTG AAAAAGCAGG GAGATCGGAT GCTGTGTGAT 
GTGTTGCTGG ATCAGAGGGT GTTGCCTGGC GTGGGCAACA TCATCAAAAA TGAAGCACTC 
TTTGACAGTG GTCTTCATCC GGCTGTTAAG GTGTGTCAAC TATCAGACAA ACAGGCCTGT 
CACCTTGTGA AGATGACTCG GGATTTCAGC ATTCTCTTCT ACAGGTGCTG TAAAGCAGGA 
TCTGCCATTT CTAAACACTG TAAGGTTTAC AAGCGTCCTA ACTGTGATCA GTGCCACAGC 
AAAATTACTG TGTGTCGCTT TGGGGAGAAC AGCAGGATGA CATATTTCTG TCCTCACTGT 
CAGAAAGAAA ACCCTCAATG TGTTCAAGTA TGCCAGCTGC CAACAAGAAA CACTGAAATC 
AGCTGGACTC CTAGGGGAGA GGATTGCTTT ACGGACTCAG TGGCTCGGAA GTCTGAAGAG 
CAGTGGTCCT GTGTGGTTTG TACTCTCATA AACAGACCCT CGGCTAAGGC CTGTGATGCT 
TGCTTGACCA CAAGGCCTCT GGATTCAGTG CTCAAGAATA GAGAAAATTC CATTGCCTTC 
AACAACTTAG TGAAGTACCC TTGTAATAAC TTTGAGAACA CACACACTGA AGTAAAGATC 
AACAGGAAAA CTGCGTTTGG AAATACGACC CTTGTTTTGA CTGATTTAAG CAATAAATCC 
AGTGCTTTGG CCAGAAAGAA AAGAGCAAAC CACACAATAG ATGGGGAATC TCAAATGTTT 
CTCCCTACAG ACATAGGTTT TAGTGATTCA CAGCACCCCT CCAAAGAAGG AATAAACTAT 
ATAACTCAAC CATCCAATAA GGTAAACATA TCACCTACAG TTTGTGCCCA GTCTAAATTA 
TTTAGTTCAG CACATAAAAA ATTCAAACCA GCTCACACTT CTGCAACAGA ACTTAAAAGT 
TACAACTCTG GACTTTCTAA CAGTGAACTC CAAACCAATA GGACACGTGG CCATCATTCC 
AAAAGTGATG GCAGCCCTCT GTGCAAGATG CACCACCGCC GTTGTGTTCT CCGAGTTGTG 
AGGAAAGATG GAGAAAACAA GGGGAGGCAG TTTTATGCCT GTTCTCTGCC GAGAGGAGCA 
CAGTGCGGAT TTTTTGAATG GGCAGACCTG TCCTTCCCGT TCTGCAGACA TGGCAAGCGC 
TCCATTATGA AAACTGTGCT GAAGATTGGA CCTAATAATG GGAAGAATTT TTTTGTATGT 
CCTTTGGAGA AAAAAAAGCA GTGTAATTTT TTCCAGTGGG CCGAAAATGG ACCAGGAATG 
GAAATTGTTC CAGGATGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666320.1
CDS	155..1975
Translation	MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALQSLLGPAMSPAASLADVATSAAPMNAKDSGWKLLRLFNGYVYSGVETLGKELFMYFGPRALRIHFGMKGSILINPREGENRAGASPALAVQLTRDLICFYDSSVELRNSVESQQRVRVMEELDICSPKFSFSRAESEVKKQGDRMLCDVLLDQRVLPGVGNIIKNEALFDSGLHPAVKVCQLSDKQACHLVKMTRDFSILFYRCCKAGSAISKHCKVYKRPNCDQCHSKITVCRFGENSRMTYFCPHCQKENPQCVQVCQLPTRNTEISWTPRGEDCFTDSVARKSEEQWSCVVCTLINRPSAKACDACLTTRPLDSVLKNRENSIAFNNLVKYPCNNFENTHTEVKINRKTAFGNTTLVLTDLSNKSSALARKKRANHTIDGESQMFLPTDIGFSDSQHPSKEGINYITQPSNKVNISPTVCAQSKLFSSAHKKFKPAHTSATELKSYNSGLSNSELQTNRTRGHHSKSDGSPLCKMHHRRCVLRVVRKDGENKGRQFYACSLPRGAQCGFFEWADLSFPFCRHGKRSIMKTVLKIGPNNGKNFFVCPLEKKKQCNFFQWAENGPGMEIVPGC

Target ORF information:

RefSeq Version	NM_146208.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nei like 3 (E. coli) (Neil3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146208.2

ORF Insert Sequence:

ATGGTGGAAG GGCCAGGGTG TACACTGAAT GGAGAGAAGA TCCGGGCACG AGTGCTACCG 
GGGCAGGCGG TGACTGGTGT GCGGGGCACA GCTCTGCAGA GCCTCCTGGG CCCTGCCATG 
TCCCCTGCCG CCTCCCTGGC TGATGTCGCT ACCTCGGCTG CTCCAATGAA TGCTAAGGAT 
TCTGGCTGGA AACTCTTGAG ACTGTTTAAT GGATATGTTT ACAGTGGCGT GGAAACCTTA 
GGGAAGGAGC TGTTTATGTA CTTTGGCCCC AGAGCTTTAC GGATTCATTT CGGAATGAAA 
GGCTCCATCT TGATTAACCC ACGGGAGGGT GAGAACAGAG CTGGGGCTTC TCCAGCCTTG 
GCGGTGCAGC TCACCAGAGA CTTGATCTGC TTCTATGACT CTTCAGTAGA ACTCAGAAAT 
TCGGTGGAAA GCCAACAGAG AGTCAGAGTG ATGGAAGAGT TGGATATATG TTCACCAAAG 
TTCAGTTTCT CAAGAGCAGA GAGTGAAGTG AAAAAGCAGG GAGATCGGAT GCTGTGTGAT 
GTGTTGCTGG ATCAGAGGGT GTTGCCTGGC GTGGGCAACA TCATCAAAAA TGAAGCACTC 
TTTGACAGTG GTCTTCATCC GGCTGTTAAG GTGTGTCAAC TATCAGACAA ACAGGCCTGT 
CACCTTGTGA AGATGACTCG GGATTTCAGC ATTCTCTTCT ACAGGTGCTG TAAAGCAGGA 
TCTGCCATTT CTAAACACTG TAAGGTTTAC AAGCGTCCTA ACTGTGATCA GTGCCACAGC 
AAAATTACTG TGTGTCGCTT TGGGGAGAAC AGCAGGATGA CATATTTCTG TCCTCACTGT 
CAGAAAGAAA ACCCTCAATG TGTTCAAGTA TGCCAGCTGC CAACAAGAAA CACTGAAATC 
AGCTGGACTC CTAGGGGAGA GGATTGCTTT ACGGACTCAG TGGCTCGGAA GTCTGAAGAG 
CAGTGGTCCT GTGTGGTTTG TACTCTCATA AACAGACCCT CGGCTAAGGC CTGTGATGCT 
TGCTTGACCA CAAGGCCTCT GGATTCAGTG CTCAAGAATA GAGAAAATTC CATTGCCTTC 
AACAACTTAG TGAAGTACCC TTGTAATAAC TTTGAGAACA CACACACTGA AGTAAAGATC 
AACAGGAAAA CTGCGTTTGG AAATACGACC CTTGTTTTGA CTGATTTAAG CAATAAATCC 
AGTGCTTTGG CCAGAAAGAA AAGAGCAAAC CACACAATAG ATGGGGAATC TCAAATGTTT 
CTCCCTACAG ACATAGGTTT TAGTGATTCA CAGCACCCCT CCAAAGAAGG AATAAACTAT 
ATAACTCAAC CATCCAATAA GGTAAACATA TCACCTACAG TTTGTGCCCA GTCTAAATTA 
TTTAGTTCAG CACATAAAAA ATTCAAACCA GCTCACACTT CTGCAACAGA ACTTAAAAGT 
TACAACTCTG GACTTTCTAA CAGTGAACTC CAAACCAATA GGACACGTGG CCATCATTCC 
AAAAGTGATG GCAGCCCTCT GTGCAAGATG CACCACCGCC GTTGTGTTCT CCGAGTTGTG 
AGGAAAGATG GAGAAAACAA GGGGAGGCAG TTTTATGCCT GTTCTCTGCC GAGAGGAGCA 
CAGTGCGGAT TTTTTGAATG GGCAGACCTG TCCTTCCCGT TCTGCAGACA TGGCAAGCGC 
TCCATTATGA AAACTGTGCT GAAGATTGGA CCTAATAATG GGAAGAATTT TTTTGTATGT 
CCTTTGGAGA AAAAAAAGCA GTGTAATTTT TTCCAGTGGG CCGAAAATGG ACCAGGAATG 
GAAATTGTTC CAGGATGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports18(1)82-92(2017 01)
Olsen MB,Hildrestrand GA,Scheffler K,Vinge LE,Alfsnes K,Palibrk V,Wang J,Neurauter CG,Luna L,Johansen J,?gaard JDS,Ohm IK,Slupphaug G,Ku?nierczyk A,Fiane AE,Brorson SH,Zhang L,Gullestad L,Louch WE,Iversen PO,?stlie I,Klungland A,Christensen G,Sjaastad I,S?trom P,Yndestad A,Aukrust P,Bj?r?s M,Finsen AV

Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Scientific reports637844(2016 Nov)
Jalland CM,Scheffler K,Benestad SL,Moldal T,Ersdal C,Gunnes G,Suganthan R,Bj?r?s M,Tranulis MA

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation126(11)4219-4236(2016 Nov)
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Scientific reports628337(2016 Jun)
Skarpengland T,Holm S,Scheffler K,Gregersen I,Dahl TB,Suganthan R,Segers FM,?stlie I,Otten JJ,Luna L,Ketelhuth DF,Lundberg AM,Neurauter CG,Hildrestrand G,Skjelland M,Bj?rndal B,Svardal AM,Iversen PO,Hedin U,Nyg?rd S,Olstad OK,Krohg-S?rensen K,Slupphaug G,Eide L,Ku?nierczyk A,Folkersen L,Ueland T,Berge RK,Hansson GK,Biessen EA,Halvorsen B,Bj?r?s M,Aukrust P

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Neil3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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